Article
Engineering, Biomedical
Ruqi Huang, Caiyi Zhang, Yeyang Bu, Zheng Li, Xin Zheng, Shang Qiu, Jeremiah Ong'achwa Machuki, Lijie Zhang, Yun Yang, Kaijin Guo, Fenglei Gao
Summary: The study designed a metal/semiconductor composite for combination therapy of rheumatoid arthritis, aiming to remove hyperplasia of the synovium using photothermal therapy, photodynamic therapy, and chemotherapy. The findings showed that this composite nanomaterial may provide a potential treatment option for rheumatoid arthritis.
Article
Pharmacology & Pharmacy
Xiaoke Yang, Bo Chen, Mingyue Zhang, Shengqian Xu, Zongwen Shuai
Summary: The study explored the association between TTP gene polymorphisms and mRNA levels with RA susceptibility in Chinese populations. The results indicated that the T allele of rs3746083 in the TTP gene increased susceptibility to RA, with a significant difference found under the dominant model. However, the association of rs251864 with RA was not statistically significant. Furthermore, TTP expression levels were significantly reduced in RA patients, supporting its potential involvement in RA pathogenesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Zhicheng Yang, Weixi Liu, Ting Yan, Ruiping Liu
Summary: The study revealed that HLA-DPB1 rs9277535 polymorphism is associated with a decreased risk of rheumatoid arthritis in the Chinese population, particularly among women and those at least 55 years old. Additionally, certain genotypes were linked to inflammatory markers and levels of HLA-DPB1 plasma and mRNA in RA patients.
Article
Immunology
Milena Iwaszko, Joanna Wielinska, Jerzy Swierkot, Katarzyna Kolossa, Renata Sokolik, Bartosz Bugaj, Monika Chaszczewska-Markowska, Slawomir Jeka, Katarzyna Bogunia-Kubik
Summary: The IL-33 gene polymorphisms are closely associated with clinical parameters, disease activity, and response to TNF inhibitor treatment in patients with RA and AS, with the rs16924159 AA genotype potentially linked to higher disease activity and poor treatment response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Antti Palomaki, Aarno Palotie, Jukka Koskela, Kari K. Eklund, Matti Pirinen, Samuli Ripatti, Tarja Laitinen, Nina Mars
Summary: The study utilized Finnish national hospital and biobank databases to link MUC5B variant with increased risk of RA-ILD. In patients with RA, MUC5B promoter variant was also identified as a strong risk factor for ILD.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Eunji Ha, Sang-Cheol Bae, Kwangwoo Kim
Summary: A large trans-ancestral meta-analysis identified 11 new susceptibility loci for RA, explaining a significant portion of the heritability in East Asians and Europeans, and confirmed 71 known non-HLA susceptibility loci. The study also highlighted the importance of CD4(+) T-cell activation and potential non-immune organs in RA pathogenesis, providing insights into genetic etiology and variant-driven RA pathogenesis.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Ji-Jun Mo, Wei Zhang, Qin-Wen Wen, Ting -Hui Wang, Wen Qin, Zhen Zhang, Hua Huang, Han Cen, Xiu-Di Wu
Summary: The study identified a significant association between the ATG16L1 rs2241880 polymorphism and rheumatoid arthritis (RA) in the Chinese population, as well as a genetic interaction between ATG16L1 and ATG16L2 in determining the development of RA, suggesting the involvement of autophagy in the pathogenesis of RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Rheumatology
Young Bin Joo, Soo Min Ahn, So-Young Bang, Youngho Park, Su Jin Hong, Youkyung Lee, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim, Jae-Bum Jun, Dae Hyun Yoo, Sang-Cheol Bae, Hye-Soon Lee
Summary: The MUC5B variant rs35705950 is a rare but significant risk factor for Asian patients with RA-ILD with usual interstitial pneumonia (UIP), suggesting a shared genetic background between Asian and Western populations.
Article
Rheumatology
Saedis Saevarsdottir, Lilja Stefansdottir, Patrick Sulem, Gudmar Thorleifsson, Egil Ferkingstad, Gudrun Rutsdottir, Bente Glintborg, Helga Westerlind, Gerdur Grondal, Isabella C. Loft, Signe Bek Sorensen, Benedicte A. Lie, Mikael Brink, Lisbeth Arlestig, Asgeir Orn Arnthorsson, Eva Baecklund, Karina Banasik, Steffen Bank, Lena Bjorkman, Torkell Ellingsen, Christian Erikstrup, Oleksandr Frei, Inger Gjertsson, Daniel F. Gudbjartsson, Sigurjon A. Gudjonsson, Gisli H. Halldorsson, Oliver Hendricks, Jan Hillert, Estrid Hogdall, Soren Jacobsen, Dorte Vendelbo Jensen, Helgi Jonsson, Alf Kastbom, Ingrid Kockum, Salome Kristensen, Helga Kristjansdottir, Margit H. Larsen, Asta Linauskas, Ellen-Margrethe Hauge, Anne G. Loft, Bjorn R. Ludviksson, Sigrun H. Lund, Thorsteinn Markusson, Gisli Masson, Pall Melsted, Kristjan H. S. Moore, Heidi Munk, Kaspar R. Nielsen, Gudmundur L. Norddahl, Asmundur Oddsson, Thorunn A. Olafsdottir, Pall Olason, Tomas Olsson, Sisse Rye Ostrowski, Kim Horslev-Petersen, Solvi Rognvaldsson, Helga Sanner, Gilad N. Silberberg, Hreinn Stefansson, Erik Sorensen, Inge J. Sorensen, Carl Turesson, Thomas Bergman, Lars Alfredsson, Tore K. Kvien, Soren Brunak, Kristjan Steinsson, Vibeke Andersen, Ole A. Andreassen, Solbritt Rantapaa-Dahlqvist, Merete Lund Hetland, Lars Klareskog, Johan Askling, Leonid Padyukov, Ole Bv Pedersen, Unnur Thorsteinsdottir, Ingileif Jonsdottir, Kari Stefansson
Summary: This study identified causal genes for rheumatoid arthritis (RA) and its subsets through a genome-wide association study. Most of these genes encode proteins related to interferon and IL-12/23 signaling, particularly in the JAK/STAT pathway. Variants in some of these genes were found to increase or decrease the risk of seropositive RA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Katriona Goldmann, Athina Spiliopoulou, Andrii Iakovliev, Darren Plant, Nisha Nair, Cankut Cubuk, Paul McKeigue, Michael R. Barnes, Anne Barton, Costantino Pitzalis, Myles J. Lewis
Summary: This study conducted expression quantitative trait locus (eQTL) analysis using RNA-Sequencing to explore the link between genetic variants and gene expression in rheumatoid arthritis (RA) patients. The analysis identified 898 eQTL genes in synovium and blood, with 232 genes in common. A specific eQTL at HLA-DPB2 was found to be associated with clinical severity and the lympho-myeloid pathotype.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Chemistry, Multidisciplinary
Cong Xu, Shuanghu Wang, Hong Wang, Kun Liu, Shiyu Zhang, Bin Chen, Hao Liu, Fei Tong, Fei Peng, Yingfeng Tu, Yingjia Li
Summary: Hydrogen therapy is a promising strategy for inflammation-related diseases, but its efficacy is limited due to nonpolarity and low solubility. A biocompatible magnesium micromotor coated with hyaluronic acid was developed as a hydrogen generator, showing great potential for rheumatoid arthritis therapy by producing hydrogen bubbles for motion and scavenging reactive oxygen species and inflammation. Through ultrasound-guided intra-articular injection, the micromotors effectively relieved oxidative stress, reduced inflammation cytokines, and ameliorated joint damage, showing prominent therapeutic efficacy.
Article
Health Care Sciences & Services
Ekaterina A. Vetchinkina, Dmitry S. Mikhaylenko, Ekaterina B. Kuznetsova, Tatiana A. Deryagina, Ekaterina A. Alekseeva, Irina Bure, Andrey A. Zamyatnin, Marina Nemtsova
Summary: Rheumatoid arthritis is a multifactorial disease influenced by genetic predisposition and environmental factors. Genotyping of RA patients revealed significant associations between certain alleles and genotypes with the development of RA, as well as clinical criteria and biochemical factors. Targeted NGS panel application contributes to expanded genotyping to identify risk groups among RA patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Lianying Zhang, Wei Meng, Xiaotong Chen, Libo Wu, Mingwa Chen, Zhaoxi Zhou, Yongjian Chen, Lixia Yuan, Ming Chen, Jinxiang Chen, Pixian Shui
Summary: Researchers constructed a microwave-sensitive metal-organic framework, UiO-66-NH2, for coating with cerium oxide nanoenzyme and loading with the drug celastrol to form a nanocomposite UCCH. UCCH showed potential in treating rheumatoid arthritis by inhibiting excessive proliferation of inflammatory cells, alleviating hypoxia, and scavenging reactive oxygen species. Microwave-enhanced multisynergistic effects of UCCH could inspire new treatment modalities in rheumatoid arthritis therapies.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Immunology
Wentao Huang, Xue Li, Chen Huang, Yukuan Tang, Quan Zhou, Wenli Chen
Summary: Rheumatoid arthritis (RA) is a chronic autoinflammatory disease that causes synovial hyperplasia, pannus formation, articular cartilage damage, and bone matrix destruction. Recent studies have shown the importance of long non-coding RNAs (LncRNAs) in mediating the development and progression of RA, highlighting the potential of LncRNAs in diagnosis and therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Kai Wei, Ping Jiang, Jianan Zhao, Yehua Jin, Runrun Zhang, Cen Chang, Lingxia Xu, Linshuai Xu, Yiming Shi, Shicheng Guo, Dongyi He
Summary: Rheumatoid arthritis, a common immune system disease, has a severe impact on the quality of life for patients. Despite advancements in treatment, there are still limitations in the evaluation system. Biomarkers have been gradually used in clinical practice to evaluate the therapeutic effect of rheumatoid arthritis, aiding in accurate treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Pawel Dec, Andrzej Modrzejewski, Andrzej Pawlik
Summary: The treatment of bone defects is a major challenge in modern clinical practice due to the increased incidence of bone disease. Biomaterials play a crucial role in bone tissue engineering and their selection is a key issue in designing tissue scaffolds for patient-specific regeneration. This article provides a comprehensive literature review of existing and novel biomaterials, highlighting their advantages and disadvantages for bone defect regeneration. The materials are categorized into organic, inorganic, and synthetic polymers, considering current trends in the field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Jaroslaw Przybycinski, Sylwester Drozdzal, Aleksandra Wilk, Violetta Dziedziejko, Kamila Szumilas, Andrzej Pawlik
Summary: The intestinal microflora has significant effects on absorption, digestion, vitamin biosynthesis, and the immune and cognitive functions of the human body. It is also correlated with events such as graft rejection, kidney fibrosis, infections, and graft tolerance. The composition of gut microbiota also plays a role in metabolic complications and viral infections after transplantation. However, there is still a lack of knowledge on the direct mechanisms of microbiota action and evidence on pro- and prebiotic supplementation in kidney transplant patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Agata Poniewierska-Baran, Oliwia Bochniak, Paulina Warias, Andrzej Pawlik
Summary: Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that causes joint destruction. The development of RA is believed to be influenced by various factors, including hereditary factors, immune system defects, gender, infectious agents, nicotine, and stress. Epigenetic changes, particularly the involvement of sirtuins, have been found to play a role in the aggressive phenotype of RA. Sirtuins, enzymes found in all living organisms, can slow down aging processes, reduce cell death, counteract inflammation, and regulate metabolism. This review discusses the role of all sirtuins (1-7) in the pathogenesis of rheumatoid arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Agata Poniewierska-Baran, Sylwia Sluczanowska-Glabowska, Paulina Malkowska, Olga Sierawska, Lukasz Zadroga, Andrzej Pawlik, Paulina Niedzwiedzka-Rystwej
Summary: Melanoma is an aggressive and progressive skin cancer that develops from melanocytes. Understanding the mechanisms behind its transformation is crucial. The study of metastasis mechanisms is important for comprehending neoplastic cell biology. MicroRNA (miRNA) plays a role in various steps of the metastatic process. This review discusses the involvement of miRNA molecules in the development and progression, as well as the immune response, to melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kajetan Kielbowski, Estera Bakinowska, Andrzej Pawlik
Summary: Connexins are involved in intercellular communication through hemichannels and gap junctions, playing a crucial role in regulating cell homeostasis, proliferation, and differentiation. Changes in Cx distribution, degradation, and post-translational modifications have been linked to cancer, cardiovascular, and neurological diseases. Depending on the isoform, Cx can either promote or suppress the development of atherosclerosis by affecting endothelial dysfunction, monocyte recruitment, vascular smooth muscle cell activation, or autophagy inhibition. Inhibition or modulation of specific Cx isoforms could potentially serve as therapeutic targets in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Filip Machaj, Jakub Rosik, Bartosz Szostak, Damian Malinowski, Krzysztof Safranow, Gabriela Oledzka, Emilia Wiechec, Andrzej Pawlik
Summary: The aim of this study was to determine the association between common CYB5A gene polymorphism and the response to leflunomide in women with RA. The results suggest a possible association of the CYB5A rs1790834 polymorphism with some disease activity parameters in RA patients treated with leflunomide during the initial therapy period. However, further studies are needed to confirm the effect of this polymorphism on the efficacy of leflunomide treatment.
CLINICAL RHEUMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Agata Poniewierska-Baran, Lukasz Zadroga, Edo Danilyan, Paulina Malkowska, Paulina Niedzwiedzka-Rystwej, Andrzej Pawlik
Summary: Melanoma, the most serious type of skin cancer, is responsible for the majority of deaths but accounts for only about 1% of all skin cancer cases. Its incidence is increasing globally and poses a significant socio-economic problem. The early detection of cutaneous malignant melanoma (CMM) is crucial in reducing mortality, and researchers are exploring the use of microRNAs (miRNAs) as potential biomarkers and therapeutic drugs for melanoma treatment. This article provides a review of miRNA's role in melanoma and highlights ongoing clinical trials worldwide targeting miRNAs for melanoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Joanna Szostak, Anna Goracy, Damian Durys, Pawel Dec, Andrzej Modrzejewski, Andrzej Pawlik
Summary: Diabetic nephropathy is a common and severe complication of diabetes mellitus, and it affects one in every five diabetic patients. The exact pathogenesis is still unclear, but reactive oxygen species and the renin-angiotensin-aldosterone system are known to be involved. Recent research shows significant changes in miRNA expression in diabetic nephropathy patients. This review focuses on the role of miRNA in various pathways and its potential as biomarkers and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kajetan Kielbowski, Estera Bakinowska, Piotr Ostrowski, Bartlomiej Pala, Ewa Gromowska, Klaudia Gurazda, Pawel Dec, Andrzej Modrzejewski, Andrzej Pawlik
Summary: Psoriasis is a chronic skin condition mediated by the immune system, characterized by inflammation and excessive skin cell growth. Dendritic cells, T lymphocytes, and keratinocytes play key roles in the development of psoriasis, while the IL-23/IL-17 pathway contributes to disease progression. Adipokines secreted by adipose tissue, such as adiponectin, leptin, visfatin, and resistin, have immunomodulatory effects and may influence the progression or suppression of psoriasis. Understanding the relationship between psoriasis and adipokines could lead to new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Violetta Dziedziejko, Krzysztof Safranow, Miros lawa Kijko-Nowak, Damian Malinowski, Leszek Domanski, Andrzej Pawlik
Summary: This study examined the association between leptin receptor gene polymorphisms and the development of post-transplant diabetes mellitus (PTDM) in patients treated with tacrolimus after kidney transplantation. The results found that patients with the LEPR gene rs1137101 G allele may have an increased risk of PTDM development.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gabriela Filipowicz, Anna Wajda, Barbara Stypinska, Tomasz Kmiolek, Anna Felis-Giemza, Sandra Stanczyk, Zenobia Czuszynska, Marcela Walczyk, Marzena Olesinska, Agnieszka Paradowska-Gorycka
Summary: Mixed connective tissue disease (MCTD) is a rare disorder with unclear pathogenesis. This study analyzed whole blood samples from MCTD, SSc, SLE patients, and healthy donors, and found that hypomethylation distinguishes MCTD patients from SSc and SLE patients. However, global DNA methylation may not be a good diagnostic marker to distinguish MCTD from other ACTDs patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Violetta Dziedziejko, Krzysztof Safranow, Miroslawa Kijko-Nowak, Jerzy Sienko, Damian Malinowski, Kamila Szumilas, Andrzej Pawlik
Summary: This study evaluated the association between genetic polymorphisms affecting carbohydrate metabolism and post-transplant diabetes mellitus (PTDM) in kidney transplant patients. CDKAL1 rs10946398 gene polymorphism was found to be associated with the development of PTDM. Patients with the CC genotype had a higher risk of PTDM compared to those with the AC + AA genotypes. The results suggest that CDKAL1 rs10946398 CC genotype is a risk factor for PTDM development in kidney transplant patients treated with tacrolimus.
Review
Cell Biology
Adam Ejma-Multanski, Anna Wajda, Agnieszka Paradowska-Gorycka
Summary: Cell cultures play a significant role in the research and treatment of autoimmune connective tissue diseases (ACTDs). Culturing different cell types involved in ACTDs helps broaden knowledge of these diseases, potentially leading to finding cures. By analyzing gene expression patterns, surface proteins, and cytokine profiles in cell cultures, potential biomarkers can be identified for diagnosing, monitoring disease activity, and predicting treatment response. Moreover, cell culturing allows evaluation of the effects of therapies on patient-specific cell populations, aiding in personalized medicine.
Review
Biochemistry & Molecular Biology
Lukasz Ustianowski, Jakub Udzik, Joanna Szostak, Anna Goracy, Klaudia Ustianowska, Andrzej Pawlik
Summary: This narrative review discusses the role of genetic and epigenetic factors in the pathogenesis of gestational diabetes mellitus (GDM) and explores the risk factors of GDM, including obesity, advanced maternal age, and polycystic ovary syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Magdalena Chmielinska, Marzena Olesinska, Anna Felis-Giemza, Agnieszka Paradowska-Gorycka, Karolina Palej, Julita Rejmer-Szczesniak, Dariusz Szukiewicz
Summary: Based on the ASAS-EULAR recommendations, patients with axial spondyloarthritis who have failed to respond to at least two courses of NSAID therapy may be considered for modified NSAID treatment. This study aimed to identify risk factors for treatment failure and found that higher zonulin levels, ankylosing spondylitis, X-ray sacroiliitis, magnetic resonance imaging sacroiliitis, long duration of symptoms, high BASDAI score, and high spinal pain intensity were associated with treatment failure. Additionally, positive correlations were observed between haptoglobin concentration with C-reactive protein and erythrocyte sedimentation rate, and between zonulin levels and white blood count.
RHEUMATOLOGY INTERNATIONAL
(2023)