期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 19, 页码 5525-5528出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201801424
关键词
artemisinin; chlorophyll; extraction; natural product synthesis; photooxidation
资金
- International Max Planck Research School Advanced Methods in Process and Systems Engineering (IMPRS ProEng)
- Max Planck Society
Active pharmaceutical ingredients are either extracted from biological sourceswhere they are synthesized in complex, dynamic environmentsor prepared in stepwise chemical syntheses by reacting pure reagents and catalysts under controlled conditions. A combination of these two approaches, where plant extracts containing reagents and catalysts are utilized in intensified chemical syntheses, creates expedient and sustainable processes. We illustrate this principle by reacting crude plant extract, oxygen, acid, and light to produce artemisinin, a key active pharmaceutical ingredient of the most powerful antimalarial drugs. The traditionally discarded extract of Artemisia annua plants contains dihydroartemisinic acidthe final biosynthetic precursoras well as chlorophyll, which acts as a photosensitizer. Efficient irradiation with visible light in a continuous-flow setup produces artemisinin in high yield, and the artificial biosynthetic process outperforms syntheses with pure reagents.
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