期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 9, 页码 2372-2376出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201712350
关键词
aminohydroxylation; asymmetric catalysis; aza-Wacker reactions; benzoxazines; palladium
资金
- NSFC [21672197, 21502183, 21772184]
- Natural Science Foundation of Anhui Province [BJ2060190066]
- Chinese Academy of Science [XDB20000000]
A Pd-II-catalyzed asymmetric aminohydroxylation of 1,3-dienes with N-tosyl-2-aminophenols was developed by making use of a chiral pyridinebis(oxazoline) ligand. The highly regioselective reaction provides direct and efficient access to chiral 3,4-dihydro-2H-1,4-benzoxazines in high yield and enantioselectivity (up to 96:4 e.r.). The reaction employs readily available N-tosyl-2-aminophenols as a unique aminohydroxylation reagent and is complementary to known asymmetric aminohydroxylation methods.
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