Article
Mechanics
Sen Xue, Xiwen Zhang, Feng He, Zhaomiao Liu, Pengfei Hao
Summary: The study investigates the effects of the tilted angle of the acoustic field and microchannel aspect ratios on particle manipulation, proposing an optimal tilt angle for efficient separation of particles. It also identifies two typical particle migration states and observes multi-layer particle focus in the vertical direction of microchannels for the first time, providing new insights for the development of high-throughput microfluidic devices.
Article
Mechanics
Ke Wu, Bruno D. Welfert, Juan M. Lopez
Summary: This study numerically explores the behavior of a fluid-filled rotating cube under low viscosity conditions, finding that different forcing frequencies lead to different response flows and intricate patterns. Most of the results can be explained using linear inviscid ray-tracing theory, but there are still other effects not captured by ray tracing.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Chemistry, Physical
Erfan Taatizadeh, Arash Dalili, Hamed Tahmooressi, Nishat Tasnim, Isaac T. S. Li, Mina Hoorfar
Summary: Tilted standing surface acoustic wave (tSSAW) has been recently incorporated in many studies to eliminate the requirement of precise microchannel alignment for parallel surface acoustic wave (pSSAW) fabrication. Through the tilt of the microchannel and the formation of pressure node lines in the tilted direction, the separation or manipulation of particles becomes easier to control and more efficient.
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2022)
Article
Polymer Science
Ming-Lin Yeh, Geng-Ming Chang, Yi-Je Juang
Summary: This study proposed and demonstrated the conformal coating of microparticles with a positively charged polyelectrolyte using an acoustofluidic microchip. The results showed that the microfluidic approach achieved rapid and uniform coating of microparticles. The zeta potentials of the coated microparticles exhibited charge reversal, with little variation influenced by the microchannel width or PAH concentration.
Article
Acoustics
Baoguo Yuan, Jiyu Liu, Houyou Long, Ying Cheng, Xiaojun Liu
Summary: This work proposes a scheme and demonstrates a planar acoustic Luneburg lens that can focus broadband sound without aberration. The refractive indexes of the lens are obtained from acoustic metamaterials, and the lens is fabricated using 3D printing technology. The experimental results agree well with numerical simulations, and the lens is further utilized to construct a wide-angle acoustic reflector.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2022)
Article
Acoustics
Liangfen Du, Abhishek Saini, Zeqing Sun, Jian Chen, Zheng Fan
Summary: Acoustic focusing has broad applications, but traditional structures have fabrication difficulties and energy transmission limitations. This study proposes a double layered acoustic grating (DLAG) to achieve high energy transmission efficiency through optimized geometry for acoustic focusing.
JOURNAL OF SOUND AND VIBRATION
(2023)
Article
Physics, Applied
Na-Li Zhang, Sheng-Dong Zhao, Hao-Wen Dong, Yue-Sheng Wang, Chuanzeng Zhang
Summary: In this paper, a reflection-type broadband acoustic coding metasurface (BACMs) is proposed, which utilizes the coupling resonance mechanism between square helical channels and air cavities to achieve encoding and decoding functions in a wide frequency range. The application of the BACMs is demonstrated through numerical simulation and experiments, showing potential for use in the field of acoustic wave devices.
APPLIED PHYSICS LETTERS
(2022)
Article
Engineering, Electrical & Electronic
Jun Long Han, Hong Hu, Qing Yun Huang, Yu Lin Lei
Summary: In this study, an acoustofluidic platform based on standing surface acoustic waves (SSAWs) was established to analyze the influence of droplet contact angle on particle separation. Experimental results demonstrated the importance of reducing the contact angle for achieving better particle separation efficiency.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Chemistry, Analytical
Miaomiao Ji, Yukai Liu, Junping Duan, Wenxuan Zang, Yongsheng Wang, Zeng Qu, Binzhen Zhang
Summary: The combination of a new perturbed spiral channel and a slanted gold interfingered transducer is designed to achieve precise dynamic separation of target particles. The offset micropillar array solves the problem of focusing small particles in a high-width flow. The innovation of the spiral channel structure greatly improves the separation efficiency and purity of the separation chip.
Article
Engineering, Electrical & Electronic
Fangda Wu, Ming Hong Shen, Jian Yang, Hanlin Wang, Roman Mikhaylov, Aled Clayton, Xinghua Qin, Chao Sun, Zhihua Xie, Meng Cai, Jun Wei, Dongfang Liang, Fan Yuan, Zhenlin Wu, Yongqing Fu, Zhiyong Yang, Xianfang Sun, Liangfei Tian, Xin Yang
Summary: This study introduces a novel tilted-angle SAW device to manipulate cancer cells by optimizing acoustic pressure, resulting in improved separation efficiency while reducing energy consumption and footprint.
IEEE ELECTRON DEVICE LETTERS
(2021)
Article
Biochemical Research Methods
Yancheng Wang, Hemin Pan, Deqing Mei, Chengyao Xu, Wanyu Weng
Summary: This article presents a novel design of a tri-directional symmetrical acoustic tweezers device that enables precise manipulation of linear, clockwise, and anticlockwise trajectories of microparticles. By adjusting the input electric signals and the fluid's viscosity, the device is able to accurately modulate the motion parameters and manipulate various forms of microparticles as well as brine shrimp egg cells.
Article
Chemistry, Analytical
Gianluca Mezzanzanica, Olivier Francais, Stefano Mariani
Summary: Size sorting, line focusing, and isolation of microparticles or cells are essential for disease diagnostic tools in biology and biomedicine. This paper presents a finite element model of a microfluidic surface acoustic wave-based device for microparticle manipulation. Acoustic waves are used to create a standing surface acoustic wave in a microchannel, allowing for non-contact manipulation. The effects of microchannel size on microparticle actuation are discussed using sensitivity analysis and exemplary results.
Article
Engineering, Electrical & Electronic
Guojun Liu, Wanghao Shen, Yan Li, Hong Zhao, Xinbo Li, Conghui Wang, Fang He
Summary: This paper proposes a continuous separation method for multiple particles with the same volume but different densities based on a microfluidic chip. By using standing surface acoustic waves and hydrodynamic separation technology, continuous and effective separation of particles can be achieved. Experimental results show that this method can efficiently separate particles with different densities, with potential applications in biological research, disease diagnosis, and clinical practice.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Biochemical Research Methods
Naiqing Zhang, Juan P. Zuniga-Hertz, Elizabeth Yan Zhang, Tilvawala Gopesh, Mckenzie J. Fannon, Jiaying Wang, Yue Wen, Hemal H. Patel, James Friend
Summary: This study introduces a novel omnidirectional spiral surface acoustic wave (OSSAW) design for efficient separation of particles in microliter droplets, successfully extracting separated particles for the first time. The technology shows potential for whole blood separation and point-of-care diagnostics.
Article
Biochemical Research Methods
Pablo Rodriguez-Mateos, Bongkot Ngamsom, Charlotte E. Dyer, Alexander Iles, Nicole Pamme
Summary: The early detection of pathogenic microorganisms is crucial for diagnosing and preventing health and safety emergencies. Traditional detection methods rely on time-consuming culturing procedures and biochemical assays, taking over 24 hours for a diagnosis. The main challenge lies in the low concentration of pathogens within complex samples. Inertial microfluidic manipulation in curved glass channels shows promise for automating and parallelizing particle and cell separation.
Article
Chemistry, Analytical
Ghulam Destgeer, Mengxing Ouyang, Dino Di Carlo
Summary: Researchers have developed a method to manufacture concentric amphiphilic particles using 3D printing and UV exposure, allowing precise control over particle size and shape for biological entity analysis. This technology enables a wide range of droplet volumes and can increase seeding density and orientation of dropicles for imaging and analysis purposes.
ANALYTICAL CHEMISTRY
(2021)
Article
Mechanics
Qian Mao, Jiazhen Zhao, Yingzheng Liu, Hyung Jin Sung
Summary: The hydrodynamic benefits of fixed and flapping pectoral fins were explored using the penalty immersed boundary method. It was found that the vortices generated by the pectoral fins increase the pressure difference between the upper and lower sides of the plate, resulting in an enhancement of both the cruising speed and thrust. Horizontal flapping pectoral fins with low flapping frequency enhance the propulsive efficiency. Flexible flapping fins enhance the cruising speed. Additionally, the presence of one flapping fin on one side of the flexible plate induces asymmetrical heaving of the plate and increases the lateral forces, which might help fish achieve turning and maintain balance in perturbed flows.
Article
Mechanics
Jiazhen Zhao, Qian Mao, Guang Pan, QiaoGao Huang, Hyung Jin Sung
Summary: The hydrodynamics of a self-propelled flexible plate near the ground were investigated. The interaction between the plate and the ground generates a strong vortex, leading to an increase in cruising speed. The aspect ratio and gap distance from the ground also play a role in determining the performance of the plate.
Letter
Mechanics
Guo-Zhen Ma, Chun-Xiao Xu, Hyung Jin Sung, Wei-Xi Huang
Summary: This paper proposes a roughness scaling method based on the direct numerical simulation of turbulent channel flow over three-dimensional sinusoidal rough walls in a transitionally rough regime. A new coupling scale is defined and the relationships between various parameters are explored.
Article
Mechanics
Qian Mao, Jiazhen Zhao, Yingzheng Liu, Hyung Jin Sung
Summary: The hydrodynamic mechanism of drag reduction by a rotationally oscillating cylinder with a flexible filament was explored using the penalty immersed boundary method. The study found that drag reduction is achieved through different mechanisms depending on the oscillation mode.
Article
Chemistry, Multidisciplinary
Seunggyu Kim, Hyeono Nam, Beomseok Cha, Jinsoo Park, Hyung Jin Sung, Jessie S. Jeon
Summary: The cytotoxic response of natural killer (NK) cells in a microreactor to surface acoustic waves (SAWs) is investigated. Results show that SAWs do not damage suspended NK cells, and can increase intracellular Ca2+ concentrations and enhance cell-mediated cytotoxicity.
Article
Engineering, Multidisciplinary
Jun-Duo Zhang, Hyung Jin Sung, Wei-Xi Huang
Summary: In this study, the hydrodynamic interaction between the large crescent dorsal fin and caudal fin in tuna was numerically explored. The presence of the dorsal fin substantially enhanced the thrust on the caudal fin, and a constructive interaction between the leading-edge vortex on the caudal fin and the vortices shed from the dorsal fin was identified. The flapping phase of the caudal fin and the Strouhal number had an influence on the dorsal fin-caudal fin interaction, while the Reynolds number did not have a substantial effect.
BIOINSPIRATION & BIOMIMETICS
(2022)
Article
Mechanics
Qian Mao, Jiazhen Zhao, Yingzheng Liu, Hyung Jin Sung
Summary: This study investigates the hydrodynamic mechanism of drag reduction by a flexible hairy coating through simulations and experimental data comparison, revealing the importance of flexible hairy coatings in drag reduction and the effects of different parts of the coating on drag reduction.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Mechanics
Min Yoon, Hyung Jin Sung
Summary: This study explores wall-attached structures in a drag-reduced turbulent channel flow and examines their influence on drag reduction. The results show that the population density of wall-attached structures decreases and the friction density reduces with streamwise slip, leading to an overall drag reduction.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Mechanics
Qian Mao, Yingzheng Liu, Hyung Jin Sung
Summary: This study investigated the hydrodynamic mechanism of drag reduction by flapping a flexible filament behind a stationary cylinder using the penalty immersed boundary method. The effects of filament parameters on drag reduction were examined, and three distinct flapping modes were observed. The oscillation and undulation modes were found to be more beneficial for drag reduction than the vortex-dominated mode.
Article
Mechanics
Qian Mao, Yingzheng Liu, Hyung Jin Sung
Summary: The hydrodynamic mechanism of drag reduction by flapping flexible filaments behind a cylinder was investigated using the penalty immersed boundary method. The effects of phase difference, attachment height, and flapping amplitude on drag reduction were studied. Flapping filaments weaken vortex shedding through destructive interaction, with out-of-phase filaments showing better drag reduction than in-phase filaments. Minimum drag is achieved at appropriate attachment height and flapping amplitude to avoid filament collision and weaken shear-layer-filament interaction. The clapping filaments are more effective than snaking filaments. The total drag decreases with increasing Reynolds number, transitioning from 2S mode to P + S mode wake pattern.
Article
Mechanics
Guo-Zhen Ma, Chun-Xiao Xu, Hyung Jin Sung, Wei-Xi Huang
Summary: Direct numerical simulations (DNSs) were conducted to investigate the effects of roughness on statistical properties and large-scale coherent structures in turbulent channel flow over three-dimensional sinusoidal rough walls. The study examined the similarities in mean streamwise velocity and Reynolds stresses in the outer layer by varying the roughness Reynolds number and the ratio of roughness height to the half-channel height. Spectral analysis and scale-energy path display were used to explore the energy transfer mechanism of turbulent motions with different sized roughness elements. The results showed that increasing roughness Reynolds number led to a downward shift of the mean velocity profile and decreased intensity of turbulent Reynolds stresses.
JOURNAL OF FLUID MECHANICS
(2023)
Article
Mechanics
Qian Mao, Yingzheng Liu, Hyung Jin Sung
Summary: The flow-induced snap-through dynamics of a buckled flexible filament were studied by using the penalty immersed boundary method. The effects of filament length, bending rigidity, and Reynolds number on the mode transition were systematically investigated. Three different modes were observed when these parameters were varied: equilibrium mode, streamwise oscillation mode, and snap-through oscillation mode. The increase in transverse fluid force induced the snap-through oscillation mode, while a vortex-induced vibration and a self-excited vibration occurred in the streamwise oscillation mode and snap-through oscillation mode respectively.
JOURNAL OF FLUID MECHANICS
(2023)
Article
Biochemical Research Methods
Hyeono Nam, Jong-Eun Park, Waqas Waheed, Anas Alazzam, Hyung Jin Sung, Jessie S. Jeon
Summary: Traveling surface acoustic waves (SAWs) were used for the lysis of cancer cells without any chemical reagents, followed by Raman spectrum profiling to explore detailed cell-derived data. Mechanical cell lysis was achieved using polystyrene microparticles (PSMPs) and the Raman signals from the lysed cells were enhanced by gold nanoparticles (AuNPs) through nanogaps formed by the AuNPs. The lysis efficiency was evaluated by varying the size and concentration of the PSMPs.
Review
Biochemical Research Methods
Mehmet Akif Sahin, Helen Werner, Shreya Udani, Dino Di Carlo, Ghulam Destgeer
Summary: This article reviews the state-of-the-art particle manufacturing technologies based on flow-assisted photolithography in microfluidic channels. It discusses important physicochemical concepts and categorizes particles based on their structural and compositional complexity. The article highlights the advantages of different techniques and explores the potential applications of fabricated particles. It also provides a future perspective on improving particle fabrication throughput, achieving new particle shapes, automated particle measurement, and expanding the application of 'lab on a particle' technologies to other research areas.