期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 29, 页码 9088-9092出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201804177
关键词
asymmetric synthesis; chiral ethers; hemiacetals; magnesium; phosphorus ylides
资金
- NSFC [21432003, 81473095, 21602091]
- Program for Chang-jiang Scholars [IRT_15R27]
- Fundamental Research Funds [lzujbky_2017-k11, 2017-19, 2017-118, 2018-k09]
By employing a simple insitu generated magnesium catalyst, a direct asymmetric reaction between hemiacetals and phosphorus ylides was achieved through a tandem Wittig-oxa-Michael reaction sequence. Enantioenriched chromans, isochromans, and tetrahydropyrans were obtained in good chemical yields, and (-)-erythrococcamideB was synthesized in enantioenriched form. The byproduct triphenylphosphine oxide was identified as a necessary additive for this process.
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