Article
Biochemical Research Methods
Laura Kuhlmann, Thomas Goeen, Elisabeth Eckert
Summary: The presented method is a fast and sensitive UHPLC-MS/MS method allowing the simultaneous quantification of the six main TOTM metabolites in urine, with high sensitivity and proficient precision.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Environmental Sciences
Aline Murawski, Maria I. H. Schmied-Tobies, Enrico Rucic, Christoph Schmidtkunz, Katja Kuepper, Gabriele Leng, Elisabeth Eckert, Laura Kuhlmann, Thomas Goeen, Anja Daniels, Gerda Schwedler, Marike Kolossa-Gehring
Summary: The study in Germany found that exposure levels to 4-MBC in cosmetics were below health-based guidance values, while ubiquitous exposure to BHT was evident, especially in children aged 3-5 years old.
ENVIRONMENTAL RESEARCH
(2021)
Article
Toxicology
Laurence Dahbi, Amaury Farce, Nicolas Kambia, Isabelle Severin, Thierry Dine, Emmanuel Moreau, Valerie Sautou, Marie-Christine Chagnon
Summary: This study investigated the endocrine-disrupting effects of metabolites of the plasticizer TEHTM, commonly used in medical devices. The results showed that two of the metabolites (4-MEHTM and 2/1-MEHTM) had effects on hormone activity in vitro. However, the concentrations of these metabolites found in human urine were unlikely to have active effects on estrogen, androgen, thyroid receptors, and steroidogenesis-mediated effects.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Materials Science, Ceramics
Yu-Sheng Tsai, Jyun-Rong Chen, Chang-Hsueh Lee, Chih-Chen Kuo, Ya-Hsuan Lin, Chun-Chieh Wang, Yu-Cheng Chang, YewChung Sermon Wu, Hsiang Chen
Summary: In this study, different types of ZnO-based nanocomposites were fabricated and characterized. The etching of ZnO nanorods increased the surface area and defect concentration, while sulfurization of the ZnO/ZnS nanotubes reduced defects and improved surface roughness. The results indicate that ZnO and ZnO/ZnS nanotubes hold promise for sensing device applications.
CERAMICS INTERNATIONAL
(2022)
Article
Engineering, Environmental
Kun Zhao, Zi-Han Lu, Ping Zhao, Shi-Xiong Kang, Yao-Yao Yang, Deng-Guang Yu
Summary: In this study, functional nanoparticles and nanofibrous membranes were used to successfully degrade doxycycline, with the membrane loaded with beta-FeOOH/TiO2 showing the best performance and achieving a degradation efficiency of 90.14% under natural sunlight.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Materials Science, Multidisciplinary
Ahmad Naqi, Zachary Swain, Michael E. Mackay
Summary: This study demonstrates a fused filament fabrication (FFF) die design capable of extruding two thermoplastics simultaneously to produce composite structures. The use of polyethylene terephthalate glycol (PETG) and high-density polyethylene (HDPE) filaments in core-shell 3D printing results in improved impact resistance and toughness. The die design allows for the fabrication of high-performance materials suitable for various applications.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Ahmad Naqi, Zachary Swain, Michael E. Mackay
Summary: This study demonstrates a fused filament fabrication (FFF) die design that enables the simultaneous extrusion of two thermoplastics in a core-shell configuration, enabling the production of composite structures in a single step. The use of high-density polyethylene (HDPE) as a shell material, along with polyethylene terephthalate glycol (PETG) as a core material, results in enhanced impact resistance and toughness in the produced objects. The die design can open up new avenues for fabricating high impact resistance materials suitable for high performance applications and utilizing HDPE in 3D printed objects due to its superior solvent resistance.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xuhui Lin, Yirong Mo
Summary: A new type of core-shell syngenetic bonding model is proposed to describe the stability of a unique thorium-thorium bond observed in a tri-thorium cluster. The computed resonance energies confirm that this bond is truly delocalized and sigma-aromatic.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Environmental Sciences
Jing Li, Qilian Qin, Yu-Xia Li, Xin-Fu Leng, Yi-Jun Wu
Summary: Exposure to TOCP resulted in reproductive toxicity in female avian, leading to decreased egg production and quality, weakened eggshell strength, inhibited follicular development, and cell death.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Ying Wang, Lin Liu, Yuanjie Zhu, Liangzhe Wang, Deng-Guang Yu, Li-ying Liu, Duncan Craig
Summary: In this study, four different types of polymers were converted into tri-layer tri-polymer core-shell fibers through bi-fluid coaxial electrospinning, showing linear morphology and multiple-chamber structures. The model drug was loaded into the shell working fluid and exhibited sustained-release in vitro. The research provides a new route for creating tri-layer core-shell structures and developing drug delivery systems with controlled-release profiles.
Article
Chemistry, Multidisciplinary
Qing Xu, Danyang Li, Haijun Zhou, Biaoqi Chen, Junlei Wang, Shi-Bin Wang, Aizheng Chen, Nina Jiang
Summary: The synthesis of MnO2-coated porous Pt@CeO2 core-shell nanostructures (Pt@CeO2@MnO2) offers a new theranostic nano-platform with high photothermal conversion efficiency and multifunctional therapeutic properties. The combination of Pt core and porous CeO2 interlayer allows for photothermal therapy, photoacoustic imaging, and photodynamic therapy. DOX-loaded Pt@CeO2@MnO2 demonstrates remarkable therapeutic outcomes in vitro and in vivo, providing a potential avenue for designing high-performance nano-platforms.
Article
Biology
Alexandra Gotthardt, Daniel Bury, Hans-Willi Kling, Rainer Otter, Tobias Weiss, Thomas Bruening, Holger M. Koch
Summary: This study provides data on human metabolism and excretion of DINA, showing OH-MINA as the major metabolite with consistent urinary excretion fractions. Oxo-MINA and cx-MIOA were excreted in lower amounts. Urinary concentrations of these metabolites peaked quickly post dose, suggesting that the majority of the dose may be excreted as nonspecific metabolites such as adipic acid. In a pilot population without known DINA exposure, none of the three metabolites were detected, indicating lower population exposures than in the dosage study. The new method for exposure and risk assessment can be used especially in populations with potentially higher DINA exposures.
Article
Engineering, Environmental
Yongsong Ma, Xianglin Liu, Mengyi Tang, Kaifa Du, Huayi Yin, Xuhui Mao, Dihua Wang
Summary: Heteroatom-doped carbon materials have been proven as effective catalysts for organic contaminant remediation. In this study, waste eggshell and Co3O4 were converted into N, P, S tri-doped core-shell catalyst using molten salt electrolysis. The Co@NPSC/peroxymonosulfate system showed a remarkable turnover frequency value for sulfamethoxazole degradation, even at a low catalyst dosage. Density functional theory simulations helped clarify the mechanism of catalytic oxidation and confirmed the detoxification of the degraded compound.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Jing Wang, Feng Zheng, Mingjun Li, Jiao Wang, Donghua Jia, Xiaodong Mao, Pengfei Hu, Qiang Zhen, Yi Yu
Summary: V2O5 nanobelt arrays covered with RuO2 nanosheets form a core-shell heterojunction with excellent specific capacitive value, cyclic steadiness, charge transferring resistance, and effective diffusion coefficient. Assembled into an electrochemical capacitor, it exhibits superior energy density.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Physics, Applied
Samir Merad, Daniela Maria Neacsa, Jean-Paul Rusiecki, Sylvain Roger, Francois Gervais, Cecile Autret-Lambert, Olivier Motret
Summary: The study demonstrates the successful coating of silicon oxide onto CCTO grains using an innovative non-thermal plasma treatment method, resulting in improved material properties. By controlling the gas mixture and plasma conditions, the thickness and homogeneity of the shell can be controlled, offering a new approach for the synthesis of core-shell materials.
JOURNAL OF APPLIED PHYSICS
(2021)
Article
Environmental Sciences
Hans G. J. Mol, Ingrid Elbers, Claudia Paelmke, Daniel Bury, Thomas Goeen, Marta Esteban Lopez, Stefanie Nuebler, Vincent Vaccher, Jean-Philippe Antignac, Darina Dvorakova, Jana Hajslova, Amrit Kaur Sakhi, Cathrine Thomsen, Katrin Vorkamp, Argelia Castano, Holger M. Koch
Summary: A quality assurance/quality control program was implemented in the HBM4EU project, which included four rounds of proficiency tests and involved 28 laboratories. The program resulted in a significant improvement in performance and the establishment of a network of competent laboratories capable of generating comparable and accurate data for biomarker analysis.
Article
Chemistry, Analytical
Corinna Fischer, Thomas Goeen
Summary: 2-(5-Chloro-benzotriazol-2-yl)-4,6-di-(tert-butyl)phenol (UV-327) is a compound used as an ultraviolet (UV) absorber in plastic materials and coatings. This study presents a method for the determination of UV-327 and its metabolites in human blood using protein precipitation, dispersive liquid-liquid microextraction (DLLME) and derivatization. The method has been validated and shown to have high sensitivity and reliability, allowing for the analysis of UV-327 and its metabolites and the assessment of exposure in potentially exposed individuals.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Kate Jones, Karen S. Galea, Bernice Scholten, Marika Loikala, Simo P. Porras, Radia Bousoumah, Sophie Ndaw, Elizabeth Leese, Henriqueta Louro, Maria Joao Silva, Susana Viegas, Lode Godderis, Jelle Verdonck, Katrien Poels, Thomas Goeen, Radu-Corneliu Duca, Tiina Santonen
Summary: This study aims to assess occupational exposure to diisocyanates in five European countries and test the usability of different biomarkers in the assessment of exposure. It also aims to provide background data for regulatory purposes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Ana Maria Tavares, Susana Viegas, Henriqueta Louro, Thomas Goeen, Tiina Santonen, Mirjam Luijten, Andreas Kortenkamp, Maria Joao Silva
Summary: This study conducted a mixture risk assessment (MRA) based on human biomonitoring (HBM) data in Europe to evaluate the co-exposure of hexavalent chromium, nickel, and polycyclic aromatic hydrocarbons. The results indicate that there is concern regarding the occupational health risk of co-exposure to these substances, particularly in welding activities and waste incineration settings. It highlights the importance of considering exposure to the mixture rather than the individual components to manage workplace risk and protect workers' health.
Article
Environmental Sciences
Michael Poteser, Federica Laguzzi, Thomas Schettgen, Nina Vogel, Till Weber, Aline Murawski, Phillipp Schmidt, Maria Ruther, Marike Kolossa-Gehring, Sonia Namorado, An Van Nieuwenhuyse, Brice Appenzeller, Edda Dufthaksdottir, Kristin Olafsdottir, Line Smastuen Haug, Cathrine Thomsen, Fabio Barbone, Valentina Rosolen, Loic Rambaud, Margaux Riou, Thomas Goen, Stefanie Nuebler, Moritz Schaefer, Karin H. A. Zarrabi, Liese Gilles, Laura Rodriguez Martin, Greet Schoeters, Ovnair Sepai, Eva Govarts, Hanns Moshammer
Summary: This report summarizes the results of the HBM4EU project and associated studies regarding acrylamide exposure levels. The findings show an increasing trend in acrylamide exposure in children, while the trend is less significant in adults and smokers. The average acrylamide exposure still exceeds suggested benchmark levels, raising specific concerns for children. Further research is needed to confirm the declining trend observed in recent years.
Article
Multidisciplinary Sciences
Caroline Fortmann, Thomas Goeen, Norman Zinne, Soeren Wiesner, Benno M. Ure, Claus Petersen, Joachim F. Kuebler
Summary: An analysis of the kinetics of metal contamination after minimally-invasive repair of pectus excavatum (MIRPE) and after bar removal revealed a rapid systemic increase of nickel and chromium in patients' blood, urine, and local tissue. These elevated levels of trace metals could cause irritative symptoms, and the prolonged elevated systemic nickel levels beyond bar removal require further investigation of the long-term side effects of MIRPE.
Review
Environmental Sciences
Henriqueta Louro, Bruno Costa Gomes, Anne Thoustrup Saber, Anna Laura Iamiceli, Thomas Goen, Kate Jones, Andromachi Katsonouri, Christiana M. Neophytou, Ulla Vogel, Celia Ventura, Axel Oberemm, Radu Corneliu Duca, Mariana F. Fernandez, Nicolas Olea, Tiina Santonen, Susana Viegas, Maria Joao Silva
Summary: This comprehensive review aims to provide regulators and policymakers with a comprehensive overview of occupational exposure to polycyclic aromatic hydrocarbons (PAHs), including the use of exposure and effect biomarkers, as well as the knowledge needs for regulation. The review highlights the importance of advancing harmonized approaches in data and sample collection, as well as the use of appropriate biomarkers in occupational studies to obtain reliable and comparable data on PAH exposure.
Article
Biochemical Research Methods
Heike Denghel, Thomas Goeen
Summary: A simple, reliable, and highly sensitive method for simultaneous monitoring of multiple endocrine disruptors in urine was developed. The method showed good sensitivity and accuracy, making it suitable for exploring the exposome of these disruptors in the general population.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Toxicology
Corinna Fischer, Edgar Leibold, Julia Hiller, Thomas Goeen
Summary: This study provides initial information on the human in vivo metabolism of UV-327 by administering it orally to volunteers. The results show that UV-327 is well-absorbed from the intestine but only partially metabolized. Biliary excretion may be the major route of elimination for UV-327 and its hydroxylated metabolites.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Environmental Sciences
Julia Hiller, Thomas Goeen, Nina Seibold-Wulf, Sebastian Meyer, Hans Drexler
Summary: This study investigates whether a diet highly exposed to aluminum-containing food-contact materials (Al-FCM) leads to an increased aluminum load in humans. The results show that under real-world conditions, there is a measurable but fully reversible additional aluminum burden. The estimated increase from Al-FCM corresponds to 8% of the baseline concentration.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Michael Hoopmann, Aline Murawski, Michael Schuemann, Thomas Goeen, Petra Apel, Nina Vogel, Marike Kolossa-Gehring, Claudia Roehl
Summary: HBM reference values are statistically derived values that provide information on population exposure. A revision is needed to improve the standardization and transparency of the process. It is recommended to use the 95th percentile of the reference distribution as the HBM reference value.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Multidisciplinary Sciences
Caroline Fortmann, Thomas Goeen, Soeren Wiesner, Jan Hegermann, Rim Kiblawi, Martha Dohna, Benno M. Ure, Diane Miriam Renz, Claus Petersen, Joachim F. Kuebler
Summary: This study investigated the impact of titanium nitride coating on metal release and exposure in patients undergoing minimally invasive repair of pectus excavatum (MIRPE). The results showed that the use of titanium nitride coated pectus bars led to a significant increase in trace metal levels after MIRPE, compared to stainless steel bars, possibly due to wear of the coating and inter-component mobilization processes.
Article
Public, Environmental & Occupational Health
Katharina Schwarz, Katharina Bluemlein, Thomas Goeen, Stefan Hahn, Ralph Hebisch, Wolfgang Koch, Ulrich Poppek, Anja Schaeferhenrich, Urs Schlueter, Monika Krug
Summary: The application of biocidal products by foam as an alternative to droplet spraying has inhalation exposure to aerosols as a concern. The study quantified the formation of inhalable aerosols during foaming and measured the aerosol release fractions of the active substance. The results showed that the aerosol release fractions varied and could be correlated to the process and foam parameters.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Anja Schaeferhenrich, Katharina Bluemlein, Wolfgang Koch, Stefan Hahn, Katharina Schwarz, Ulrich Poppek, Ralph Hebisch, Urs Schlueter, Monika Krug, Thomas Goeen
Summary: This study provides comparative exposure data for foam and spray applications of biocidal products in occupational settings, showing that potential dermal exposure is higher than inhalation exposure. While foam application reduces inhalation exposure, it does not significantly affect potential dermal exposure.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Article
Chemistry, Analytical
Laura Kuhlmann, Frank Muench, Thomas Goeen, Elisabeth Eckert
Summary: An online SPE-LC-MS/MS method was developed for the simultaneous determination of DEHP and alternative plasticizers in urine samples. The method showed high sensitivity and a simple sample preparation procedure, making it suitable for analyzing background levels of plasticizer exposure in the general population and for monitoring studies.
ANALYTICAL METHODS
(2022)
