Analysis of type 2 diabetes and obesity genetic variants in Mexican Pima Indians: Marked allelic differentiation among Amerindians at HLA

A genomic perspective on HLA evolution

(2017) Diogo Meyer et al.   IMMUNOGENETICS

Identity-by-Descent Mapping Identifies Major Locus for Serum Triglycerides in Amerindians Largely Explained by anAPOC3Founder MutationCLINICAL PERSPECTIVE

(2017) Wen-Chi Hsueh et al.   Circulation-Cardiovascular Genetics

Role of Established Type 2 Diabetes–Susceptibility Genetic Variants in a High Prevalence American Indian Population

(2015) Robert L. Hanson et al.   DIABETES

Environmentally Driven Increases in Type 2 Diabetes and Obesity in Pima Indians and Non-Pimas in Mexico Over a 15-Year Period: The Maycoba Project

(2015) Julian Esparza-Romero et al.   DIABETES CARE

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk

(2015) Xinli Hu et al.   NATURE GENETICS

The Concordance and Heritability of Type 2 Diabetes in 34,166 Twin Pairs From International Twin Registers: The Discordant Twin (DISCOTWIN) Consortium

(2015) Gonneke Willemsen et al.   Twin Research and Human Genetics

Revisiting the Thrifty Gene Hypothesis via 65 Loci Associated with Susceptibility to Type 2 Diabetes

(2014) Qasim Ayub et al.   AMERICAN JOURNAL OF HUMAN GENETICS

selscan: An Efficient Multithreaded Program to Perform EHH-Based Scans for Positive Selection

(2014) Z. A. Szpiech et al.   MOLECULAR BIOLOGY AND EVOLUTION

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

(2014) Anubha Mahajan et al.   NATURE GENETICS

A Genome-Wide Association Study in American Indians Implicates DNER as a Susceptibility Locus for Type 2 Diabetes

(2013) R. L. Hanson et al.   DIABETES

Estimating and interpreting FST: The impact of rare variants

(2013) G. Bhatia et al.   GENOME RESEARCH

Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes

(2013) Yunhua L. Muller et al.   HUMAN GENETICS

MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation

(2013) L. Bian et al.   HUMAN MOLECULAR GENETICS

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico

(2013)   NATURE

Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study

(2013) Christopher S. Carlson et al.   PLOS BIOLOGY

Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration

(2013) Erik Corona et al.   PLoS Genetics

Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci

(2012) Richa Saxena et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Using identity by descent estimation with dense genotype data to detect positive selection

(2012) Lide Han et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Variants in theLEPRGene Are Nominally Associated With Higher BMI and Lower 24-h Energy Expenditure in Pima Indians

(2012) Michael T. Traurig et al.   Obesity

Evolutionary Analysis of Classical HLA Class I and II Genes Suggests That Recent Positive Selection Acted on DPB1*04∶01 in Japanese Population

(2012) Minae Kawashima et al.   PLoS One

Genome-wide Comparison of African-Ancestry Populations from CARe and Other Cohorts Reveals Signals of Natural Selection

(2011) Gaurav Bhatia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion

(2011) R. C. Williams et al.   DIABETOLOGIA

Statistical methods for detecting natural selection from genomic data

(2011) Yoshiyuki Suzuki   GENES & GENETIC SYSTEMS

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

(2011) Jaspal S Kooner et al.   NATURE GENETICS

A Genome-Wide Association Study of BMI in American Indians

(2011) Alka Malhotra et al.   Obesity

High-Resolution Detection of Identity by Descent in Unrelated Individuals

(2010) Sharon R. Browning et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Variants in ASK1 Are Associated With Skeletal Muscle ASK1 Expression, In Vivo Insulin Resistance, and Type 2 Diabetes in Pima Indians

(2010) L. Bian et al.   DIABETES

Natural Selection and the Distribution of Identity-by-Descent in the Human Genome

(2010) Anders Albrechtsen et al.   GENETICS

Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions

(2010) Yann C. Klimentidis et al.   HUMAN GENETICS

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

A Genome-Wide Association Study Identifies Susceptibility Variants for Type 2 Diabetes in Han Chinese

(2010) Fuu-Jen Tsai et al.   PLoS Genetics

Common Variation in SIM1 Is Reproducibly Associated With BMI in Pi ma Indians

(2009) M. Traurig et al.   DIABETES

Molecular variation at the HLA-A, B, C, DRB1, DQA1, and DQB1 loci in full heritage American Indians in Arizona: private haplotypes and their evolution

(2009) R. Williams et al.   TISSUE ANTIGENS

The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland

(2009) Alkes L. Price et al.   PLoS Genetics

Balancing selection and heterogeneity across the classical human leukocyte antigen loci: A meta-analytic review of 497 population studies

(2008) Owen D. Solberg et al.   HUMAN IMMUNOLOGY

Global burden of obesity in 2005 and projections to 2030

(2008) T Kelly et al.   INTERNATIONAL JOURNAL OF OBESITY

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

(2008) Eleftheria Zeggini et al.   NATURE GENETICS

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

(2008) Gudmar Thorleifsson et al.   NATURE GENETICS

Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation

(2008) J. Z. Li et al.   SCIENCE