Article
Biology
Giovanni Messina, Yuri Prozzillo, Francesca Delle Monache, Maria Virginia Santopietro, Patrizio Dimitri
Summary: The subunits of the SRCAP and p400/Tip60 chromatin remodeling complexes relocate from chromatin to the mitotic apparatus during cell division, playing crucial roles in the proper execution of cell division.
Review
Biochemistry & Molecular Biology
Yuri Prozzillo, Maria Virginia Santopietro, Giovanni Messina, Patrizio Dimitri
Summary: This review article focuses on the unconventional roles of epigenetic players, including chromatin remodelers and long non-coding RNAs, in cell division. The study highlights their impact on differentiation, development, and diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Chemistry, Analytical
Leicheng Zhang, Tengfei Xu, Jingtao Zhang, Stephen Choong Chee Wong, Mark Ritchie, Han Wei Hou, Yulan Wang
Summary: The study proposes a novel strategy integrating spiral inertial microfluidics and ion mobility mass spectrometry for single-cell metabolite detection and identification. The technology successfully screened the metabolic profiles of different types of cancer cells, improving confidence in metabolite identification. This approach offers a simple and efficient method for single-cell lipid profiling, with additional ion mobility separation significantly enhancing the confidence toward identification of metabolites.
ANALYTICAL CHEMISTRY
(2021)
Editorial Material
Cell Biology
Jessica N. Little, Noelle D. Dwyer
Summary: Abscission, the second stage of cytokinesis, is thought to be completed by the recruitment of ESCRTs by the coiled-coil protein Cep55. Recent studies with Cep55-knockout mice show that most cells can still complete abscission without Cep55, indicating the need for further research on abscission mechanisms in different cell types.
TRENDS IN CELL BIOLOGY
(2021)
Review
Oncology
Valentina Lodde, Rodrigo Garcia Barros, Laura Terzaghi, Federica Franciosi, Alberto Maria Luciano
Summary: This review highlights the emerging role of PGRMC1 in cell division, particularly in mitosis. Due to limited research on PGRMC1, there is still much to be explored regarding its function and mechanisms in cell division.
Article
Cell Biology
Ella F. J. Halcrow, Riccardo Mazza, Anna Diversi, Anton Enright, Pier Paolo D'Avino
Summary: This study investigates the temporal and spatial profiles of midbody proteins during mitotic exit, revealing two distinct classes of midbody proteins. The results highlight the importance of ubiquitination and phosphorylation in the dynamics and stability of midbody proteins during cytokinesis.
Article
Cell Biology
James Glover, Edward J. Scourfield, Leandro N. Ventimiglia, Xiaoping Yang, Steven Lynham, Monica Agromayor, Juan Martin-Serrano
Summary: This study reveals that UMAD1 is an important component in the process of cytokinetic abscission, facilitating the final stage of cell division by interacting with ESCRT-I.
JOURNAL OF CELL SCIENCE
(2023)
Review
Multidisciplinary Sciences
Isaac Asante, Stan Louie, Hussein N. Yassine
Summary: This review examines the impact of the APOE4 allele on brain lipid remodeling and chronic inflammation in Alzheimer's disease. The authors focus on the activation of cPLA2 by APOE4 and its effects on brain signaling pathways involving arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ji Eun Yu, Sun-Ok Kim, Jeong-Ah Hwang, Jin Tae Hong, Joonsung Hwang, Nak-Kyun Soung, Hyunjoo Cha-Molstad, Yong Tae Kwon, Bo Yeon Kim, Kyung Ho Lee
Summary: The study identifies a novel p-S60 epitope on beta-catenin generated by Plk1 kinase activity, which is crucial for the completion of cytokinesis. Depletion of beta-catenin leads to cytokinesis-defective phenotypes and apoptotic cell death, highlighting the importance of beta-catenin phosphorylation in cell division.
Article
Biology
Giovanni Messina, Yuri Prozzillo, Francesca Delle Monache, Maria Virginia Santopietro, Maria Teresa Atterrato, Patrizio Dimitri
Summary: The study found that the SRCAP protein plays previously undetected roles in cell division, associating with components of the mitotic apparatus and regulating cytokinesis. Depletion of SRCAP affects both mitosis and cytokinesis, suggesting an evolutionarily conserved role in cell division independent of its chromatin regulation functions. This surprising discovery indicates that alterations in cell division caused by SRCAP mutations may contribute to the development of Floating-Harbor syndrome.
Article
Developmental Biology
Sreelaja Nair, Elaine L. Welch, Cara E. Moravec, Ryan L. Trevena, Christina L. Hansen, Francisco Pelegri
Summary: We demonstrate that the zebrafish maternal-effect mutation too much information (tmi) corresponds to zebrafish prc1-like (prc1l), which encodes a member of the microtubule-associated proteins. Maternal Prc1l plays a crucial role in midbody formation and vegetal pole microtubule reorganization during cell division at the egg-to-embryo transition. These findings highlight the importance of maternal Prc1l for embryonic pattern formation and cell division.
Review
Oncology
Valentina Fragliasso, Annalisa Tameni, Giorgio Inghirami, Valentina Mularoni, Alessia Ciarrocchi
Summary: Defects in cytoskeleton functions play a crucial role in tumorigenesis by promoting aberrant proliferation, migratory behavior, and invasive features. Research has shown significant alterations targeting the cytoskeleton in peripheral T cell lymphomas (PTCL), indicating its importance in malignant cell division. Aberrant signaling pathways such as JAK/STAT3, NPM-ALK, RhoGTPase, and Aurora Kinase also contribute to lymphomagenesis by modifying the structure and signaling properties of the cytoskeleton.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Megan E. Bischoff, Yuanwei Zang, Johnson Chu, Adam D. Price, Birgit Ehmer, Nicholas J. Talbot, Michael J. Newbold, Anurag Paul, Jun-Lin Guan, David R. Plas, Jarek Meller, Maria F. Czyzyk-Krzeska
Summary: The canonical protein LC3C, present only in higher primates and humans, plays a role in suppressing tumor growth. LC3C-selective autophagy requires the involvement of noncanonical upstream regulatory complexes and targets postdivision midbody rings (PDMBs) involved in cancer stem-cell regulation. The C-terminal peptide of LC3C is crucial for mediating the selective degradation of PDMBs in a human-specific autophagic program relevant to cancer stem cells.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Cell Biology
Jordan M. Barrows, Erin D. Goley
Summary: Bacterial cell division is coordinated by the divisome, with FtsZ playing a central role. Recent studies have shown that the dynamics of FtsZ are regulated by intrinsic properties of FtsZ and the membrane anchoring protein FtsA. While FtsZ dynamics are broadly required for Z-ring assembly, their role during constriction may vary among bacterial species.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marcela Konjevod, Jorge Saiz, Matea Nikolac Perkovic, Gordana Nedic Erjavec, Lucija Tudor, Suzana Uzun, Oliver Kozumplik, Coral Barbas, Neven Zarkovic, Nela Pivac, Dubravka Svob Strac
Summary: Posttraumatic stress disorder (PTSD) is a complex neuropsychiatric disorder triggered by a traumatic event. This study used lipidomic analysis to identify altered lipid compounds in PTSD patients. The identified lipids are associated with biological processes such as membrane integrity and function, mitochondrial dysfunction, inflammation, and oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Editorial Material
Biochemistry & Molecular Biology
John A. Gerlt
Article
Multidisciplinary Sciences
Stephen J. Terry, Federico Dona, Paul Osenberg, Jeremy G. Carlton, Ulrike S. Eggert
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Chemistry, Multidisciplinary
Elisabeth M. Storck, Julia Morales-Sanfrutos, Remigiusz A. Serwa, Nattawadee Panyain, Thomas Lanyon-Hogg, Tanya Tolmachova, Leandro N. Ventimiglia, Juan Martin-Serrano, Miguel C. Seabra, Beata Wojciak-Stothard, Edward W. Tate
Article
Biochemical Research Methods
Cagakan Ozbalci, Elisabeth M. Storck, Ulrike S. Eggert
Review
Cell Biology
Jeremy G. Carlton, Hannah Jones, Ulrike S. Eggert
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Matteo Vietri Rudan, Ajay Mishra, Christian Klose, Ulrike S. Eggert, Fiona M. Watt
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Lisa Watson, Tanya N. Soliman, Khalil Davis, Joanna Kelly, Nicola Lockwood, Xiaoping Yang, Steven Lynham, John D. Scott, Victoria Crossland, Neil Q. McDonald, David J. Mann, Alan Armstrong, Ulrike Eggert, Peter J. Parker
Summary: The study elucidates the role of PKC-ε in exiting from the abscission checkpoint. Assembly of the 14-3-3 complex and phosphorylation of Aurora B S227 are directly linked to the activity-dependent enrichment of PKC-ε at the midbody, with 14-3-3 association shown to be unnecessary for PKC-ε control.
BIOCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Sioned F. Jones, Himanshu Joshi, Stephen J. Terry, Jonathan R. Burns, Aleksei Aksimentiev, Ulrike S. Eggert, Stefan Howorka
Summary: Equipping DNA with hydrophobic anchors enables targeted interaction with lipid bilayers for various applications. Through experiments and molecular dynamics simulations, the study reveals the complex structure and energetics of hydrophobically tagged DNA within lipid membranes. Fundamental insight gained on DNA-bilayer interactions will guide the rational design of membrane-targeting nanostructures.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Federico Dona, Cagakan Ozbalci, Andrea Paquola, Federica Ferrentino, Stephen J. Terry, Elisabeth M. Storck, Gaoge Wang, Ulrike S. Eggert
Summary: The membrane protein stomatin is found to be involved in the cytokinesis step of cell division, even though it is not a lipid biosynthetic enzyme. Depletion of stomatin leads to changes in cellular lipidomes, and exogenous phosphatidylcholines can rescue these defects.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
Struan Bourke, Federico Dona, Yurema Teijeiro Gonzalez, Basma Qazi Chaudhry, Maryna Panamarova, Eirinn Mackay, Peter S. Zammit, Lea Ann Dailey, Ulrike S. Eggert, Klaus Suhling, Mark A. Green
Summary: This study reports the encapsulation of a bright-red-emitting conjugated polymer and superparamagnetic iron oxide nanoparticles in polymer micelles. The resulting particles exhibited good emission properties and cellular uptake, making them potentially valuable for in vivo labeling applications.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Struan Bourke, Yurema Teijeiro Gonzalez, Federico Dona, Maryna Panamarova, Klaus Suhling, Ulrike Eggert, Lea Ann Dailey, Peter Zammit, Mark A. Green