Article
Surgery
Michael D. Parkes, Kieran Halloran, Alim Hirji, Shane Pon, Justin Weinkauf, Irina L. Timofte, Greg I. Snell, Glen P. Westall, Jan Havlin, Robert Lischke, Andrea Zajacova, Ramsey Hachem, Daniel Kreisel, Deborah Levine, Bartosz Kubisa, Maria Piotrowska, Stephen Juvet, Shaf Keshavjee, Peter Jaksch, Walter Klepetko, Philip F. Halloran
Summary: The study revealed that CLAD primarily reflects severe parenchymal injury-induced changes and dedifferentiation rather than inflammation. Fibrillar collagen genes were increased in CLAD, indicating matrix changes, and normal transcripts were decreased.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Daniel T. Dugger, Monica Fung, Steven R. Hays, Jonathan P. Singer, Mary E. Kleinhenz, Lorriana E. Leard, Jeffrey A. Golden, Rupal J. Shah, Joyce S. Lee, Fred Deiter, Nancy Y. Greenland, Kirk D. Jones, Chaz R. Langelier, John R. Greenland
Summary: In patients with chronic lung allograft dysfunction (CLAD) following lung transplantation, research indicated that small airway gene expression changes were associated with CLAD, and molecular analysis conducted on airway brushings showed potential for diagnosing CLAD.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Wai Wong, Brandy Johnson, Pi Chun Cheng, Maureen B. Josephson, Katsuhide Maeda, Robert A. Berg, Steven M. Kawut, Michael O. Harhay, Samuel B. Goldfarb, Nadir Yehya, Adam S. Himebauch
Summary: This study aimed to investigate the impact of grade 3 PGD within 48 or 72 hours on CLAD-free survival following pediatric lung transplantation. The study found that the occurrence of grade 3 PGD within 48 or 72 hours was associated with shorter CLAD-free survival, and gender may be a modifier of this association.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Surgery
Michael Y. Shino, Jamie L. Todd, Megan L. Neely, Jerry Kirchner, Courtney W. Frankel, Laurie D. Snyder, Elizabeth N. Pavlisko, Gregory A. Fishbein, Joanna M. Schaenman, Kristen Mason, Karen Kesler, Tereza Martinu, Lianne G. Singer, Wayne Tsuang, Marie Budev, Pali D. Shah, John M. Reynolds, Nikki Williams, Mark A. Robien, Scott M. Palmer, S. Sam Weigt, John A. Belperio
Summary: In this study, we investigated the relationship between plasma levels of CXCL9/CXCL10 and histopathologic lung allograft injuries, as well as the risk of developing CLAD. We found that elevated plasma CXCL9/CXCL10 levels were associated with injury patterns associated with CLAD, acute rejection, and acute lung injury, and there was a dose-response relationship between chemokine levels and CLAD risk. Importantly, the presence of elevated plasma chemokines was necessary for the association between histopathologic injury and CLAD. Similar associations and interactions were observed with CXCL9/CXCL10 levels in bronchoalveolar lavage fluid. Elevated plasma CXCL9/CXCL10 during allograft injury may contribute to CLAD development and could be a potential minimally invasive biomarker for immune monitoring.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Michael Keller, Errol Bush, Joshua M. Diamond, Pali Shah, Joby Matthew, Anne W. Brown, Junfeng Sun, Irina Timofte, Hyesik Kong, Ilker Tunc, Helen Luikart, Aldo Iacono, Steven D. Nathan, Kiran K. Khush, Jonathan Orens, Moon Jang, Sean Agbor-Enoh
Summary: Using %ddcfDNA as a biomarker, this study found that PGD patients exhibit increased early posttransplant allograft injury compared to non-PGD patients, with higher %ddcfDNA levels being associated with the subsequent development of CLAD. The study suggests that %ddcfDNA can identify PGD patients at greater risk of developing CLAD than PGD alone.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Review
Medicine, Research & Experimental
Ana-Maria Pasatu-Cornea, Elena Ciciu, Liliana-Ana Tuta
Summary: Chronic kidney disease is a global public health problem, and renal transplantation is considered the preferred treatment. Predictive biomarkers for graft dysfunction are crucial for ensuring the long-term survival of kidney transplants and the quality of life of patients.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Surgery
Michael Keller, Song Yang, Lucia Ponor, Ann Bon, Adam Cochrane, Mary Philogene, Errol Bush, Pali Shah, Joby Mathew, Anne W. Brown, Hyesik Kong, Ananth Charya, Helen Luikart, Steven D. Nathan, Kiran K. Khush, Moon Jang, Sean Agbor-Enoh
Summary: The development of donor-specific antibodies after lung transplantation is associated with adverse outcomes such as acute cellular rejection, antibody-mediated rejection (AMR), chronic lung allograft dysfunction (CLAD), or death. A multicenter retrospective cohort study found that early treatment of these antibodies in lung transplant patients, even in the absence of clinical signs and symptoms, reduces the risk of CLAD or death. Deferred treatment until the development of clinical AMR, on the other hand, increased the risk of CLAD or death. This study suggests the importance of early, preemptive treatment of donor-specific antibodies in improving outcomes for lung transplant patients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
David Li, Justin Weinkauf, Ali Kapasi, Alim Hirji, Rhea Varughese, Dale Lien, Jayan Nagendran, Kieran Halloran
Summary: Severe PGD is significantly associated with the frequency and severity of BLAD following lung transplantation, but not with CLAD. This highlights the impact of PGD severity on graft function, while showing no correlation with the frequency and onset of chronic lung allograft dysfunction.
RESPIRATORY MEDICINE
(2021)
Article
Immunology
Daniel T. Dugger, Daniel R. Calabrese, Ying Gao, Fred Deiter, Tasha Tsao, Julia Maheshwari, Steven R. Hays, Lorriana Leard, Mary Ellen Kleinhenz, Rupal Shah, Jeff Golden, Jasleen Kukreja, Erin D. Gordon, Jonathan P. Singer, John R. Greenland
Summary: Research indicates that lung allografts experiencing primary graft dysfunction post-transplantation have increased biological age, independent of recipient age. Airway epigenetic age is primarily influenced by donor age, with primary graft dysfunction significantly increasing the epigenetic age of the allograft.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Aparna C. Swaminathan, Jamie L. Todd, Scott M. Palmer
Summary: Lung transplantation has substantially increased in volume in recent decades, with advances being made in understanding and treating post-transplant complications like CLAD. Ongoing studies are exploring novel approaches to improve long-term outcomes for lung transplant recipients.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Review
Respiratory System
Sara Assadiasl, Mohammad Hossein Nicknam
Summary: Post-transplant care and patients' survival in lung transplantation need improvement, and cytokine monitoring pre- and post-transplant could be used for prevention and early diagnosis of inflammatory events, providing new therapeutic options to enhance lung allograft survival.
Article
Critical Care Medicine
Jamie L. Todd, Jeremy M. Weber, Francine L. Kelly, Megan L. Neely, Hillary Mulder, Courtney W. Frankel, Andrew Nagler, Christopher Mccrae, Paul Newbold, Jim Kreindler, Scott M. Palmer
Summary: BALF eosinophilia is an independent predictor of future CLAD risk in lung transplant recipients, associated with acute rejection, lung injury, and pulmonary fungal detection. Established CLAD induces expression of type 2 inflammatory signals, highlighting the need for further research to clarify the role of type 2 pathway-specific interventions in CLAD prevention or treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Paul Habert, Elsa Chetrit, Benjamin Coiffard, Fabienne Bregeon, Pascal Thomas, Anderson Loundou, Julien Bermudez, Martine Reynaud-Gaubert, Jean-Yves Gaubert
Summary: This study found that chest CT can predict the occurrence of CLAD in lung transplant patients. Moderate pulmonary artery stenosis, mosaic pattern of lung parenchyma, consolidations, and pleural effusions were identified as risk factors for CLAD.
INSIGHTS INTO IMAGING
(2023)
Article
Surgery
Michael Y. Shino, Ning Li, Jamie L. Todd, Megan L. Neely, Jerry Kirchner, Heather Kopetskie, Michelle L. Sever, Courtney W. Frankel, Laurie D. Snyder, Elizabeth N. Pavlisko, Tereza Martinu, Lianne G. Singer, Wayne Tsuang, Marie Budev, Pali D. Shah, John M. Reynolds, Nikki Williams, Mark A. Robien, Scott M. Palmer, Stephen Sam Weigt, John A. Belperio
Summary: The study found that CXCL9 and CXCL10 are associated with episodes of acute rejection (AR) and acute lung injury (ALI), potentially providing insight into the pathogenesis of these injuries.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Physiology
Anne Fu, Anastasiia Vasileva, Nour Hanafi, Natalia Belousova, Joyce Wu, Sarada Sriya Rajyam, Clodagh M. Ryan, Zoltan Hantos, Chung-Wai Chow
Summary: This study investigated whether spectral and intrabreath oscillometry can differentiate between different types of CLAD. The findings suggest that both methods can distinguish between BOS-CLAD, RAS-CLAD, and CLAD-free states, providing diagnostic and prognostic value.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Oncology
Tom Vandaele, Jan Van Slambrouck, Viktor Proesmans, Paul Clement, Maarten Lambrecht, Philippe Nafteux, Dirk Van Raemdonck, Laurens J. Ceulemans
Summary: This review provides an overview of the current literature on hyperthermic intrathoracic chemotherapy (HITHOC) for thymoma with pleural dissemination (TPD). The results suggest that combining cytoreductive surgery and HITHOC is feasible and safe for TPD, but there is significant heterogeneity in the literature, calling for further research to better understand the additional benefit of HITHOC in TPD treatment.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Tom Vandaele, Jan Van Slambrouck, Viktor Proesmans, Paul Clement, Maarten Lambrecht, Philippe Nafteux, Dirk Van Raemdonck, Laurens J. Ceulemans
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Laura P. M. H. de Rooij, Lisa M. Becker, Laure Anne Teuwen, Bram Boeckx, Sander Jansen, Simon Feys, Stijn Verleden, Laurens Liesenborghs, Anna K. Stalder, Sasha Libbrecht, Tina Van Buyten, Gino Philips, Abhishek Subramanian, Sebastien J. Dumas, Elda Meta, Mila Borri, Liliana Sokol, Amelie Dendooven, Anh Co K. Truong, Jan Gunst, Pierre Van Mol, Jasmin D. Haslbauer, Katerina Rohlenova, Thomas Menter, Robbert Boudewijns, Vincent Geldhof, Stefan Vinckier, Jacob Amersfoort, Wim Wuyts, Dirk Van Raemdonck, Werner Jacobs, Laurens J. Ceulemans, Birgit Weynand, Bernard Thienpont, Martin Lammens, Mark Kuehnel, Guy Eelen, Mieke Dewerchin, Luc Schoonjans, Danny Jonigk, Jo van Dorpe, Alexandar Tzankov, Els Wauters, Massimiliano Mazzone, Johan Neyts, Joost Wauters, Diether Lambrechts, Peter Carmeliet
Summary: This study provides new insights into the abundance, expression patterns, and interactomes of endothelial cell (EC) subtypes in COVID-19 and idiopathic pulmonary fibrosis (IPF). The findings suggest the importance of ECs in the pathophysiology of both conditions and may contribute to future investigations into the progression and treatment of COVID-19 and IPF.
CARDIOVASCULAR RESEARCH
(2023)
Meeting Abstract
Critical Care Medicine
C. De Fays, H. Beeckmans, P. Kerckhof, V. Geudens, A. Vermaut, I. Gyselinck, T. Goos, M. Vermant, J. Kaes, J. Van Slambrouck, Y. Mohamady, L. Willems, L. Aversa, K. Maes, C. Aelbrecht, S. Everaerts, J. E. Mcdonough, L. J. De Sadeleer, S. Gohy, J. Ambroise, W. A. Wuyts, W. L. Janssens, L. J. Ceulemans, D. E. M. Van Raemdonck, R. Vos, T. Hackett, J. C. Hogg, N. Kaminski, C. Pilette, G. Gayan-Ramirez, B. Vanaudenaerde
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Annalisa Barbarossa, Dirk Van Raemdonck, Walter Weder, Laurens J. Ceulemans
Summary: Secondary pneumothorax due to emphysema is a life-threatening condition that often requires surgery. In this case, we used LVRS to not only remove part of the lung but also close the fistula. The patient experienced improved lung function and quality of life after urgent and elective LVRS surgeries, with resolution of the air leak.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
H. Beeckmans, P. Kerckhof, J. McDonough, L. De Sadeleer, J. Kaes, A. Sacreas, C. Aelbrecht, A. Vanstapel, K. Maes, H. Schoemans, E. Wauters, A. Neyrinck, G. Verleden, L. Dupont, L. Godinas, D. Van Raemdonck, B. Vanaudenaerde, R. Vos
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
J. Kaes, E. Vanhulle, L. Seldeslachts, C. Hooft, H. Beeckmans, X. Jin, P. Kerckhof, J. Van Slambrouck, D. Van Raemelonck, G. Vande Velde, L. Naesens, D. Schols, L. J. Ceulemans, R. Vos, K. Vertneire, B. M. Vanaudenaerde
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
P. Kerckhof, G. P. Ambrosio, H. Beeckmans, J. Kaes, V. Geudens, J. Slambrouck, S. Bos, M. Vermant, C. Aelbrecht, W. Lynn, V. Astrid, L. Aversa, Y. Mohamady, X. Jin, D. Charlott, T. Goos, G. Iwein, A. Vanstapel, M. Orlitova, M. Boone, W. Janssens, I. Josipovic, V. Varghese, L. Dupont, L. Godinas, G. Verleden, D. Van Raemdonck, L. Ceulemans, A. Neyrinck, J. McDonough, G. Gayan-Ramirez, B. Vanaudenaerde, R. Vos
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Meeting Abstract
Allergy
Erika Penz, Thomas Rothe, Lieven Dupont, Tanja Plate, Sheena Kayaniyil, Peter Van Iperen, Isabelle Fovel, Vivian Shih, Trung Tran, Douglas Arbetter, David Cohen, Rohit Katial, Anat Shavit, Benjamin Emmanuel, Marek Lommatzsch
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Surgery
Hanne Beeckmans, Elfri Van Roy, Janne Kaes, Annelore Sacreas, Vincent Geudens, Astrid Vermaut, Lynn Willems, Xin Jin, Saskia Bos, Arno Vanstapel, Jan Van Slambrouck, Michaela Orlitova, Bart Vanaudenaerde, Laurens J. J. Ceulemans, Dirk Van Raemdonck, Arne P. P. Neyrinck, Laurent Godinas, Lieven J. J. Dupont, Geert M. M. Verleden, Robin Vos
Summary: Fungal exposure and sensitization negatively impact respiratory diseases, including lung transplant recipients. This study examines the correlation between fungal-specific antibodies, fungal isolation, chronic lung allograft dysfunction (CLAD), and overall survival in 311 lung transplant patients. The results show that elevated levels of Aspergillus fumigatus or Aspergillus flavus IgG are associated with more fungal isolation and CLAD. However, IgE levels and fungal isolation are not correlated with CLAD or death. Mold and Aspergillus species isolation are associated with CLAD occurrence, while Aspergillus species isolation is also linked to impaired survival. Fungus-specific IgG could serve as a non-invasive marker for fungal exposure and a diagnostic tool for identifying high-risk patients in long-term follow-up post-lung transplant.
TRANSPLANT INTERNATIONAL
(2023)
Article
Biochemical Research Methods
Jan Van Slambrouck, Charlotte Schoenaers, Lies Laenen, Xin Jin, Kurt Beuselinck, Ann Verdonck, Joost Wauters, Geert Molenberghs, Bart M. Vanaudenaerde, Robin Vos, Peter Mombaerts, Katrien Lagrou, Laurens J. Ceulemans
Summary: The ability to detect SARS-CoV-2 RNA or antigen in BAL fluid samples using point-of-care tests (POCTs) can reduce the risk of developing severe COVID-19 after lung transplantation.
JOURNAL OF VIROLOGICAL METHODS
(2024)