期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 23, 页码 6915-6920出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201802540
关键词
alkynes; gold redox catalysis; sulfonium cations; thioallylation; vinyl gold intermediates
资金
- NSF [CHE-1665122, CHE-1709075]
- NIH [1R01GM120240-01]
- NSFC [21629201]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM120240] Funding Source: NIH RePORTER
Stereoselective thioallylation of alkynes under possible gold redox catalysis was accomplished with high efficiency (as low as 0.1% catalyst loading, up to 99% yield) and broad substrate scope (various alkynes, inter-and intramolecular fashion). The gold(I) catalyst acts as both a p-acid for alkyne activation and a redox catalyst for AuI/III coupling, whereas the sulfonium cation generated in situ functions as a mild oxidant. This novel methodology provides an exciting system for gold redox catalysis without the need for a strong oxidant.
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