Article
Chemistry, Analytical
Sanlei Xie, Yuehong Yue, Guoyang Xu
Summary: To prevent the hazard concerns of amantadine (AMD) on humans, a sensitive and reliable detection method is urgently required. We developed a one-pot method for in situ synthesis of carbon nanoparticles (CNPs) that exhibited yellow color and green fluorescence. These CNPs were used as signal tags in a dual-signal immunoassay for colorimetric and fluorometric monitoring of AMD residues in poultry foodstuffs.
MICROCHEMICAL JOURNAL
(2023)
Article
Food Science & Technology
Marzieh Sepahvand, Forough Ghasemi, Hossein Mir Seyed Hosseini
Summary: This paper discusses the serious threat of irregular and unknowing use of chemical compounds to the environment, human health, and living organisms, emphasizing the importance of monitoring nitrite and nitrate. It comprehensively discusses the application and advantages of nanoplasmonic colorimetric sensors in the measurement of nitrite and nitrate.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Pharmacology & Pharmacy
Rile Ou, Gerile Aodeng, Jun Ai
Summary: Cancer is a global health challenge that imposes a tremendous burden on individuals and society. To mitigate its impact, global collaboration is essential, with a focus on prevention, early detection, and effective treatment strategies. The utilization of the Fenton reaction, facilitated by nanotechnology, shows promise in selectively destroying cancer cells. This article reviews the progress and potential applications of the Fenton reaction in the cancer microenvironment.
Article
Chemistry, Analytical
Geetika Bhardwaj, Randeep Kaur, Navneet Kaur, Narinder Singh
Summary: A new receptor R1 was synthesized and prepared as nanoparticles to detect azidothymidine. The nanoparticle probe showed better sensing performance for azidothymidine in various techniques such as cyclic voltammetry.
Article
Chemistry, Analytical
Stylianos Grammatikos, Ioannis Svoliantopoulos, Electra Gizeli
Summary: This study presents a simple yet highly efficient and sensitive methodology for the colorimetric visualization of a single target copy in saliva using chitosan-capped gold nanoparticles. The developed method shows enhanced sensitivity compared to commonly used pH-sensitive dyes, making it suitable for point-of-care applications.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xiang-Yu Xiao, Zong-Yin Song, Pei-Hua Li, Shi-Hua Chen, Li-Na Li, Meng Yang, Chu-Hong Lin, Xing-Jiu Huang
Summary: The study successfully stabilizes Au-25 nanoclusters on Fe2O3 nanoplates, forming Au-25/OV-Fe2O3 with superhigh electrochemical reduction catalytic activity, breaking sensitivity records and offering promising applications in the analysis of organic and bioactive substances. The Au-Fe bond and S atoms in Au-25 nanoclusters play important roles in the reduction of As(III). The fantastic stability and catalytic ability of Au-25/OV-Fe2O3 provide guidelines for stabilizing Au nanoclusters on metal oxides.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Chenyu Cui, Ting-Hsuan Chen
Summary: The integration of microfluidic particle accumulation with a Cu(II)-catalyzed Fenton reaction allows for visual and quantitative detection of trace copper ions in drinking water. This method shows good selectivity, tolerance to pH and hardness, and a low detection limit, making it a potential platform for routine monitoring of copper contamination in water sources.
Article
Chemistry, Analytical
Yan Tan, Jianxing Zhou, Xiaotong Xing, Junren Wang, Jinkun Huang, Huiyu Liu, Jiajie Chen, Mingjie Dong, Qin Xiang, Haifeng Dong, Xueji Zhang
Summary: In this study, the controllable self-assembly of DNA-linked gold nanoparticles (AuNPs) for in vivo biomedical applications was achieved by using programmable DNA tetrahedral structures. Three different sizes of AuNPs (20nm, 10nm, and 5nm) were organized and positioned using this method. The density and arrangement of the satellite AuNPs around the core AuNPs were controlled by tuning the size and amount of DNA tetrahedron functionalized on the core AuNPs, resulting in strong electromagnetic field enhancement. With the conjugation of Raman molecules, strong surface-enhanced Raman scattering photoacoustic imaging signals were generated, allowing for the imaging of microRNA-21 and tumor tissues in vivo. This study provides an efficient strategy for building precision plasmonic superstructures in plasmonic-based bioanalysis and imaging.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yandong Ran, Mohammed Moursy, Robert C. Hider, Agostino Cilibrizzi
Summary: Investigation was made on an aromatic substrate for hydroxylation by hydroxyl radicals ((OH)-O-center dot). The probe, N,N'-(5-nitro-1,3-phenylene)-bis-glutaramide, and its hydroxylated product were found not to bind either iron(III) or iron(II), thus not interfering with the Fenton reaction. A spectrophotometric assay based on the hydroxylation of the substrate was developed, providing univocal and sensitive (OH)-O-center dot detection. The assay demonstrated the lack of Fenton activity of iron(III) complexes of long-chain fatty acids under biological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Sebastian Franco-Ulloa, Andrea Cesari, Laura Riccardi, Federico De Biasi, Daniele Rosa-Gastaldo, Fabrizio Mancin, Marco De Vivo, Federico Rastrelli
Summary: Nanoparticle-assisted nuclear magnetic resonance (NMR) chemosensing is a technique that uses monolayer-protected nanoparticles as supramolecular hosts to detect small molecules in complex mixtures. The structure-sensitivity relationships that determine the detection limits of this technique are still not well understood. This study combines NMR spectroscopy and atomistic molecular dynamics simulations to investigate the factors that affect the sensitivity of different NMR chemosensing experiments. The results show that the intensity of the observed signals is correlated with the spin-spin interactions between the analytes and the nanoparticles, as well as the analytes and the nanoparticles' solvation molecules.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Analytical
Monika Yadav, Manita Das, Shivangi Bhatt, Pranav Shah, Rajendrasinh Jadeja, Sonal Thakore
Summary: In this study, a novel cyclodextrin phthalate ester polymer was used to synthesize gold and silver nanoparticles for the rapid and accurate detection of sulfur-based pollutants in aqueous solutions. The gold nanoparticles selectively agglomerated upon interaction with cysteine and SDDC, allowing for visual readout. Detection and quantification of the compounds occurred within seconds due to the dual binding ability of cyclodextrin, with satisfactory limits of detection. The nanosensor demonstrated superior performance in detecting sulfur-containing compounds and can be potentially applied in environmental monitoring.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Zhongchao Yi, Xiaoyue Yang, Ying Liang, Fanny Chapelin, Sheng Tong
Summary: Iron oxide nanoparticles have shown great potential as a platform for ROS-dependent disease treatment. In this study, wustite nanoparticles were found to exhibit higher catalytic activity than magnetite or maghemite nanoparticles of similar size and coating. The presence of internal low-valence iron was identified as the key factor contributing to the high catalytic activity of wustite nanoparticles. Furthermore, the synthesis of ultrasmall wustite nanoparticles resulted in even higher Fenton reaction rate compared to an FDA-approved IONP. These findings provide important insights into improving the development of efficient ROS-inducing nanozymes.
Article
Chemistry, Analytical
Wing Kiu Yeung, Shu-Cheng Lo, Sheng-Hann Wang, Pei-Kuen Wei, Ji-Yen Cheng
Summary: The COVID-19 pandemic has highlighted the need for a highly specific and rapid diagnostic system. A spectral imaging-based surface plasmon resonance platform combined with an integrated microfluidic biosensor is proposed as a promising alternative for infectious diseases, offering safe and straightforward use. The use of unmodified PEG to control probe density has shown to be a particularly promising functionalization strategy in SPR spectral imaging assays for highly specific detection of COVID-19 target sequences.
Article
Chemistry, Analytical
Shuai Wen, Min Huang, Ru Cheng, Jie Gao, Jian Wang
Summary: In this study, silver-coated gold nanorods were used as an optical probe for the sensitive detection of ascorbic acid. The detection was based on the inhibition effect of ascorbic acid on the Fenton reaction, resulting in a shift in the longitudinal absorption wavelength of the nanorods.
Article
Food Science & Technology
Rajib Deb, Prasanna Pal, Parul Chaudhary, Sanat Bhadsavle, Manisha Behera, Parmanand, Devika Gautam, Mayank Roshan, Ashutosh Vats, Ashutosh Ludri, Vivek Kumar Gupta, Sachinandan De
Summary: A rapid, sensitive, and precise method for identifying microbial DNA in veterinary clinical samples, particularly from cows affected with mastitis, was developed. The method utilized multiple gold nanoparticles on a magnetic microbead surface to enhance plasmonic signals, allowing for improved sensitivity. This visual assay is quick, user-friendly, and can detect Escherichia coli DNA with high accuracy in clinical samples such as cow milk with mastitis.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Yuchen Bai, Rui Liu, Leina Dou, Weilin Wu, Wenbo Yu, Kai Wen, Xuezhi Yu, Jianzhong Shen, Zhanhui Wang
Summary: This study investigated the influence of spacer arm length on antibody titer, affinity, and assay performance. It found that spacer arms of 6-8 carbon atoms induced the strongest antibody response, while shorter and longer spacer arms failed to do so.
ANALYTICA CHIMICA ACTA
(2023)
Review
Chemistry, Analytical
Liang Luo, Yantong Pan, Qing Li, Yingjie Zhang, Chaochao Chen, Jianzhong Shen, Zhanhui Wang
Summary: Adrenergic receptor agonists are analogues of adrenergic transmitters that bind and stimulate adrenergic receptors. They have been illegally used in animal husbandry for their growth-promoting and fat-reducing properties. It is important to detect these residues for food safety and human health.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Leina Dou, Qing Li, Yuchen Bai, Jiaqian Kou, Xiaonan Wang, Qian Zhao, Xuezhi Yu, Kai Wen, Zhanhui Wang, Jianzhong Shen, Wenbo Yu
Summary: Aggregation-induced emission luminogens (AIE-gens) have great potential for bacterial imaging and detection without complicated labeling or washing steps. In this study, we investigated the mechanism of their bacterial Light-Up behavior using large-scale molecular dynamics simulations. We proposed that the triphenylamine motif of TBP-1 plays a crucial role in the fluorescence turn-on and bacterial Light-Up. Based on this, we developed a heterogeneous lateral flow immunoassay (LFIA) for foodborne pathogen detection with improved sensitivity and specificity.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Xiya Zhang, Yuchen Bai, Qianqian Tang, Minggang Liu, Li Nan, Kai Wen, Xuezhi Yu, Wenbo Yu, Jianzhong Shen, Zhanhui Wang
Summary: Antibody is a crucial biomolecule for the sensitivity and specificity of immunoassays. Predicting the effectiveness of hapten molecules before synthesis can improve success rate, cost-effectiveness, and controllability. In this study, a rational hapten design method was proposed and evaluated, leading to the production of highly specific antibodies with enhanced affinity, which were successfully applied in antigen detection.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Food Science & Technology
Changfei Duan, Huiyan Zhang, Yingjie Zhang, Qiang Li, Peipei Li, Ghulam Mujtaba Mari, Sergei A. Eremin, Jianzhong Shen, Zhanhui Wang
Summary: A highly sensitive, specific, robust, and rapid fluorescence polarization immunoassay (FPIA) was developed for the determination of erythromycin (ERY) in milk samples. The method utilized five tracers of ERY and three monoclonal antibodies to achieve high sensitivity. The developed FPIA showed a detection limit of 14.08 μg/L and recoveries of 96.08-107.77% with coefficients of variations of 3.41-10.97%. The total detection time was less than 5 minutes. The proposed FPIA method is a rapid, accurate, and simple screening tool for ERY in milk samples.
Editorial Material
Nanoscience & Nanotechnology
Yuan Li, Zhanhui Wang
Summary: This article describes some technical concerns for the single transgenic hybridoma selection method (STHSM) that we developed, and outlines how we innovated the specific procedures in the STHSM to address the questions raised by Listek's group.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Xuesong Li, Jie Cheng, Kun Zeng, Shulin Wei, Jiaxuan Xiao, Yanyan Lu, Fang Zhu, Zhanhui Wang, Kun Wang, Xiangyang Wu, Zhen Zhang
Summary: Traditional hybridization chain reaction (HCR) is a popular isothermal amplification technique in bioanalysis, however, its slow kinetics limits its application. In this study, a poly DNA tetrahedrons (pTDNs)-mediated HCR was developed to enhance the kinetics by stretching the HCR initiator through electrostatic forces. The pTDNs-mediated HCR was successfully applied to develop a sensitive immunoassay for rapid detection of aflatoxin B1.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Jie Fei, Jiaqun Jiang, Yuchen Bai, Weilin Wu, Xiangjun Zhao, Wenbo Yu, Kai Wen, Xuezhi Yu, Jianzhong Shen, Zhanhui Wang
Summary: This study demonstrates the importance of careful hapten design and extensive antibody screening in the development of sandwich immunoassays for small molecules, using ABM as an example. Through combinatorial associations of antibody pairs, a sandwich immunoassay for ABM was successfully established.
ANALYTICAL CHEMISTRY
(2023)
Review
Biochemical Research Methods
Jiaqian Kou, Jianzhong Shen, Zhanhui Wang, Wenbo Yu
Summary: As a rapidly developing cell engineering technique, cell electrofusion has been increasingly applied in the field of hybridoma preparation in recent years. However, its complete replacement of the polyethylene glycol-mediated cell fusion is difficult due to high operation requirements, cost of electrofusion instruments, and lack of prior research. This review summarizes the current state of cell electrofusion in hybridoma preparation, focusing on instruments, process control, and cell treatment. It provides important information and insights for further development in this field.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Agriculture, Multidisciplinary
Jianyu Zhu, Jiaqian Kou, Licai Ma, Xuezhi Yu, Chenglong Li, Zhanhui Wang, Jianzhong Shen, Kai Wen, Wenbo Yu
Summary: Amatoxins are polypeptides that cause the majority of fatalities from unintentional consumption of poisonous mushrooms. This study focused on preparing high-affinity antibodies against amatoxins and investigating the recognition mechanism. The researchers also developed a fully automated immunoassay using a microfluidics chip, which showed improved sensitivity compared to conventional ELISA. This platform has important implications for confirming poison agents and diagnosing patients with mushroom poisoning.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Xuesong Li, Jie Cheng, Kun Zeng, Shulin Wei, Jiaxuan Xiao, Yanyan Lu, Fang Zhu, Zhanhui Wang, Kun Wang, Xiangyang Wu, Zhen Zhang
Summary: A poly DNA tetrahedrons (pTDNs)-mediated hybridization chain reaction (HCR) was developed, which significantly enhanced the kinetics of HCR and was applied in the detection of aflatoxin B1. The increased G4 DNAzyme loaded on the second antibody contributed to the signal amplification. This work provides a promising approach to improve the speed and signal amplification of HCR in bioanalysis using simple DNA frameworks.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Agriculture, Multidisciplinary
Jianyu Zhu, Jiaqian Kou, Licai Ma, Xuezhi Yu, Chenglong Li, Zhanhui Wang, Jianzhong Shen, Kai Wen, Wenbo Yu
Summary: Researchers have developed a monoclonal antibody against amatoxins and investigated its recognition mechanism. They have also designed a microfluidics chip and a fully automated immunoassay for the rapid and accurate detection of amatoxins poisoning.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)