Article
Medicine, General & Internal
Jakob Christensen, Betina B. Trabjerg, Yuelian Sun, Julie Werenberg Dreier
Summary: This study examined the association between maternal antidepressant prescription during pregnancy and standardized test scores among Danish schoolchildren. Results showed that children born to mothers filling antidepressant prescriptions during pregnancy had significantly lower math test scores but no significant difference in language test scores compared to children whose mothers did not fill antidepressant prescriptions. The difference in math scores was small and of uncertain clinical importance, suggesting the need to balance the findings against the benefits of treating maternal depression during pregnancy.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Review
Cardiac & Cardiovascular Systems
Anna Calvi, Ilaria Fischetti, Ignazio Verzicco, Martino Belvederi Murri, Stamatula Zanetidou, Riccardo Volpi, Pietro Coghi, Stefano Tedeschi, Mario Amore, Aderville Cabassi
Summary: Patients with depression who take antidepressant medication may have an increased risk of developing hypertension. Different types of antidepressants have varying effects on blood pressure, with selective serotonin reuptake inhibitors being the safest class, while dopamine-norepinephrine reuptake inhibitors may lead to blood pressure increases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Psychiatry
Brian P. Brennan, Jiana Schnabel, Harrison G. Pope, James I. Hudson
Summary: The use of serotonergic antidepressants in hospitalized COVID-19 patients did not show a significant difference in outcomes compared to those not using antidepressants, based on the results of a study that aimed to replicate previous findings.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Clinical
Chittaranjan Andrade
Summary: The exposure to antidepressants during pregnancy, especially SSRIs, is associated with a slightly increased risk of postpartum hemorrhage. However, the findings should be interpreted with caution, and precautionary measures are still recommended.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Abeer Essam Hakam, Gabriela Vila, Poliana Mendes Duarte, Marcia Phemba Mbadu, Dannia Sulaiman Ai Angary, Ikramuddin Aukhil, Rodrigo Neiva, Helio Doyle Pereira da Silva, Jia Chang
Summary: This study found that patients taking antidepressants are at higher risk of dental implant failure, with users of SNRI and TCA having the highest risk of implant loss. However, conclusions about TCA are based on a limited number of cases.
JOURNAL OF PERIODONTOLOGY
(2021)
Review
Psychiatry
Jianjun Wang, Fiammetta Cosci
Summary: This study systematically evaluated the symptoms and risks of neonatal SSRI withdrawal syndrome, and proposed relevant preventive measures.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2021)
Review
Public, Environmental & Occupational Health
Courtney De Vries, Svetla Gadzhanova, Matthew J. Sykes, Michael Ward, Elizabeth Roughead
Summary: Antidepressant use during the first trimester of pregnancy is common, with some types of antidepressants increasing the risk of congenital heart defects. This study found that selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors carry a higher risk compared to tricyclic antidepressants. Individual antidepressants within each class also vary in their risk profiles.
Article
Obstetrics & Gynecology
Julie A. Vignato, S. Banu Gumusoglu, Heather A. Davis, Sabrina M. Scroggins, Wendy S. Hamilton, Debra S. Brandt, Gary L. Pierce, Boyd A. Knosp, Donna A. Santillan, Mark K. Santillan
Summary: Depression and preeclampsia are bi-directionally associated with each other, and SSRIs may attenuate the risk of preeclampsia. This study found that SSRIs use was associated with decreased risk of preeclampsia and reduced copeptin levels in early pregnancy, suggesting a potential therapeutic effect.
REPRODUCTIVE SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Hugo R. Arias, Katarzyna M. Targowska-Duda, Jesus Garcia-Colunga, Marcelo O. Ortells
Summary: SSRIs are believed to alleviate depression symptoms by elevating synaptic 5-HT levels through inhibiting serotonin reuptake transporters and may also modulate other neurotransmitter systems by inhibiting nAChRs. There is a strong association between major depression and smoking, but SSRIs are not effective for smoking cessation therapy. In patients with major depressive disorder, there is lower availability of functional nAChRs, possibly due to higher endogenous ACh levels.
Article
Oncology
Naiqi Zhang, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: This population-based cohort study suggests that the use of SSRIs is associated with a reduced risk of CRC among individuals with a family history of CRC. The decreased risk of CRC showed a non-linear, dose-dependent pattern. Furthermore, the use of SSRIs was strongly associated with advanced-stage CRC rather than early-stage CRC.
Article
Public, Environmental & Occupational Health
Avital Fischer, Hedy S. Rennert, Gad Rennert
Summary: The study found that the use of SSRIs before and after breast cancer diagnosis is associated with increased mortality in breast cancer patients. Research is needed to further understand the mechanisms behind this association.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Psychiatry
Dogukan Koc, Henning Tiemeier, Bruno H. Stricker, Ryan L. Muetzel, Manon Hillegers, Hanan El Marroun
Summary: This study aims to investigate the association between intrauterine SSRI exposure and maternal depressive symptoms and structural brain development in offspring from mid-childhood to early puberty.
Article
Multidisciplinary Sciences
A. C. Pronk, L. J. Seppala, K. Trajanoska, N. Stringa, B. van de Loo, L. C. P. G. M. de Groot, N. M. van Schoor, F. Koskeridis, G. Markozannes, E. Ntzani, A. G. Uitterlinden, F. Rivadeneira, B. H. Stricker, N. van der Velde
Summary: This study reveals that certain genetic variants may modify the fall risk associated with antidepressant use, but inconsistent results across studies highlight the need for validation in a prospective-designed study. Pharmacogenetics could potentially have value in preventing falls through antidepressant (de)prescribing.
Article
Psychology, Clinical
Chittaranjan Andrade
Summary: Over the past decade, numerous observational studies have examined the cognitive neurodevelopmental outcomes in children exposed to antidepressant drugs during pregnancy. While some studies found associations between exposure and poorer outcomes in language, cognition, intellectual skills, and academic performance, these associations were often related to maternal depression during pregnancy and other confounding factors, rather than the use of antidepressants. A recent large-scale population-based study specifically focused on language and mathematics performance and found that gestational exposure to antidepressant drugs was associated with a small, statistically significant decline in mathematics performance but not in language. After adjusting for confounding factors, the remaining deficits may be attributed to unmeasured variables associated with untreated maternal depression. This suggests that prenatal antidepressant exposure may serve as a marker rather than the direct cause of cognitive neurodevelopmental deficits. While the literature does not support withholding antidepressants from depressed pregnant women, decision-making should be a shared process.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Nam-Ju Ji, Seung-Yeon Jeon, Kyung-Joon Min, Myung Ki, Weon-Young Lee
Summary: This study investigated the relationship between the type of initial antidepressants and treatment adherence in outpatients with new onset depression. The results showed a significant association between initial antidepressant type and treatment adherence during the first three- and six-month treatment periods for employed and self-employed patients newly diagnosed with major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Health Care Sciences & Services
Ursina Wernli, Desiree Hischier, Christoph R. Meier, Sibylle Jean-Petit-Matile, Alice Panchaud, Andrea Kobleder, Carla Meyer-Massetti
Summary: This study retrospectively analyzed prescription records of inpatients from a Swiss hospice, and found a gradual reduction in polypharmacy rates before the end-of-life. These findings emphasize the importance of deprescribing in the terminal stage and suggest further research on the role of clinical guidance in optimizing drug therapy and deprescribing in inpatient hospice care.
AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE
(2023)
Review
Obstetrics & Gynecology
Emily R. Smith, Erin Oakley, Gargi Wable Grandner, Gordon Rukundo, Fouzia Farooq, Kacey Ferguson, Sasha Baumann, Kristina Maria Adams Waldorf, Yalda Afshar, Mia Ahlberg, Homa Ahmadzia, Victor Akelo, Grace Aldrovandi, Elisa Bevilacqua, Nabal Bracero, Justin S. Brandt, Natalie Broutet, Jorge Carrillo, Jeanne Conry, Erich Cosmi, Fatima Crispi, Francesca Crovetto, Maria del Mar Gil, Camille Delgado-Lopez, Hema Divakar, Amanda J. Driscoll, Guillaume Favre, Irene Fernandez Buhigas, Valerie Flaherman, Christopher Gale, Christine L. Godwin, Sami Gottlieb, Eduard Gratacos, Siran He, Olivia Hernandez, Stephanie Jones, Sheetal Joshi, Erkan Kalafat, Sammy Khagayi, Marian Knight, Karen L. Kotloff, Antonio Lanzone, Valentina Laurita Longo, Kirsty Le Doare, Christoph Lees, Ethan Litman, Erica M. Lokken, Shabir A. Madhi, Laura A. Magee, Raigam Jafet Martinez-Portilla, Torri D. Metz, Emily S. Miller, Deborah Money, Sakita Moungmaithong, Edward Mullins, Jean B. Nachega, Marta C. Nunes, Dickens Onyango, Alice Panchaud, Liona C. Poon, Daniel Raiten, Lesley Regan, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Olof Stephansson, Marleen Temmerman, Anna Thorson, Soe Soe Thwin, Beth A. Tippett Barr, Jorge E. Tolosa, Niyazi Tug, Miguel Valencia-Prado, Silvia Visentin, Peter von Dadelszen, Clare Whitehead, Mollie Wood, Huixia Yang, Rebecca Zavala, James M. Tielsch
Summary: This sequential, prospective meta-analysis aimed to identify risk factors among pregnant and postpartum women with COVID-19 for adverse outcomes related to disease severity, maternal morbidities, neonatal mortality and morbidity, and adverse birth outcomes. Data from 21 participating studies were included, and risk factors and outcomes were analyzed. The study found that women with comorbidities, HIV infection, prepregnancy underweight, and anemia were at increased risk for severe COVID-19-related outcomes and adverse birth outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
Helene Legardeur, Alexia Cuenoud, Alice Panchaud, Francesco Grandoni, Ana Batista Mesquita Sauvage, Lorenzo Alberio, David Baud, Mathilde Gavillet
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Pharmacology & Pharmacy
Guillaume Favre, Eva Gerbier, Emeline Maisonneuve, Leo Pomar, Ursula Winterfeld, Karine Lepigeon, Kitty W. M. Bloemenkamp, Odette de Bruin, Eimir Hurley, Hedvig Nordeng, Satu J. Siiskonen, Miriam C. J. M. Sturkenboom, David Baud, Alice Panchaud
Summary: This study aimed to describe the use of COVID-19-related medicines during pregnancy and how it evolved between the early and late periods of the pandemic. The results showed that the proportion of pregnant women who used COVID-19-related medicines increased with disease severity. The use of antibiotics, antivirals, and hydroxychloroquine was lower during the late period of the pandemic.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kim Dao, Svetlana Shechtman, Orna Diav-Citrin, Nathan George, Jonathan Luke Richardson, Victoria Rollason, Alessandra Pistelli, Georgios Eleftheriou, Maya Berlin, Pierre Ekobena, Valentin Rousson, Marie-Claude Addor, David Baud, Thierry Buclin, Alice Panchaud, Ursula Winterfeld
Summary: This study aimed to assess the risks associated with trazodone exposure during pregnancy, as limited safety data are available. The findings suggest that exposure to trazodone in early pregnancy is not significantly associated with the risk of major congenital anomalies compared with selective serotonin reuptake inhibitors (SSRIs).
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Fatima Tauqeer, Michael Ceulemans, Eva Gerbier, Anneke Passier, Alison Oliver, Veerle Foulon, Alice Panchaud, Angela Lupattelli, Hedvig Nordeng
Summary: This study aims to describe the mental health of perinatal women in five European countries during the third pandemic wave and identify risk factors related to depressive and anxiety symptoms. The study found that 16.1% of pregnant women and 17.0% of postpartum women had major depressive symptoms, while 17.3% of pregnant women and 17.7% of postpartum women had moderate to severe generalized anxiety symptoms. Risk factors associated with poor mental health included pre-existing mental illness, chronic somatic illness, COVID-19 infection or symptoms, smoking, unplanned pregnancy, and country of residence.
Article
Oncology
Carole Bandiera, Isabella Locatelli, Perrine Courlet, Evelina Cardoso, Khalil Zaman, Athina Stravodimou, Ana Dolcan, Apostolos Sarivalasis, Jean-Philippe Zurcher, Veronica Aedo-Lopez, Jennifer Dotta-Celio, Solange Peters, Monia Guidi, Anna Dorothea Wagner, Chantal Csajka, Marie P. Schneider
Summary: This study evaluated medication adherence to palbociclib in breast cancer patients and found that the intervention group had higher and more stable adherence. The intervention had a larger effect on older patients and those with longer treatment and disease experience. The study also found that catching up on missed doses at the end of the cycle increased the risk of severe neutropenia in the next cycle. Therefore, close monitoring of patients' cycle management is important to improve prescriptions and decrease toxicity.
Review
Endocrinology & Metabolism
Nazanin Abolhassani, Ursula Winterfeld, Yusuf C. Kaplan, Cecile Jaques, Beatrice Minder Wyssmann, Cinzia Del Giovane, Alice Panchaud
Summary: This study conducted a systematic review and meta-analysis to assess the risk of major congenital malformations (MCMs) after first-trimester exposure to metformin in women with polycystic ovary syndrome (PCOS) and pregestational diabetes mellitus (PGDM). The findings suggest that metformin use during the first trimester of pregnancy in women with PCOS or PGDM does not significantly increase the overall risk of MCMs. However, further research is needed to address remaining safety concerns.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Public, Environmental & Occupational Health
Emily R. Smith, Erin Oakley, Gargi Wable Grandner, Kacey Ferguson, Fouzia Farooq, Yalda Afshar, Mia Ahlberg, Homa Ahmadzia, Victor Akelo, Grace Aldrovandi, Beth A. Tippett Barr, Elisa Bevilacqua, Justin S. Brandt, Nathalie Broutet, Irene Fernandez Buhigas, Jorge Carrillo, Rebecca Clifton, Jeanne Conry, Erich Cosmi, Fatima Crispi, Francesca Crovetto, Camille Delgado-Lopez, Hema Divakar, Amanda J. Driscoll, Guillaume Favre, Valerie J. Flaherman, Chris Gale, Maria M. Gil, Sami L. Gottlieb, Eduard Gratacos, Olivia Hernandez, Stephanie Jones, Erkan Kalafat, Sammy Khagayi, Marian Knight, Karen Kotloff, Antonio Lanzone, Kirsty Le Doare, Christoph Lees, Ethan Litman, Erica M. Lokken, Valentina Laurita Longo, Shabir A. Madhi, Laura A. Magee, Raigam Jafet Martinez-Portilla, Elizabeth M. McClure, Tori D. Metz, Emily S. Miller, Deborah Money, Sakita Moungmaithong, Edward Mullins, Jean B. Nachega, Marta C. Nunes, Dickens Onyango, Alice Panchaud, Liona C. Poon, Daniel Raiten, Lesley Regan, Gordon Rukundo, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Jonas Soderling, Olof Stephansson, Marleen Temmerman, Anna Thorson, Jorge E. Tolosa, Julia Townson, Miguel Valencia-Prado, Silvia Visentin, Peter von Dadelszen, Kristina Adams Waldorf, Clare Whitehead, Murat Yassa, Jim M. Tielsch
Summary: Despite heterogeneity in study design and quality, a sequential, prospective meta-analysis found that SARS-CoV-2 infection during pregnancy increases the risk of maternal mortality, severe maternal morbidity, and neonatal morbidity. However, there is no association with stillbirth or intrauterine growth restriction. The findings highlight the importance of preventing and managing SARS-CoV-2 infection in pregnant women. Overall, the study is rated 8 out of 10 in terms of importance.
Review
Biochemistry & Molecular Biology
Evelina Cardoso, Monia Guidi, Nina Nauwelaerts, Hedvig Nordeng, Marie Teil, Karel Allegaert, Anne Smits, Peggy Gandia, Andrea Edginton, Shinya Ito, Pieter Annaert, Alice Panchaud
Summary: PBPK and popPK modeling are promising approaches to fill the gap in knowledge of medicine safety in breastfeeding, as illustrated with our escitalopram example. These methods can provide a more complete characterization of infant medicine exposure through human milk and simulate extreme situations while decreasing the burden of sampling in breastfeeding women.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Article
Virology
Emeline Maisonneuve, Eva Gerbier, Fatima Tauqeer, Leo Pomar, Guillaume Favre, Ursula Winterfeld, Anneke Passier, Alison Oliver, David Baud, Hedvig Nordeng, Michael Ceulemans, Alice Panchaud
Summary: COVID-19 vaccination willingness varies greatly among pregnant and postpartum women, depending on factors such as country of residence and personal medical history.
Article
Psychiatry
Anaelle Monfort, Evelina Cardoso, Chin B. Eap, Celine J. Fischer Fumeaux, Myriam Bickle Graz, Mathilde Morisod Harari, Etienne Weisskopf, Peggy Gandia, Karel Allegaert, Hedvig Nordeng, Jean-Michel Hascoet, Olivier Claris, Manuella Epiney, Chantal Csajka, Monia Guidi, Ema Ferreira, Alice Panchaud
Summary: Two women diagnosed with depression were treated with 50 mg fluvoxamine during pregnancy and lactation. The results showed minimal exposure to fluvoxamine during lactation, which is consistent with previous studies. Larger clinical and pharmacokinetic studies are needed to assess the long-term safety of this drug during lactation and the variability of its exposure through breastmilk.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Sylvain Goutelle, Monia Guidi, Verena Gotta, Chantal Csajka, Thierry Buclin, Nicolas Widmer
Summary: Imatinib is a targeted cancer therapy that has improved the care of patients with CML and GIST, but the recommended dosages may not achieve the target plasma concentration in many patients. This study developed a novel model-based dosing approach and compared its performance with other methods.
Article
Health Care Sciences & Services
Guillaume Favre, Emeline Maisonneuve, Leo Pomar, Charlotte Daire, Christophe Poncelet, Thibaud Quibel, Cecile Monod, Begona Martinez de Tejada, Leonhard Schaffer, Andrea Papadia, Anda Petronela Radan, Monya Todesco-Bernasconi, Yves Ville, Cora Alexandra Voekt, Beatrice Eggel-Hort, Romina Capoccia-Brugger, Silke Johann, Claudia Grawe, Sophie Defert, Nicolas Mottet, Christian R. Kahlert, Charles Garabedian, Loic Sentilhes, Brigitte Weber, Steffi Leu, Dirk Bassler, Karine Lepigeon, Ursula Winterfeld, Alice Panchaud, David Baud
Summary: Unvaccinated pregnant women infected with SARS-CoV-2 are at higher risk of adverse outcomes. This study found that the risk of severe maternal adverse outcome was higher during the Delta period and lower during the Omicron period compared to the pre-Delta era.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Pharmacology & Pharmacy
Hedvig Nordeng, Christine Wegler, Annika Lindqvist, Erik Melander, Mikaela Magnusson, Peggy Gandia, Alice Panchaud, Pawel Baranczewski, Olav Spigset
Summary: This study demonstrates that the transfer of cetirizine and levocetirizine into breast milk is low and compatible with breastfeeding.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)