Review
Immunology
Pailin Chiaranunt, Siu Ling Tai, Louis Ngai, Arthur Mortha
Summary: Intestinal macrophages, the largest macrophage population in the body, not only play a role in immunity but also have crucial non-immune functions. Recent research suggests that the functional diversity of macrophages in the gut goes beyond classical immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Neurosciences
Ellen Merrick Schill, Alexandria N. Floyd, Rodney D. Newberry
Summary: This article explores the interactions between the enteric nervous system, immune system, and gut microbiota in maintaining intestinal homeostasis in adults, with a focus on their development and roles in early life, as well as the potential impact of early-life antibiotic exposure on gut health.
TRENDS IN NEUROSCIENCES
(2022)
Review
Immunology
Niki Chalkidi, Christina Paraskeva, Vasiliki Koliaraki
Summary: The mammalian intestine is a self-renewing tissue that relies on various cell types such as intestinal epithelial cells, stem cells, immune cells, and stromal cells to maintain its homeostasis. When the mucosal homeostasis is disrupted due to injury or inflammation, a series of events are triggered, leading to tissue repair and restoration of organ function. Fibroblasts play significant roles in maintaining epithelial and immune homeostasis, as well as responding to tissue damage in the intestine through secretion of soluble mediators and remodeling of extracellular matrix. The heterogeneity of fibroblasts in both normal and inflammatory conditions suggests diverse functions, but there is still limited understanding on the number, terminology, and functional properties of these subsets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pieter A. Louwe, Stuart J. Forbes, Cecile Benezech, Clare Pridans, Stephen J. Jenkins
Summary: This study describes two populations of omental macrophages distinguished by CD102 expression and investigates their origin and migration to the omentum using an adoptive cell transfer approach. The findings suggest that monocyte-derived resident macrophages readily migrate to the omentum after resolution of peritoneal inflammation, while established resident macrophages only partially reconstitute the omental niche via recruitment of monocytes.
Article
Immunology
Jonathan D. Cherry, Zach H. Baucom, Kaleb G. Eppich, Daniel Kirsch, Erin R. Dixon, Yorghos Tripodis, Kevin F. Bieniek, Kurt Farrell, Kristen Whitney, Madeline Uretsky, John F. Crary, Dennis Dickson, Ann C. McKee
Summary: This study found that neuroinflammatory changes may be specific among different tauopathies, highlighting their potential as mechanistic targets and biomarker candidates. The use of distinct neuroinflammatory signatures could help differentiate between these diseases and increase specificity for in-life diagnoses.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Food Science & Technology
Yuanjie Guo, Yu Ma, Liyuan Ma, Zixin Guo, Yingliang Xiao, Yunjun Liu, Jie Li, Shengnan Wang, Yixiang Liu
Summary: The study found that oleuropein can prevent food allergies by enhancing intestinal epithelial barrier function, improving immune homeostasis, and regulating intestinal flora. Diets rich in oleuropein are recommended for individuals with food allergies.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Neurosciences
Nicolas Jacquelot, Gabrielle T. Belz, Cyril Seillet
Summary: The Earth's rotation creates biological clocks that regulate physiological processes and immune system. Neuroimmune interactions play a role in rhythmic activity of immune cells, and disruption of these rhythms can lead to chronic inflammation in murine models.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Genetics & Heredity
Mehdi Jorfi, Anna Maaser-Hecker, Rudolph E. Tanzi
Summary: Alzheimer's disease is a genetically complex and heterogeneous disorder with various neuropathological features, and emerging evidence suggests the involvement of immune genes and immune cells, including T cells, in its pathogenesis. The interplay between adaptive and innate immune systems inside and outside the brain plays a critical role in the development of Alzheimer's disease.
Article
Chemistry, Multidisciplinary
Qianming Li, Quan Liu, Zhengxi Wang, Xianzuo Zhang, Ruixiang Ma, Xianli Hu, Jiawei Mei, Zheng Su, Wanbo Zhu, Chen Zhu
Summary: A novel strategy using bovine serum albumin-iridium oxide nanoparticles as biofilm homeostasis interrupter and immunomodulator, along with singlet oxygen-sensitized mild hyperthermia, is reported for combating biofilm-associated infections.
Article
Multidisciplinary Sciences
Ashutosh Pandey, Antonio Galeone, Seung Yeop Han, Benjamin A. Story, Gaia Consonni, William F. Mueller, Lars M. Steinmetz, Thomas Vaccari, Hamed Jafar-Nejad
Summary: Intestinal barrier dysfunction can cause inflammation and metabolic changes. However, the impact of gut bacteria versus non-bacterial insults on animal health in the context of barrier dysfunction is not well understood. This study establishes that loss of Drosophila N-glycanase 1 (Pngl) in a specific intestinal cell type leads to gut barrier defects, causing starvation and JNK overactivation. Loss of Pngl also results in immune and metabolic abnormalities, contributing to lethality.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Ping-Ping Liu, Zhe Wei, Zi-Hua Cheng, Xian-Wei Wang
Summary: The study demonstrates the coordination of small immune effectors in regulating intestinal immunity in shrimp. A lysozyme digests peptidoglycan into muropeptides, inducing the expression of a bactericidal peptide and a lectin. The bactericidal peptide and lysozyme restrict intestinal bacteria, while the lectin counteracts their functions. By controlling rather than eliminating intestinal bacteria, these small effectors achieve a dynamic balance in the shrimp gut.
Review
Biochemistry & Molecular Biology
Xinmin Qian, Xia Meng, Shan Zhang, Wenwen Zeng
Summary: White adipose tissues are energy reserves and endocrine organs in the body, regulated by intercellular communications and neuronal control. Cellular diversity in response to energy states contributes to metabolic homeostasis and potential therapeutic opportunities for metabolic disorders are highlighted.
Review
Multidisciplinary Sciences
Saad Khan, Helen Luck, Shawn Winer, Daniel A. Winer
Summary: The interaction between intestinal microbiota and immune system is crucial in intestinal health, obesity, and metabolic syndrome. Understanding these interactions is essential for developing better therapeutic options.
NATURE COMMUNICATIONS
(2021)
Review
Immunology
Lies van Baarle, Michelle Stakenborg, Gianluca Matteoli
Summary: The enteric nervous system is an autonomous neuronal circuit that regulates various processes, including intestinal neuro-immune interactions. These interactions play a crucial role in maintaining intestinal homeostasis and can have both protective and detrimental effects in intestinal diseases. This review highlights the different immune cell types involved in neuronal crosstalk during intestinal health and disease and discusses the potential of targeting these neuro-immune interactions for novel strategies in treating intestinal diseases.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Immunology
Zili Lei, Wanwan Liu, Ya Nie, Yanhong Yang, Guibin Chen, Li Huang, Huijuan Wu, Yuting Lei, Lei Chen, Qing Hu, Hedong Rong, Siping Yu, Qi Song, Fengxue Tong, Jiao Guo
Summary: EpCAM deficiency leads to aggravated intestinal inflammation, upregulation of genes related to inflammatory factors and immune cells, activation of multiple signaling pathways, and downregulation of pIgR expression in the intestines. EpCAM plays a crucial role in maintaining intestinal immune homeostasis by regulating pIgR expression.
FRONTIERS IN IMMUNOLOGY
(2022)
