Article
Multidisciplinary Sciences
Joan T. Price, Bellington Vwalika, Michael France, Jacques Ravel, Bing Ma, Humphrey Mwape, Katelyn J. Rittenhouse, Kristina De Paris, Marcia Hobbs, Julie A. Nelson, Margaret P. Kasaro, Elizabeth M. Stringer, Jeffrey S. A. Stringer
Summary: A Lactobacillus-deficient, anaerobe-rich vaginal microbiome is associated with local inflammation and spontaneous preterm birth (sPTB) in the setting of HIV. Inflammatory scores positively correlate with vaginal microbiome diversity. HIV is associated with anaerobe-rich vaginal microbiome. High abundance of a novel Gardnerella metagenomic subspecies in the vaginal microbiome predicts sPTB. The risk for sPTB among women with HIV may be mediated by the vaginal microbiome and inflammation.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Anne L. Dunlop, Glen A. Satten, Yi-Juan Hu, Anna K. Knight, Cherie C. Hill, Michelle L. Wright, Alicia K. Smith, Timothy D. Read, Bradley D. Pearce, Elizabeth J. Corwin
Summary: An early pregnancy vaginal community state type III or IV was associated with an increased risk of spontaneous preterm birth (sPTB) but not early term birth (sETB) in African American women. Specific taxa within the early pregnancy vaginal microbiome were associated with either sPTB or sETB.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Shan Sun, Myrna G. Serrano, Jennifer M. Fettweis, Patricia Basta, Emma Rosen, Kim Ludwig, Alicia A. Sorgen, Ivory C. Blakley, Michael C. Wu, Nancy Dole, John M. Thorp, Anna Maria Siega-Riz, Gregory A. Buck, Anthony A. Fodor, Stephanie M. Engel
Summary: This study investigated the associations between the vaginal microbiome and preterm birth, specifically focusing on the differences between Black and White women. The results showed that the microbiome composition differed between the two racial groups, with Black women having higher alpha-diversity and abundance of Lactobacillus iners, and lower abundance of Lactobacillus crispatus. The study also found that the abundance of L. crispatus was inversely associated with the risk of spontaneous preterm birth (sPTB), independent of racial differences in microbial community structures. Vaginal douching was found to affect the associations between the microbiome, race, and sPTB. Overall, this study highlights the importance of considering vaginal microbiome and douching in relation to preterm birth, and provides insights into potential interventions and biomarkers for predicting sPTB.
Article
Multidisciplinary Sciences
Alina Luca, Angela Vinturache, Ciprian Ilea, Andreea Avasiloaiei, Luminita Paduraru, Alexandru Carauleanu, Ioana Sripcariu, Demetra Socolov
Summary: This study compared birth injuries between spontaneous vaginal and caesarean section deliveries in preterm and term pregnancies. The results showed that while spontaneous vaginal deliveries had a higher incidence of all types of birth trauma, there was no difference in the risk of major birth trauma between preterm babies delivered vaginally and those delivered by caesarean section.
Article
Oncology
Tove Wikstrom, Sanna Abrahamsson, Johan Bengtsson-Palme, Joakim Ek, Pihla Kuusela, Elham Rekabdar, Peter Lindgren, Ulla-Britt Wennerholm, Bo Jacobsson, Lil Valentin, Henrik Hagberg
Summary: This study used a transcriptomic approach to investigate the differences in the active vaginal microbiome and human transcriptome at midgestation between women delivering spontaneously preterm and those delivering at term. The study found that primarily bacterial species of low occurrence were differentially expressed at midgestation in women who delivered preterm. However, specific human transcripts, such as KLK2, KLK3, and several isoforms of MT1s, were found to be expressed at higher levels in preterm cases, indicating their potential involvement in critical inflammatory pathways associated with spontaneous preterm delivery.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Anoop Rehal, Zsofia Benko, Catalina De Paco Matallana, Argyro Syngelaki, Deepa Janga, Simona Cicero, Ranjit Akolekar, Mandeep Singh, Petya Chaveeva, Jorge Burgos, Francisca S. Molina, Makrina Savvidou, Maria De la Calle, Nicola Persico, Maria Soledad Quezada Rojas, Ashis Sau, Elena Greco, Neil O'Gorman, Walter Plasencia, Susana Pereira, Jacques C. Jani, Nuria Valino, Maria del Mar Gil, Kate Maclagan, Alan Wright, David Wright, Kypros H. Nicolaides
Summary: Research indicates that vaginal progesterone does not reduce the incidence of spontaneous preterm birth in women with twin pregnancies. Post hoc analysis suggests that progesterone may reduce the risk of spontaneous preterm birth before 32 weeks' gestation in women with a cervical length of <30 mm, but increase the risk for those with a cervical length of >= 30 mm.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Pharmacology & Pharmacy
Asad Mir, Richa V. Vartak, Ketan Patel, Steven M. Yellon, Sandra E. Reznik
Summary: Preterm birth is a major cause of infant morbidity and mortality worldwide. Advances in nanomedicine have allowed for the delivery of drugs to the female reproductive tract through vaginal administration, providing new possibilities for treating preterm birth. Studies using murine models have also provided insights into the role of the cervix in pregnancy and parturition. These recent developments indicate a paradigm shift in the field of reproductive biology for treating preterm birth.
Review
Pharmacology & Pharmacy
Hannah C. Zierden, Rachel L. Shapiro, Kevin DeLong, Davell M. Carter, Laura M. Ensign
Summary: Preterm birth is defined as delivery before 37 weeks of gestation, with 15 million infants born prematurely globally each year, increasing the risk of mortality and health challenges. While the only FDA approved therapy for preventing preterm birth in the U.S. has faced recent setbacks, interdisciplinary efforts are underway to develop next generation therapies to prevent preterm birth and save infant lives. This research aims to better identify women at risk for preterm birth, prevent premature labor, and ultimately improve outcomes for newborns.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Microbiology
Sunwha Park, Jeongsup Moon, Nayeon Kang, Young-Han Kim, Young-Ah You, Eunjin Kwon, AbuZar Ansari, Young Min Hur, Taesung Park, Young Ju Kim
Summary: An association between the vaginal microbiome and preterm birth has been reported, but predicting premature birth using the microbiome is difficult due to high variability among individuals. This study used machine learning to select markers and develop a prediction algorithm that combines clinical information, improving the predictive power for preterm birth.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Zhengyuan Wang, Shenglu Zhao, Xueying Cui, Qi Song, Zehuan Shi, Jin Su, Jiajie Zang
Summary: This study aimed to analyze dietary patterns during pregnancy in Shanghai and their impact on preterm birth. It found that the Animal Food Pattern was significantly associated with preterm birth risk, with higher scores indicating a higher risk.
Article
Obstetrics & Gynecology
Rupsa C. Boelig, Corina N. Schoen, Heather Frey, Alexis C. Gimovsky, Edward Springel, Sami Backley, Vincenzo Berghella
Summary: This study aimed to compare vaginal progesterone with 17-hydroxyprogesterone caproate in preventing recurrent preterm birth in singleton pregnancies with previous spontaneous preterm birth. The results showed that vaginal progesterone did not reduce the risk of recurrent preterm birth by 50% compared to 17-OHPC, but it may lead to increased latency to delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Immunology
Shakti Kumar, Naina Kumari, Daizee Talukdar, Akansha Kothidar, Mousumi Sarkar, Ojasvi Mehta, Pallavi Kshetrapal, Nitya Wadhwa, Ramachandran Thiruvengadam, Bapu Koundinya Desiraju, G. Balakrish Nair, Shinjini Bhatnagar, Souvik Mukherjee, Bhabatosh Das
Summary: The study found that specific species of Lactobacillus and other facultative anaerobes are associated with birth outcomes in Indian women, suggesting a protective role in reducing the risk of preterm birth.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Obstetrics & Gynecology
C. Williams, R. Fong, S. Murray, S. J. Stock
Summary: This study found that cesarean birth may increase the risk of preterm birth in subsequent pregnancies, especially when performed at full dilatation.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Medicine, General & Internal
Chandrashekara Kyathanahalli, Madeline Snedden, Lavisha Singh, Camilla Regalia, Lauren Keenan-Devlin, Ann E. Borders, Emmet Hirsch
Summary: This study examined the prevalence and viral load of TTV and TTMV in plasma and saliva during pregnancy, and their association with preterm birth. The results showed that TTMV in the third trimester plasma was associated with preterm birth, but whether this association is causal remains to be determined.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Charlotte-Eve S. Short, Rachael A. Quinlan, Xuan Wang, Veronica Georgiana Preda, Ann Smith, Julian R. Marchesi, Yooni S. Lee, David A. MacIntyre, Phillip R. Bennett, Graham P. Taylor
Summary: The study shows that pregnant women living with HIV infection have elevated rates of preterm birth, which may be related to genital tract inflammation and adverse vaginal microbiota. There are strong correlations between MMP-9, TIMP-1, local inflammation, and vaginal bacteria in this population.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Editorial Material
Obstetrics & Gynecology
Jonathan S. Hirshberg, Alison G. Cahill
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2018)
Article
Obstetrics & Gynecology
Alison G. Cahill, Methodius G. Tuuli, Molly J. Stout, Julia D. Lopez, George A. Macones
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2018)
Article
Endocrinology & Metabolism
Alison G. Cahill, Debra Haire-Joshu, W. Todd Cade, Richard I. Stein, Candice L. Woolfolk, Kelle Moley, Amit Mathur, Kenneth Schechtman, Samuel Klein
Editorial Material
Obstetrics & Gynecology
Joshua I. Rosenbloom, Bethany A. Sabol, Carla Chung, George A. Macones, Roxane M. Rampersad, Alison G. Cahill, Emily Cooke
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2019)
Article
Endocrinology & Metabolism
Debra Haire-Joshu, Alison G. Cahill, Richard I. Stein, W. Todd Cade, Candice L. Woolfolk, Kelle Moley, Amit Mathur, Cynthia D. Schwarz, Kenneth B. Schechtman, Samuel Klein
Article
Cell Biology
Wenjie Wu, Hui Wang, Peinan Zhao, Michael Talcott, Shengsheng Lai, Robert C. McKinstry, Pamela K. Woodard, George A. Macones, Alan L. Schwartz, Alison G. Cahill, Philip Cuculich, Yong Wang
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Obstetrics & Gynecology
Joshua I. Rosenbloom, Candice L. Woolfolk, Leping Wan, Molly J. Stout, Methodius G. Tuuli, George A. Macones, Alison G. Cahill
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2019)
Article
Obstetrics & Gynecology
Adam K. Lewkowitz, Joshua I. Rosenbloom, Matt Keller, Julia D. Lopez, George A. Macones, Margaret A. Olsen, Alison G. Cahill
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2019)
Article
Obstetrics & Gynecology
Adam K. Lewkowitz, Methodius G. Tuuli, Alison G. Cahill, George A. Macones, Jeffrey M. Dicke
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2019)