标题
Novel investigational drugs targeting IL-6 signaling for the treatment of depression
作者
关键词
-
出版物
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Volume 24, Issue 4, Pages 459-475
出版商
Informa Healthcare
发表日期
2015-01-14
DOI
10.1517/13543784.2014.998334
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Effect of Newer Serotonin-Noradrenalin Antidepressants on Cytokine Production: A Review of the Current Literature
- (2017) D. De Berardis et al. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
- Vagal nerve stimulation blocks interleukin 6-dependent synaptic hyperexcitability induced by lipopolysaccharide-induced acute stress in the rodent prefrontal cortex
- (2015) Francisco Garcia-Oscos et al. BRAIN BEHAVIOR AND IMMUNITY
- A Vision for Drug Discovery and Development: Novel Targets and Multilateral Partnerships
- (2014) Roger S. McIntyre ADVANCES IN THERAPY
- OP0043 Twenty-Four Weeks of Treatment with a Novel Anti-IL-6 Receptor Nanobody® (ALX-0061) Resulted in 84% ACR20 Improvement and 58% DAS28 Remission in a Phase I/Ii Study in RA
- (2014) J.-B. Holz et al. ANNALS OF THE RHEUMATIC DISEASES
- Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study
- (2014) Mark C Genovese et al. ANNALS OF THE RHEUMATIC DISEASES
- Sirukumab, a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy
- (2014) Josef S Smolen et al. ANNALS OF THE RHEUMATIC DISEASES
- Insights from interferon-α-related depression for the pathogenesis of depression associated with inflammation
- (2014) Carolina Hoyo-Becerra et al. BRAIN BEHAVIOR AND IMMUNITY
- Responsiveness of the EuroQol EQ-5D and Hospital Anxiety and Depression Scale (HADS) in rheumatoid arthritis patients receiving tocilizumab
- (2014) L. Traki et al. CLINICAL RHEUMATOLOGY
- CHALLENGING THE MYTH OF AN “EPIDEMIC” OF COMMON MENTAL DISORDERS: TRENDS IN THE GLOBAL PREVALENCE OF ANXIETY AND DEPRESSION BETWEEN 1990 AND 2010
- (2014) Amanda J. Baxter et al. DEPRESSION AND ANXIETY
- A review of the relationship between proinflammatory cytokines and major depressive disorder
- (2014) Juan Joseph Young et al. JOURNAL OF AFFECTIVE DISORDERS
- C-reactive protein, interleukin-6, soluble tumor necrosis factor α receptor 2 and incident clinical depression
- (2014) Patricia O. Chocano-Bedoya et al. JOURNAL OF AFFECTIVE DISORDERS
- β-arrestin 2 mediates the anti-inflammatory effects of fluoxetine in lipopolysaccharide-stimulated microglial cells
- (2014) Ren-Wei Du et al. Journal of Neuroimmune Pharmacology
- Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain
- (2014) I. L. Campbell et al. JOURNAL OF NEUROSCIENCE
- Siltuximab for multicentric Castleman's disease: a randomised, double-blind, placebo-controlled trial
- (2014) Frits van Rhee et al. LANCET ONCOLOGY
- Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
- (2014) Jan Mauer et al. NATURE IMMUNOLOGY
- Imipramine and fluoxetine inhibit LPS-induced activation and affect morphology of microglial cells in the rat glial culture
- (2014) Ewa Obuchowicz et al. Pharmacological Reports
- Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials
- (2014) Giuseppe Grosso et al. PLoS One
- Elevated IL-6 levels in patients with atypical depression but not in patients with typical depression
- (2014) Sebastian Rudolf et al. PSYCHIATRY RESEARCH
- Sarilumab, a fully human monoclonal antibody against IL-6Rα in patients with rheumatoid arthritis and an inadequate response to methotrexate: efficacy and safety results from the randomised SARIL-RA-MOBILITY Part A trial
- (2013) Tom W J Huizinga et al. ANNALS OF THE RHEUMATIC DISEASES
- Omega-3 PUFAs improved endothelial function and arterial stiffness with a parallel antiinflammatory effect in adults with metabolic syndrome
- (2013) Dimitris Tousoulis et al. ATHEROSCLEROSIS
- Association between serum brain-derived neurotrophic factor and plasma interleukin-6 in major depressive disorder with melancholic features
- (2013) Konstantinos Patas et al. BRAIN BEHAVIOR AND IMMUNITY
- SUICIDAL IDEATION IS ASSOCIATED WITH ELEVATED INFLAMMATION IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER
- (2013) Aoife O'Donovan et al. DEPRESSION AND ANXIETY
- Plasma levels of interleukin-6 and selective serotonin reuptake inhibitor response in patients with major depressive disorder
- (2013) Reiji Yoshimura et al. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
- Pharmacokinetics and safety of sirukumab following a single subcutaneous administration to healthy Japanese and Caucasian subjects
- (2013) Yanli Zhuang et al. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
- Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder
- (2013) Daimei Sasayama et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Effects of zinc supplementation on efficacy of antidepressant therapy, inflammatory cytokines, and brain-derived neurotrophic factor in patients with major depression
- (2013) Elham Ranjbar et al. NUTRITIONAL NEUROSCIENCE
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- (2013) Xin Yao et al. PHARMACOLOGY & THERAPEUTICS
- Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: A meta-analysis
- (2013) Kyoung-Sae Na et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Serotonin and interleukin-6: The role of genetic polymorphisms in IFN-induced neuropsychiatric symptoms
- (2013) Marc Udina et al. PSYCHONEUROENDOCRINOLOGY
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- (2013) Jürgen Scheller et al. SEMINARS IN IMMUNOLOGY
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- (2012) Virginia Elderkin-Thompson et al. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
- Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation
- (2012) Martina M. Hughes et al. BRAIN BEHAVIOR AND IMMUNITY
- Bupropion pre-treatment of endotoxin-induced depressive symptoms
- (2012) Nicole DellaGioia et al. BRAIN BEHAVIOR AND IMMUNITY
- Dysregulated relationship of inflammation and oxidative stress in major depression
- (2012) B.J. Rawdin et al. BRAIN BEHAVIOR AND IMMUNITY
- IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6
- (2012) Stefan Rose-John International Journal of Biological Sciences
- Interleukin-6, a Major Cytokine in the Central Nervous System
- (2012) María Erta et al. International Journal of Biological Sciences
- Increased inflammation and lower platelet 5-HT in depression with metabolic syndrome
- (2012) Ante Silić et al. JOURNAL OF AFFECTIVE DISORDERS
- Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: Randomized double-blind placebo-controlled study
- (2012) Seyed-Hesameddin Abbasi et al. JOURNAL OF AFFECTIVE DISORDERS
- IL-1β, IL-6, IL-8, IL-10, IFN-γ, TNF-α and its relationship with lipid parameters in patients with major depression
- (2012) Cicek Hocaoglu et al. METABOLIC BRAIN DISEASE
- Pro-inflammatory cytokines as predictors of antidepressant effects of exercise in major depressive disorder
- (2012) C D Rethorst et al. MOLECULAR PSYCHIATRY
- Randomized Trial of Tocilizumab in Systemic Juvenile Idiopathic Arthritis
- (2012) Fabrizio De Benedetti et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2012) Tsuyoshi Miyaoka et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
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- (2012) Bojana Dunjic-Kostic et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
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- (2012) Dalibor Karlović et al. PSYCHIATRY RESEARCH
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- (2012) A. J. Ferrari et al. PSYCHOLOGICAL MEDICINE
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- (2012) B.T. Baune et al. PSYCHONEUROENDOCRINOLOGY
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- (2012) Charles L. Raison et al. JAMA Psychiatry
- Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes
- (2012) S J Sukoff Rizzo et al. Translational Psychiatry
- Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder
- (2012) T Frodl et al. Translational Psychiatry
- Deep Brain Stimulation for Treatment-Resistant Depression: Follow-Up After 3 to 6 Years
- (2011) Sidney H. Kennedy et al. AMERICAN JOURNAL OF PSYCHIATRY
- Therapeutic Targeting of the Interleukin-6 Receptor
- (2011) Toshio Tanaka et al. Annual Review of Pharmacology and Toxicology
- Trajectories of Depression Severity in Clinical Trials of Duloxetine
- (2011) Ralitza Gueorguieva ARCHIVES OF GENERAL PSYCHIATRY
- The pro- and anti-inflammatory properties of the cytokine interleukin-6
- (2011) Jürgen Scheller et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Interleukin-6, a mental cytokine
- (2011) Anneleen Spooren et al. BRAIN RESEARCH REVIEWS
- Pharmacokinetics, pharmacodynamics and safety of a human anti-IL-6 monoclonal antibody (sirukumab) in healthy subjects in a first-in-human study
- (2011) Zhenhua Xu et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Assessing the ‘true’ effect of active antidepressant therapy v. placebo in major depressive disorder: use of a mixture model
- (2011) Michael E. Thase et al. BRITISH JOURNAL OF PSYCHIATRY
- PROINFLAMMATORY AND “RESILIENCY” PROTEINS IN THE CSF OF PATIENTS WITH MAJOR DEPRESSION
- (2011) Jose M. Martinez et al. DEPRESSION AND ANXIETY
- Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases
- (2011) Toshio Tanaka et al. FEBS LETTERS
- Plasma levels of brain-derived neurotrophic factor and interleukin-6 in patients with dysthymic disorder: comparison with age- and sex-matched major depressed patients and healthy controls
- (2011) Reiji Yoshimura et al. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
- Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor
- (2011) Christoph Garbers et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?
- (2011) Johann Steiner et al. Journal of Neuroinflammation
- Major depressive disorder: new clinical, neurobiological, and treatment perspectives
- (2011) David J Kupfer et al. LANCET
- Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C
- (2011) A K Smith et al. MOLECULAR PSYCHIATRY
- Fluctuations in Endogenous Kynurenic Acid Control Hippocampal Glutamate and Memory
- (2011) Ana Pocivavsek et al. NEUROPSYCHOPHARMACOLOGY
- The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis
- (2011) Jonas Hannestad et al. NEUROPSYCHOPHARMACOLOGY
- Acetylsalicylic acid as an augmentation agent in fluoxetine treatment resistant depressive rats
- (2011) Ying Wang et al. NEUROSCIENCE LETTERS
- Role of cytokines in atypical depression
- (2011) Ho-Kyoung Yoon et al. NORDIC JOURNAL OF PSYCHIATRY
- Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline
- (2011) Shiho Arakawa et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine
- (2011) Kathleen S. Alexander et al. PSYCHOPHARMACOLOGY
- Inflammatory Biomarkers in Depression: An Opportunity for Novel Therapeutic Interventions
- (2011) Madeline Li et al. Current Psychiatry Reports
- Toward an Anti-Inflammatory Strategy for Depression
- (2011) Shawn Hayley Frontiers in Behavioral Neuroscience
- Genome-Wide Pharmacogenetics of Antidepressant Response in the GENDEP Project
- (2010) Rudolf Uher et al. AMERICAN JOURNAL OF PSYCHIATRY
- Research Domain Criteria (RDoC): Toward a New Classification Framework for Research on Mental Disorders
- (2010) Thomas Insel et al. AMERICAN JOURNAL OF PSYCHIATRY
- Citalopram reduces endotoxin-induced fatigue
- (2010) Jonas Hannestad et al. BRAIN BEHAVIOR AND IMMUNITY
- Cytokine levels in the blood may distinguish suicide attempters from depressed patients
- (2010) Shorena Janelidze et al. BRAIN BEHAVIOR AND IMMUNITY
- The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer
- (2010) Athena Chalaris et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- IL-6: Regulator of Treg/Th17 balance
- (2010) Akihiro Kimura et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- A psychoneuroimmunological review on cytokines involved in antidepressant treatment response
- (2010) Debbie G. A. Janssen et al. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
- Understanding the role of inflammatory-related pathways in the pathophysiology and treatment of psychiatric disorders: evidence from human peripheral studies and CNS studies
- (2010) Brian Dean INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Exercise-induced release of cytokines in patients with major depressive disorder
- (2010) Ludvig Hallberg et al. JOURNAL OF AFFECTIVE DISORDERS
- Electroconvulsive therapy has acute immunological and neuroendocrine effects in patients with major depressive disorder
- (2010) Sjoerd B.A.H.A. Fluitman et al. JOURNAL OF AFFECTIVE DISORDERS
- Depression, cytokines and experimental pain: Evidence for sex-related association patterns
- (2010) Frank Euteneuer et al. JOURNAL OF AFFECTIVE DISORDERS
- Siltuximab, a Novel Anti–Interleukin-6 Monoclonal Antibody, for Castleman's Disease
- (2010) Frits van Rhee et al. JOURNAL OF CLINICAL ONCOLOGY
- Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir
- (2010) Toshio HIRANO PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
- Inflammatory changes upon a single maximal exercise test in depressed patients and healthy controls
- (2010) Silke Boettger et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Effects of eicosapentaenoic acid and fluoxetine on plasma cortisol, serum interleukin-1beta and interleukin-6 concentrations in patients with major depressive disorder
- (2010) Shima Jazayeri et al. PSYCHIATRY RESEARCH
- Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: a systematic literature review and meta-analysis of randomized controlled trials
- (2010) L. Campbell et al. RHEUMATOLOGY
- Prevalence and predictors of recurrence of major depressive disorder in the adult population
- (2009) F. Hardeveld et al. ACTA PSYCHIATRICA SCANDINAVICA
- Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity
- (2009) Neil A. Harrison et al. BIOLOGICAL PSYCHIATRY
- Interleukin-6 Is Elevated in the Cerebrospinal Fluid of Suicide Attempters and Related to Symptom Severity
- (2009) Daniel Lindqvist et al. BIOLOGICAL PSYCHIATRY
- Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
- (2009) Andrew H. Miller et al. BIOLOGICAL PSYCHIATRY
- A Meta-Analysis of Cytokines in Major Depression
- (2009) Yekta Dowlati et al. BIOLOGICAL PSYCHIATRY
- A prospective evaluation of the directionality of the depression–inflammation relationship
- (2009) Jesse C. Stewart et al. BRAIN BEHAVIOR AND IMMUNITY
- Clinical trial of adjunctive celecoxib treatment in patients with major depression: a double blind and placebo controlled trial
- (2009) Shahin Akhondzadeh et al. DEPRESSION AND ANXIETY
- Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals?
- (2009) Lucile Capuron et al. JOURNAL OF AFFECTIVE DISORDERS
- Depression, traumatic stress and interleukin-6
- (2009) Petr Bob et al. JOURNAL OF AFFECTIVE DISORDERS
- Altered expression of CD4+CD25+ regulatory T cells and its 5-HT1a receptor in patients with major depression disorder
- (2009) Yi Li et al. JOURNAL OF AFFECTIVE DISORDERS
- A Preliminary Study of Cytokines in Suicidal and Nonsuicidal Adolescents with Major Depression
- (2009) Vilma Gabbay et al. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
- Inflammation and the Phenomenology, Pathophysiology, Comorbidity, and Treatment of Bipolar Disorder
- (2009) Benjamin I. Goldstein et al. JOURNAL OF CLINICAL PSYCHIATRY
- Increase in Plasma Proinflammatory Cytokines After Electroconvulsive Therapy in Patients With Depressive Disorder
- (2009) Kai Lehtimäki et al. JOURNAL OF ECT
- Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis
- (2009) M Bryant Howren et al. PSYCHOSOMATIC MEDICINE
- A Discriminating Messenger RNA Signature for Bipolar Disorder Formed by an Aberrant Expression of Inflammatory Genes in Monocytes
- (2008) Roos C. Padmos et al. ARCHIVES OF GENERAL PSYCHIATRY
- Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study
- (2008) Fabiano G. Nery et al. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
- Structure-guided Optimization of the Interleukin-6 Trans-signaling Antagonist sgp130
- (2008) Stephanie Tenhumberg et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Functional polymorphisms in the interleukin-6 and serotonin transporter genes and depression and fatigue induced by interferon-α and ribavirin treatment
- (2008) S J Bull et al. MOLECULAR PSYCHIATRY
- Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study
- (2008) D. Gimeno et al. PSYCHOLOGICAL MEDICINE
- Common Genetic Contributions to Depressive Symptoms and Inflammatory Markers in Middle-Aged Men: The Twins Heart Study
- (2008) Shaoyong Su et al. PSYCHOSOMATIC MEDICINE
- Fatigue in patients with advanced cancer: a pilot study of an intervention with infliximab
- (2008) A. J. Tookman et al. SUPPORTIVE CARE IN CANCER
- The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer
- (2008) Willscott E. Naugler et al. TRENDS IN MOLECULAR MEDICINE
- The HPA axis in major depression: classical theories and new developments
- (2008) Carmine M. Pariante et al. TRENDS IN NEUROSCIENCES
- Inflammatory markers in late-life depression: Results from a population-based study
- (2007) M.A. Bremmer et al. JOURNAL OF AFFECTIVE DISORDERS
- From inflammation to sickness and depression: when the immune system subjugates the brain
- (2007) Robert Dantzer et al. NATURE REVIEWS NEUROSCIENCE
- Differences in cytokines between non-suicidal patients and suicidal patients in major depression
- (2007) Yong-Ku Kim et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Accelerated apoptosis of blood leukocytes and oxidative stress in blood of patients with major depression
- (2007) Agnieszka Szuster-Ciesielska et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Pro-inflammatory cytokines and treatment response to escitaloprsam in major depressive disorder
- (2007) Triin Eller et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Patient-Reported Outcomes and Health-Care Resource Utilization in Patients with Psoriasis Treated with Etanercept: Continuous versus Interrupted Treatment
- (2007) Joel M. Gelfand et al. VALUE IN HEALTH
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