Article
Dentistry, Oral Surgery & Medicine
Hengameh Bakhtiar, Sarah Rajabi, Mohammad Pezeshki-Modaress, Mohammad Reza Ellini, Mahsa Panahinia, Solmaz Alijani, Amir Mazidi, Amir Kamali, Amir Azarpazhooh, Anil Kishen
Summary: The study aimed to characterize the effects of various decellularization protocols on bovine dental pulp ECM. Results showed successful decellularization in all groups, with protocol P7 (12E-0S-1T) demonstrating the highest retention of glycosaminoglycan and minimal DNA content. Overall, the tested treatments hold potential for producing xenogeneic dental pulp ECM scaffolds, with P7 being a promising option due to its minimal structural damage and acceptable host immune response.
JOURNAL OF ENDODONTICS
(2021)
Article
Biochemistry & Molecular Biology
Monica Cicuendez, Laura Casarrubios, Maria Jose Feito, Iratxe Madarieta, Nerea Garcia-Urkia, Olatz Murua, Beatriz Olalde, Nerea Briz, Rosalia Diez-Orejas, Maria Teresa Portoles
Summary: The study investigated the impact of decellularized ECM obtained from human and porcine adipose tissue on macrophage phenotypes and fungal phagocytosis. Results revealed that porcine DAMs promote an M2 phenotype, regardless of the decellularization method used. Biochemical characterization of the biomaterials and proteomic analysis provided insights into the correlation between ECM composition and macrophage function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Ifeolu Akinnola, Daniel R. Rossi, Carolyn Meyer, Ashley Lindsey, Douglas R. Haase, Samuel Fogas, Michael J. Ehrhardt, Rachel E. Blue, Andrew P. Price, Max Johnson, Diego F. Alvarez, Doris A. Taylor, Angela Panoskaltsis-Mortari
Summary: This study evaluated the recellularization of blood vessel conduits of acellular lung scaffolds with different types of endothelial cells, showing that RMEPCs have the capability to repopulate all vascular segments, while PAECs and MVECs exhibit selective tropism for larger vessels or microvasculature, respectively. The RMEPC phenotype described in the study could be valuable for identifying suitable endothelial progenitors for efficient vascular organ and tissue engineering, regeneration, and repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Qian Zhang, Yixin Hu, Xuan Long, Lingling Hu, Yu Wu, Ji Wu, Xiaobing Shi, Runqi Xie, Yu Bi, Fangyuan Yu, Pinxue Li, Yu Yang
Summary: Cartilage regeneration relies on cellular-ECM interactions. Traditional tissue engineering methods have not been able to replicate the physiological structure of natural cartilage, but recent advances in ECM-based scaffolds show promise in improving cartilage regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell & Tissue Engineering
Sara Reis Moura, Jaime Freitas, Claudia Ribeiro-Machado, Jorge Lopes, Nuno Neves, Helena Canhao, Ana Maria Rodrigues, Mario Adolfo Barbosa, Maria Ines Almeida
Summary: This study decodes the regulatory network of the lncRNA H19 on the extracellular matrix (ECM) and reveals its impact on bone regeneration. Inhibition of H19 expression results in decreased ECM density and collagen content, and promotes adipogenic differentiation of bone marrow-derived stem cells. Furthermore, H19 is targeted by miR-29c, which is downregulated in osteoporotic bone tissue and affects MSC proliferation and collagen production. These findings suggest that H19 is a potential therapeutic target for controlling cell behavior and engineering the bone ECM.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Ali Doryab, Otmar Schmid
Summary: Chronic lung diseases are a leading cause of death worldwide, and lung transplantation is currently the only treatment option but limited by donor availability. Lung tissue engineering offers a promising approach to regenerate damaged lung tissue. Researchers have developed an extracellular matrix-integrated scaffold that closely mimics the microenvironment of lung cells and shows potential for lung tissue engineering applications.
Article
Engineering, Biomedical
Ming Pei, Yixuan Amy Pei, Sheng Zhou, Elmira Mikaeiliagah, Christopher Erickson, Benjamin Giertych, Halima Akhter, Lei Wang, Amanda Stewart, Joshua Parenti, Bin Wang, Sijin Wen, Sotcheadt Sim, Eric Quenneville, Kirk C. Hansen, Steven Frisch, Gangqing Hu
Summary: Articular cartilage has limited self-healing capacity. Tissue-specific stem cells can be used for cartilage regeneration, but ex vivo expansion leading to cell senescence is a challenge. Cell-derived extracellular matrix (C-dECM) has been shown to rejuvenate stem cells and promote cartilage regeneration. In this study, the authors evaluated the rejuvenation of rabbit stem cells by C-dECM in both ex vivo and in vivo models, and identified potential cellular and molecular mechanisms involved.
BIOACTIVE MATERIALS
(2023)
Article
Microbiology
Monica Cicuendez, Laura Casarrubios, Maria Jose Feito, Iratxe Madarieta, Nerea Garcia-Urkia, Olatz Murua, Beatriz Olalde, Nerea Briz, Rosalia Diez-Orejas, Maria Teresa Portoles
Summary: The study focused on the effects of human and porcine decellularized adipose matrices (DAMs) on the interaction between macrophages and Candida albicans. Differences in macrophage activation and morphological changes were observed when cultured on different DAMs, highlighting the influence of the extracellular matrix on macrophage response to fungal pathogens. This work contributes to understanding how ECM components can affect macrophage metabolism, immune function, and response to the microenvironment during an infection scenario.
Article
Polymer Science
Huynh-Quang-Dieu Nguyen, Chen-Yu Kao, Chien-Ping Chiang, Yu-Han Hung, Chun-Min Lo
Summary: This study investigates the immunomodulatory properties of extracellular matrix (ECM) and mesenchymal stem cells (MSCs). The results show that degradation products from porcine bladder ECM can reduce inflammation and increase the production of anti-inflammatory cytokines from macrophages. MSCs cultured on the ECM hydrogel demonstrate immunomodulatory properties at both gene and protein levels. The findings provide a basis for further research on immunomodulation therapy.
Article
Engineering, Biomedical
Daniela Trindade, Nuno Alves, Carla Moura
Summary: Research on tissue-engineered materials for TMJ disc replacement is crucial, with decellularization showing great potential, but its application to the TMJ disc is still being studied. Current literature has gaps in characterisation, which is crucial for success.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Review
Biochemistry & Molecular Biology
JamesD Melrose
Summary: This study aimed to explore the recent developments in neural repair by using hyaluronan as a carrier of olfactory bulb stem cells and new bioscaffolds. Hyaluronan interacts with hyalectan proteoglycans in the brain to protect neurons and promote synaptic plasticity. Special stem cell niches called fractones migrate to the olfactory bulb from the dentate gyrus of the hippocampus, and these niches contain hyaluronan, perlecan, and laminin alpha 5, which regulate the activity of stem cells and aid in their participation in neural repair processes. Significant improvement in spinal cord injury and brain trauma repair has been achieved using this approach, and further advancements are expected with the use of recombinant perlecan domain I and domain V.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Xiaopeng Zhou, Ning Shen, Yiqing Tao, Jingkai Wang, Kaishun Xia, Liwei Ying, Yuang Zhang, Xianpeng Huang, Jianming Hua, Chengzhen Liang, Qixin Chen, Fangcai Li
Summary: In this study, nucleus pulposus cells (NPCs) were aggregated into pellets and NPC-derived efficient microcarriers (NPCMs) were fabricated by optimized decellularization. The injectable NPCMs exhibited good biostability and no cytotoxicity. In vitro experiments showed that the NPCMs promoted the NP-specific differentiation of adipose-derived stem cells (ADSCs). In vivo experiments in a rabbit model demonstrated that ADSC-loaded NPCMs partly restored degenerated nucleus pulposus.
Article
Engineering, Biomedical
Gilles S. van Tienderen, Oskar Rosmark, Ruby Lieshout, Jorke Willemse, Floor de Weijer, Linda Elowsson Rendin, Gunilla Westergren-Thorsson, Michail Doukas, Bas Groot Koerkamp, Martin E. van Royen, Luc J. W. van der Laan, Monique M. A. Verstegen
Summary: Patient-derived tumor organoids were combined with native tumor and liver scaffolds through decellularization to study the interaction between tumor cells and the extracellular matrix (ECM). The use of decellularized scaffolds resulted in a more accurate representation of the in vivo tumor environment and increased chemoresistance. This method also revealed environment-dependent proliferation dynamics and stimulated the production of collagen types.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Camila Hochman-Mendez, Fernanda C. P. Mesquita, Jacquelynn Morrissey, Ernesto Curty da Costa, Jorn Hulsmann, Karis Tang-Quan, Yutao Xi, Po-Feng Lee, Luiz C. Sampaio, Doris A. Taylor
Summary: In this study, we successfully revascularized and repopulated a large, full-thickness portion of a ventricle using human induced pluripotent stem cell-derived endothelial and cardiac cells. The histologic analysis at 60 days showed that the microanatomical organization and cellular composition of this region was similar to that of the native heart. The recellularized heart exhibited visible beating and responded appropriately to heartbeat-altering drugs.
ACTA BIOMATERIALIA
(2022)
Article
Nanoscience & Nanotechnology
My Thi Ngoc Nguyen, Ha Le Bao Tran
Summary: The study aimed to prepare injectable acellular adipose matrix (AAM) through delipidating and decellularizing, showing that mechanical disruption improved fat removal efficiency and the decellularization strategy was effective. AAM powder was non-toxic to human adipose derived stem cells and supported cell migration and proliferation.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2021)
Article
Nanoscience & Nanotechnology
Run Huang, Weiren Liu, Qinghao Zhang, Guiqi Zhu, Weifeng Qu, Chenyang Tao, Jun Gao, Yuan Fang, Xiutao Fu, Jian Zhou, Yinghong Shi, Jia Fan, Zheng Tang
Summary: In this study, biocompatible MIL-100 nanoparticles were used as an effective vehicle to deliver oxaliplatin for hepatocellular carcinoma treatment. The nanoparticles were coated with polydopamine and NH2-PEGTK-COOH and loaded with oxaliplatin to create a multi-functional system. These nanoparticles are activated in the tumor microenvironment, resulting in the release of oxaliplatin and the generation of cytotoxic reactive oxygen species. Moreover, under near-infrared irradiation, the nanoparticles can generate hyperthermia at tumor sites.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Gastroenterology & Hepatology
A-Na Liu, Cui-Fang Xu, Ya-Ru Liu, Dan-Qin Sun, Ling Jiang, Liang-Jie Tang, Pei-Wu Zhu, Sui-Dan Chen, Wen-Yue Liu, Xiao-Dong Wang, Giovanni Targher, Christopher D. D. Byrne, Vincent Wai-Sun Wong, Junfen Fu, Ming-Ming Su, Rohit Loomba, Ming-Hua Zheng, Yan Ni
Summary: This study found that in patients with NAFLD, dysregulated bile acid metabolism was associated with liver fibrosis. Serum levels of secondary bile acids were increased in patients with mild fibrosis, along with other clinical and biochemical abnormalities. Combining serum bile acids with clinical/biochemical biomarkers showed good accuracy in identifying mild fibrosis, but performed less well in identifying significant fibrosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Multidisciplinary Sciences
Lei Miao, Giovanni Targher, Christopher D. Byrne, Ming-Hua Zheng
Article
Medicine, General & Internal
Ibrahim Ayada, Laurens A. van Kleef, Huai Zhang, Kuan Liu, Pengfei Li, Yasir J. Abozaid, Marla Lavrijsen, Harry L. A. Janssen, Luc J. W. van der Laan, Mohsen Ghanbari, Maikel P. Peppelenbosch, Ming-Hua Zheng, Robert J. de Knegt, Qiuwei Pan
Summary: This study comprehensively investigated the potential benefits and mechanism-of-action of statins in relation to non-alcoholic fatty liver disease (NAFLD). The results showed that statin use was associated with a lower prevalence of NASH and fibrosis and might prevent NAFLD. This may be due to the anti-lipid and anti-inflammatory characteristics of statins.
Article
Medicine, General & Internal
Huai Zhang, Rafael S. Rios, Jerome Boursier, Rodolphe Anty, Wah-Kheong Chan, Jacob George, Yusuf Yilmaz, Vincent Wai-Sun Wong, Jiangao Fan, Jean-Francois Dufour, George Papatheodoridis, Li Chen, Joern M. Schattenberg, Junping Shi, Liang Xu, Grace Lai-Hung Wong, Naomi F. Lange, Margarita Papatheodoridi, Yuqiang Mi, Yujie Zhou, Christopher D. Byrne, Giovanni Targher, Gong Feng, Minghua Zheng
Summary: This study aimed to investigate the utility of cytokeratin-18 (CK-18) M30 concentrations as a non-invasive diagnostic tool for non-alcoholic steatohepatitis (NASH). The results showed that there was a difference in CK-18 M30 levels between NASH and non-alcoholic fatty liver (NAFL) patients, but the sensitivity and positive predictive value were not ideal. Therefore, measurement of CK-18 M30 levels alone has limited value for non-invasively diagnosing NASH.
CHINESE MEDICAL JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Clemence M. Canivet, Ming-Hua Zheng, Sami Qadri, Luisa Vonghia, Kee-Huat Chuah, Charlotte Costentin, Jacob George, Angelo Armandi, Leon A. Adams, Naomi F. Lange, Odile Blanchet, Valerie Moal, Ramy Younes, Marine Roux, Wah-Kheong Chan, Nathalie Sturm, Mohammed Eslam, Elisabetta Bugianesi, Zhengyi Wang, Jean-Francois Dufour, Sven Francque, Hannele Yki-Jaervinen, Kenneth I. Zheng, Jerome Boursier
Summary: The blood test MACK-3 is an accurate tool to improve patient selection in NASH therapeutic trials.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Rong Fan, Guanlin Li, Ning Yu, Xiujuan Chang, Tamoore Arshad, Wen-Yue Liu, Yan Chen, Grace Lai-Hung Wong, Yiyue Jiang, Xieer Liang, Yongpeng Chen, Xiao-Zhi Jin, Zheng Dong, Howard Ho-Wai Leung, Xiao-Dong Wang, Zhen Zeng, Terry Cheuk-Fung Yip, Qing Xie, Deming Tan, Shaoli You, Dong Ji, Jun Zhao, Arun J. Sanyal, Jian Sun, Ming-Hu Zheng, Vincent Wai-Sun Wong, Yongping Yang, Jinlin Hou
Summary: This study evaluated the performance of the aMAP score in diagnosing fibrosis in patients with chronic hepatitis B (CHB). The results showed that the aMAP score had higher accuracy in diagnosing cirrhosis and advanced fibrosis compared to other markers. The combination of aMAP and LSM further improved the accuracy in detecting cirrhosis and advanced fibrosis. The aMAP-LSM model had satisfactory performance in diagnosing fibrosis stage for treated CHB patients, especially those with a significant decrease in LSM after treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Grazia Pennisi, Marco Enea, Vincenzo Falco, Guruprasad P. Aithal, Naaventhan Palaniyappan, Yusuf Yilmaz, Jerome Boursier, Christophe Cassinotto, Victor de Ledinghen, Wah Kheong Chan, Sanjiv Mahadeva, Peter Eddowes, Philip Newsome, Thomas Karlas, Johannes Wiegand, Vincent Wai-Sun Wong, Joern M. Schattenberg, Christian Labenz, Won Kim, Myoung Seok Lee, Monica Lupsor-Platon, Jeremy F. L. Cobbold, Jian-Gao Fan, Feng Shen, Katharina Staufer, Michael Trauner, Rudolf Stauber, Atsushi Nakajima, Masato Yoneda, Elisabetta Bugianesi, Ramy Younes, Silvia Gaia, Ming-Hua Zheng, Calogero Camma, Quentin M. Anstee, Ferenc E. Mozes, Michael Pavlides, Salvatore Petta
Summary: This study evaluated the diagnostic accuracy of simple, noninvasive tests (NITs) in patients with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). The results showed that liver stiffness measurement (LSM) and AGILE 3+ were better at determining advanced fibrosis compared to serum tests. The evaluation of diagnostic methods for NAFLD with T2D is clinically significant.
Article
Gastroenterology & Hepatology
Xiao-Dong Zhou, Giovanni Targher, Christopher D. Byrne, Virend Somers, Seung Up Kim, C. Anwar A. Chahal, Vincent Wai-Sun Wong, Jingjing Cai, Michael D. Shapiro, Mohammed Eslam, Philippe Gabriel Steg, Ki-Chul Sung, Anoop Misra, Jian-Jun Li, Carlos Brotons, Yuli Huang, George V. Papatheodoridis, Aijun Sun, Yusuf Yilmaz, Wah Kheong Chan, Hui Huang, Nahum Mendez-Sanchez, Saleh A. Alqahtani, Helena Cortez-Pinto, Gregory Y. H. Lip, Robert J. de Knegt, Ponsiano Ocama, Manuel Romero-Gomez, Marat Fudim, Giada Sebastiani, Jang Won Son, John D. Ryan, Ignatios Ikonomidis, Sombat Treeprasertsuk, Daniele Pastori, Monica Lupsor-Platon, Herbert Tilg, Hasmik Ghazinyan, Jerome Boursier, Masahide Hamaguchi, Mindie H. Nguyen, Jian-Gao Fan, George Boon-Bee Goh, Mamun Al Mahtab, Saeed Hamid, Nilanka Perera, Jacob George, Ming-Hua Zheng
Summary: Metabolic (dysfunction)-associated fatty liver disease (MAFLD) is closely linked to cardiovascular disease (CVD), but the CVD risk is often underestimated. An international panel of experts conducted a Delphi survey to establish the association between MAFLD and CVD risk, and identified potential areas for future research.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Cell Biology
Gui-Qi Zhu, Zheng Tang, Run Huang, Wei-Feng Qu, Yuan Fang, Rui Yang, Chen-Yang Tao, Jun Gao, Xiao-Ling Wu, Hai-Xiang Sun, Yu-Fu Zhou, Shu-Shu Song, Zhen-Bin Ding, Zhi Dai, Jian Zhou, Dan Ye, Duo-Jiao Wu, Wei-Ren Liu, Jia Fan, Ying-Hong Shi
Summary: Hepatocellular carcinoma (HCC) is a type of cancer that is resistant to immunotherapy due to its high cellular heterogeneity. The heterogeneity of cancer-associated fibroblast (CAF) in HCC tumors was identified through single cell RNA sequencing. CD36(+) CAFs were found to have high-level lipid metabolism and expression of macrophage migration inhibitory factor (MIF). These cells were derived from hepatic stellate cells. CD36 mediated the expression of MIF through oxidized LDL uptake and activated the lipid peroxidation/p38/CEBPs axis in CD36(+) CAFs, which recruited myeloid-derived suppressor cells (MDSCs) in a MIF- and CD74-dependent manner. Co-implantation of CD36(+) CAFs with HCC cells promoted HCC progression in vivo. Furthermore, a CD36 inhibitor was shown to enhance the effect of anti-PD-1 immunotherapy by restoring antitumor T-cell responses in HCC.
Article
Gastroenterology & Hepatology
Ferenc E. Mozes, Jenny A. Lee, Yasaman Vali, Osama Alzoubi, Katharina Staufer, Michael Trauner, Rafael Paternostro, Rudolf E. Stauber, Adriaan G. Holleboom, Anne-Marieke van Dijk, Anne Linde Mak, Jerome Boursier, Marc de Saint Loup, Toshihide Shima, Elisabetta Bugianesi, Silvia Gaia, Angelo Armandi, Shalimar, Monica Lupsor-Platon, Vincent Wai-Sun Wong, Guanlin Li, Grace Lai-Hung Wong, Jeremy Cobbold, Thomas Karlas, Johannes Wiegand, Giada Sebastiani, Emmanuel Tsochatzis, Antonio Liguori, Masato Yoneda, Atsushi Nakajima, Hannes Hagstrom, Camilla Akbari, Masashi Hirooka, Wah-Kheong Chan, Sanjiv Mahadeva, Ruveena Rajaram, Ming-Hua Zheng, Jacob George, Mohammed Eslam, Salvatore Petta, Grazia Pennisi, Mauro Vigano, Sofia Ridolfo, Guruprasad Padur Aithal, Naaventhan Palaniyappan, Dae Ho Lee, Mattias Ekstedt, Patrik Nasr, Christophe Cassinotto, Victor de Ledinghen, Annalisa Berzigotti, Yuly P. Mendoza, Mazen Noureddin, Emily Truong, Celine Fournier-Poizat, Andreas Geier, Miljen Martic, Theresa Tuthill, Quentin M. Anstee, Stephen A. Harrison, Patrick M. Bossuyt, Michael Pavlides
Summary: Non-invasive tests show comparable prognostic performance to histologically assessed fibrosis in predicting clinical outcomes in NAFLD patients, suggesting they could be considered as alternatives to liver biopsy.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mohamed Omran, Mona Omr, Amal A. Mohamed, Reem A. Abdelghafour, Nashwa M. Muharram, Mohamed B. Hassan, Abobakrelsedik Fangry, Tarek Emran, Juan P. Arab, Jorge Arnold, Luis Antonio Diaz, Ming-Hua Zheng, Mohamed El-Kassas
Summary: The aim of this study was to develop a noninvasive test for identifying patients with NAFLD based on clinical and routine laboratory data. Elevated CRP, cholesterol, BMI, and ALT levels were significantly associated with NAFLD. The developed NAFLD test showed high diagnostic performance with an AUC of 0.92 and was validated in patients from Egypt, China, and Chile.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Gang Li, Tian-Lei Zheng, Xiao-Ling Chi, Yong-Fen Zhu, Jin-Jun Chen, Liang Xu, Jun-Ping Shi, Xiao-Dong Wang, Wei-Guo Zhao, Christopher D. Byrne, Giovanni Targher, Rafael S. Rios, Ou-Yang Huang, Liang-Jie Tang, Shi-Jin Zhang, Shi Geng, Huan-Ming Xiao, Sui-Dan Chen, Rui Zhang, Ming-Hua Zheng
Summary: The study developed a deep neural network algorithm (LEARN) based on impedance-based measurements of body composition, which can identify non-alcoholic steatohepatitis (NASH) with good discriminatory ability in the validation group.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Letter
Gastroenterology & Hepatology
Lei Miao, Herbert Tilg, Ming-Hua Zheng
Summary: Wang K. et al. introduced the concept of Microbial-Host isozymes (MHIs) and emphasized their role in mediating microbiota-host interactions. They discovered bacterial-derived DPP4 as an isoenzyme that affects glucose tolerance and demonstrated that host DPP4 inhibitors may not effectively target bacterial DPP4. By developing an MHI screen system, they identified 71 MHIs in healthy gut microbiota, among which DPP4 isozymes degrade GLP-1, explaining the variable responses to sitagliptin. This breakthrough offers new avenues for the treatment of metabolic disorders, and precise interventions in gut microbiota provide personalized approaches to metabolic diseases.
Article
Gastroenterology & Hepatology
Guoqiang Li, Lijun Zhu, Mingwei Guo, Dongmei Wang, Meiyao Meng, Yinzhao Zhong, Zhijian Zhang, Yi Lin, Caizhi Liu, Jiawen Wang, Yahui Zhang, Yining Gao, Yuxiang Cao, Zhirui Xia, Jin Qiu, Yu Li, Shuang Liu, Haibing Chen, Wenyue Liu, Yu Han, Minghua Zheng, Lingyan Xu, Xinran Ma
Summary: This study demonstrates that Foxa3 is an important regulator of liver regeneration, maintaining normal liver cell proliferation and repair by governing Cebpb transcription. It was found that pharmacological activation of Foxa3 can accelerate hepatocyte proliferation without interfering with the termination of liver regeneration. These findings contribute to a better understanding of the mechanism of liver regeneration and provide a potential therapeutic target for treating liver injury.
