Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Dulce C. Macias-Ceja, Maria D. Barrachina, Dolores Ortiz-Masia
Summary: Chronic inflammation is associated with excessive deposition of extracellular matrix and leads to fibrosis. Intestinal fibrosis is a common complication of inflammatory bowel disease (IBD), and deregulated autophagy is linked to fibrosis progression. Understanding the role of autophagy in fibrosis may provide new targets for antifibrotic therapy. This review focuses on the relevance of autophagy in fibrosis, with a special emphasis on IBD-related fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Bing Xia, Xiaoning Liu, Zhiqing Li, Jiaoyan Ren, Xuebo Liu
Summary: Inflammatory bowel disease (IBD) is a global disease with a complex pathogenesis, and its initiation and progression are closely related to perturbations in the gut microbiota. This article summarizes the latest understanding of the gut microbiota in the context of IBD, including its interactions with susceptibility genes, the intestinal barrier, host immunity, and metabolites. The effects of microbiota-targeted nutritional strategies, such as probiotics, probiotic foods, and prebiotics, are also discussed. More clinical trials and mechanistic studies on IBD are needed to further explore their potential as dietary supplements or functional foods.
CURRENT OPINION IN FOOD SCIENCE
(2023)
Article
Food Science & Technology
Paulo Sergio Loubet Filho, Thais Otranto Dias, Vitoria Helena de Oliveira Teixeira Reis, Amanda Maria Tomazini Munhoz Moya, Elisvania Freitas dos Santos, Cinthia Bail Betim Cazarin
Summary: The incidence of inflammatory bowel diseases (IBD) has increased and its etiology remains unknown. Risk factors, including food intake, are associated with developing IBD. Functional foods (FF) can modulate the gut microbiota and improve the health quality of IBD patients.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rolf Reiter, Florian N. Loch, Carsten Kamphues, Christian Bayerl, Stephan R. Marticorena Garcia, Britta Siegmund, Anja A. Kuehl, Bernd Hamm, Juergen Braun, Ingolf Sack, Patrick Asbach
Summary: This study tested the feasibility of MR elastography of the gut in healthy volunteers and IBD patients, showing excellent diagnostic performance in predicting IBD.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Engineering, Environmental
Han Liu, Jinru Sun, Mingkai Wang, Sicheng Wang, Jiacan Su, Can Xu
Summary: Inflammatory bowel disease (IBD) is a serious gastrointestinal disease characterized by pain, diarrhea, and bloody stools. Intestinal organoids and organoids extracellular vesicles (OEVs) have shown great potential in IBD treatment. Intestinal organoids have various applications in disease modeling, drug development, and host-microbe interactions, while OEVs have physiological effects and can participate in physiological and pathological processes. This review provides an overview of IBD and its current treatments, as well as the construction and applications of intestinal organoids and OEVs in IBD treatment. The advantages and challenges of these approaches are also discussed.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Kairuo Wang, Qian Chen, Li Ding, Yefei Zhu, Xinyue Wang, Mengting Zhou, Meiqi Chang, Manman Pei, Yuanyuan Zhang, Yang Zhang, Yu Chen, Huanlong Qin
Summary: This study developed a mucoadhesive probiotic-mediated therapeutic strategy to achieve bioadhesion and prolong the residence time of oral medication in the intestinal tract. It effectively modulated intestinal inflammation and microbiota, enhancing the therapeutic effect.
Review
Biochemistry & Molecular Biology
Shaghayegh Baradaran Ghavami, Hamid Asadzadeh Aghdaei, Dario Sorrentino, Shabnam Shahrokh, Maryam Farmani, Fatemeh Ashrafian, Maria Pina Dore, Shahrbanoo Keshavarz Azizi Raftar, Seyed Mobin Khoramjoo, Mohammad Reza Zali
Summary: Inflammatory bowel diseases (IBDs) are immune-mediated, chronic relapsing diseases with a rising prevalence worldwide. Probiotic bacteria may impact immunomodulation by regulating dendritic cells to produce tolerogenic DCs, which could play a role in the treatment of IBD and associated conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Samantha Gonzalez Delgado, Idalia Garza-Veloz, Fabiola Trejo-Vazquez, Margarita L. Martinez-Fierro
Summary: This study aims to integrate scientific data on the role of the intestinal microbiota in regulating gut serotonin signaling and reuptake and its involvement in the pathogenesis of IBD. It is found that the use of selective serotonin reuptake inhibitors as an adjuvant therapy can improve disease activity and extraintestinal manifestations in IBD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Ayano Kondo, Siyuan Ma, Michelle Y. Y. Lee, Vivian Ortiz, Daniel Traum, Jonathan Schug, Benjamin Wilkins, Natalie A. Terry, Hongzhe Lee, Klaus H. Kaestner
Summary: This study used imaging mass cytometry platform to analyze multiple imaging of IBD and healthy intestinal tissues, revealing increased proliferation and HLA-DR expression in intestinal epithelia of IBD patients, positively correlated with inflammation severity. Neighborhood analysis showed enrichment of regulatory T cell interactions with macrophages, T cells, and plasma cells in IBD.
Article
Nutrition & Dietetics
Adelaide Teofani, Irene Marafini, Federica Laudisi, Daniele Pietrucci, Silvia Salvatori, Valeria Unida, Silvia Biocca, Giovanni Monteleone, Alessandro Desideri
Summary: This study investigated the impact of lifestyle and dietary habits on the intestinal microbiota diversity and relative abundance in patients with IBD, identifying specific confounders and covariates that influence the association between certain bacterial taxa and disease status. The results suggest that variables related to an IBD-associated lifestyle and dietary habits play a role in modulating the gut microbiota in IBD patients compared to healthy controls.
Review
Cell Biology
Jayshree Mishra, Madyson Stubbs, Longxiang Kuang, Nitza Vara, Priyam Kumar, Narendra Kumar
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract. Probiotics and their engineering show great potential in treating chronic inflammatory conditions, including IBD. Personalized probiotic treatment is important due to the diversity of the gut microbiome in different populations.
MEDIATORS OF INFLAMMATION
(2022)
Article
Gastroenterology & Hepatology
Alka A. Potdar, Shishir Dube, Takeo Naito, Katherine Li, Gregory Botwin, Talin Haritunians, Dalin Li, David Casero, Shaohong Yang, Janine Bilsborough, Jacqueline G. Perrigoue, Lee A. Denson, Mark Daly, Stephan R. Targan, Phillip Fleshner, Jonathan Braun, Subra Kugathasan, Thaddeus S. Stappenbeck, Dermot P. B. McGovern
Summary: The study identified differences in intestinal ACE2 expression levels in patients with Crohn's disease and ulcerative colitis, associated with inflammation and disease severity. Treatment with anti-cytokine therapy restored ACE2 expression, potentially impacting outcomes of severe acute respiratory syndrome coronavirus 2 infection.
Review
Biochemistry & Molecular Biology
Carolina Battistini, Rafael Ballan, Marcos Edgar Herkenhoff, Susana Marta Isay Saad, Jun Sun
Summary: Inflammatory bowel disease is a chronic inflammation of the GI tract, including Crohn's disease and ulcerative colitis, associated with microbiota dysbiosis and vitamin D deficiency. Further studies are needed to explore the mechanisms and therapeutic potential related to vitamin D/VDR in gut microbiota modulation for IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Lizi M. Hegarty, Gareth-Rhys Jones, Calum C. Bain
Summary: This Review provides detailed insights into the biology of macrophages in the context of inflammatory bowel disease and discusses future perspectives.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Dermatology
Maria Del Carmen V. Pereda, Gustavo Dieamant, Cecilia Nogueira, Samara Eberlin, Gustavo Facchini, Lilian Mussi, Marcio A. Polezel, Divino Martins-Oliveira, Paulo T. V. Rosa, Luiz C. Di Stasi
JOURNAL OF COSMETIC DERMATOLOGY
(2019)
Article
Medicine, Research & Experimental
Marcos F. F. Calabresi, Alexandre Tanimoto, Andre G. Prospero, Fabio P. F. Mello, Guilherme Soares, Luiz C. Di Stasi, Jose R. A. Miranda
Article
Multidisciplinary Sciences
Camila Vaz de Souza, Maira Vidor Salvador, Priscila Tunes, Luiz Claudio Di Stasi, Elza Guimaraes
Article
Dermatology
Edson Katekawa, Jeanifer Caverzan, Lilian Mussi, Flavio B. Camargo-Junior, Bianca Sufi, Giovana Padovani, Lucas Nazato, Cecilia Nogueira, Wagner Magalhaes, Luiz C. Di Stasi
JOURNAL OF COSMETIC DERMATOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Alexandre Tanimoto, Aline Witaicenis, Icaro P. Caruso, Hemily M. R. Piva, Gabriela C. Araujo, Fabio R. Moraes, Marcelo C. Fossey, Marinonio L. Cornelio, Fatima P. Souza, Luiz C. Di Stasi
CHEMICO-BIOLOGICAL INTERACTIONS
(2020)
Article
Plant Sciences
Ana E. Quaglio, Vinicius M. Cruz, Luiz D. Almeida-Junior, Celso A. R. A. Costa, Luiz C. Di Stasi
Article
Food Science & Technology
T. F. S. Curimbaba, L. D. Almeida-Junior, A. S. Chagas, A. E. V. Quaglio, A. M. Herculano, L. C. Di Stasi
Review
Biochemistry & Molecular Biology
Luiz C. Di Stasi
Summary: Inflammatory bowel disease is a chronic inflammatory disease without definitive pharmacological treatment. The unclear etiology limits the development of new drugs, leading to high rates of refractory patients. Natural products, such as coumarins, show potential as alternative therapies in IBD.
Article
Gastroenterology & Hepatology
Ana Elisa Valencise Quaglio, Felipe Jose Santaella, Maria Aparecida Marchesan Rodrigues, Ligia Yukie Sassaki, Luiz Claudio Di Stasi
Summary: The study aimed to investigate the miRNA expression profiles in UC and CD patients, as well as the potential pathophysiological contributions of differentially expressed miRNA. The results showed significant differences in miRNA expression between patients with different diseases, aiding in the differentiation of UC from CD and providing insights into the distinct pathophysiology of each disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Dermatology
Rafael C. Biscaro, Lilian Mussi, Bianca Sufi, Giovana Padovani, Flavio B. Camargo Junior, Wagner V. Magalhaes, Luiz C. Di Stasi
Summary: The study evaluated the effects of a phytocosmetic formulation containing Myrothamnus flabellifolia leaf and Coffea arabica seed plant extracts on human dermal fibroblasts, and found that it improved various skin features in a clinical trial, positioning it as an innovative and safe herbal preparation for skin anti-aging and lightening effects.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Immunology
Ellen Cristina Souza de Oliveira, Lesvi Moya Dalmau, Celso Acacio Rodrigues de Almeida Costa, Luiz Domingues de Almeida Junior, Cintia Reis Ballard, Mario Roberto Marostica Junior, Marcella Aparecida Stahl, Renato Grimaldi, Aline Witaicenis, Luiz Claudio Di Stasi
Summary: This study evaluated the anti-inflammatory effects of avocado fruit pulp on intestinal inflammation in rats. The results showed that dietary intervention with 20% avocado pulp could reduce the severity of colonic lesions, inhibit the production of inflammatory factors, and did not cause adverse effects on biochemical or behavioral parameters in rats.
INFLAMMOPHARMACOLOGY
(2023)
Article
Dermatology
Jeanifer Caverzan, Lilian Mussi, Bianca Sufi, Giovana Padovani, Lucas Nazato, Flavio B. Camargo, Wagner V. Magalhaes, Luiz C. Di Stasi
Summary: The study showed that ThymLec 2% can reduce facial wrinkles and expression lines while promoting face oval remodeling. In in vitro studies, ThymLec upregulated PPAR-gamma expression, increased adiponectin production, and stimulated the process of adipogenesis.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Ana Quaglio, Gabriela Batista, Luiz Almeida, Ligia Sassaki, Luiz Di Stasi
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Ana Quaglio, Gabriela Batista, Ligia Sassaki, Luiz Di Stasi
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2020)