Article
Biochemistry & Molecular Biology
Hui-Chuan Chang, Shih-Feng Liu, Ying-Chun Li, Ho-Chang Kuo, Yun-Chyn Tsai, Min-Hui Chen
Summary: The study demonstrates that influenza vaccination is more effective in reducing hospital and emergency department utilization, as well as respiratory failure, in COPD patients with moderate, severe, and very severe airflow obstruction compared to those with mild obstruction.
Article
Cardiac & Cardiovascular Systems
Yun Seok Kim, Yong Il Hwang, Jae Ha Lee, Yong Bum Park, Cheon Woong Choi, Ki-Suck Jung, Kwang Ha Yoo, Seong Yong Lim, Ju Sang Kim, Joon Young Choi
Summary: This study compared the clinical features and prognosis of patients with FEV1/FVC<0.70 at baseline, based on the normalized airflow obstruction status during follow-up. The results showed that transient airflow obstruction in the normalized obstruction group may represent an early manifestation of COPD. Monitoring is needed for such patients to ensure early detection and management.
RESPIRATORY MEDICINE
(2023)
Review
Medicine, General & Internal
Stephanie A. Christenson, Benjamin M. Smith, Mona Bafadhel, Nirupama Putcha
Summary: Chronic obstructive pulmonary disease (COPD) is a global health problem that leads to high morbidity, mortality, and healthcare utilization. Its main causes are exposure to harmful particles, such as tobacco smoke and pollutants. Recent research has shown that various factors throughout the life course increase the risk of developing COPD. Innovations in omics and imaging techniques have provided greater understanding of the disease's pathophysiology, potentially leading to advancements in its prevention, diagnosis, and treatment. This review focuses on recent advances in the epidemiology, pathophysiology, imaging, diagnosis, and treatment of COPD.
Article
Infectious Diseases
Hye Jung Park, Min Kwang Byun, Jaeuk Lee, Chi Young Kim, Sojung Shin, Youlim Kim, Chin Kook Rhee, Ki Suck Jung, Kwang Ha Yoo
Summary: Pulmonary tuberculosis is a risk factor for airflow obstruction and chronic obstructive pulmonary disease. Even if there are no TB sequelae observed on chest X-ray, TB patients may still develop airway obstruction and COPD.
INFECTIOUS DISEASES
(2023)
Article
Critical Care Medicine
Surya P. Bhatt, Arie Nakhmani, Spyridon Fortis, Matthew J. Strand, Edwin K. Silverman, Frank C. Sciurba, Sandeep Bodduluri
Summary: The study tested a new severity classification scheme for COPD based on airflow obstruction measurement, and found that this scheme can better differentiate patients' symptoms, disease burden, and prognosis, and is less sensitive to race/ethnicity and other demographic characteristics.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Vasiliy V. Polosukhin, Sergey S. Gutor, Rui-Hong Du, Bradley W. Richmond, Pierre P. Massion, Pingsheng Wu, Justin M. Cates, Kim L. Sandler, Stephen Rennard, Timothy S. Blackwell
Summary: In patients with COPD, thickening of epithelial and subepithelial tissue, mucus plugging, reduced collagen density in the airway wall, and loss of radial alveolar attachments were associated with airflow limitation. The major determinant of airflow limitation related to small airways was found to be the loss of alveolar attachments, which may be mediated by neutrophilic inflammation. Additionally, quantitative analysis of CT scans found an association between the extent of emphysema and loss of alveolar attachments.
Article
Medicine, General & Internal
Alejandro A. Diaz, Jose L. Orejas, Scott Grumley, Hrudaya P. Nath, Wei Wang, Wojciech R. Dolliver, Andrew Yen, Seth J. Kligerman, Kathleen Jacobs, Padma P. Manapragada, Mostafa Abozeed, Muhammad Usman Aziz, Mohd Zahid, Asmaa N. Ahmed, Nina L. Terry, Ruben San Jose Estepar, Victor Kim, Barry J. Make, MeiLan K. Han, Sushilkumar Sonavane, George R. Washko, Michael Cho, Raul San Jose Estepar
Summary: The presence of mucus plugs in patients with COPD is associated with increased all-cause mortality, as observed in this study.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Chalerm Liwsrisakun, Warawut Chaiwong, Chaicharn Pothirat
Summary: This study compares spirometry and impulse oscillometry (IOS) for the detection and prevalence of small airway dysfunction (SAD) in COPD and asthma patients. The results demonstrate that IOS is more sensitive in detecting SAD in asthma patients without fixed airflow obstruction (FAO), whereas spirometry is more sensitive in COPD and asthma patients with FAO.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, Research & Experimental
Caspar Schiffers, Cheryl van de Wetering, Robert A. Bauer, Aida Habibovic, Milena Hristova, Christopher M. Dustin, Sara Lambrichts, Pamela M. Vacek, Emiel F. M. Wouters, Niki L. Reynaert, Albert van der Vliet
Summary: The downregulation of DUOX1 in the airways of patients with Chronic Obstructive Pulmonary Disease (COPD) may contribute to the pathogenesis of COPD, leading to airway remodeling and emphysema. Animal studies also demonstrate that Duox1 deficiency exacerbates lung pathology induced by smoke exposure.
Article
Critical Care Medicine
Ian A. Yang, Christine R. Jenkins, Sundeep S. Salvi
Summary: Chronic obstructive pulmonary disease (COPD) is not only caused by smoking, but also related to non-smoking factors such as air pollution and occupational exposure. COPD in never-smokers has milder symptoms but frequent exacerbations.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Environmental Sciences
Yinglin Wu, Shiyu Zhang, Bingting Zhuo, Miao Cai, Zhengmin Min Qian, Michael G. Vaughn, Stephen Edward McMillin, Zilong Zhang, Hualiang Lin
Summary: This study aimed to investigate the burden of chronic obstructive pulmonary disease (COPD) globally. The results showed that there was a significant decrease in COPD deaths attributable to household air pollution from solid fuels (HAP) over the past 30 years, but an increase in COPD deaths attributable to ambient particulate matter (APM). In 2019, the global burden of COPD attributable to APM was higher than that attributable to HAP, except in low socio-demographic index (SDI) regions. Years of life lost (YLLs) continued to be the predominant component of the disability-adjusted life-years (DALYs) for COPD, with an average YLLs per death of over 10 years in different regions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Energy & Fuels
Agnieszka Drobniak, Maria Mastalerz, Zbigniew Jelonek, Iwona Jelonek, Tushar Adsul, Neza Malensek Andolsek, Omid Haeri Ardakani, Tara Congo, Batbold Demberelsuren, Bryon S. Donohoe, Ashley Douds, Deolinda Flores, Ranjin Ganzorig, Santanu Ghosh, Andrew Gize, Paula Alexandra Goncalves, Paul Hackley, Javin Hatcherian, James C. Hower, Stavros Kalaitzidis, Slawomir Kedzior, Wayne Knowles, Jolanta Kus, Kacper Lis, Grzegorz Lis, Bei Liu, Qingyong Luo, Meili Du, Divya Mishra, Magdalena Misz-Kennan, Theophile Mugerwa, Jennifer L. Nedzweckas, Jennifer M. K. O'Keefe, Jackie Park, Richard Pearson, Henrik I. Petersen, Julito Reyes, Joana Ribeiro, Genaro de la Rosa-Rodriguez, Piotr Sosnowski, Brett Valentine, Atul Kumar Varma, Malgorzata Wojtaszek-Kalaitzidi, Zhanjie Xu, Alexander Zdravkov, Konrad Ziemianin
Summary: Given global market trends and concerns about climate change and sustainability, the use of biomass for energy is expected to increase. Reflective light microscopy (RLM) has the potential to enhance the quality assessment of biomass fuels, but the petrographic classification used in this study requires further refinement before standardization.
INTERNATIONAL JOURNAL OF COAL GEOLOGY
(2023)
Article
Medicine, General & Internal
HuanYu Long, ZhenZhen Xing, Di Chai, WeiMing Liu, YaQi Tong, YuXia Wang, YaLi Ma, MingMing Pan, Jia Cui, YanFei Guo
Summary: This study confirmed the significant burden of COPD among never-smokers and identified the risk factors for COPD in this population. Additionally, a positive association was found between solid fuel exposure and both COPD and small airway dysfunction.
FRONTIERS IN MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Marija Gredic, Isabel Blanco, Gabor Kovacs, Zsuzsanna Helyes, Peter Ferdinandy, Horst Olschewski, Joan Albert Barbera, Norbert Weissmann
Summary: This article summarizes the pathophysiology and treatment options for PH in COPD patients, pointing out that current research still does not fully understand its underlying mechanisms, and some of the treatment methods tested in clinical settings have not been effective. Preclinical studies have proposed some treatment approaches.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Allergy
Prapaporn Pornsuriyasak, Supattra Khiawwan, Sasivimol Rattanasiri, Nattawut Unwanatham, Tananchai Petnak
Summary: The prevalence of SAD in non-FAO asthma was found to be lower than in FAO-asthma and COPD.
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Respiratory System
Jate Ratanachina, Andre F. S. Amaral, Sara De Matteis, Herve Lawin, Kevin Mortimer, Daniel O. Obaseki, Imed Harrabi, Meriam Denguezli, Emiel F. M. Wouters, Christer Janson, Rune Nielsen, Amund Gulsvik, Hamid Hacene Cherkaski, Filip Mejza, Padukudru Anand Mahesh, Asma Elsony, Rana Ahmed, Wan Tan, Li Cher Loh, Abdul Rashid, Michael Studnicka, Asaad A. Nafees, Terence Seemungal, Althea Aquart-Stewart, Mohammed Al Ghobain, Jinping Zheng, Sanjay Juvekar, Sundeep Salvi, Rain Jogi, David Mannino, Thorarinn Gislason, A. Sonia Buist, Paul Cullinan, Peter Burney
Summary: This study aimed to assess the association between chronic obstructive pulmonary disease and occupation. Through cross-sectional data analysis of 28,823 adults aged 40 and above in 34 countries, it was found that working in environments with potential exposure to dusts or fumes was associated with respiratory symptoms but not lung function differences. Therefore, respiratory surveillance should be encouraged among high-risk dusty and fume job workers, especially in low- and middle-income countries.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Critical Care Medicine
Nirav R. Bhakta, Christian Bime, David A. Kaminsky, Meredith C. McCormack, Neeta Thakur, Sanja Stanojevic, Aaron D. Baugh, Lundy Braun, Stephanie Lovinsky-Desir, Rosemary Adamson, Jonathan Witonsky, Robert A. Wise, Sean D. Levy, Robert Brown, Erick Forno, Robyn T. Cohen, Meshell Johnson, John Balmes, Yolanda Mageto, Cathryn T. Lee, Refiloe Masekela, Daniel J. Weiner, Charlie G. Irvin, Erik R. Swenson, Margaret Rosenfeld, Richard M. Schwartzstein, Anurag Agrawal, Enid Neptune, Juan P. Wisnivesky, Victor E. Ortega, Peter Burney
Summary: The use of race and ethnicity in pulmonary function test (PFT) interpretation is being questioned due to concerns of perpetuating false fixed differences between races and masking the effects of differential exposures. The American Thoracic Society (ATS) recommended replacing race and ethnicity-specific reference equations with race-neutral average equations, accompanied by a broader re-evaluation of how PFTs are used in clinical, employment, and insurance decisions. Further research and education are also recommended to better understand the impact of this change and improve the evidence for PFT use.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Infectious Diseases
R. Ahmed, N. Osman, B. Noory, R. Osman, H. ElHassan, H. Eltigani, R. Nightingale, A. F. S. Amaral, J. Patel, P. G. Burney, K. Mortimer, A. El Sony
Summary: This study aimed to determine the prevalence and determinants of chronic respiratory diseases in Khartoum, Sudan. The prevalence of chronic airflow obstruction was found to be 10%, with older age being the main risk factor. Lower education, high body mass index, and a history of TB were also identified as significant risk factors.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2023)
Article
Respiratory System
Johanna Feary, Valentina Quintero-Santofimio, James Potts, Roel Vermeulen, Hans Kromhout, Ben Knox-Brown, Andre F. S. Amaral
Summary: This study examined the association between small airways obstruction (SAO) and occupational exposures using data from the UK Biobank. The results showed a relationship between SAO and occupational exposures.
Article
Environmental Sciences
Iana Markevych, Tianyu Zhao, Elaine Fuertes, Alessandro Marcon, Payam Dadvand, Danielle Vienneau, Judith Garcia Aymerich, Dennis Nowak, Kees de Hoogh, Deborah Jarvis, Michael J. Abramson, Simone Accordini, Andre F. S. Amaral, Hayat Bentouhami, Randi Jacobsen Bertelsen, Anne Boudier, Roberto Bono, Gayan Bowatte, Lidia Casas, Shyamali C. Dharmage, Bertil Forsberg, Thorarinn Gislason, Marco Gnesi, Mathias Holm, Benedicte Jacquemin, Christer Janson, Rain Jogi, Ane Johannessen, Dirk Keidel, Benedicte Leynaert, Jose Antonio Maldonado Perez, Pierpaolo Marchetti, Enrica Migliore, Jesus Martinez-Moratalla, Hans Orru, Isabelle Pin, James Potts, Nicole Probst-Hensch, Andrea Ranzi, Jose Luis Sanchez-Ramos, Valerie Siroux, David Soussan, Jordi Sunyer, Isabel Urrutia Landa, Simona Villani, Joachim Heinrich
Summary: This study examined the association between residential greenspace and change in lung function over 20 years in middle-aged European adults. The findings showed that living in more greenspaces was not associated with better lung function, but instead there were slight but consistent declines in lung function parameters. These findings need to be verified in future studies.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Engineering, Environmental
Max J. Oosterwegel, Dorina Ibi, Lutzen Portengen, Nicole Probst-Hensch, Sonia Tarallo, Alessio Naccarati, Medea Imboden, Ayoung Jeong, Nivonirina Robinot, Augustin Scalbert, Andre F. S. Amaral, Erik van Nunen, John Gulliver, Marc Chadeau-Hyam, Paolo Vineis, Roel Vermeulen, Pekka Keski-Rahkonen, Jelle Vlaanderen
Summary: This study assessed the within- and between-subject variability of untargeted metabolomic measurements in human serum samples. The results showed that over half of the metabolic features were fairly stable over a period of 100 days. This has important implications for the interpretation of metabolomic results.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Andre F. S. Amaral, James Potts, Ben Knox-Brown, Emmanouil Bagkeris, Imed Harrabi, Hamid Hacene Cherkaski, Dhiraj Agarwal, Sanjay Juvekar, Mahesh Padukudru Anand, Thorarinn Gislason, Asaad Ahmed Nafees, Kevin Mortimer, Christer Janson, Li Cher Loh, Stefanni Nonna Paraguas, Meriam Denguezli, Mohammed Al Ghobain, David Mannino, Martin W. Njoroge, Graham Devereux, Terence Seemungal, Cristina Barbara, Ali Kocabas, Rana Ahmed, Althea Aquart-Stewart, Michael Studnicka, Tobias Welte, Wan C. Tan, Richard N. van Zyl-Smit, Parvaiz Koul, Vanessa Garcia-Larsen, Cosetta Minelli, A. Sonia Buist, Peter Burney, BOLD Study Collaborative Network
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ben Knox-Brown, Jaymini Patel, James Potts, Rana Ahmed, Althea Aquart-Stewart, Hamid Hacene Cherkaski, Meriam Denguezli, Mohammed Elbiaze, Asma Elsony, Frits M. E. Franssen, Mohammed Al Ghobain, Imed Harrabi, Christer Janson, Rain Jogi, Sanjay Juvekar, Herve Lawin, David Mannino, Kevin Mortimer, Asaad Ahmed Nafees, Rune Nielsen, Daniel Obaseki, Stefanni Nonna M. Paraguas, Abdul Rashid, Li-Cher Loh, Sundeep Salvi, Terence Seemungal, Michael Studnicka, Wan C. Tan, Emiel E. F. M. Wouters, Cristina Barbara, Thorarinn Gislason, Kirthi Gunasekera, Peter Burney, Andre F. S. Amaral, BOLD Collaborative Res Grp
Summary: Small airways obstruction is common worldwide and has a higher prevalence than chronic airflow obstruction. It shares the same risk factors as chronic airflow obstruction. Further research is needed to investigate its association with respiratory symptoms and lung function decline.
LANCET GLOBAL HEALTH
(2023)
Article
Respiratory System
Ben Knox-Brown, Jaymini Patel, James Potts, Rana Ahmed, Althea Aquart-Stewart, Cristina Barbara, A. Sonia Buist, Hamid Hacene Cherkaski, Meriam Denguezli, Mohammed Elbiaze, Gregory E. Erhabor, Frits M. E. Franssen, Mohammed Al Ghobain, Thorarinn Gislason, Christer Janson, Ali Kocabas, David Mannino, Guy Marks, Kevin Mortimer, Asaad Ahmed Nafees, Daniel Obaseki, Stefanni Nonna M. Paraguas, Li Cher Loh, Abdul Rashid, Sundeep Salvi, Terence Seemungal, Michael Studnicka, Wan C. Tan, Emiel F. M. Wouters, Hazim Abozid, Alexander Mueller, Peter Burney, Andre F. S. Amaral
Summary: This study found that spirometric small airways obstruction (SAO) is associated with respiratory symptoms, cardiovascular disease, and quality of life (QoL). The results suggest that measurement of FEF25-75 and FEV3/FVC should be considered in spirometry.
RESPIRATORY RESEARCH
(2023)