期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 17, 页码 4612-4616出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201800829
关键词
aerobic catalysis; boron; copper; cross-coupling; decarboxylation
资金
- NSERC Canada
The copper-catalyzed decarboxylative benzylation of aryl and alkenyl boronic esters with electron-deficient aryl acetates is reported. The oxidative coupling proceeds under mild, aerobic conditions and tolerates a host of potentially reactive electrophilic functional groups that would be problematic with traditional benzylation methods (aryl iodides and bromides, protic heteroatoms, aldehydes, Michael acceptors). A reaction pathway in which a benzylic nucleophile is generated by aryl acetate decarboxylation and in turn is intercepted by the catalyst to form diarylmethane products is supported by mechanistic studies.
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