期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 36, 页码 11673-11677出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201806132
关键词
alkylation; cobalt; homogeneous catalysis; hydrogenation; tailor-made triphos
资金
- analytic department (LIKAT)
- State of Mecklenburg-Western Pomerania
- Federal State of Germany (BMBF)
- EU [670986]
The first cobalt-catalyzed hydrogenative N-methylation and alkylation of amines with readily available carboxylic acid feedstocks as alkylating agents and H-2 as ideal reductant is described. Combination of tailor-made triphos ligands with cobalt(II) tetrafluoroborate significantly improved the efficiency, thus promoting the reaction under milder conditions. This novel protocol allows for a broad substrate scope with good functional group tolerance, even in the presence of reducible alkenes, esters, and amides.
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