Article
Psychiatry
Sidney Zisook, Beata Planeta, Paul B. Hicks, Peijun Chen, Lori L. Davis, Gerardo Villarreal, Mamta Sapra, Gary R. Johnson, Somaia Mohamed
Summary: The study explores the association between specific types of childhood adversity and clinical features and treatment outcomes in adults with Major Depressive Disorder (MDD). It shows that childhood adversities are linked to demographic characteristics, severity of depression and anxiety, treatment response, and long-term outcomes, emphasizing the importance of considering childhood maltreatment histories in treating individuals with MDD.
GENERAL HOSPITAL PSYCHIATRY
(2022)
Article
Medicine, Research & Experimental
Fuquan Zhang, Shuquan Rao, Hongbao Cao, Xiangrong Zhang, Qiang Wang, Yong Xu, Jing Sun, Chun Wang, Jiu Chen, Xijia Xu, Ning Zhang, Lin Tian, Jianmin Yuan, Guoqiang Wang, Lei Cai, Mingqing Xu, Ancha Baranova
Summary: This study investigates the relationship between PTSD and three types of depressive phenotypes, namely MDD, DAF, and DEP. The results suggest that PTSD shares genetic factors with MDD and supports the idea that PTSD can be considered as a subtype of MDD, which can help reduce heterogeneity in psychiatric diagnosis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Clinical Neurology
Vincenzo Oliva, Giuseppe Fanelli, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Diego Albani, Gianluigi Forloni, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Chiara Fabbri, Alessandro Serretti
Summary: This study found that different clinical subtypes of major depressive disorder (MDD), particularly melancholic features and typical neurovegetative symptoms, may be associated with distinct underlying genetics. These findings contribute to a better understanding of the genetic heterogeneity of MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, General & Internal
Regina L. Triplett, Rachel E. Lean, Amisha Parikh, J. Philip Miller, Dimitrios Alexopoulos, Sydney Kaplan, Dominique Meyer, Christopher Adamson, Tara A. Smyser, Cynthia E. Rogers, Deanna M. Barch, Barbara Warner, Joan L. Luby, Christopher D. Smyser
Summary: This prospective study found that prenatal exposure to maternal social disadvantage is associated with global reductions in brain volumes and cortical folding in newborns, highlighting the importance of addressing parental socioeconomic hardships in preventive interventions for fetal brain development.
Article
Psychiatry
Jackson G. Thorp, Zachary F. Gerring, Lucia Colodro-Conde, Enda M. Byrne, Sarah E. Medland, Christel M. Middeldorp, Eske M. Derks
Summary: This study analyzed data from the large-scale UK Biobank population cohort to investigate the association between trauma exposure, depression polygenic risk scores (PRS), and their interaction with major depressive disorder (MDD) and individual depression symptoms. The results showed significant associations between trauma, depression PRS, and both current depression and lifetime MDD. Trauma exposure and depression PRS were also associated with specific patterns of depression symptoms.
PSYCHIATRY RESEARCH
(2023)
Article
Geriatrics & Gerontology
Xiaoling Xiang, Xiafei Wang
Summary: This study found that childhood adversities such as physical abuse, trouble with the police, receiving help due to financial difficulties, and parental substance abuse were associated with a higher risk of major depression in later life. Men may be more susceptible to the mental health detriments of childhood adversities.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Bing-Biao Lin, Han-Qi Lei, Hai-Yun Xiong, Xing Fu, Fu Shi, Xiang-Wei Yang, Ya-Fei Yang, Guo-Long Liao, Yu-Peng Feng, Dong-Gen Jiang, Jun Pang
Summary: This study identified four distinct molecular subtypes of prostate cancer through clustering analysis, which showed differences in clinical and biological features, providing guidance for early risk stratification and treatment.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Review
Psychology, Clinical
Matteo Malgaroli, Adam Calderon, George A. Bonanno
Summary: There has been a significant increase in network studies of Major Depressive Disorder, with 254 studies from 2010 to 2020 examined in a systematic review. Results showed substantial variability in study samples, depression measures, and network features, with Fatigue and Depressed Mood identified as the most central symptoms.
CLINICAL PSYCHOLOGY REVIEW
(2021)
Article
Multidisciplinary Sciences
Raluca Petrican, Amy L. Paine, Valentina Escott-Price, Katherine H. Shelton
Summary: Early life adversity (ELA) accelerates neurobiological ageing, increasing vulnerability to major depressive disorder (MDD) and Alzheimer's disease (AD). Both disorders are related, with MDD potentially being a risk factor or early symptom of AD. This study analyzed multimodal data from the Adolescent Brain and Cognitive Development study and found that genetic risk scores (GRS) for AD and MDD predicted neurodevelopmental alterations associated with superior fluid cognition. Specifically, greater AD GRS were related to accelerated structural maturation, while higher MDD GRS were linked to delayed functional neurodevelopment in adoptees. The study highlights compensatory mechanisms related to MDD risk and cognitive benefits of accelerated maturation linked to AD vulnerability in late childhood.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Kai Ma, Pan Song, Zhenghuan Liu, Luchen Yang, Linchun Wang, Jing Zhou, Junhao Chen, Qiang Dong
Summary: The study found that genetically predicted depression may play a potentially causal role in the occurrence of erectile dysfunction (ED) through Mendelian randomization methods. Sensitivity analysis methods indicated a consistent association between depression and ED.
FRONTIERS IN GENETICS
(2022)
Article
Neurosciences
Yiwen Zhu, Min-Jung Wang, Katherine M. Crawford, Juan Carlos Ramirez-Tapia, Alexandre A. Lussier, Kathryn A. Davis, Christiaan de Leeuw, Anne E. Takesian, Takao K. Hensch, Jordan W. Smoller, Erin C. Dunn
Summary: The study found that genes regulating sensitive periods are associated with increased depression risk, with a gene set opening sensitive periods particularly linked to vulnerability. There was also a statistical interaction identified between caregiver abuse during ages 1-5 and genetic risk for depression. These findings highlight the importance of gene-by-development interplay in understanding the complexity of depression etiology.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Clinical
Kenneth S. Kendler, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
Summary: Although creative occupations are associated with an increased genetic risk for various psychiatric disorders, religious, helping, and teaching professions also have similar or even greater elevations in risk. This association is stronger for internalizing disorders rather than psychotic disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Yanlin Wang, Shi Tang, Lianqing Zhang, Xuan Bu, Lu Lu, Hailong Li, Yingxue Gao, Xinyu Hu, Weihong Kuang, Zhiyun Jia, John A. Sweeney, Qiyong Gong, Xiaoqi Huang
Summary: This study identified two distinct subtypes of major depressive disorder patients: insomnia-dominated and anhedonia-dominated. These subtypes exhibit specific neurobiological and clinical symptom profiles, highlighting the heterogeneity of MDD.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Psychology, Clinical
Yinghao Yao, Yi Xu, Zhen Cai, Qiang Liu, Yunlong Ma, Andria N. Li, Thomas J. Payne, Ming D. Li
Summary: Cigarette smoking is strongly associated with major depressive disorder (MDD), with genetic overlap identified in 43 genes involved in membrane potential, gamma-aminobutyric acid receptor activity, and retrograde endocannabinoid signaling pathways. Linkage disequilibrium score regression showed a positive correlation between MDD and current smoking, as well as a negative correlation between MDD and former smoking. Mendelian randomization analysis suggested that genetic predisposition to depression increases smoking behavior.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Clinical Neurology
Melinda Kinney-Huang, Talia Leibovitz, Kate L. Harkness, Christopher R. Bowie
Summary: Cognitive impairment in major depressive disorder (MDD) is associated with sustained disability, and recent studies have explored the relationship between childhood adversity (CA) and cognitive impairment in MDD. However, unreliable measures of CA and lack of research on its influence on cognitive remediation response limit the understanding of this relationship. This study highlights the importance of CA and clinical characteristics in explaining cognitive variance in MDD and investigates whether CA affects response to cognitive remediation. Results show that CA, repeated depressive episodes, and earlier age at diagnosis are associated with poorer cognition, but no difference in treatment response based on CA is observed.
JOURNAL OF NERVOUS AND MENTAL DISEASE
(2023)
Article
Psychology, Clinical
Katherine L. Musliner, Klaus K. Andersen, Esben Agerbo, Clara Albinana, Bjarni J. Vilhjalmsson, Veera M. Rajagopal, Jonas Bybjerg-Grauholm, Marie Baekved-Hansen, Carsten B. Pedersen, Marianne G. Pedersen, Trine Munk-Olsen, Michael E. Benros, Thomas D. Als, Jakob Grove, Thomas Werge, Anders D. Borglum, David M. Hougaard, Ole Mors, Merete Nordentoft, Preben B. Mortensen, Major Depressive Disorder Working Group Of The Psychiatric Genomics Consortium, Nis P. Suppli
Summary: This study examined the relationship between polygenic liability for depression and number of stressful life events (SLEs) as risk factors for early-onset depression treated in psychiatric hospitals in Denmark. The results showed that the risk for depression increased with higher polygenic liability and more SLEs, and there was a small interaction between these two factors. Combining information on these two risk factors could potentially be useful for identifying high-risk individuals.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Yiwen Zhu, Min-Jung Wang, Katherine M. Crawford, Juan Carlos Ramirez-Tapia, Alexandre A. Lussier, Kathryn A. Davis, Christiaan de Leeuw, Anne E. Takesian, Takao K. Hensch, Jordan W. Smoller, Erin C. Dunn
Summary: The study found that genes regulating sensitive periods are associated with increased depression risk, with a gene set opening sensitive periods particularly linked to vulnerability. There was also a statistical interaction identified between caregiver abuse during ages 1-5 and genetic risk for depression. These findings highlight the importance of gene-by-development interplay in understanding the complexity of depression etiology.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Clinical
Kenneth S. Kendler, Henrik Ohlsson, Silviu Bacanu, Jan Sundquist, Kristina Sundquist
Summary: Genetic risk profiles for DUD, MD, and ADHD vary significantly depending on age at onset, recurrence, mode of ascertainment, and treatment. Replication of psychiatric studies, particularly those examining genetic factors, may be challenging without considering important clinical characteristics.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Terrell A. Hicks, Karen G. Chartier, Tommy D. Buckley, Diamond Reese, Jasmin Vassileva, Danielle M. Dick, Ananda B. Amstadter, Roseann E. Peterson, Oswaldo Moreno
Summary: This study aimed to explore the factors influencing substance use among racial/ethnic minorities during the COVID-19 pandemic. The results showed that substance use patterns changed during the pandemic, with a decrease in infrequent use, an increase in abstinence rates, and an increase in high-frequency use. Mental health and environmental factors were the main contributors to these changes, and there were minimal differences among racial/ethnic minority groups.
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
(2022)
Editorial Material
Genetics & Heredity
Andrew J. Schork, Roseann E. Peterson, Andrew Dahl, Na Cai, Kenneth S. Kendler
Summary: The largest genetic study of educational attainment suggests that genetic associations with educational attainment and its health benefits might be mostly indirect. Future genetic studies on human social and behavioral traits should therefore incorporate diversity in population, demographic, and environmental contexts.
Article
Genetics & Heredity
Nathan A. Gillespie, Amanda Elswick Gentry, Robert M. Kirkpatrick, Chandra A. Reynolds, Ravi Mathur, Kenneth S. Kendler, Hermine H. Maes, Bradley T. Webb, Roseann E. Peterson
Summary: Genome-wide association studies have shown that genetic influences on BMI remain stable and highly correlated from middle age to early old age, suggesting a common set of genetic factors influencing BMI throughout adulthood.
Article
Psychology, Clinical
Kaitlin E. Bountress, Daniel Bustamante, Stacey Subbie-Saenz De Viteri, Chris Chatzinakos, Christina Sheerin, Nikolaos P. Daskalakis, Howard J. Edenberg, Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group, Roseann E. Peterson, Bradley T. Webb, Jackie Meyers, Ananda Amstadter
Summary: This study found that the genetic associations between consumption and problem alcohol phenotypes and PTSD differ in both strength and direction. The genetic factors that may lead someone to develop PTSD and high levels of alcohol consumption are not the same as those that lead someone to develop PTSD and alcohol-related problems.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Kaprea F. Johnson, Kristina B. Hood, Oswaldo Moreno, Lisa Fuentes, Chelsea Derlan Williams, Jasmin Vassileva, Ananda B. Amstadter, Danielle M. Dick
Summary: This study examines the relationship between COVID-19-induced social, economic, and educational inequalities and mental health (anxiety and depression). It also investigates whether self-rated health (SRH) and race/ethnicity moderate these relationships.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2023)
Article
Psychology, Clinical
Jeanne E. Savage, Danielle M. Dick
Summary: This study investigates two etiological pathways involved in the development of alcohol misuse, specifically looking at internalizing and externalizing domains of psychopathology. The study finds that drinking motives, particularly positive reinforcement motives, play a role in characterizing these pathways. The findings provide additional support for the association between internalizing and externalizing traits and subtypes of alcohol misuse.
ADDICTIVE BEHAVIORS
(2023)
Article
Psychiatry
Mohammad Ahangari, Daniel Bustamante, Robert Kirkpatrick, Tan-Hoang Nguyen, Brian C. Verrelli, Ayman Fanous, Kenneth S. Kendler, Bradley T. Webb, Silviu-Alin Bacanu, Brien P. Riley
Summary: This study found that polygenic risk scores for schizophrenia are associated with negative/disorganized symptoms in participants with a history of a psychotic episode and negative symptoms in participants without a history of a psychotic episode in multiplex families with schizophrenia.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Amanda Elswick C. Gentry, Jeffry Alexander, Mohammad E. Ahangari, Roseann F. Peterson, Michael C. Miles, Jill G. Bettinger, Andrew Davies, Mike A. Groteweil, Silviu S. Bacanu, Kenneth P. Kendler, Brien T. Riley, Bradley Webb, VCU Alcohol Res Ctr working Grp
Summary: Variation in genes involved in ethanol metabolism influences risk for alcohol dependence. This study used a unique case-only design and whole exome sequencing to analyze functional variation in genes of severe alcohol dependence cases from Ireland. The results showed different patterns of variation in genes associated with ethanol metabolism and response compared to other genes, providing a computationally viable and statistically appropriate approach for genetic analysis of case-only data.
Article
Clinical Neurology
Alexis C. Edwards, Amanda Elswick Gentry, Roseann E. Peterson, Bradley T. Webb, Eve K. Moscicki
Summary: This study analyzed data from the UK Biobank to differentiate between non-suicidal self-injury and suicide attempt. The findings suggest that sociodemographic features, such as race, depressive symptoms, trauma history, and financial problems, differentiate between the two outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Genetics & Heredity
Amanda Elswick Gentry, Robert M. Kirkpatrick, Roseann E. Peterson, Bradley T. Webb
Summary: The availability of large-scale biobanks linking genetic data, rich phenotypes, and biological measures provides a powerful opportunity for scientific discovery. However, missing data is a common issue in real-world collections. To address this, we developed the MAGIC-LASSO method, which uses hierarchical clustering and sequential Group LASSO to predict missing data. The results show that the method has significant accuracy and utility for predicting unmeasured AUDIT scores.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Ying Yu Liang, Smaranda Bacanu, Lekshmy Sreekumar, Anderson Daniel Ramos, Lingyun Dai, Martin Michaelis, Jindrich Cinatl, Takahiro Seki, Yihai Cao, Cynthia R. Coffill, David P. Lane, Nayana Prabhu, Par Nordlund
Summary: The lack of detailed understanding of the mechanism of action of many cancer drugs is hindering their optimal use. This study used a high-resolution implementation of the proteome-wide cellular thermal shift assay to investigate the protein interaction changes induced by the antimetabolite 5-fluorouracil (5-FU) and related nucleosides. The findings revealed the expected effects on the known main target and enzymes in specific pathways, but also identified novel protein interactions and pathways associated with 5-FU, including RNA-modification and-processing pathways. The study further highlighted key components of the 5-FU mechanism of action, indicating that the inhibition of a specific target is not necessary for cell proliferation.
CELL CHEMICAL BIOLOGY
(2022)