期刊
ANALYST
卷 143, 期 12, 页码 2812-2818出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8an00157j
关键词
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资金
- Touchsensor for enklere og raskere urinprovetaking og analyse [234972, 272037]
- Disruptiv Innovasjon for Vannovervaking - Forbedring i Styringen av Vannkvalitet [272037]
- RFF Hovedstaden project: Biologisk Vannalarmsystem for a styrke offentlig vannkvalitetsstyring [273869]
- Research Council of Norway (RCN) [268481, 276650]
- National Natural Science Foundation of China [61531008, 61550110253, 61650410655, 11702045]
- EU Erasmus + Capacity Building in Higher Education: Internationalised Master Degree Education in Nanoelectronics in Asian Universities [573828-EPP-1-2016-1-BG-EPPKA2-CBHE-JP]
- Chongqing Research Program of Basic Research and Frontier Technology [cstc2015jcyjBX0004, cstc2015jcyjA20023, cstc2016jcyjA2161, cstc2017jcyjA1842]
- Chongqing Education Commission - Science and Technology Research Program [KJ1600602, KJ1600604, KJ1500609, KJ15006XX]
- Chongqing Innovation Team of Colleges and Universities - Smart Micro-Nano Systems Technology Applications [CXTDX201601025]
- The 13th Recruitment Program of Global Experts (known as the Thousand Talents Plan)
- Chongqing Key Laboratory of Micro-Nanosystems Technology and Smart Transduction [KFJJ2017087]
- Recruitment Program for Innovative Talents Chinese government, Xinjiang University
In this study, we developed a novel wearable and low-cost device for qualitative screening of glucose (GLU), leukocytes (LEU), and nitrite (NIT) and for semi-quantitative analysis of blood (BLD) and proteins (PRO) in the urine samples. The device can be attached to a diaper, and the results can be read by an app. The main functions of the device can be divided into sample collection, valve closing, and pad saturation; the recorded times for valve closing and pad saturation at four corners and pad saturation at the central parts are pseudo-medians (Hodges-Lehmann estimator) of 3.55 (95% WCI, 3.45-3.72), 6.5 (95% WCI, 6-7), and 6 (95% WCI, 5.5-6.5) minutes, respectively. The RGB values in the reagent pads remain stable from 20 min to 480 min, which satisfies the requirement of regular diaper-wearing time. Pre-diagnostic results indicate high accuracy with good accuracy for the app recognition of five biomarkers in the urine samples, which makes it a promising tool for screening diseases, especially for the elderly healthcare.
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