Article
Pharmacology & Pharmacy
Atabak Ghanizadeh Tabriz, Uttom Nandi, Nicolaos Scoutaris, Karifa Sanfo, Bruce Alexander, Yuchuan Gong, Ho-Wah Hui, Sumit Kumar, Dennis Douroumis
Summary: Three-dimensional printing is a promising technology for the development of personalized paediatric dosage forms. In this study, micro-extrusion printing was used to fabricate chewable paediatric ibuprofen tablets. The printing process resulted in high-quality tablets with uniform distribution of the drug and effective taste masking.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Meihui Zhao, Dongmei You, Jiaojiao Yin, Wanxiao Sun, Tian Yin, Jingxin Gou, Yu Zhang, Yanjiao Wang, Haibing He, Xing Tang
Summary: This study developed a quaternary enteric solid dispersion (QESD) to mask the bitterness of drugs, enhance drug dissolution rate in the intestine, and improve the physicochemical stability of the formulation during storage. By forming a solid emulsion-like structure within the enteric continuous phase, QESD slowed down the chemical degradation of the drug and increased the system stability.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Boyang Huang, Yaxin Wang, Cian Vyas, Paulo Bartolo
Summary: This study compares two different extrusion additive manufacturing techniques for fabricating polymer-based 3D bone scaffolds. The results show that the scaffolds produced using these techniques exhibit distinct physiochemical properties. Melt-printed scaffolds have stronger mechanical properties, while solvent-printed scaffolds have a rougher surface, higher degradation rate, and faster stress relaxation. These differences are attributed to the different crystal growth kinetics and result in different cell-scaffold interactions.
Review
Food Science & Technology
Andriana E. Lazou
Summary: Extrusion is a versatile process that can produce a variety of new and novel foods and ingredients. It can provide nutritious, safe, sustainable, and affordable foods tailored to individual consumer needs. Further research is needed to refine, redesign, or develop new extrusion processing technologies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Seth P. Forster, David B. Lebo
Summary: The study aimed to produce taste-masked ibuprofen granules using twin-screw melt granulation. Ibuprofen release was inversely related to granule size.
Article
Engineering, Chemical
Qiuhong Liu, Mao Li, Chen Liu, Jieli Yin, Xuan Zhu, Dengyue Chen
Summary: The solid hollow-fiber cooling crystallizer (SHFCC) device was developed to manufacture polymer-coated drug nanoparticles in a continuous and controllable manner, improving drug bioavailability and enabling sustained drug release. The temperature differences in the device led to the precipitation of polymer-coated nanoparticles, protecting fragile substances and enhancing drug efficacy. This scalable method met the demands of the modern pharmaceutical industry.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Juliana dos Santos, Gabriela de Souza Balbinot, Silvio Buchner, Fabricio Mezzomo Collares, Maike Windbergs, Monique Deon, Ruy Carlos Ruver Beck
Summary: The use of 3D printing in pharmaceutics has increased, and studies have focused on the impact of the composition of these formulations on their properties. This study examined the effect of the drug solubility and size of the dosage forms on the controlled release properties of 3D printed solid forms. The results showed that the drug release behavior can be customized by adjusting the size of the 3D printed forms without changing their controlled release behavior.
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
(2023)
Article
Chemistry, Medicinal
Garba M. Khalid, Umberto M. Musazzi, Francesca Selmin, Silvia Franze, Paola Minghetti, Francesco Cilurzo
Summary: The potential application of hot-melt ram extrusion printing for producing diclofenac orodispersible films (ODF) made of maltodextrin was studied, focusing on the effects of taste-masking agents and an opacifier. The study demonstrated the feasibility of printing ODF loaded with a thermosensitive drug using hot-melt technologies, showing improved tensile properties and disintegration time. The addition of diclofenac significantly enhanced the ODF tensile strength, while titanium dioxide played a role in reducing peel forces and improving detachment from packaging material.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Pharmacology & Pharmacy
Derick Muhindo, Eman A. Ashour, Mashan Almutairi, Michael A. Repka
Summary: This study investigated the use of the CELLINK BIO X bioprinter and DPE 3D printing technique to fabricate and evaluate the impact of different shapes of drug-loaded subdermal implants on drug release. The results showed that the release of the drug could be controlled and tuned by altering the implant shape and surface area, which could contribute to personalized medicine and improved patient compliance.
Article
Engineering, Chemical
Qiuhong Liu, Mao Li, Chen Liu, Jieli Yin, Xuan Zhu, Dengyue Chen
Summary: A solid hollow-fiber cooling crystallizer device was developed to manufacture polymer-coated drug nanoparticles in a continuous and controllable manner, improving drug bioavailability and providing sustained drug release. The device allows for the fabrication of uniformly dispersed polymer-coated nanoparticles for controlled drug release, with minimal changes to the underlying properties of the substances.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Medicine, Research & Experimental
Dennis Douroumis, Atabak Ghanizadeh Tabriz, Ho-Wah Hui, Nathan Boersen, Sandra Roberts, John Jones
Summary: In recent years, 3D printing technologies have been gaining interest in the development of personalized medicinal products. The printing of drug products allows for customization in dose, shape/design, and flavor, potentially improving acceptability in pediatric populations. This study successfully designed and developed flavored chewable dosage forms of ibuprofen using microextrusion for processing powdered blends. The optimized processing parameters resulted in high-quality tablets with various designs and a glossy appearance. The physicochemical characterization revealed the dispersion of ibuprofen in the polymer matrix and the formation of hydrogen bonding. Taste masking and aroma evaluation were excellent when strawberry and orange flavors were used. Dissolution studies showed rapid dissolution rates of ibuprofen in acidic media. Microextrusion is an effective 3D printing technology for generating patient-specific dosage forms for children at the point of care.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Zara-Louise Farmer, Emilia Utomo, Juan Dominguez-Robles, Caterina Mancinelli, Essyrose Mathew, Eneko Larraneta, Dimitrios A. Lamprou
Summary: This study investigated the use of thermoplastic polyurethane (TPU) as an alternative material for surgical mesh implants instead of polypropylene (PP), and hormone-loaded meshes were produced using fused deposition modelling. The results showed that TPU meshes were more suitable for pelvic floor repair than PP, and 3D printed meshes exhibited linear release of 17-beta-estradiol (E2) over a two weeks period.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
An Chen, Peishan Cai, Minqian Luo, Minshan Guo, Ting Cai
Summary: The aim of this study was to prepare a celecoxib-carbamazepine (CEL-CBZ) cocrystal by melt crystallization for synchronized drug release. The results showed that the formation of the drug-drug cocrystal altered the dissolution rates of the drugs and enabled synchronized release. Melt crystallization was found to be an alternative and efficient method for large-scale preparation of drug-drug cocrystals.
PHARMACEUTICAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Andreea Cornila, Sonia Iurian, Ioan Tomuta, Alina Porfire
Summary: The paediatric population has lacked medicines tailored to their needs in terms of accurate dosage, stability, and acceptability. Nanostructures offer a solution to these challenges by their size and variety, allowing the development of safe, stable, and acceptable medicines for children.
Article
Pharmacology & Pharmacy
Yanping Deng, Lian Shen, Yan Yang, Jie Shen
Summary: This study developed a nanoparticle-based orodispersible pediatric drug delivery platform to improve the oral bioavailability and taste of poorly water-soluble and unpalatable therapeutics. Through in vitro and in vivo testing, it was found that the platform effectively enhanced the oral bioavailability and taste of LPV and RTV, while maintaining good stability of the raw drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)