期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 6, 页码 1640-1644出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201709025
关键词
C-H activation; electron transfer; heteroaryls; photocatalysis; radicals
资金
- National Natural Science Foundation of China [21722205]
- Project of Scientific and Technologic Infrastructure of Suzhou [SZS201708]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Reported for the first time is a tertiary-alcohol-guided heteroarylation of remote C(sp(3))-H bonds. The mild and direct generation of alkoxyl radicals from alcohols is enabled by visible-light photocatalysis. A remote hydrogen atom and heteroaryl migration sequence are involved in the reaction. Many sensitive groups remain intact in the reaction, thus illustrating wide functional-group compatibility. This protocol provides a practical strategy for the late-stage modification of alkyl ketones.
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