期刊
ANNUAL REVIEW OF BIOPHYSICS, VOL 47
卷 47, 期 -, 页码 595-616出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biophys-062215-010954
关键词
fluctuations; navigation; signal transduction; single-cell behavior; chemical sensing; adaptation
类别
资金
- NIGMS NIH HHS [R01 GM106189] Funding Source: Medline
Living cells detect and process external signals using signaling pathways that are affected by random fluctuations. These variations cause the behavior of individual cells to fluctuate over time (behavioral variability) and generate phenotypic differences between genetically identical individuals (phenotypic diversity). These two noise sources reduce our ability to predict biological behavior because they diversify cellular responses to identical signals. Here, we review recent experimental and theoretical advances in understanding the mechanistic origin and functional consequences of such variation in Escherichia coli chemotaxis-a well-understood model of signal transduction and behavior. After briefly summarizing the architecture and logic of the chemotaxis system, we discuss determinants of behavior and chemotactic performance of individual cells. Then, we review how cell-to-cell differences in protein abundance map onto differences in individual chemotactic abilities and how phenotypic variability affects the performance of the population. We conclude with open questions to be addressed by future research.
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