Article
Biology
Wenyu Ding, Changjiang Zhang, Baisong Wang, Xin Zhou, Le Sun, Suijuan Zhong, Jing Liu, Junjing Zhang, Xiaoqun Wang, Qian Wu
Summary: The study reveals the crucial roles of the centrosomal protein Cenpj in neurogenesis, cerebral cortex development, and body weight regulation. Deletion of Cenpj leads to obesity in mice and affects hypothalamic cell proliferation, neuron number, and function, providing insights into the pathological mechanisms of related diseases.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Endocrinology & Metabolism
Marilena Marraudino, Beatriz Carrillo, Brigitta Bonaldo, Ricardo Llorente, Elia Campioli, Iciar Garate, Helena Pinos, Luis Miguel Garcia-Segura, Paloma Collado, Daniela Grassi
Summary: The study evaluated the distribution of GPER in the rat hypothalamus, showing that GPER immunoreactivity is expressed in neurons, astrocytes, and oligodendrocytes, with differences observed in different sexes, regions, and stages of the estrous cycle in females.
NEUROENDOCRINOLOGY
(2021)
Article
Anatomy & Morphology
Maria G. Bilbao, Daniel Garrigos, Marta Martinez-Morga, Angel Toval, Yevheniy Kutsenko, Rosario Bautista, Alberto Barreda, Bruno Ribeiro Do-Couto, Luis Puelles, Jose Luis Ferran
Summary: In this study, a prosomeric immunohistochemical mapping of hypothalamic cells expressing tyrosine hydroxylase (TH) in rats was conducted. The results showed that TH-positive cells were predominantly located in the periventricular stratum of the paraventricular and subparaventricular alar domains, as well as in the acroterminal arcuate nucleus and the terminal periventricular stratum in the tuberal region. The prosomeric model proved useful for determining the precise location of TH-positive cells relative to morphogenetic signals and provided potential causal explanation for the specification of this hypothalamic cell type.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Neurosciences
Xu Wang, Haohong Li
Summary: This study found that synaptic remodeling, lipid droplet accumulation, and synaptic dysfunction occur in feeding-related brain regions of obese mice induced by high-fat diet. These impairments are associated with energy homeostasis and reward regulation, which may contribute to overeating in obesity.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Caroline L. Wee, Erin Song, Maxim Nikitchenko, Kristian J. Herrera, Sandy Wong, Florian Engert, Samuel Kunes
Summary: This study reveals the impact of social isolation on the oxytocinergic circuit in the zebrafish brain and how chemical signals from conspecific animals modulate this circuit. The results provide a model for understanding how social stimuli mediate adaptive behaviors through neural circuits.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Liufang Yin, Lijun Zhang, Lingling Luo, Yalei Liu, Fei Wang, Yaru Feng, Hongqing Wang, Yongli Han, Yingxuan Yan, Cheng Huang, Shengjie Fan
Summary: It has been discovered that berbamine (BBM) can improve obesity by inhibiting the activity of Rab8a GTPase and activating anorexigenic neurons in the paraventricular nucleus of the hypothalamus (PVH), leading to weight loss and improved metabolic balance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bailey Halter, Nicholas Ildari, Mark A. Cline, Elizabeth R. Gilbert
Summary: Ferulic acid (FA) was found to have transient appetite suppressing effects on food intake in chicks, possibly mediated through the hypothalamic arcuate nucleus (ARC) involving POMC. This effect did not impact defecation frequency or other behaviors in the chicks.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
D. J. Innes, N. J. Hudson, S. T. Anderson, D. P. Poppi, S. P. Quigley
Summary: A reduction in voluntary feed intake is observed in ruminants consuming nutrient-deficient diets, such as those with a low CP or P content, and has been attributed to active metabolic regulation, rather than a physical constraint. The hypothalamus is the key integrator of feed intake regulation in mammals. The objectives of this experiment were to establish a model of metabolic feed intake regulation in ruminants consuming diets of variable CP and P content, and determine key biochemical pathways and influential points of regulation within the hypothalamus.
Article
Multidisciplinary Sciences
Mary P. LaPierre, Katherine Lawler, Svenja Godbersen, I. Sadaf Farooqi, Markus Stoffel
Summary: The loss of microRNA-7 in hypothalamic neurons causes obesity, increased growth, and endocrine dysfunction in mice. The study also found genetic evidence linking microRNA-7 to height and adiposity in humans. These findings provide insights into the role of microRNA-7 in regulating mammalian energy homeostasis.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Ying Li, Salman Zafar, Rawya Mohamed Salih Ibrahim, Hong-Li Chi, Tong Xiao, Wen-jie Xia, Hong-Bao Li, Yu-Ming Kang
Summary: Exercise and vitamin C supplementation can lower blood pressure in spontaneously hypertensive rats by modulating gut microbiota composition and inflammatory state in the hypothalamus and intestine. Combining the two treatments enhances their effects and may serve as a non-medical aid for hypertensive patients.
Article
Biology
Simona Sacchini, Cristiano Bombardi, Manuel Arbelo, Pedro Herraez
Summary: This study provides the first description of the hypothalamic structure in beaked whales and identifies the presence of the suprachiasmatic nucleus, a structure not previously observed in other marine mammals. These findings have important implications for understanding the neuroanatomy of beaked whales.
Article
Nutrition & Dietetics
Pedro Castillo, Mariona Palou, Zhi Xin Yau-Qiu, Ana M. Rodriguez, Andreu Palou, Catalina Pico
Summary: It was found in this study that myo-inositol supplementation during lactation can reverse the effects of fetal malnutrition on hypothalamic structure and metabolic health biomarkers in PBMC in rats, partially due to increased leptin sensitivity.
Article
Neurosciences
Jessica A. Fawley, Deborah M. Hegarty, Sue A. Aicher, Eric Beaumont, Michael C. Andresen
Summary: The study examined the synaptic characteristics of PVN-projecting NTS neurons in rat brainstem slices, revealing that these neurons receive direct and indirect information from the vagus nerve and are associated with TRPV1 expression.
Article
Multidisciplinary Sciences
Jin Tanaka, Fuka Ishikawa, Tomoki Jinno, Motoki Miyakita, Haruka Miyamori, Tsutomu Sasaki, Takumi Yokokawa, Tsuyoshi Goto, Kazuo Inoue, Shigenobu Matsumura
Summary: cAMP responsive element binding protein (CREB)-regulated transcription coactivators (CRTCs) play important roles in energy metabolism, and CRTCs in Sim1 cells have critical regulatory functions in energy homeostasis, especially in female mice.
Article
Neurosciences
Clarisse Dumont, Guangping Li, Julien Castel, Serge Luquet, Giuseppe Gangarossa
Summary: The regulation of food intake and energy balance relies on the integration of signals monitoring nutritional, metabolic, cognitive, and emotional states. The paraventricular thalamus (PVT) is a central hub that may contribute to the regulation of feeding and homeostatic/allostatic processes. This study reveals the role of catecholaminergic (CA) inputs from the hindbrain to the PVT in scaling feeding and metabolic efficiency, as well as the modulation of downstream hypothalamic neuron activity.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)