Article
Rheumatology
Carlo Scognamiglio Renner Araujo, Ana Cristina Medeiros-Ribeiro, Carla G. S. Saad, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Matheus Santos Rodrigues Silva, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Tatiana Pedrosa, Leonard de Vinci Kanda Kupa, Gioanna Zou, Rosa M. R. Pereira, Clovis Artur Silva, Nadia Emi Aikawa, Eloisa Bonfa
Summary: This study evaluated the effect of discontinuing methotrexate (MTX) for 2 weeks after each dose of the Sinovac-CoronaVac vaccine on immunogenicity and safety in patients with rheumatoid arthritis (RA). The results showed that the group that discontinued MTX had a higher rate of seroconversion and higher antibody titers compared to the group that continued MTX. However, there was an increased risk of flare after the second MTX withdrawal.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Rheumatology
Lotte van Ouwerkerk, Andriko Palmowski, Isabell S. Nevins, Frank Buttgereit, Patrick Verschueren, Josef S. Smolen, Robert B. M. Landewe, Johannes J. W. Bijlsma, Andreas Kerschbaumer, Rene Westhovens, Tom W. J. Huizinga, Cornelia F. Allaart, Sytske Anne Bergstra
Summary: Studies on the success rate of glucocorticoid discontinuation in newly diagnosed rheumatoid arthritis patients using temporary GC as initial therapy are limited. Most clinical trials showed a successful discontinuation rate of 78% at 12 months and 90% at 24 months, despite substantial heterogeneity.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
Borja Hernandez-Breijo, Claudia M. Brenis, Chamaida Plasencia-Rodriguez, Ana Martinez-Feito, Marta Novella-Navarro, Dora Pascual-Salcedo, Alejandro Balsa
Summary: The study found that TNFi survival did not depend on seropositivity status, but seropositive patients who received concomitant MTX had significantly longer median survival time. Additionally, the co-administration of prednisone in seropositive patients receiving TNFi was highly associated with TNFi discontinuation.
FRONTIERS IN MEDICINE
(2021)
Article
Rheumatology
Paul Studenic, Daniel Aletaha, Maarten de Wit, Tanja A. Stamm, Farideh Alasti, Diane Lacaille, Josef S. Smolen, David T. Felson
Summary: This study aimed to externally validate a revised Boolean remission criteria using a higher patient global assessment (PtGA) threshold and validate the provisionally endorsed index-based criteria. The results showed that using the higher PtGA threshold increased the proportion of patients classified as achieving remission under the "Boolean2.0" criteria, improved agreement with index-based criteria, and did not compromise predictive value for radiographic or functional outcomes. The study findings were endorsed by ACR and EULAR.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Renske C. F. Hebing, Marry Lin, Maja Bulatovic Calasan, Ittai B. Muller, Sohaila Mahmoud, Sandra Heil, Eduard A. Struys, Bart J. F. van den Bemt, Jos W. R. Twisk, Willem Lems, Michael T. Nurmohamed, Gerrit Jansen, Robert de Jonge
Summary: This study investigates the pharmacokinetics of methotrexate polyglutamate (MTX-PG) accumulation in red blood cells (RBCs) and peripheral blood mononuclear cells (PBMCs) in patients with early rheumatoid arthritis (RA) after oral and subcutaneous MTX treatment. The results show that there are disparate pharmacokinetic profiles between PBMCs and RBCs, with higher accumulation of MTX-PG in PBMCs. The distribution profile of MTX-PG in PBMCs remains constant over 6 months, while in RBCs, the main PG-moiety changes from MTX-PG(1) to MTX-PG(3).
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Delila Singh, Nina Hesse, Alla Skapenko, Hendrik Schulze-Koops
Summary: Methotrexate is associated with rare bone lesions that are often misdiagnosed as osteoporotic fractures. Early diagnosis is crucial for treatment and prevention of further osteopathology. This case highlights the importance of raising awareness and taking appropriate therapeutic measures, including discontinuing methotrexate.
Article
Chemistry, Analytical
Junqing He, Junyan Wang, Min Zhang, Guoyue Shi
Summary: As a folate antagonist, methotrexate (MTX) has been widely used in clinics for treating various tumors and inflammatory diseases. However, the dosage and clearance of MTX vary between individuals, and it may cause life-threatening side effects at high doses. Therefore, a convenient and simple method for MTX sensing is highly demanded.
Article
Rheumatology
Clement Triaille, Gaelle Tilman, Tatiana Sokolova, Axelle Loriot, Joelle Marchandise, Stephanie De Montjoye, Adrien Nzeusseu-Toukap, Laurent Meric de Bellefon, Caroline Bouzin, Christine Galant, Patrick Durez, Bernard R. Lauwerys, Nisha Limaye
Summary: This study used transcriptomic profiling to explore clinically relevant subgroups in early, untreated rheumatoid arthritis (RA) patients. The synovial transcriptome closely mirrored clinical disease activity, and the ratio of M2:M1 macrophages was inversely correlated with inflammation and disease activity, suggesting a protective role for tissue resident macrophages in RA.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Claire Daien, Marek Krogulec, Paul Gineste, Jean-Marc Steens, Laurence Desroys du Roure, Sophie Biguenet, Didier Scherrer, Julien Santo, Hartmut Ehrlich, Patrick Durez
Summary: This study evaluated the safety and efficacy of ABX464 in patients with moderate-to-severe active rheumatoid arthritis. The results showed that ABX464 at a 50 mg dose was safe, well tolerated, and showed promising efficacy. The 100 mg dose had a high dropout rate due to gastrointestinal adverse events.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Siddharth Jain, Varun Dhir, Amita Aggarwal, Ranjan Gupta, Bidyalaxmi Leishangthem, Shankar Naidu, Aastha Khullar, Supriya Maurya, Veena Dhawan, Shefali Khanna Sharma, Aman Sharma, Sanjay Jain
Summary: This study compared the efficacy and safety of different dose escalation strategies of oral MTX in RA patients over a period of 16-24 weeks. The results showed that a faster escalation strategy was not more effective than the usual strategy, but was associated with higher gastrointestinal adverse events in the initial phase.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Yasumori Sobue, Mochihito Suzuki, Yoshifumi Ohashi, Hiroshi Koshima, Nobuyuki Okui, Koji Funahashi, Hisato Ishikawa, Hidenori Inoue, Shuji Asai, Kenya Terabe, Kenji Kishimoto, Daisuke Kihira, Masataka Maeda, Ryo Sato, Shiro Imagama
Summary: This study aimed to investigate the relationship between frailty and discontinuation of methotrexate (MTX) due to adverse events (AEs) in rheumatoid arthritis (RA) patients. The study found that frailty is a significant factor contributing to MTX discontinuation due to AEs, highlighting the importance of monitoring AEs in frail RA patients using MTX.
CLINICAL RHEUMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Helen R. Gosselt, Costanza L. Vallerga, Pooja R. Mandaviya, Erik Lubberts, Johanna M. W. Hazes, Robert de Jonge, Sandra G. Heil
Summary: The study did not identify genome-wide significant differences as biomarkers for Methotrexate (MTX) therapy response, necessitating meta-analyses.
Article
Rheumatology
Ulf Lindstrom, Daniela di Giuseppe, Sofia Exarchou, Gerd-Marie Alenius, Tor Olofsson, Eva Klingberg, Lennart Jacobsson, Johan Askling, Johan K. Wallman
Summary: This study aimed to compare the treatment outcomes of patients with newly diagnosed psoriatic arthritis (PsA) and rheumatoid arthritis (RA) using methotrexate (MTX) monotherapy. The results showed that PsA patients were less likely to continue the use of MTX compared to RA patients, and the effectiveness of MTX was also lower in PsA.
Review
Pharmacology & Pharmacy
Gurleen Kour, Syed Assim Haq, Bijender Kumar Bajaj, Prem N. Gupta, Zabeer Ahmed
Summary: Phytochemicals have long been known for their therapeutic potential in autoimmune disorders such as rheumatoid arthritis, but their combination with DMARDs can increase the efficacy of treatment while reducing toxic side effects. Studies have shown promising results in experimental and clinical settings when combining phytochemicals with DMARDs, highlighting the importance of this approach in future RA therapy.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
F. Robin, S. Cadiou, J-D Albert, G. Bart, G. Coiffier, P. Guggenbuhl
Summary: Methotrexate (MTX)-related osteopathy, characterized by pain, osteoporosis, and atypical fractures, is a rare condition that has been reported in patients treated with low doses of MTX for inflammatory diseases. Pathophysiological studies suggest a possible dose-dependent residual effect of MTX on osteo-forming bone cells.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Rheumatology
Se Rim Choi, Jun Won Park, Eun Bong Lee, Jin Kyun Park
Summary: The study aimed to determine if the initial methotrexate (MTX) dosage is associated with increased risk of liver toxicity in rheumatoid arthritis (RA) patients. Results showed that the initial MTX dosage was not linked to higher hepatotoxicity risk, but elevated baseline AST and/or ALT levels above ULN and concomitant leflunomide use were associated with MTX hepatotoxicity.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Jina Yeo, Ju Yeon Kim, Mi Hyeon Kim, Jun Won Park, Jin Kyun Park, Eun Bong Lee
Summary: This study evaluated the clinical utility and reliability of the breath-holding test (BHT) in assessing cardiopulmonary function in patients with SSc. The results showed that BHT had significant correlations with the Borg dyspnea scale, SHAQ, and pulmonary parameters, suggesting that it may be a useful surrogate marker of pulmonary capacity in SSc patients.
Article
Multidisciplinary Sciences
Jina Yeo, Eun-Ah Park, Eun Bong Lee, Jin Kyun Park
Summary: Compared to polyarteritis nodosa, peripheral angiographic features of idiopathic inflammatory myopathies and systemic sclerosis show more frequent diffuse narrowing, tapered occlusion, and delayed distal flow.
SCIENTIFIC REPORTS
(2022)
Article
Rheumatology
Jin Kyun Park, Yun Jong Lee, Kichul Shin, Eun Ha Kang, You-Jung Ha, Jun Won Park, Min Jung Kim, Mi Hyeon Kim, Se Rim Choi, Youjin Jung, Ju Ho Lee, Ji In Jung, Ju Yeon Kim, Kevin L. Winthrop, Eun Bong Lee
Summary: This study found that discontinuing methotrexate for 1 week after seasonal influenza vaccination is noninferior to discontinuing for 2 weeks in terms of inducing a satisfactory vaccine response in patients with rheumatoid arthritis.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Philip Seo, Kevin Winthrop, Amr H. Sawalha, Serim Choi, Hyun Ah Park, Woochang Hwang, Eun Bong Lee, Jin Kyun Park
Summary: Physicians caring for patients with AIIRD generally agree on the effectiveness and safety of vaccines for these patients. However, they often fail to ensure adequate vaccination coverage for their patients.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Se Rim Choi, Joo Young Shin, Anna Shin, Hokyung Choung, Se Joon Woo, Sang Jun Park, You-Jung Ha, Yun Jong Lee, Eun Bong Lee, Jin Kyun Park, Eun Ha Kang
Summary: Patients with Behcet's disease have a higher risk of blindness and vision-threatening ocular comorbidities compared to the general population. Males are at a higher risk of blindness due to greater severity rather than a lower incidence of uveitis. The risk of uveitis and blindness decreases with higher age at BD diagnosis.
Article
Rheumatology
Philip Seo, Kevin Winthrop, Amr Hakam Sawalha, Serim Choi, Woochang Hwang, Hyun Ah Park, Eun Bong Lee, Jin Kyun Park
Summary: This study evaluated the perspectives of healthcare professionals towards the 2019 EULAR vaccination guideline for patients with AIIRD through an online survey. The results showed that healthcare professionals generally considered the guideline important, but actual implementation of vaccination was often lacking.
JOURNAL OF RHEUMATIC DISEASES
(2023)
Letter
Medical Laboratory Technology
Jihoon G. Yoon, Seungbok Lee, Sheehyun Kim, Man Jin Kim, Yoon Hwan Chang, Jin Kyun Park, Dong-Yeop Shin, Jangsup Moon
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Rheumatology
Young Mi Jung, Jin Kyun Park, Min-Jeong Oh, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Seung Mi Lee, Geum Joon Cho
Summary: The aim of this study was to determine the risk of congenital malformations in offspring born to women with systemic lupus erythematosus (SLE). The study found that neonates born to SLE mothers have a slightly increased risk of congenital malformations affecting the nervous system, head and neck, cardiovascular system, and musculoskeletal system compared to the general population.
Article
Rheumatology
Siew Khei Liew, Jin Kyun Park, Hyun Sik Gong
Summary: Hand involvement in sarcoidosis is rare, but this case describes an unusual presentation of progressive intrinsic muscle contracture in both hands. The patient experienced painful swelling and weakness in all four extremities. Although systemic symptoms improved with corticosteroid treatment, the hand muscle contracture remained. However, serial soft tissue releases greatly improved hand function. Surgery can be a viable option in treating chronic sarcoid myopathy complicated with severe muscle contracture.
JOURNAL OF RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Jin Kyun Park, Yun Jong Lee, Eun Ha Kang, Kichul Shin, Min Jung Kim, You-Jung Ha, Se Rim Choi, Jun Won Park, Mi Hyeon Kim, Ju Yeon Kim, Ji In Jung, Yunhee Choi, Kevin L. Winthrop, Eun Bong Lee
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Sung Hae Chang, Se Rim Choi, Yong Seok Choi, Dong Jin Go, Jun Won Park, You-Jung Ha, Jin Kyun Park, Eun Ha Kang, Eun Young Lee, Kichul Shin, Eun Bong Lee, Yeong Wook Song, Yun Jong Lee
Summary: The study investigated the diagnostic performance of band intensity (BI) cut-offs adjusted by a positive control band (PCB) in a line-blot assay (LBA) for myositis-related autoantibodies (MRAs). Sera from 153 idiopathic inflammatory myositis (IIM) patients and 79 healthy controls were tested. The study found that adjusting BI using PCB improved the diagnostic performance of the LBA, and an aBI cut-off value of > 20 was optimal for IIM diagnosis using the EUROLINE LBA panel.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Oncology
Ju Yeon Kim, Min Jung Kim, Eun Bong Lee, Tae-Yong Kim, Kyung-Hun Lee, Seock-Ah Im, Jin Kyun Park
Summary: Breast cancer patients often experience musculoskeletal pain, primarily due to osteoarthritis and enthesopathy/tendinopathy, rather than rheumatoid arthritis.
JOURNAL OF BREAST CANCER
(2022)
Correction
Medicine, General & Internal
Jin Kyun Park, Eun Bong Lee, Kichul Shin, Yoon-Kyoung Sung, Tae-Hwan Kim, Seong-Ryul Kwon, Myeung Su Lee, Seung-Jae Hong, Byoong Yong Choi, Shin-Seok Lee, Han Joo Baek
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Jin Kyun Park, Eun Bong Lee, Kichul Shin, Yoon-Kyoung Sung, Tae Hwan Kim, Seong-Ryul Kwon, Myeung Su Lee, Seung-Jae Hong, Byoong Yong Choi, Shin-Seok Lee, Han Joo Back
Summary: COVID-19 vaccines are considered safe and effective for patients with autoimmune inflammatory rheumatic disease (AIIRD). It is important for rheumatologists to play a leading role in educating and vaccinating these patients, while also adjusting their treatment regimens to optimize vaccine response.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)