Review
Biochemistry & Molecular Biology
Katarzyna Kluszczynska, Malgorzata Czyz
Summary: Extracellular vesicles (EVs) play an important role in cell-to-cell communication, carrying functional biomolecules that influence melanoma development and immune evasion. They are involved in various steps of melanoma progression and can contribute to resistance to immunotherapy and targeted therapy. Furthermore, EVs have potential applications in melanoma diagnostics and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mengyi Zhu, Daoyang Chen, Chuangdong Ruan, Penghui Yang, Jinrong Zhu, Rongxin Zhang, Yan Li
Summary: This article summarizes the properties, functions, and biogenesis of circular RNAs (circRNAs), focusing on the progress of current research on circRNAs in oral squamous cell carcinoma (OSCC). It has been found that circRNAs are dysregulated in OSCC tissues and thus associated with the clinicopathological characteristics and prognosis of OSCC patients. Furthermore, circRNAs have the potential to serve as biomarkers for the diagnosis and treatment of OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Rui Chen, Junxia Shi, Hongguang Yang, Minzhe Zhang, Qiutong Chen, Qiqiang He
Summary: The expression profile of extracellular vesicles (EVs)-derived miRNAs (EVs-miRNAs) in schizoaffective disorder (SAD) patients was analyzed through small RNA sequencing. The results showed 32 differentially expressed (DE) miRNAs in SAD patients compared to healthy controls. Weighted gene co-expression network analysis identified a module of 42 miRNAs closely related to SAD, with has-miR-15b-5p, has-miR-301a-3p, has-miR-342-3p, has-miR-219b-5p, and has-miR-145-5p identified as hub miRNAs. Further analysis revealed dysregulation of EVs-miRNAs in SAD patients, suggesting their potential as biomarkers.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Genetics & Heredity
Sung Hye Kim, David A. MacIntyre, Lynne Sykes, Maria Arianoglou, Phillip R. Bennett, Vasso Terzidou
Summary: This study examined the effect of whole blood holding time on the stability of plasma miRNA expression profiles. The results demonstrated that holding time can have dramatic effects on analytical reliability and reproducibility.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Jan Roska, Joao Lobo, Danica Ivovic, Lenka Wachsmannova, Thomas Mueller, Rui Henrique, Carmen Jeronimo, Miroslav Chovanec, Dana Jurkovicova
Summary: Testicular germ cell tumours (TGCTs) are the most common solid malignancy among young men, and their incidence is still increasing. We identified specific miRNA expression patterns that discriminate chemoresistant phenotypes in TGCTs and proposed miR-218-5p, miR-31-5p, miR-375-5p, miR-517-3p, miR-20b-5p and miR-378a-3p as potential biomarkers for predicting chemoresistance and aggressive phenotypes in non-seminomatous TGCTs. These miRNAs were found to be upregulated in CDDP-resistant TGCT cell lines, tumor samples from metastatic TGCT patients, and plasma samples from TGCT patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Hang Yan, Shengjie Tang, Shoujun Tang, Jun Zhang, Haiyang Guo, Chao Qin, Haiyang Hu, Chuan Zhong, Li Yang, Yunhe Zhu, Haining Zhou
Summary: Non-small cell lung cancer (NSCLC) is a common malignant tumor with suboptimal clinical success due to late diagnosis, limited treatment options, high recurrence rates, and drug resistance. MicroRNAs (miRNAs), small non-coding RNAs, have emerged as important players in NSCLC initiation, progression, and drug resistance. This review provides an overview of miRNA dysregulation and resistance in NSCLC and discusses their potential applications in different anti-cancer treatments.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexandra Perricos, Katharina Proestling, Heinrich Husslein, Lorenz Kuessel, Quanah J. Hudson, Rene Wenzl, Iveta Yotova
Summary: The study found that hsa-mir-135a is significantly overexpressed in the saliva and plasma of women with endometriosis, suggesting its potential as a noninvasive biomarker for the disease. Further validation studies are needed to assess its clinical value.
Article
Obstetrics & Gynecology
Delnya Gholami, Farzane Amirmahani, Reza Salman Yazdi, Tahereh Hasheminia, Hossein Teimori
Summary: The study found that up-regulation of miR-182-5p, miR-192-5p, and miR-493-5p may serve as potential biomarkers for TZ. Additionally, the expression level of the CRISP3 glycosylated isoform was significantly lower in TZ patients compared to those with normal sperm. These results suggest a significant role of CRISP3 protein and miRs in male infertility.
REPRODUCTIVE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dora Geczi, Balint Nagy, Melinda Szilagyi, Andras Penyige, Almos Klekner, Adrienn Jenei, Jozsef Virga, Zsuzsanna Birko
Summary: This study identified significantly differentially expressed circulating miRNAs in plasma samples of GBM patients, suggesting their potential as diagnostic biomarkers. Functional annotation and pathway enrichment analysis of target genes of these miRNAs were conducted to assess their functional connections. Plasma microRNA profiles show promise as diagnostic and prognostic biomarkers for GBM, with further validation studies needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
T. Yildirim, E. Yesilada, F. Eren, H. Apaydin, G. Gulbay
Summary: The study identified abnormal miRNA expressions in the plasma of patients with radiographic axial spondyloarthropathy, indicating a potential for these miRNAs to serve as diagnostic biomarkers for disease activity in ankylosing spondylitis.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Bin Sheng, Niansheng Lai, Tao Tao, Xiangxin Chen, Sen Gao, Qi Zhu, Wei Li, Qingrong Zhang, Chunhua Hang
Summary: This study characterized plasma extracellular vesicles in patients with aSAH using microRNAs (miRNAs) as diagnostic tools. Next-generation sequencing identified four differentially expressed miRNAs, which were validated in a large cohort. The results showed that miR-369-3p, miR-410-3p, miR-193b-3p, and miR-486-3p could predict the neurological outcomes of aSAH patients and have potential clinical utility as prognostic biomarkers.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Lei Wang, Jinxiang Wu, Naikuan Ye, Feng Li, Hanxiang Zhan, Shihong Chen, Jianwei Xu
Summary: Plasma-derived Exo-miR-19b is a promising diagnostic marker for pancreatic cancer, showing superior diagnostic value when normalized using miR-1228 in differentiating patients with Pca from healthy volunteers. The study suggests that Exo-miR-19b may be a potential alternative or supplement to serum CA19-9 for diagnosing Pca.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Fabian Sanchis-Gomar, Miriam Arnau-Moyano, Lidia Daimiel, Giuseppe Lippi, Roman Leischik, Nestor Vallecillo, Thomas Yvert, Sergio L. Jimenez, Catalina Santiago, Helios Pareja-Galeano
Summary: miRNAs participate in gene expression regulation and their circulating levels can fluctuate during exercise, showing relevance to cardiac biological and physiological effects. Most circulating cardiac-related miRNAs were upregulated immediately after a marathon and returned to basal levels at longer times.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Review
Microbiology
Gokulakannan Venkatesan, Wan Suriana Wan Ab Rahman, Wan Nazatul Shima Shahidan, Salfarina Iberahim, Alwi bin Muhd Besari Hashim
Summary: Early disease diagnosis is crucial for effective management and treatment. Diagnostic methods should be accurate, consistent, low-cost, and non-invasive. Exosomal microRNA (miRNA) has shown potential as biomarkers for various diseases, but its application in vector-borne diseases is limited. This review focuses on discussing miRNAs derived from exosomal plasma that may serve as disease biomarkers for early detection of vector-borne diseases.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Reproductive Biology
Zehua Zhu, Zhaojun Chen, Mingxing Wang, Min Zhang, Yiwen Chen, Xiao Yang, Changjun Zhou, Yuhua Liu, Liquan Hong, Lahong Zhang
Summary: In this study, liquid biopsy technology was used to detect the expression levels of miR-205, CA125, HE4, and TCF21 genes in plasma exosomes of OC patients. The results showed that the expression level of miR-205 in plasma exosomes was significantly higher in OC patients compared to the benign and control groups, and it was elevated during advanced stages of OC and lymph node metastasis. This suggests that miR-205 in plasma exosomes is a valuable tumor biomarker for improving OC diagnosis.
JOURNAL OF OVARIAN RESEARCH
(2022)
Review
Medical Laboratory Technology
Yuqing He, Juanjuan Lin, Danli Kong, Mingyuan Huang, Chengkai Xu, Taek-Kyun Kim, Alton Etheridge, Yanhong Luo, Yuanlin Ding, Kai Wang
CLINICAL CHEMISTRY
(2015)
Review
Oncology
Yuqing He, Juanjuan Lin, Yuanlin Ding, Guodong Liu, Yanhong Luo, Mingyuan Huang, Chengkai Xu, Taek-Kyun Kim, Alton Etheridge, Mi Lin, Danli Kong, Kai Wang
INTERNATIONAL JOURNAL OF CANCER
(2016)
Review
Cell Biology
Bernardo A. Petriz, Clarissa P. C. Gomes, Jeeser A. Almeida, Getulio P. de Oliveira, Filipe M. Ribeiro, Rinaldo W. Pereira, Octavio L. Franco
JOURNAL OF CELLULAR PHYSIOLOGY
(2017)
Review
Medicine, Research & Experimental
Clarissa P. C. Gomes, Helen Spencer, Kerrie L. Ford, Lauriane Y. M. Michel, Andrew H. Baker, Costanza Emanueli, Jean-Luc Balligand, Yvan Devaux
MOLECULAR THERAPY-NUCLEIC ACIDS
(2017)
Review
Medicine, Research & Experimental
Clarissa P. C. Gomes, David de Gonzalo-Calvo, Rocio Toro, Tiago Fernandes, Daniel Theisen, Da-Zhi Wang, Yvan Devaux
Review
Cardiac & Cardiovascular Systems
Ioanna Andreadou, Hector A. Cabrera-Fuentes, Yvan Devaux, Nikolaos G. Frangogiannis, Stefan Frantz, Tomasz Guzik, Elisa A. Liehn, Clarissa P. C. Gomes, Rainer Schulz, Derek J. Hausenloy
CARDIOVASCULAR RESEARCH
(2019)
Article
Pharmacology & Pharmacy
Jeeser Alves Almeida, Daisy Motta-Santos, Bernardo Assis Petriz, Clarissa Pedrosa Da Costa Gomes, Murilo Esteves Nogueira, Rinaldo Wellerson Pereira, Ronaldo Carvalho Araujo, Jonato Prestes, Octavio Luiz Franco
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2020)
Article
Cardiac & Cardiovascular Systems
Clarissa Pedrosa da Costa Gomes, Blanche Schroen, Gabriela M. Kuster, Emma L. Robinson, Kerrie Ford, Iain B. Squire, Stephane Heymans, Fabio Martelli, Costanza Emanueli, Yvan Devaux
Article
Cardiac & Cardiovascular Systems
Sandrine Lecour, Ioanna Andreadou, Hans Erik Botker, Sean M. Davidson, Gerd Heusch, Marisol Ruiz-Meana, Rainer Schulz, Coert J. Zuurbier, Peter Ferdinandy, Derek J. Hausenloy
Summary: The researchers proposed a set of standards called IMPACT to improve the evaluation of cardioprotective interventions before entering clinical studies, aiming to increase the likelihood of translating novel cardioprotective interventions into beneficial clinical practice for patients.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Neurosciences
L. Pavelka, A. Rauschenberger, Z. Landoulsi, S. Pachchek, P. May, E. Glaab, R. Krueger
Summary: The study found that age significantly affects motor and non-motor symptoms in Parkinson's disease (PD) patients, with only the associations of age at assessment with burden of motor symptoms and cognitive impairment significantly different between PD and healthy controls. Furthermore, a significant inverse correlation of age at onset and polygenic risk score was identified in PD.
NPJ PARKINSONS DISEASE
(2022)
Article
Neurosciences
Lukas Pavelka, Armin Rauschenberger, Zied Landoulsi, Sinthuja Pachchek, Taina Marques, Clarissa P. C. Gomes, Enrico Glaab, Patrick May, Rejko Krueger
Summary: This study identified a specific subtype of PD that is characterized by RBD, predominant autonomic dysfunction, hallucinations, and depression, supporting the concept of a distinctive body-first subtype of PD. The study did not find a significant association between APOE epsilon 4 and pRBD, suggesting that both factors have an independent effect on cognitive decline in iPD.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Emma Louise Robinson, Clarissa Pedrosa Costa Gomes, Ines Potocnjak, Jan Hellemans, Fay Betsou, David de Gonzalo-Calvo, Monika Stoll, Mehmet Birhan Yilmaz, Bence Agg, Dimitris Beis, Maria Carmo-Fonseca, Francisco J. Enguita, Soner Dogan, Bilge G. Tuna, Blanche Schroen, Wim Ammerlaan, Gabriela M. Kuster, Irina Carpusca, Thierry Pedrazzini, Costanza Emanueli, Fabio Martelli, Yvan Devaux
Article
Biochemistry & Molecular Biology
Clarissa Pedrosa da Costa Gomes, Bence Agg, Andrejaana Andova, Serdal Arslan, Andrew Baker, Monika Bartekova, Dimitris Beis, Fay Betsou, Stephanie Bezzina Wettinger, Branko Bugarski, Gianluigi Condorelli, Gustavo Jose Justo da Silva, Sabrina Danilin, David de Gonzalo-Calvo, Alfonso Buil, Maria Carmo-Fonseca, Francisco J. Enguita, Kyriacos Felekkis, Peter Ferdinandy, Mariann Gyoengyoesi, Matthias Hackl, Kanita Karaduzovic-Hadziabdic, Jan Hellemans, Stephane Heymans, Marketa Hlavackova, Morten Andre Hoydal, Aleksandra Jankovic, Amela Jusic, Dimitris Kardassis, Risto Kerkela, Gabriela M. Kuster, Paivi Lakkisto, Przemyslaw Leszek, Mitja Lustrek, Lars Maegdefessel, Fabio Martelli, Susana Novella, Timothy O'Brien, Christos Papaneophytou, Thierry Pedrazzini, Florence Pinet, Octavian Popescu, Ines Potocnjak, Emma Robinson, Shlomo Sasson, Markus Scholz, Maya Simionescu, Monika Stoll, Zoltan V. Varga, Manlio Vinciguerra, Angela Xuereb, Mehmet Birhan Yilmaz, Costanza Emanueli, Yvan Devaux
