期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 18, 页码 4956-4959出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201713225
关键词
amination; C-H oxidation; reaction mechanisms; rhodium; sulfamates
资金
- National Science Foundation through the CCI Center for Selective C-H Functionalization [CHE-1700982]
- Novartis
A general and operationally convenient method for intermolecular amination of C(sp(3))-H bonds is described. This technology allows for efficient functionalization of complex molecules, including numerous pharmaceutical targets. The combination of pivalonitrile as a solvent, Al2O3 as an additive, and phenyl sulfamate as a nitrogen source affords differential reaction performance and substrate scope. Mechanistic data strongly implicate a pathway for catalyst decomposition that initiates with solvent oxidation, thus providing rationale for the marked influence of pivalonitrile on this reaction process.
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