期刊
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
卷 15, 期 9, 页码 1159-1169出版社
TAYLOR & FRANCIS AS
DOI: 10.1586/14737159.2015.1069183
关键词
cell-to-cell communication; diagnosis; exosomes; miRNAs; prognosis; signal pathways
类别
资金
- ERC (European Research Council) Advanced Investigator Grant [ERC-2010 AsG 20100317 DISSECT]
In cancer, deregulated expression levels of miRNAs are associated with tumorigenesis, tumor progression, metastasis and drug resistance. Apart from their release by apoptotic and necrotic cells, miRNAs can also be actively secreted into the blood circulation by exosomes. Exosomal miRNAs are thought to play an important role in cell-to-cell communication. Based on their biological functions and the possibility of quantifying miRNAs in patient blood in real time, these small non-coding RNA molecules may be a new promising class of potential non-invasive biomarkers. Screening of these liquid biopsies may provide information on target molecules of miRNAs and aberrant signaling pathways that can be blocked by a chosen targeted therapy. Consequently, therapy-associated modulations may facilitate treatment decisions. The present article discusses the potential clinical use of exosomal miRNAs as diagnostic and prognostic tumor markers. The emerging role of exosomes as a mediator of cell-to-cell signaling, to transfer miRNAs between cells, is also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据