Article
Neurosciences
Camilo Miguel Signorelli, Lynn Uhrig, Morten Kringelbach, Bechir Jarraya, Gustavo Deco
Summary: The study suggests that anesthesia results in a reconfiguration of functional brain states, and loss of consciousness may be related to a general dynamical rearrangement of the hierarchical organization of the cortex. Higher values of Intrinsic Ignition correspond to rich and flexible brain dynamics, while lower values correspond to poor and rigid brain dynamics.
Article
Clinical Neurology
William C. Palmer, Brenna A. Cholerton, Cyrus P. Zabetian, Thomas J. Montine, Thomas J. Grabowski, Swati Rane
Summary: The study found significant differences in cerebello-cortical functional connectivity between PD patients and normal controls, particularly in the somatomotor network. Cognitive function was found to be associated with connectivity of the cerebellar SMN and dorsal attention network. Altered cerebellar connectivity with frontoparietal and default mode networks was also correlated with the severity of motor function in PD.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Li-Ling Hope Pan, Fu-Jung Hsiao, Wei-Ta Chen, Shuu-Jiun Wang
Summary: Studies on event-related evoked potentials and resting state cortical activity have revealed the association between altered cortical processing and the pathology of migraine. Specifically, abnormal connectivity and neuroplasticity in pain-related regions have been observed in chronic migraine patients, suggesting potential brain signatures for migraine. Further research is needed to explore the role of these assessments in precision medicine.
CURRENT PAIN AND HEADACHE REPORTS
(2022)
Article
Biology
Idan E. Nemirovsky, Nicholas J. M. Popiel, Jorge Rudas, Matthew Caius, Lorina Naci, Nicholas D. Schiff, Adrian M. Owen, Andrea Soddu
Summary: This study applies Integrated Information Theory 3.0 to functional MRI data to explain and quantify consciousness. The results show that the measure of integrated information, & phi;(max), is modulated by sedation in different resting-state networks. Changes in & phi;(max) closely reflect changes in conscious level in the frontoparietal and dorsal attention networks.
COMMUNICATIONS BIOLOGY
(2023)
Review
Neurosciences
Nicholas S. Card, Omar A. Gharbawie
Summary: Resting state fMRI with high contrast and resolution can reveal cortical connectivity with columnar granularity. Comparisons with microstimulation-evoked activation and anatomical connections demonstrate a high correspondence in connectivity patterns. The fidelity of functional connectivity maps to cortical connections indicates that granular details of network organization are embedded in resting state signals. Intrinsic signal optical imaging provides a bridge between fMRI and invasive approaches, allowing high-resolution mapping of cortical networks in living animals.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Neurosciences
Rika Haraguchi, Hideyuki Hoshi, Sayuri Ichikawa, Mayuko Hanyu, Kohei Nakamura, Keisuke Fukasawa, Jesus Poza, Victor Rodriguez-Gonzalez, Carlos Gomez, Yoshihito Shigihara
Summary: Resting-state neural oscillations are affected by the menstrual cycle, with changes in frequency power spectrum, Shannon spectral entropy, and intensity of specific brain waves observed during different phases of the cycle. This highlights the importance of considering menstrual cycle variations when interpreting functional neuroimaging data in clinical practice.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Karolina Armonaite, Massimo Bertoli, Luca Paulon, Eugenia Gianni, Marco Balsi, Livio Conti, Franca Tecchio
Summary: Neurodynamics describes the time course of neuronal activity in the brain network, and this study investigates the specific spectral features and fractal dimensions of primary motor, somatosensory, and auditory cortices using intracranial recordings. The findings suggest that neurodynamics properties can be used to analyze the structure and functionality of the brain.
Article
Neurosciences
John Thomas, Dixit Sharma, Sounak Mohanta, Neeraj Jain
Summary: Information processing in the brain is mediated through a complex functional network architecture, with different nodes integrating and segregating themselves on various timescales. Our study identified distinct networks in the somatosensory area 3b, showing different correlation patterns among face, hand, and medial representations in macaque monkeys and humans. The results suggest that different body part representations in area 3b have independent functional networks, reflecting differences in the behavioral use of those body parts.
Article
Neurosciences
Bo Rao, Dan Xu, Chaoyang Zhao, Shouchao Wang, Xuan Li, Wenbo Sun, Yadong Gang, Jian Fang, Haibo Xu
Summary: This study identified 8 RSNs in monkeys, showing similar development patterns as humans but with fine-tuning adjustments. The results suggest that monkeys can be a good animal model for studying human brain function.
Article
Multidisciplinary Sciences
Z. Moradimanesh, R. Khosrowabadi, M. Eshaghi Gordji, G. R. Jafari
Summary: The complexity of a network is determined not only by its size but also by the interactions between elements. The complexity of brain networks also arises from interactions beyond pair connections, particularly in genetically complex brain impairments like ASD. By analyzing ASD and control networks using structural balance theory, it was found that balanced triads are overrepresented in the ASD networks, providing empirical evidence for the concept of structural balance on brain networks.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Costanza Iester, Monica Biggio, Simone Cutini, Sabrina Brigadoi, Charalambos Papaxanthis, Giampaolo Brichetto, Marco Bove, Laura Bonzano
Summary: This study used fNIRS to investigate differences in functional cortical connectivity at rest linked to the time of the day. The results showed that there were significant differences in inter-hemispheric parietal cortices connectivity, with higher connectivity in the morning and intra-hemispheric fronto-parietal connectivity, with higher connectivity in the afternoon. Additionally, the questionnaire survey revealed higher scores for imaginative thinking in the afternoon compared to the morning. These findings suggest that there may be variations in brain connectivity and thought processes during resting-state at different times of the day.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Daniel Vereb, Marton Attila Kovacs, Szabolcs Antal, Krisztian Kocsis, Nikoletta Szabo, Balint Kincses, Bence Bozsik, Peter Farago, Eszter Toth, Andras Kiraly, Peter Klivenyi, Denes Zadori, Zsigmond Tamas Kincses
Summary: This study investigates functional connectivity modulation during a visuospatial attention task in patients with Parkinson's disease. The findings suggest that task-related networks function differently in these patients in association with motor symptoms, while impaired modulation of visual and default-mode network connectivity was not correlated with motor function.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Xiaodi Zhang, Eric A. Maltbie, Shella D. Keilholz
Summary: Recent resting-state fMRI studies have shown that brain activity exhibits temporal variations in functional connectivity using various methods. However, the results from these methods are just a simplification of the continuous process of brain activity.
Article
Multidisciplinary Sciences
Jinghao Lu, Bin Chen, Manuel Levy, Peng Xu, Bao-Xia Han, Jun Takatoh, P. M. Thompson, Zhigang He, Vincent Prevosto, Fan Wang
Summary: The study discovers that pain relief can be achieved through vibrotactile touch by modulating the primary somatosensory cortex (S1) in the brain. Specifically, self-generated signals from whisking play a crucial role in reducing facial nociception.
Article
Neurosciences
Patricia Pais-Roldan, Seong Dae Yun, Nicola Palomero-Gallagher, N. Jon Shah
Summary: Recent laminar-fMRI studies have improved understanding of cortical responses in sub-systems, however, the laminar component of resting-state networks has been less studied. Using EPIK, this study found that the default mode network (DMN) connectivity in humans is primarily supported by intermediate and superficial layers of the cortex, with different cortical depths used for communication in different networks. The study also observed changes in laminar connectivity profiles and low-frequency fluctuations during motor tasks, suggesting potential diagnostic value for psychiatric disorders.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Gerald Hahn, Gorka Zamora-Lopez, Lynn Uhrig, Enzo Tagliazucchi, Helmut Laufs, Dante Mantini, Morten L. Kringelbach, Bechir Jarraya, Gustavo Deco
Summary: During the sleep-wake cycle, the brain undergoes profound dynamical changes, with different consciousness states reliably distinguished by differences in brain-wide signals. A whole-brain computational model accurately reproduces changes in global synchronization across vigilance states, while connectivity hubs in the posterior brain and subcortical nuclei are crucial for maintaining the awake state.
Article
Neurosciences
Adam Messinger, Nikoloz Sirmpilatze, Katja Heuer, Kep Kee Loh, Rogier B. Mars, Julien Sein, Ting Xu, Daniel Glen, Benjamin Jung, Jakob Seidlitz, Paul Taylor, Roberto Toro, Eduardo A. Garza-Villarreal, Caleb Sponheim, Xindi Wang, R. Austin Benn, Bastien Cagna, Rakshit Dadarwal, Henry C. Evrard, Pamela Garcia-Saldivar, Steven Giavasis, Renee Hartig, Claude Lepage, Cirong Liu, Piotr Majka, Hugo Merchant, Michael P. Milham, Marcello G. P. Rosa, Jordy Tasserie, Lynn Uhrig, Daniel S. Margulies, P. Christiaan Klink
Summary: Neuroimaging in non-human primates is specialized and requires custom solutions. Efforts have been made to transform the field towards more open and collaborative practices. PRIME-RE is an online platform for the exchange of knowledge and tools related to NHP neuroimaging.
Article
Neurosciences
Camilo Miguel Signorelli, Lynn Uhrig, Morten Kringelbach, Bechir Jarraya, Gustavo Deco
Summary: The study suggests that anesthesia results in a reconfiguration of functional brain states, and loss of consciousness may be related to a general dynamical rearrangement of the hierarchical organization of the cortex. Higher values of Intrinsic Ignition correspond to rich and flexible brain dynamics, while lower values correspond to poor and rigid brain dynamics.
Article
Behavioral Sciences
Santiago Alcaide, Jacobo Sitt, Tomoyasu Horikawa, Alvaro Romano, Ana Carolina Maldonado, Agustin Ibanez, Mariano Sigman, Yukiyasu Kamitani, Pablo Barttfeld
Summary: This study suggests that waking up from early sleep stages involves a sequence of cortical and subcortical brain activity, with subcortical structures playing a key role in the initiation and maintenance of conscious states.
Article
Clinical Neurology
L. Naccache, J. Luaute, S. Silva, J. D. Sitt, B. Rohaut
Summary: Probing consciousness and cognitive abilities in non-communicating patients is a challenging task that requires combining behavioral measures with brain structure and activity data. The establishment of local and regional centers, along with a national common register, can systematize the provision of expertise and improve diagnostic accuracy and decision-making.
REVUE NEUROLOGIQUE
(2022)
Article
Neurosciences
Melanie Strauss, Jacobo D. Sitt, Lionel Naccache, Federico Raimondo
Summary: The study aims to better characterize the drowsiness period before sleep by exploring neurophysiological predictors. The results indicate that the drowsiness period is distinct from wakefulness and sleep, and the rapid fluctuations of brain states during this period reflect the decreasing probabilities to be responsive to external stimuli. The study also reveals that the global P300 is only present in responsive trials.
Article
Biology
Anira Escrichs, Yonatan Sanz Perl, Carme Uribe, Estela Camara, Basak Turker, Nadya Pyatigorskaya, Ane Lopez-Gonzalez, Carla Pallavicini, Rajanikant Panda, Jitka Annen, Olivia Gosseries, Steven Laureys, Lionel Naccache, Jacobo D. Sitt, Helmut Laufs, Enzo Tagliazucchi, Morten L. Kringelbach, Gustavo Deco
Summary: By studying neuroimaging data from different brain states, we found that different brain states are underpinned by dissociable spatiotemporal dynamics. A framework using turbulence theory provides excellent tools for describing and differentiating between brain states.
COMMUNICATIONS BIOLOGY
(2022)
Article
Clinical Neurology
Moshgan Amiri, Patrick M. Fisher, Federico Raimondo, Annette Sidaros, Melita Cacic Hribljan, Marwan H. Othman, Ivan Zibrandtsen, Simon A. Albrechtsen, Ove Bergdal, Adam Espe Hansen, Christian Hassager, Joan Lilja S. Hojgaard, Elisabeth Waldemar Jakobsen, Helene Ravnholt Jensen, Jacob Moller, Vardan Nersesjan, Miki Nikolic, Markus Harboe Olsen, Sigurdur Thor Sigurdsson, Jacobo D. Sitt, Christine Solling, Karen Lise Welling, Lisette M. Willumsen, John Hauerberg, Vibeke Andree Larsen, Martin Ejler Fabricius, Gitte Moos Knudsen, Jesper Kjaergaard, Kirsten Moller, Daniel Kondziella
Summary: This study aimed to assess the accuracy of fMRI and EEG in identifying residual consciousness in patients with acute disorders of consciousness (DoC) in the intensive care unit (ICU). The study found that a combination of fMRI and EEG features can predict the level of consciousness in patients, which is important for clinical decision-making.
Article
Neurosciences
Maria Niedernhuber, Federico Raimondo, Jacobo D. Sitt, Tristan A. Bekinschtein
Summary: To ensure survival in a dynamic environment, the human neocortex monitors input streams from different sensory organs for important sensory events. This study investigates the principles governing whether different senses share common or modality-specific brain networks for sensory target detection. The findings suggest that complex targets evoke sustained supramodal activity while simple targets rely on modality-specific networks with short-lived supramodal contributions. Each sense implements a cortical hierarchy orchestrating supramodal target detection responses, which operate at different timescales in successive processing stages.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Fernando Soler-Toscano, Javier A. Galadi, Anira Escrichs, Yonatan Sanz Perl, Ane Lopez-Gonzalez, Jacobo D. Sitt, Jitka Annen, Olivia Gosseries, Aurore Thibaut, Rajanikant Panda, Francisco J. Esteban, Steven Laureys, Morten L. Kringelbach, Jose A. Langa, Gustavo Deco
Summary: This study presents a novel framework for characterizing brain states by modeling the time-dependent dynamics, capturing the hidden topological structures across time in neuroimaging data. The framework has shown great potential in accurately classifying different brain states, as demonstrated by its high precision in classifying resting-state BOLD fMRI signals from post-comatose patients compared with healthy controls.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Clinical Neurology
L. Willacker, T. M. Raiser, M. Bassi, A. Bender, A. Comanducci, M. Rosanova, N. Sobel, A. Arzi, L. Belloli, S. Casarotto, M. Colombo, C. C. Derchi, E. Flo Rama, E. Grill, M. Hohl, K. Kuehlmeyer, D. Manasova, M. J. Rosenfelder, C. Valota, J. D. Sitt
Summary: The PerBrain project aims to provide individualized diagnosis and prognosis predictions for patients with disorders of consciousness (DoC) through multimodal assessments, thereby guiding rehabilitation strategies and treatment decisions. The project also focuses on the mental well-being and attitudes of the patients' family members, conducting assessments at multiple time points to gain a comprehensive understanding of the patients' situation and needs.
Article
Neurosciences
Clemens Neudorfer, Konstantin Butenko, Simon Oxenford, Nanditha Rajamani, Johannes Achtzehn, Lukas Goede, Barbara Hollunder, Ana Sofia Rios, Lauren Hart, Jordy Tasserie, Kavisha B. Fernando, T. A. Khoa Nguyen, Bassam Al-Fatly, Matteo Vissani, Michael Fox, R. Mark Richardson, Ursula van Rienenm, Andrea A. Kuehn, Andreas D. Husch, Enrico Opri, Till Dembek, Ningfei Li, Andreas Horn
Summary: Since its introduction in 2014, Lead-DBS, an open-source toolbox, has become a comprehensive neuroimaging platform for deep brain stimulation (DBS) and epilepsy monitoring. To meet the increasing clinical demands, Lead-DBS has undergone development efforts, resulting in a complete solution for DBS-based neuroimaging analysis. This multi-institutional collaborative effort represents an important stage in the evolution of a comprehensive, open-source pipeline for DBS imaging and connectomics.
Article
Multidisciplinary Sciences
Jordy Tasserie, Lynn Uhrig, Jacobo D. Sitt, Dragana Manasova, Morgan Dupont, Stanislas Dehaene, Bechir Jarraya
Summary: Loss of consciousness can be restored by deep brain stimulation of the central thalamus, leading to increased brain activity in multiple regions and restoring the two dimensions of consciousness, arousal and conscious access. This discovery opens up potential therapeutic applications for patients with consciousness disorders.