期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 6, 页码 1663-1667出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201710731
关键词
aldehydes; difluoromethylthioesters; fluorine; radical reactions; reaction mechanisms
资金
- National Natural Science Foundation of China [NSFC-21572178, NSFC-21702162]
- Natural Science Basic Research Plan in Shaanxi Province of China [2017JM2006]
- Key Science and Technology Innovation Team of Shaanxi Province [2017KCT-37]
Difluoromethylthioester compounds are yet another important kind of organofluorine compound and are reported here for the first time. They can be efficiently synthesized from various aldehydes. The synthetic method features mild reaction conditions, good tolerance of functional groups, broad substrate scope, and importantly, no metal is involved in the reaction. The approach has the potential to become an important tool for the late-stage functionalization of advanced synthetic intermediates, and should have many applications in medicinal chemistry.
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