Article
Chemistry, Analytical
Tatiana G. Choleva, Christina Matiaki, Afroditi Sfakianaki, Athanasios G. Vlessidis, Dimosthenis L. Giokas
Summary: A novel method for determining chloride anions in sweat has been developed, utilizing the photochemical response of silver ions and silver chloride crystals to UV light. The method is simple, with low detection limits and a wide detection range.
Article
Chemistry, Multidisciplinary
R. Jeyaseelan, M. Utikal, C. G. Daniliuc, L. Naesborg
Summary: We developed a formal [2 + 2]-cycloaddition of unsaturated ketones using a green-to-ultraviolet triplet-triplet annihilation upconversion (TTA-UC) pair, consisting of commercially available Ru(bpy) (2+)(3) as the sensitizer and pyrene as the annihilator. Visible light irradiation at λ(max) = 520 nm was sufficient for the reaction to proceed without the need for UV-light, and the use of an aqueous medium eliminated the requirement for oxygen removing protocols. This study expands the application of the readily available upconversion pair to include cyclization reactions, showcasing its utility in generating valuable bioisosteres for pharmaceuticals, such as bicyclo[2.1.1]hexanes.
Article
Materials Science, Multidisciplinary
Yueyue Pan, Zhen Qin, Sina Kheiri, Binbin Ying, Peng Pan, Ran Peng, Xinyu Liu
Summary: The article presents a visible light-induced printing technique for highly conductive silver patterns on nanopaper, which is simple and cost-effective and can be used for fabricating flexible circuits and biosensors.
ADVANCED ENGINEERING MATERIALS
(2022)
Review
Chemistry, Analytical
Muthaiah Shellaiah, Kien Wen Sun
Summary: Biothiols, such as cysteine, homocysteine, and glutathione, play a crucial role in various biological processes, but abnormal levels can lead to serious diseases. Carbon-dots (CDs) have emerged as a promising tool for biothiols quantification due to their easy synthesis, nanosize, low toxicity, and real-time applicability. However, a comprehensive review on fluorescent CDs-based biothiols detection is lacking. This review provides valuable information on the assays, mechanisms, applications, selection of probes/CDs, sensory requirements, merits, limitations, and future prospects.
Article
Chemistry, Analytical
Nigar Anzar, Shariq Suleman, Husnara Bano, Suhel Parvez, Manika Khanuja, Roberto Pilloton, Jagriti Narang
Summary: We developed an electrochemical paper-based analytical device (ePAD) for the rapid detection of methamphetamine, a stimulant used as an addictive narcotic. The ePAD is simple, affordable, and recyclable, and it was created by immobilizing a methamphetamine-binding aptamer onto Ag-ZnO nanocomposite electrodes. The sensor exhibited a limit of detection of 0.1 μg/mL and an optimum response time of 25 s, making it suitable for forensic diagnostic applications.
Article
Biochemical Research Methods
Jun Liao, Zhicheng Yu, Li Fu, Jia Liu, Li Jia
Summary: The rapid and on-site detection of biothiols in complex samples remains a challenge, but this study developed a simple and enzyme-free colorimetric approach using 3,3',5,5'-tetramethylbenzidine (TMB) as the chromogenic substrate. A smartphone-based portable device integrated with test strips was constructed by 3D printing, allowing for the photocatalytic oxidation of TMB and the detection of biothiols within 5 minutes. The successful detection of cysteine in urine and milk samples demonstrates the device's potential for on-site assays.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Jacopo Emilio Giaretta, Farshad Oveissi, Fariba Dehghani, Sina Naficy
Summary: The article presents a 3D printable paper-based sensor for detecting H2O2, which simplifies the fabrication process and detects H2O2 concentration by observing the change in resistance. The integration of enzyme enhances the detection performance of the sensor.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Review
Materials Science, Multidisciplinary
Mariadel Mar Gonzalez del Campo, Andreu Vaquer, Roberto de la Rica
Summary: In recent years, paper has become a widely used material for developing various types of sensors, and a polymer-based toolbox has emerged to enhance the functionalities of these devices. This article compiles examples from recent literature on microfluidic systems and polymer-based transducers implemented in paper-based analytical platforms. The use of printing methods to pattern polymers allows for mass production of these advanced paper-based devices without requiring specialized facilities.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Chemistry, Analytical
Kawin Khachornsakkul, Jung-Jung Chang, Ping-Heng Lin, Yi-Han Lin, Wijitar Dungchai, Chih-Hsin Chen
Summary: The study introduces a highly sensitive distance-based liquid crystalline visualization for paper-based analytical devices, allowing for quantification of bilirubin concentration through naked eye measurement of color change on paper. This device offers a wide linear detection range, low detection limit, and high reproducibility, suitable for various biological samples.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Applied
Danning Fu, Ruibin Wang, Yang Wang, Qianyu Sun, Chen Cheng, Xiaohui Guo, Rendang Yang
Summary: In this study, a rational strategy was used to design a silver nanowires-dual-cellulose conductive paper. The conductive paper showed good mechanical properties, electrical properties, and adhesion stability. It was demonstrated to be suitable for versatile flexible pressure sensors with fast response and high sensitivity to finger motion, voice recognition, and human pulse.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Disiya Davis, Swathi Krishna Narayanan, Arya Ajeev, Jayashree Nair, Jithin Jeeji, Ananthu Vijayan, Midhun Viyyur Kuttyadi, Arun Nelliparambil Sathian, Arul Kashmir Arulraj
Summary: In this study, a paper-based, room-temperature-operatable acetone sensor using ZnO-polyaniline-based acetone-sensing inks was proposed. The fabricated paper-based electrodes exhibited good electrical conductivity and mechanical stability. The acetone sensors showed a fast response and recovery time at room temperature and delivered a wide sensitivity range over physiological conditions. The correlation between the surface, interfacial, microstructure, electrical, and electromechanical properties of the paper-based sensor devices with the sensitivity and room-temperature recovery was investigated.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Azad H. Alshatteri, Khalid M. Omer
Summary: Ratiometric-based dual-emission fluorescence probe constructed by a dual-nanocluster was used to measure the amount of cysteine. The addition of cysteine caused a noticeable fluorescence color shift from red to blue. The probe showed satisfactory accuracy and precision in measuring cysteine in human serum.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Arezoo Saadati, Fatemeh Farshchi, Mohammad Hasanzadeh, Yuqian Liu, Farzad Seidi
Summary: In this study, a fast and sensitive colorimetric method was developed to accurately detect trace amounts of arsenic. By changing the morphology of silver nanoparticles, the color of the nanoparticles changed, which was visible to the naked eye. The proposed probes showed good performance in the experiments and could be used to detect arsenic levels in human urine samples.
Article
Engineering, Electrical & Electronic
Gerald Gerlach, Margarita Guenther, Thomas Haertling
Summary: Hydrogels are cross-linked polymer networks capable of absorbing or releasing large amounts of water, with swelling induced by various physical and chemical factors. The sensitivity of hydrogels can be tailored by adjusting their composition or functionalization, and if the interaction with the analyte is reversible, they can be promising candidates for miniaturized, cost-effective, and inline-capable sensors.
IEEE SENSORS JOURNAL
(2021)
Article
Engineering, Environmental
Liang Zhu, Xuecui Mei, Zhengchun Peng, Jiang Liu, Jiao Yang, Yingchun Li
Summary: This study developed a paper-based fluorescence sensor-array platform for the rapid and simple identification of biothiols. The platform employed carbon quantum dots modified with three biothiol receptors on paper substrates. The biothiols reacted with the modified carbon quantum dots, resulting in a partial recovery of fluorescence and unique fluorescence response patterns for different biothiols. The platform showed great potential for clinical point-of-care and on-site testing towards multiple analytes.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Dionysios C. Christodouleas, Balwinder Kaur, Parthena Chorti
ACS CENTRAL SCIENCE
(2018)
Article
Chemistry, Analytical
Tatiana G. Choleva, George Z. Tsogas, Dimosthenis L. Giokas
Editorial Material
Medical Laboratory Technology
Dionysios C. Christodouleas
CLINICAL CHEMISTRY
(2019)
Review
Chemistry, Analytical
George Giannoulas, George Z. Tsogas, Dimosthenis L. Giokas
Article
Environmental Sciences
Tatiana G. Choleva, George Z. Tsogas, Athanasios G. Vlessidis, Dimosthenis L. Giokas
ENVIRONMENTAL POLLUTION
(2020)
Article
Nanoscience & Nanotechnology
Abbas Parvez Kazi, Anna Maria Routsi, Balwinder Kaur, Dionysios C. Christodouleas
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Nanoscience & Nanotechnology
Tanmoy Maji, Anna Maria Rousti, Abbas Parvez Kazi, Christopher Drew, Jayant Kumar, Dionysios C. Christodouleas
Summary: Thermoelectric composites of organic and inorganic materials show enhanced thermoelectric properties compared to pristine organic materials, with 3D paper PEDOT:tosylate/CuI composites demonstrating improved power density and Seebeck coefficient. The wearable thermoelectric device utilizing these composites can generate significant power at a temperature difference of 20 K, offering potential applications in skin-attached or embedded clothing devices.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Parthena Chorti, Abbas Parvez Kazi, Michael Wiederoder, Dionysios C. Christodouleas
Summary: This study introduces a novel flow-through direct immunoassay (FTDI) methodology for targeted detection of bacteria in liquid samples, providing rapid and sensitive detection, as well as ensuring accuracy and precision in various types of samples.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Parthena Chorti, Dionysios C. Christodouleas
Summary: This study presents a new type of sink/float magnetic immunoassays for the rapid detection of biomarkers in untreated biological samples, which are simple to operate and may meet regulatory authorities' criteria for field use.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Parthena Chorti, Abbas Parvez Kazi, Al-Monsur Jiaul Haque, Michael Wiederoder, Dionysios C. Christodouleas
Summary: This study introduces a new electrochemical immunoassay for targeted detection of bacteria, which can support portable bacteria biosensors for field use. By using disposable syringes and a flow-through detection cell, the proposed assay can analyze higher sample volumes efficiently.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Materials Science, Multidisciplinary
Anna Maria Rousti, Tanmoy Maji, Christopher Drew, Jayant Kumar, Dionysios C. Christodouleas
Summary: Fabric-based thermoelectrics embedded with PEDOT:Tosylate and CuI nanocrystals, especially using NYCO fabric, showed significant improvement in thermoelectric performance. The integration of CuI nanocrystals increased the power density of the composites significantly. A wearable thermoelectric device utilizing NYCO/PEDOT:Tos/CuI was able to generate up to 70 nW of power.
APPLIED MATERIALS TODAY
(2021)
Article
Chemistry, Analytical
Maria Tarara, Dimosthenis L. Giokas, George Z. Tsogas
Summary: In this work, a new method for controlling fluid transport rate on paper-based analytical devices is explored. Delay and acceleration of fluid flow are achieved by wax printing linear patterns of variable width and overlaying hydrophobic stripes. The combination of these methods allows for a wide timing adjustment of fluid transport.
Article
Chemistry, Analytical
Panagiotis A. Bizirtsakis, Maria Tarara, Apostolia Tsiasioti, Paraskevas D. Tzanavaras, George Z. Tsogas
Summary: The study introduces a novel, direct and simple colorimetric method using microanalytical paper-based devices for selective determination of bismuth. This low-cost, easy-to-use and high-precision method does not require experimental apparatus, making it suitable for on-site analysis.
Article
Chemistry, Analytical
Maria Tarara, Apostolia Tsiasioti, Paraskevas D. Tzanavaras, George Z. Tsogas
Summary: This study presents a direct fluorimetric method for the selective determination of histidine using micro-analytical paper-based devices. The method is cost-effective and easy to use, making it suitable for practical applications.
Article
Chemistry, Multidisciplinary
Anastasia Kostara, George Z. Tsogas, Athanasios G. Vlessidis, Dimosthenis L. Giokas
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)