Article
Surgery
Gray B. Peery, Joyce Pak, Laura Burkbauer, Chris B. Agala, Julia M. Selfridge, Kristalyn K. Gallagher, Philip M. Spanheimer
Summary: The study aimed to investigate the omission of axillary lymph node dissection (ALND) in patients with ypN + breast cancer after neoadjuvant systemic therapy (NST). The results showed that despite guidelines recommending ALND, omission of ALND is common in these patients and has been increasing over time.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Surgery
Sherko Kuemmel, Joerg Heil, Simona Bruzas, Elisabeth Breit, Dorothea Schindowski, Hakima Harrach, Ouafaa Chiari, Karin Hellerhoff, Elena Bensmann, Volker Hanf, Sven-Thomas Grasshoff, Petra Deuschle, Kerstin Belke, Silke Polata, Stefan Paepke, Mathias Warm, Johannes Meiler, Christian Schindlbeck, Wencke Ruhwedel, Ulrike Beckmann, Ulrich Groh, Peter Dall, Jens-Uwe Blohmer, Alexander Traut, Mattea Reinisch
Summary: This study aims to assess the 3-year clinical outcomes in patients with node-positive breast cancer who underwent targeted axillary dissection (TAD) alone or TAD with axillary lymph node dissection (ALND). The results suggest that TAD alone may confer similar survival outcomes and recurrence rates as TAD with ALND.
Editorial Material
Surgery
Abigail Suzanne Caudle
Summary: The surgical management of node-positive breast cancer after neoadjuvant chemotherapy is a focus and debate. The standard approach is axillary lymph node dissection, which carries risks of complications. Finding an accurate way to assess nodal response and defining the impact of minimizing axillary surgery on outcomes are the challenges. Ongoing trials may provide insights in the future.
Article
Oncology
Joseph Dux, Mehran Habibi, Hadi Malik, Lisa Jacobs, Pamela A. Wright, Julie Lange, Melissa Camp, Maureen O'Donnell, Bonnie Sun, Hanh-Tam Tran, David Euhus
Summary: It is unclear whether axillary lymph node dissection (ALND) improves outcome for breast cancer patients with clinically node positive disease (cN1).
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Medicine, General & Internal
Wenyan Wang, Xin Wang, Jiaqi Liu, Qiang Zhu, Xiang Wang, Pilin Wang
Summary: A predictive clinical model was developed to assess the pathological complete response of axillary lymph nodes in breast cancer patients after neoadjuvant chemotherapy. The model performed well in external validation and could provide information to surgeons regarding additional lymph node dissection.
CHINESE MEDICAL JOURNAL
(2022)
Article
Surgery
Maria Luisa Gasparri, Jana de Boniface, Philip Poortmans, Oreste D. Gentilini, Orit Kaidar-Person, Maggie Banys-Paluchowski, Rosa Di Micco, Laura Niinikoski, David Murawa, Eduard Alexandru Bonci, Andrei Pasca, Isabel T. Rubio, Guldeniz Karadeniz Cakmak, Michalis Kontos, Thorsten Kuehn
Summary: This study investigates the clinical practice of axillary management after neoadjuvant therapy in patients with clinically node-positive breast cancer. The results reveal wide discrepancies in surgical approaches among different countries and physicians, emphasizing the need for further clinical research to standardize guidelines.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Surgery
Kristalyn K. Gallagher, Kathleen Iles, Cherie Kuzmiak, Raphael Louie, Kandace P. McGuire, David W. Ollila
Summary: This study evaluated the feasibility and accuracy of RLR-TAD in node-positive breast cancer patients after neoadjuvant systemic therapy. The results showed that RLR-TAD performed well in accurately predicting axillary status.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Oncology
Sungchan Gwark, Woo Chul Noh, Sei Hyun Ahn, Eun Sook Lee, Yongsik Jung, Lee Su Kim, Wonshik Han, Seok Jin Nam, Gyungyub Gong, Seon-Ok Kim, Hee Jeong Kim
Summary: This study evaluated ALND rates and prognosis in ER+/HER2-, LN-positive, premenopausal breast cancer patients after NCT and NET treatment. The NCT group had a lower ALND rate, higher axillary pCR rate, but there was no significant difference in survival rates compared to the NET group.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zhuoxuan Li, Yiwei Tong, Xiaosong Chen, Kunwei Shen
Summary: Ultrasound changes during neoadjuvant chemotherapy can improve the accuracy of predicting node response in clinically node-positive breast cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Amparo Garcia-Tejedor, Carlos Ortega-Exposito, Sira Salinas, Ana Luzardo-Gonzalez, Catalina Falo, Evelyn Martinez-Perez, Hector Perez-Montero, M. Teresa Soler-Monso, Maria-Teresa Bajen, Ana Benitez, Raul Ortega, Anna Petit, Anna Guma, Miriam Campos, Maria J. Pla, Sonia Pernas, Judith Penafiel, Carlos Yeste, Miguel Gil-Gil, Ferran Guedea, Jordi Ponce, Maria Laplana
Summary: This study aims to evaluate whether axillary radiotherapy (ART) is non-inferior to axillary lymph node dissection (ALND) in patients with limited lymphatic involvement after neoadjuvant systemic treatment (NST), and whether it reduces surgery-related adverse effects.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Si-Yu Wu, Jian-Wei Li, Yu-Jie Wang, Kai-Rui Jin, Ben-Long Yang, Jun-Jie Li, Xiao-Li Yu, Miao Mo, Na Hu, Zhi-Ming Shao, Guang-Yu Liu
Summary: This study suggests that targeted axillary dissection is feasible in initially cN1 breast cancer patients with biopsy-confirmed nodal metastases. For patients with negativity or a low volume of nodal positivity, axillary lymph node dissection can safely be foregone, with a low nodal failure rate and no compromise of 3-year recurrence-free survival.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Massimiliano Gennaro, Chiara Listorti, Luigi Mariani, Marco Maccauro, Giulia Bianchi, Giuseppe Capri, Ilaria Maugeri, Laura Lozza, Maria Carmen De Santis, Secondo Folli
Summary: In this study, we followed up on 100 consecutive axillary node-positive patients treated with ARM-SAD and found a low rate of axillary failure, indicating that the ARM-SAD procedure is oncologically safe.
Article
Oncology
Masakuni Noguchi, Masafumi Inokuchi, Miki Yokoi-Noguchi, Emi Morioka, Yusuke Haba, Tomoko Takahashi, Akihiro Shioya, Sohsuke Yamada
Summary: Axillary reverse mapping (ARM) nodes are involved in a significant proportion of clinically node-positive breast cancer patients. Neoadjuvant chemotherapy (NAC) effectively reduces the incidence of nodal metastases in these patients. However, the rate of ARM node metastases after NAC is still too high to spare ARM nodes. F-18-FDG-PET/CT can detect a low risk of ARM node metastases after NAC, but it is not suitable for detecting residual metastatic disease in the axilla. Therefore, suspicious ARM nodes must be removed while sparing ARM lymphatics to minimize arm lymphedema.
Article
Oncology
Miaomiao Jia, Lihui Pan, Haibo Yang, Jinnan Gao, Fan Guo
Summary: This study aimed to evaluate the association between neoadjuvant chemotherapy (NAC) and breast cancer-related lymphedema (BCRL) in patients undergoing axillary lymph node dissection (ALND). The results showed that NAC was an independent risk factor for BCRL, and patients receiving NAC had a higher risk of developing BCRL. Subgroup analyses indicated that NAC consistently increased the risk of BCRL across different clinical characteristics.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Qianqian Yuan, Jinxuan Hou, Yukun He, Yiqian Liao, Lewei Zheng, Gaosong Wu
Summary: ALND based on BLL can minimize surgical extent for node-positive breast cancer patients, potentially reducing the occurrence of BCRL.
Article
Oncology
Mohamed A. Abd El Aziz, Nicholas P. McKenna, James W. Jakub, Christopher L. Hallemeier, Scott R. Kelley, Zhaohui Jin, Kellie L. Mathis
Summary: This study aimed to compare the survival of patients with isolated inguinal lymph node metastases to patients with inguinal and additional synchronous distant metastases from rectal cancer who received curative therapy. The results showed that patients with isolated inguinal lymph node metastases had a longer survival period, and further research is needed.
Article
Surgery
Aida K. Sarcon, Wenxia Zhang, Amy C. Degnim, Rebecca L. Johnson, William S. Harmsen, Amy E. Glasgow, James W. Jakub
Summary: A study found that the use of local anesthesia during mastectomy can reduce postoperative opioid use, alleviate pain, shorten hospital stay, and has no impact on nausea and vomiting.
Editorial Material
Oncology
James W. Jakub, Michael Lowe, J. Harrison Howard, Jeffrey M. Farma, Amod Sarnaik, Todd Tuttle, Heather B. Neuman, Charlotte E. Ariyan, Abhineet Uppal, Steve Trocha, Georgia M. Beasley, Nabil Wasif, Karl Y. Bilimoria, Alan A. Thomay, Jacob B. Allred, Lucia Chen, Alicia M. Terando, Jeffrey D. Wayne, John F. Thompson, Alistair J. Cochran, Myunlg-Shin Sim, David E. Elashoff, Keith A. Delman, Mark B. Faries
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Oncology
James W. Jakub, Mark B. Faries
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
James W. Jakub, Michael Lowe, J. Harrison Howard, Jeffrey M. Farma, Amod Sarnaik, Todd Tuttle, Heather B. Neuman, Charlotte E. Ariyan, Abhineet Uppal, Steve Trocha, Georgia M. Beasley, Nabil Wasif, Karl Y. Bilimoria, Alan A. Thomay, Jacob B. Allred, Lucia Chen, Alicia M. Terando, Jeffrey D. Wayne, John F. Thompson, Alistair J. Cochran, Myung-Shin Sim, David E. Elashoff, Keith A. Delman, Mark B. Faries
Summary: This study retrospectively analyzed the oncologic outcomes of minimally invasive inguinal lymphadenectomy (MILND) in patients with melanoma. The results showed that MILND is safe and has favorable oncologic outcomes compared to traditional open inguinal lymphadenectomy (OILND).
ANNALS OF SURGICAL ONCOLOGY
(2022)
Letter
Dermatology
Anagha Bangalore Kumar, Margot S. Peters, James W. Jakub, William Harmsen, Christian L. Baum
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Surgery
James W. Jakub, Wenexia Zhang, Malvika Solanki, Jennifer Yonkus, Judy C. Boughey, Scott Harmsen, Karthik Giridhar
Summary: This study retrospectively examined the effectiveness of neoadjuvant therapy for breast cancer. The results showed that the potential for achieving a complete pathological response in HER2-negative cases is low with either neoadjuvant chemotherapy or neoadjuvant endocrine therapy. Most patients' nodal status and tumor size remained unchanged after neoadjuvant therapy, and there is a potential for the pathological stage to be higher at surgery than the clinical stage prior to neoadjuvant therapy.
Article
Oncology
Alexandra M. Adams, Elizabeth L. Carpenter, Guy T. Clifton, Timothy J. Vreeland, Robert C. Chick, Anne E. O'Shea, Patrick M. McCarthy, Phillip M. Kemp Bohan, Annelies T. Hickerson, Franklin A. Valdera, Ankur Tiwari, Diane F. Hale, John R. Hyngstrom, Adam C. Berger, James W. Jakub, Jeffrey J. Sussman, Montaser F. Shaheen, Xianzhong Yu, Thomas E. Wagner, Mark B. Faries, George E. Peoples
Summary: This study examined the efficacy of the TLPLDC vaccine in patients with melanoma and found that patients who did not receive pretreatment with G-CSF had improved overall survival and disease-free survival. Direct collection of dendritic cells without G-CSF resulted in higher expression of genes associated with dendritic cell maturation, potentially improving clinical efficacy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Amanda L. Nash, Samantha M. Thomas, Suniti N. Nimbkar, Tina J. Hieken, Kandice K. Ludwig, Lisa K. Jacobs, Megan E. Miller, Kristalyn K. Gallagher, Jasmine Wong, Heather B. Neuman, Jennifer Tseng, Taryn E. Hassinger, Tari A. King, E. Shelley Hwang, James W. Jakub, Laura H. Rosenberger
Summary: This study explores racial-ethnic differences in a large US cohort of women with phyllodes tumors (PT) and finds that age, tumor size, and subtype have small differences. However, there are no differences in recurrence-free survival according to race-ethnicity.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Amy C. Degnim, Brittany L. Siontis, Safia K. Ahmed, Tanya L. Hoskin, Tina J. Hieken, James W. Jakub, Christian L. Baum, Courtney Day, Sarah E. Schrup, Lauren Smith, Jodi M. Carter, Tiffany M. Sae Kho, Katrina N. Glazebrook, Aparna Vijayasekaran, Scott H. Okuno, Ivy A. Petersen
Summary: This study evaluated the impact of trimodality treatment compared to monotherapy or dual therapy for radiation-associated angiosarcoma of the breast (RAASB) after prior breast cancer treatment. The study found that trimodality therapy demonstrated a higher rate of pathological complete response and improved 5-year recurrence-free survival, but had more surgical complications and toxic effects.
CLINICAL CANCER RESEARCH
(2023)
Editorial Material
Oncology
Molly M. Benolken, Sarah McLaughlin, Mara Piltin, Mary Mrdutt, Zhuo Li, James W. Jakub
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Molly M. Benolken, Sarah McLaughlin, Mara Piltin, Mary Mrdutt, Zhuo Li, James W. Jakub
Summary: This study aimed to determine the frequency of metastatic involvement of an axillary reverse mapping (ARM) lymph node (LN) among patients undergoing axillary lymph node dissection (ALND). Among the 139 patients enrolled, 20% of the patients had a positive ARM LN.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Haeyoung Kim, Tina J. Hieken, Feven Abraha, James W. Jakub, Kimberly S. Corbin, Keith M. Furutani, Judy C. Boughey, Bradley J. Stish, Christopher L. Deufel, Amy C. Degnim, Dean A. Shumway, Safia K. Ahmed, Mara A. Piltin, Nicole P. Sandhu, Amy L. Conners, Kathryn J. Ruddy, Robert W. Mutter, Sean S. Park
Summary: This study evaluated the long-term outcome of accelerated partial breast irradiation using intraoperatively placed applicator-based brachytherapy in early-stage breast cancer. The results showed that patients treated with this method had a low rate of breast tumor recurrence, and it was correlated with menopausal status, BMI, and adherence to endocrine therapy.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
James W. Jakub, Gina K. Hesley, Nicholas B. Larson, Michael J. Yaszemski, A. Lee Miller, James F. Greenleaf, Matthew W. Urban, Christine U. Lee
Summary: This study evaluates the short-term safety and comparability of a nonmetallic twinkle marker to standard breast biopsy clips and radioactive seeds in terms of their visibility on color Doppler ultrasound. The results demonstrate that the twinkle marker is easily identifiable and has comparable safety and detection ease to the biopsy clip, suggesting its potential for clinical use.
RADIOLOGY-IMAGING CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christine U. Lee, Matthew W. Urban, A. Lee Miller, Susheil Uthamaraj, James W. Jakub, Gina K. Hesley, Benjamin G. Wood, Nathan J. Brinkman, James L. Herrick, Nicholas B. Larson, Michael J. Yaszemski, James F. Greenleaf
Summary: Color Doppler twinkling is a valuable ultrasound feature in diagnosing urinary stones. This study investigates a polymeric material, PMMA, which twinkles and has measurable surface roughness and porosity. The comparison of different materials used for breast biopsy markers shows how twinkling can improve ultrasound detection.
EUROPEAN RADIOLOGY EXPERIMENTAL
(2022)