期刊
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
卷 315, 期 2, 页码 H291-H302出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00691.2017
关键词
adipose tissue; microRNAs; mitochondrial dysfunction; obesity
资金
- Netherlands CardioVascular Research Initiative
- Dutch Heart Foundation
- Dutch Federation of University Medical Centers
- ZonMW
- Royal Netherlands Academy of Sciences
- ISCIII (Spain) [CP17/00133]
Obesity, which has become a major global epidemic, is associated with numerous comorbidities and nearly every chronic condition. Mitochondria play a central role in this disorder, as they control cell metabolism, regulating important processes, such as ATP production, lipid beta-oxidation, oxidative stress, and inflammation. MicroRNAs (miRs) have been shown to regulate many biological processes associated with obesity, comprising adipocyte differentiation, insulin action, and fat metabolism. In addition, recent studies have confirmed that miRs are important regulators of mitochondrial function by either directly modulating mitochondrial proteins or targeting mitochondrial regulators, thereby modulating metabolic process in the context of obesity. In this review, we describe the different roles of mitochondria in obesity, specifically in adipose tissue, and those miRs that are involved in mitochondrial dysfunction in this disease.
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