Article
Multidisciplinary Sciences
Sahar Gelfman, Arden Moscati, Santiago Mendez Huergo, Rujin Wang, Veera Rajagopal, Neelroop Parikshak, Vijay Kumar Pounraja, Esteban Chen, Michelle Leblanc, Ralph Hazlewood, Jan Freudenberg, Blerta Cooper, Ann J. Ligocki, Charles G. Miller, Tave Van Zyl, Jonathan Weyne, Carmelo Romano, Botir Sagdullaev, Olle Melander, Aris Baras, Eli A. Stahl, Giovanni Coppola
Summary: In this study, the authors performed genome-wide association analysis and whole-exome analysis to uncover the underlying genetics of HLA-B*27 positive and negative forms of anterior uveitis (AU).
NATURE COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Ju Li, Zhongyuan Zhang, Xinhua Wu, Jie Zhou, Deqian Meng, Ping Zhu
Summary: This meta-analysis found that treatment with anti-TNF alpha agents may increase the risk of infectious adverse events while the risk of tuberculosis was not significantly different. The use of anti-TNF agents should be carefully considered based on the risk-benefit ratio suggested by the meta-analysis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Xinyi Gao, Tonglian Lv, Guangping Li, Gary Tse, Tong Liu
Summary: Uveitis may increase the risk of cardiovascular disease through the atherosclerotic pathway. For autoimmune disease patients with uveitis, early screening of cardiovascular risk factors and implementation of corresponding prevention strategies may be associated with a better prognosis.
Review
Immunology
Dong Liu, Budian Liu, Churong Lin, Jieruo Gu
Summary: Ankylosing spondylitis is a complex autoimmune disease involving genetic and environmental factors. B cells were found to be significantly increased in AS patients, while Tregs were decreased and Th17 cells were increased. The imbalance between Th17 and Tregs, as well as between Th1 and Th2, may play a role in the pathogenesis of ankylosing spondylitis. Further research is needed to clarify the interactions between different lymphocyte subsets in AS patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Orthopedics
Feifei Ni, Yanchao Zhang, Yi Peng, Xiaoxiao Peng, Jianjun Li
Summary: The study found that sRANKL levels were significantly higher in Chinese patients with AS than in healthy controls, indicating a positive correlation between sRANKL levels and AS pathogenesis among Chinese patients. Subgroup analyses showed that patients from South China had higher sRANKL levels, especially in those with a BASFI of > 4, and patients with AS for > 8 years had higher sRANKL levels than health controls.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Haihuan Feng, Ying Zhao, Weihong Kuang, Yanping Dai, Xiaobo Cen, Feng Qin
Summary: This meta-analysis examined the adverse events in patients with ankylosing spondylitis treated with tumor necrosis factor alpha inhibitors. The analysis found that while serious adverse events were not significantly increased, common adverse events such as nasopharyngitis, headache, and injection-site reactions were more frequent in patients receiving tumor necrosis factor alpha inhibitors compared to placebo.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Xiao Zhang, Zhe Sun, Aihong Zhou, Lei Tao, Yingxin Chen, Xinyu Shi, Jia Yin, Zheng Sun, Guoyong Ding
Summary: This meta-analysis identified that infections significantly elevate the risks of ankylosing spondylitis, particularly in individuals with unadjusted comorbidities and other types of infection. These findings provide valuable insights for future prevention efforts focused on avoiding infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Mark D. Russell, Christopher Stovin, Edward Alveyn, Olukemi Adeyemi, Chun Kit David Chan, Vishit Patel, Maryam A. Adas, Fabiola Atzeni, Kenrick K. H. Ng, Andrew Rutherford, Sam Norton, Andrew P. Cope, James B. Galloway
Summary: This study aimed to evaluate the association between Janus kinase inhibitors (JAKi) and the incidence of malignancy. The results showed that JAKi were associated with a higher incidence of malignancy compared with TNFi.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Clinical Neurology
Naiwen Hu, Xi Chen, Shanjuan Wang, Gangying Yuan, Qinqin Wang, Huae Shu, Hongsheng Sun
Summary: The polymorphisms of the TNF gene are associated with ankylosing spondylitis susceptibility, with certain gene variations showing significance in different ethnic populations. However, the results may vary between subgroups and the overall population.
EUROPEAN SPINE JOURNAL
(2021)
Review
Rheumatology
Sizheng Steven Zhao, Bradley Pittam, Nicholas L. Harrison, Ashar E. Ahmed, Nicola J. Goodson, David M. Hughes
Summary: This study found that there is a significant global variation in delay to diagnosis for axial SpA patients, with longer delays reported in high-income countries compared to middle-income countries. Patient factors like lower education levels, younger age at symptom onset, and absence of extra-articular manifestations are associated with longer delays. In contrast, the diagnostic delay for PsA patients is significantly shorter.
Review
Endocrinology & Metabolism
Fei Yan, Linfeng Wu, Juan Lang, Zongju Huang
Summary: This study conducted a meta-analysis of 39 studies and found that patients with ankylosing spondylitis (AS) have decreased bone mineral density (BMD) and an elevated risk of fractures. The study also analyzed the risk factors associated with fractures in these patients.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Immunology
Yi-Fen Lai, Ting-Yi Lin, Wu-Chien Chien, Chien-An Sun, Chi-Hsiang Chung, Yi-Hao Chen, Jiann-Torng Chen, Ching-Long Chen
Summary: This study found that patients with AS who have uveitis are at a significantly higher risk of developing acute myocardial infarction (AMI) compared to those without uveitis. Regardless of gender or age group, patients with uveitis in the AS population have an increased risk for AMI.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Zhiyong Long, Ying Deng, Qi He, Kailin Yang, Liuting Zeng, Wensa Hao, Yuxuan Deng, Jiapeng Fan, Hua Chen
Summary: The objective of this study was to explore the efficacy and safety of Iguratimod (IGU) intervention in the treatment of Ankylosing Spondylitis (AS). A meta-analysis of 10 randomized controlled trials involving 622 patients showed that IGU could significantly decrease the BASDAI score, BASFI score, and VAS. Additionally, the addition of IGU to conventional therapy did not increase adverse events. Therefore, IGU may be an effective and safe intervention for AS.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Rheumatology
Shanshan Xu, Xiaoyi Zhang, Yuting Chen, Yubo Ma, Jixiang Deng, Xing Gao, Shiyang Guan, Faming Pan
Summary: Anti-CD74 IgG and IgA antibodies are significantly elevated in patients with spondyloarthritis, indicating a high diagnostic specificity for the disease.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Genetics & Heredity
Yiyuan Ao, Yaokai Wen, Yutian Li, Haoxin Peng, Xiangrong Wu, Zhufeng Wang, Yu Jiang, Yuechun Lin, Shuben Li
Summary: This study conducted a meta-analysis and Mendelian randomization analysis to evaluate the correlation between ankylosing spondylitis and lung cancer. The meta-analysis results showed no significant association between ankylosing spondylitis and lung cancer. However, after excluding a study with high heterogeneity, ankylosing spondylitis was found to be associated with a 19% increased risk of lung cancer. Subgroup analyses indicated that ankylosing spondylitis was not associated with increased risks of lung cancer in both European and non-European patients. Nevertheless, the Mendelian randomization results indicated that genetically determined ankylosing spondylitis was causally correlated with a remarkably increased risk of lung cancer among European populations. Subgroup analyses further elucidated that genetically determined ankylosing spondylitis was causally associated with a notably higher risk of only squamous cell lung cancer, rather than lung adenocarcinoma. In addition, the results indicated the absence of pleiotropy.
FRONTIERS IN GENETICS
(2022)
