期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 8, 页码 2253-2258出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201713327
关键词
desymmetrization; enamines; enantioselective dehydrogenation; organocatalysis; oxidation
资金
- Natural Science Foundation of China [21390400, 21521002, 21572232, 21672217]
- Chinese Academy of Science [QYZDJ-SSW-SLH023]
- National Program of Top-Notch Young Professionals
A desymmetrizing dehydrogenation process catalyzed by a chiral primary amine is described herein. The reaction proceeds through the oxidation of a ketone enamine by IBX and enables the highly enantioselective desymmetrization of 4-substituted cyclohexanones with the generation of chiral 4-substituted cyclohexenones containing a remote gamma-stereocenter.
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