Review
Chemistry, Multidisciplinary
Seyedmohammad Hosseininezhad, Ali Ramazani
Summary: Thiazole ring is an important heterocycle scaffold in organic and medicinal chemistry, with significant biological activities. This review highlights the advances in antimicrobial, anti-inflammatory, and anticancer activities of structures containing thiazole scaffold, and analyzes the effects of various groups on this scaffold. The results indicate that thiazole hybrids have potential antimicrobial, anti-inflammatory, and anticancer activities.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Hosam M. Habib, Hamada El-Gendi, Esmail M. El-Fakharany, Mohamed G. El-Ziney, Ahmed F. El-Yazbi, Fatima T. Al Meqbaali, Wissam H. Ibrahim
Summary: The polyphenolic profile of pomegranate juice concentrate was investigated for the first time, revealing its potential health benefits and antioxidant activity. The concentrate exhibited inhibitory effects on oxidative damage and enzyme activities. It also demonstrated antibacterial effects and dose-dependent apoptosis on cancer cells.
Review
Polymer Science
Muhammad Azeem, Muhammad Hanif, Khalid Mahmood, Nabeela Ameer, Fazal Rahman Sajid Chughtai, Usman Abid
Summary: Flavonoids, such as quercetin, are powerful natural antioxidants and cytotoxic compounds found in many fruits and vegetables. A recent review highlighted the various roles of quercetin in the medical field, including antioxidant, antimicrobial, antidiabetic, anticancerous, and anti-inflammatory effects. The review also discussed the use of quercetin complexes in drug delivery systems and therapeutic interventions.
Article
Multidisciplinary Sciences
Hung-Yin Liu, Yi-Hung Lin, Pei-Ju Lin, Pei-Chien Tsai, Shu-Fen Liu, Ying-Chou Huang, Jia-Jiun Tsai, Ching- Huang, Ming-Lun Yeh, Po-Cheng Liang, Zu-Yau Lin, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Chung-Feng Huang, Ming-Lung Yu
Summary: The study found that anti-HCV titer is a reliable predictor of HCV viremia, which holds true for both patients with HCV mono-infection and HBV dual-infection.
Article
Chemistry, Multidisciplinary
Po-Hsien Li, Yun-Jhen Shih, Wen-Chien Lu, Ping-Hsiu Huang, Chiun-Chuang R. Wang
Summary: This study investigated the effects of different concentrations of ethanol solvents on the chemical compositions and biological activities of Bull Camphor tree leaves extract. The 50% ethanol extract showed the highest total polyphenols and total flavonoids content, as well as the best antioxidant and antibacterial activities.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Plant Sciences
Qi-Xuan Kuang, Yan Luo, Li-Rong Lei, Wen-Xiu Guo, Xin-Ai Li, Yu-Mei Wang, Xue-Yan Huo, Meng-Dan Liu, Qi Zhang, Dan Feng, Li-Jun Huang, Dong Wang, Yu-Cheng Gu, Yun Deng, Da-Le Guo
Summary: Transcriptome analysis identified hydroanthraquinones with anti-inflammatory effects, which were confirmed through in vitro and in vivo assays. Further experiments revealed that one of the compounds could suppress the NF-kappa B signaling pathway, leading to its anti-inflammatory activity.
JOURNAL OF NATURAL PRODUCTS
(2022)
Review
Biochemistry & Molecular Biology
Hesham R. El-Seedi, Nermeen Yosri, Bishoy El-Aarag, Shaymaa H. Mahmoud, Ahmed Zayed, Ming Du, Aamer Saeed, Syed G. Musharraf, Islam M. El-Garawani, Mohamed R. Habib, Haroon Elrasheid Tahir, Momtaz M. Hegab, Xiaobo Zou, Zhiming Guo, Thomas Efferth, Shaden A. M. Khalifa
Summary: Cardiotonic steroids are hormones found in the blood of amphibians and toads, as well as in natural products like plants, herbs, and marines. They have effects against congestive heart failure and atrial fibrillation, and are divided into two groups: cardenolides and bufadienolides. This review focuses on their chemistry, antiviral, and anticancer activities, particularly in combating chronic health problems caused by cancer, viruses, and inflammations. Various cardiotonic steroids from toad venom have been isolated and shown to exhibit superior activities. Identification of these compounds and their bioactivities has been achieved using molecular and biotechnological techniques.
Article
Polymer Science
Alba Cano-Vicent, Andrea Martinez-Agut, Alberto Tunon-Molina, Hamid Bakshi, Roser Sabater i Serra, Iman M. Alfagih, Murtaza M. Tambuwala, Angel Serrano-Aroca
Summary: Alginate crosslinked with calcium cations is a promising hydrogel for biomedical applications due to its non-toxicity, suitable mechanical properties, and insolubility in water. This study explored the biological properties of alginate films crosslinked with Ca2+ and Co2+ ions, including antiviral capacity, antibacterial properties, and anticancer activity. The results showed that the hydrogel exhibited biocompatibility in vivo and in vitro, as well as antibacterial and antiviral activity against methicillin-resistant Staphylococcus aureus and a surrogate of SARSCoV-2. Additionally, the hydrogel showed anticancer properties against melanoma and colon cancer cells.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Infectious Diseases
Firzan Nainu, Ayu Masyita, Muh. Akbar Bahar, Muhammad Raihan, Shajuthi Rahman Prova, Saikat Mitra, Talha Bin Emran, Jesus Simal-Gandara
Summary: Bee products have been traditionally used for treating various disorders, including cancer and microbial-related diseases. Compounds found in bee products show potential in anticancer, antibacterial, antiviral, and antiparasitic activity, making them promising for cancer and infectious disease management.
Article
Materials Science, Multidisciplinary
Ahmad M. Eid, Mohammed Hawash, Murad Abualhasan, Sabreen Naser, Mjd Dwaikat, Madleen Mansour, Miroslav Kohl, Andrea Kalendova
Summary: This study developed a Capparis spinosa oil nanoemulgel and evaluated its antimicrobial, anticancer, and anti-inflammatory effects. The nanoemulgel showed significant activity against Methicillin-Resistant Staphylococcus Aureus and Klebsiella pneumoniae, as well as on MCF-7, HepG2, and HeLa cancer cell lines. Additionally, it exhibited anti-inflammatory effects by targeting COX-1 and COX-2.
Article
Fisheries
W. A. D. L. R. Warnakula, H. M. V. Udayantha, D. S. Liyanage, W. K. M. Omeka, Chaehyeon Lim, Gaeun Kim, D. M. K. P. Sirisena, B. P. M. Vileka Jayamali, Qiang Wan, Jehee Lee
Summary: This study demonstrates for the first time that PhGal9 promotes M2 macrophage polarization and prevents VHSV attachment and replication by neutralizing virion and autophagy in teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Maja Friscic, Roberta Petlevski, Ivan Kosalec, Josip Madunic, Maja Matulic, Franz Bucar, Kroata Hazler Pilepic, Zeljan Males
Summary: This study evaluated the medicinal potential of species from the genus Globularia, specifically focusing on their antidiabetic, antioxidant, anti-inflammatory, antibacterial, and anticancer properties. The results showed that Globularia alypum and other related species exhibited significant biological activities, with G. punctata demonstrating the strongest antibacterial potential.
Article
Chemistry, Physical
R. Narmadha, R. Siranjeevi, M. Kannan, K. Kala
Summary: Cancer drugs can be found in natural sources, and capsaicin incorporated chitosan nanoparticles have been shown to have anticancer properties. However, their limited water solubility and bioavailability hinder their medicinal potential. This study synthesized and characterized CAP@CS nanoparticles encapsulated in a cellulose acetate membrane for potential use in cancer therapy and diabetes treatment. The synthesized membrane demonstrated efficacy in inhibiting tumor growth and inhibiting carbohydrate digesting enzymes, showing promising potential for cancer and diabetes treatment.
SURFACES AND INTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Antonella Di Sotto, Mehdi Valipour, Aala Azari, Silvia Di Giacomo, Hamid Irannejad
Summary: Tylophorine and lycorine, two potential antiviral agents derived from plants, show broad-spectrum antiviral properties and anti-inflammatory effects. They may help combat respiratory viral infections, mitigate the oncogenic effects of viruses, and contribute to cancer research. However, further research is needed to address pharmacologic development issues.
Article
Endocrinology & Metabolism
Lu Shi, Huijing Ye, Jun Huang, Yanbing Li, Xing Wang, Zhihui Xu, Jingqiao Chen, Wei Xiao, Rongxin Chen, Huasheng Yang
Summary: The study revealed that IL-38 levels were lower in patients with TAO compared to healthy controls, negatively correlated with disease activity, and exhibited anti-inflammatory and antifibrotic effects. IL-38 may be a promising marker of TAO disease activity and a potential target for TAO therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Energy & Fuels
Maira Sadaqat, Sumaira Manzoor, Salma Aman, Laraib Nisar, Muhammad Najam-Ul-Haq, Afzal Shah, Ahmed M. Shawky, H. Elhosiny Ali, Muhammad Naeem Ashiq, T. A. Taha
Summary: In this study, single-phase zirconium nickel oxide nanospheres with different concentrations of Ni were successfully fabricated for the first time using a sol-gel method. Among these, Zr0.012Ni4.3O0.68 exhibited remarkable OER performance on a glassy carbon electrode, requiring only 294 mV overpotential at 10 mA cm(-2). This performance is attributed to the presence of a large number of oxygen vacancies in the non-stoichiometric compound Zr0.012Ni4.3O0.68.
Article
Chemistry, Physical
Satya Kumar Avula, Saeed Ullah, Sobia Ahsan Halim, Ajmal Khan, Muhammad U. Anwar, Rene Csuk, Ahmed Al-Harrasi
Summary: In this study, 26 compounds of substituted quinoline derivatives were synthesized and their alpha-glucosidase inhibition activity was investigated. Most of the synthesized compounds showed good inhibitory activity against alpha-glucosidase, and some exhibited very promising results. Compound 12's structure was confirmed through single crystal X-ray diffraction. The study revealed a new series of substituted quinoline derivatives as potential inhibitors of alpha-glucosidase.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Faiza Rehman, Nazish Parveen, Jibran Iqbal, Murtaza Sayed, Noor S. Shah, Sabah Ansar, Javed Ali Khan, Afzal Shah, Farrukh Jamil, Grzegorz Boczkaj
Summary: The removal of norfloxacin, a widely used pharmaceutical and emerging water pollutant, was studied using various oxidative processes. The use of peroxides, in conjunction with UV-C and UV-C/Fe2+, significantly enhanced the degradation of norfloxacin. Among the processes tested, UV-C/Fe2+/HSO5- showed the best performance.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Amjad Hussain, Marie-Lise Bourguet-Kondracki, Maryam Majeed, Muhammad Ibrahim, Muhammad Imran, Xian-Wen Yang, Ishtiaq Ahmed, Ataf Ali Altaf, Anees Ahmed Khalil, Abdur Rauf, Polrat Wilairatana, Hassan A. Hemeg, Riaz Ullah, Ivan R. Green, Iftikhar Ali, Syed Tasadaque A. Shah, Hidayat Hussain
Summary: Breast cancer, as a significant tumor, lacks effective treatment. Natural products as bioactive metabolites are being considered as substitute treatments. Marine sources, particularly marine sponges, demonstrate diverse bioactive compounds with potential therapeutic effects against breast cancer cells. This review focuses on marine-derived secondary metabolites isolated from various marine organisms that have cytotoxic effects on breast cancer cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Shengxin Sun, Xia Wang, Renei Csuk, Shengkun Li
Summary: Drimane meroterpenoids have attracted attention for their structural diversity and bioactivity, but the lack of an efficient synthetic route has hindered further development. A nickel-catalyzed decarboxylative cross-coupling method has been established to access a variety of drimane meroterpenoids, featuring mild conditions and tolerance for challenging functional groups. This method enables the scalable synthesis of advanced intermediates for late-stage functionalizations, which has led to the discovery of new antifungal leads against Rhizoctonia solani.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Anatomy & Morphology
Shah Faisal, Riaz Ullah, Amal Alotaibi, Sania Zafar, Muhammad Rizwan, Muhammad Hamza Tariq
Summary: The current study utilized Paraclostridium benzoelyticum strain 5610 to synthesize biogenic silver nanoparticles (AgNPs). Various characterization techniques were used to analyze the AgNPs, including UV-spectroscopy, XRD, FTIR, SEM, and EDX. The AgNPs exhibited antibacterial activity against sinusitis pathogens, antioxidant potential, anti-inflammatory activity, and high toxicity against HepG2 cell line. These biogenic AgNPs have potential for anti-aging treatments and could be used as therapy for cancer, bacterial infections, and inflammatory diseases.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Biochemistry & Molecular Biology
Sajid Ali, Nazma Faqir, Falak Naz, Muhammad Ishtiaq Jan, Naeem Khan, Amal Alotaibi, Riaz Ullah
Summary: The study found that complexes 1 and 2 can effectively inhibit the formation of bacterial biofilms and cause damage to the bacterial membrane. The minimum inhibitory concentration and minimum bactericidal concentration of complexes 1 and 2 were 46.87 +/- 1.822 and 93.75 +/- 1.345 and 47.87 +/- 1.345 and 94.85 +/- 1.466 mu g/mL, respectively. Both complexes also showed good interactions with E. coli DNA. Therefore, complexes 1 and 2 are good antibiofilm agents that can restrict the development of bacterial biofilms on therapeutic implants by disrupting the bacterial membrane and interacting with bacterial DNA.
Article
Chemistry, Multidisciplinary
Nasiara Karim, Inbisat Khan, Imran Khan, Sobia Ahsan Halim, Asaad Khalid, Ashraf N. Abdalla, Najeeb Ur Rehman, Ajmal Khan, Ahmed Al-Harrasi
Summary: This study explored newly synthesized phthalimide derivatives (compounds 1-3) for their potential in improving memory impairment associated with Alzheimer's disease. The compounds exhibited significant inhibition of acetylcholinesterase and butyrylcholinesterase, as well as excellent antioxidant potential. In vivo studies showed that the compounds reversed scopolamine-induced amnesia, indicating their potential as novel therapeutics for Alzheimer's disease.
Article
Chemistry, Multidisciplinary
Faiz Talab, Saeed Ullah, Aftab Alam, Sobia Ahsan Halim, Najeeb Ur Rehman, Zainab, Mumtaz Ali, Abdul Latif, Ajmal Khan, Ahmed Al-Harrasi, Manzoor Ahmad
Summary: Polyhydroquinoline derivatives (1-15) were synthesized through an unsymmetrical Hantzsch reaction in ethanol solvent. The synthesized compounds were analyzed using spectroscopic techniques and were found to have potential for inhibiting α-glucosidase. In silico methods were used to explore the mechanism of inhibition and the results matched experimental data.
Article
Chemistry, Analytical
Najeeb Ur Rehman, Faisal F. Albaqami, Mohammad Ayman A. Salkini, Noureldin M. Farahat, Hatim H. Alharbi, Saad M. Almuqrin, Maged S. Abdel-Kader, Asmaa E. Sherif
Summary: In this study, three types of cinnamon available in the Saudi Arabian market, Cinnamomum verum, C. cassia, and C. loureiroi, were compared for their tracheal relaxant effects. The essential oil of C. verum showed the strongest relaxation effect on guinea pig isolated tracheal muscles. Cinnamaldehyde, the main component in all three oils, induced complete relaxation of low K+-evoked contractions.
Article
Chemistry, Applied
Abeeda Mushtaq, Sajad Mohd Wani, A. R. Malik, Amir Gull, Seema Ramniwas, Gulzar Ahmad Nayik, Sezai Ercisli, Romina Alina Marc, Riaz Ullah, Ahmed Bari
Summary: The increasing demand for healthy diet by consumers has led to the adoption of cutting-edge methods for maintaining the quality of fruits and vegetables without preservatives. Emulsion based coating approach is considered a viable way to extend the shelf life of fresh produce. The developing field of nanoemulsions has created new opportunities in industries such as medicines, cosmetics, and food, as they efficiently encapsulate active ingredients and improve biological activity.
Article
Biochemistry & Molecular Biology
Niels V. Heise, Toni C. Denner, Selina Becker, Sophie Hoenke, Rene Csuk
Summary: In this study, Asiatic acid was converted into different types of rhodamine conjugates with piperazinyl, homopiperazinyl, and 1,5-diazocinyl spacers. The compounds were tested for cytotoxic activity, and compound 12 showed the highest cytotoxicity with an EC50 of 0.8 nM. However, compound 18, with a ring expanded 1,5-diazocinyl moiety and n-propyl substituents, exhibited the highest selectivity with a selectivity factor of almost 190 while maintaining high cytotoxicity (EC50 = 1.9 nM for A2780 ovarian carcinoma).
Review
Engineering, Chemical
Abdul Haleem, Jian-Ming Pan, Afzal Shah, Hazrat Hussain, Wei-dong He
Summary: This review article focuses on the synthetic routes and applications of macro-porous cryogels. Different feasible synthetic routes for cryogels synthesis have been highlighted, including redox initiation cryo-polymerization which is time-consuming and expensive, and alternative routes such as UV radiation and gamma-radiation which have shown better results. The porosity and applications of cryogels have been studied, particularly in the areas of oil/water separation, dye adsorption, and triboelectric nanogenerators.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Maria Sadia, Jehangir Khan, Rizwan Khan, Syed Wadood Ali Shah, Adil Zada, Muhammad Zahoor, Riaz Ullah, Essam A. Ali
Summary: This work synthesized a curcumin-based fluorescence-on sensor (P) capable of selectively responding to Ni2+ ions in aqueous solution. P exhibited high selectivity towards Ni(2+) ions with negligible interferences from other metal cations. It had a fast response, sensitive detection limit (LOD = 2 x 10(-10) M), and a high association constant (K = 3.6 x 10(5) M-2) for complex formation with Ni(2+) ions. P could be recovered using EDTA as a chelating agent and showed great potential as a chemosensor for environmental applications.
Article
Chemistry, Medicinal
Hamid Ali, Abdus Samad, Amar Ajmal, Amjad Ali, Ijaz Ali, Muhammad Danial, Masroor Kamal, Midrar Ullah, Riaz Ullah, Muhammad Kalim
Summary: Yersinia pestis, a Gram-negative bacterium, is the causative agent of plague. If left untreated, it can lead to rapid death. There are three types of plague: bubonic, pneumonic, and septicemic. Bubonic plague can progress to septicemic plague if not diagnosed and treated in time, with high mortality rates for pneumonic and septicemic plague.
