Article
Acoustics
E. Meler, E. Mazarico, E. Eixarch, A. Gonzalez, A. Peguero, J. Martinez, D. Boada, K. Vellve, M. D. Gomez-Roig, E. Gratacos, F. Figueras
Summary: This study reports a 10-year experience of protocol-based management of suspected SGA fetuses in late pregnancy based on standardized clinical and Doppler criteria. The results show that protocol-based risk stratification with different management and monitoring schemes enables identification of high-risk FGR and allows expectant management with safe perinatal outcome for low-risk SGA fetuses.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Ricardo Saviron-Cornudella, Luis Mariano Esteban, Rocio Aznar-Gimeno, Pena Dieste-Perez, Faustino R. Perez-Lopez, Jose Manuel Campillos, Berta Castan-Larraz, Gerardo Sanz, Mauricio Tajada-Duaso
Summary: This study assessed the predictive ability of ultrasound-estimated percentile weight at 35 weeks of gestational age for late-onset SGA and APOs, finding that all standards had good predictive ability for SGA, with non-customized standards slightly better. Detection rates for SGA increased as ultrasound-delivery intervals decreased, and APO detection rates were significantly higher for non-customized standards.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Alizee Montvignier Monnet, Delphine Savoy, Lise Preaubert, Pascale Hoffmann, Cecile Betry
Summary: The pre-pregnancy BMI and gestational weight gain are important factors in determining pregnancy outcomes. This study aimed to investigate the impact of insufficient gestational weight gain on obstetric outcomes in women with a pre-pregnancy BMI < 18.5 kg/m(2). The findings showed that insufficient weight gain during pregnancy was associated with lower adjusted birth weight percentiles and a higher proportion of small-for-gestational-age newborns. Additionally, it was found that insufficient weight gain increased the risks of premature rupture of membranes, anemia, and intrauterine growth restriction. Future research should focus on identifying risk factors for inadequate weight gain and developing specific care guidelines for underweight pregnant women.
Article
Public, Environmental & Occupational Health
Suryadi Nicolaas Napoleon Tatura
Summary: A case of a neonate with severe COVID-19 and a sepsis-like illness is presented. The baby's condition initially improved but deteriorated on the sixth day, and after appropriate treatment, the baby was discharged without any complications. This case highlights the challenges in differentiating and managing between severe COVID-19 and neonatal sepsis, emphasizing the importance of thorough anamnesis and careful observation.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Health Care Sciences & Services
Daniela-Loredana Bujorescu, Adrian Ratiu, Cosmin Citu, Florin Gorun, Oana Maria Gorun, Doru Ciprian Crisan, Alina-Ramona Cozlac, Ioana Chiorean-Cojocaru, Mihaela Tunescu, Zoran Laurentiu Popa, Roxana Folescu, Andrei Motoc
Summary: The optimal timing of delivery in cases of early onset fetal growth restriction is challenging to determine due to the opposing risks of stillbirth and prematurity. This study aimed to assess the likelihood of neonatal complications based on the time of birth, using Doppler parameters in fetuses with early onset fetal growth restriction. The findings suggest that infants delivered at the onset of umbilical arteries absent/reversed end-diastolic flow are less likely to develop intraventricular hemorrhage grades III/IV and bronchopulmonary dysplasia.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Acoustics
R. Peasley, L. A. Abrego Rangel, D. Casagrandi, V. Donadono, M. Willinger, G. Conti, Y. Seminara, N. Marlow, A. L. David, G. Attilakos, P. Pandya, A. Zaikin, D. Peebles, R. Napolitano
Summary: The objective of this study was to evaluate a novel protocol for managing late-onset fetal growth restriction (FGR) using ultrasound criteria. The study found that risk stratification based on ultrasound criteria was associated with a reduced rate of adverse neonatal outcome in low-risk pregnancies. This study suggests that appropriate risk stratification can guide the management of late FGR and improve neonatal outcomes.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
Odessa P. Hamidi, Camille Driver, Jon G. Steller, Emma E. Peek, Lorenzo Monasta, Tamara Stampalija, Diane L. Gumina, Greggory R. DeVore, John C. Hobbins, Henry L. Galan
Summary: This study compares the differences and abnormal rates of umbilical vein flow (UVF) between fetal growth restriction (FGR) fetuses meeting Delphi criteria (FGR-D), small-for-gestational age (SGA) fetuses, and appropriate-for-gestational age (AGA) controls. The results show that absolute UVF is decreased in FGR-D, and the incidence of abnormal UVF is higher in late-onset FGR fetuses. UVF may provide additional diagnostic value for fetuses affected by growth restriction.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Developmental Biology
M. Bos, M. J. M. Koenders, K. L. Dijkstra, L. E. van der Meeren, P. G. J. Nikkels, K. W. M. Bloemenkamp, M. Eikmans, H. J. Baelde, M. L. P. van der Hoorn
Summary: Chronic histiocytic intervillositis (CHI) is a rare placental histopathological lesion associated with poor reproductive outcomes. The severity of intervillous infiltrate and clinical outcomes of CHI vary between cases. This study aims to determine the relationship between severity of intervillous infiltrate and clinical outcomes of CHI.
Article
Medicine, General & Internal
Chiara Lubrano, Emanuela Taricco, Chiara Coco, Fiorenza Di Domenico, Chiara Mando, Irene Cetin
Summary: Alterations in intrauterine fetal growth increase the risk of adverse perinatal and neonatal outcomes. Risk factors for fetal growth alterations include advanced age, being primiparous, and a lower pregestational BMI. Prematurity, hyperlactacidemia, and hypoxemia are the main factors contributing to worse neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Acoustics
A. Basso, L. Youssef, A. Nakaki, C. Paules, J. Miranda, G. Casu, L. Salazar, E. Gratacos, E. Eixarch, F. Crispi, F. Crovetto
Summary: This study aims to explore the pattern of fetal cortical development in pregnancies complicated by pre-eclampsia (PE), with and without a small-for-gestational-age (SGA) fetus, compared to uncomplicated pregnancies. The results showed that pregnancies with PE, whether with a SGA or AGA fetus, had similar cortical development patterns that were comparable to those observed in small fetuses.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Pediatrics
Natasha S. Ching, Jim P. Buttery, Emily Lai, Andrew C. Steer, Jane Standish, Joel Ziffer, Andrew J. Daley, Richard Doherty
Summary: The study found no association between breastfeeding and the increased risk of LOGBS. Breast milk should not be tested for GBS during the initial episode of LOGBS.
Article
Oncology
Tomasz Geca, Aleksandra Stupak, Robert Nawrot, Anna Gozdzicka-Jozefiak, Anna Kwasniewska, Wojciech Kwasniewski
Summary: Fetal growth restriction (FGR) is a condition where the fetus does not reach its full potential for growth and can lead to obstetric and neonatal complications. This study compared the placental proteome of normal pregnancies and pregnancies complicated by FGR, revealing significant differences between the two groups. Further research is needed to better understand maternal and fetal adaptations to FGR.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Multidisciplinary Sciences
Natasha L. Pritchard, Stephen Tong, Susan P. Walker, Anthea C. Lindquist
Summary: Using a single centile per week to measure growth standards during gestation overestimates the proportion of small-for-gestational-age infants at the beginning of the week and underestimates it at the end of the week. This distorts the assessment of stillbirth risk among small-for-gestational-age infants based on their birth timing.
Article
Multidisciplinary Sciences
Hale Teka, Awol Yemane, Hiluf Ebuy Abraha, Ephrem Berhe, Habtom Tadesse, Fanos Gebru, Mohammedtahir Yahya, Ytbarek Tadesse, Daniel Gebre, Marta Abrha, Bisrat Tesfay, Ashenafi Tekle, Tsega Gebremariam, Birhane Amare, Mohamedawel Mohamedniguss Ebrahim, Yibrah Berhe Zelelow, Afework Mulugeta
Summary: This study aimed to investigate the clinical presentation and maternal-fetal and neonatal outcomes of early and late onset preeclampsia. The results showed that women with early onset disease had unfavorable maternal outcomes, such as severe preeclampsia with severity features, liver dysfunction, uncontrolled diastolic blood pressure, and prolonged hospitalization. They also had increased unfavorable perinatal outcomes, including low APGAR score at the 5th minute, low birth weight, and neonatal death.
Article
Obstetrics & Gynecology
Ivan Hurtado, Erika Bonacina, Pablo Garcia-Manau, Berta Serrano, Mireia Armengol-Alsina, Manel Mendoza, Nerea Maiz, Elena Carreras
Summary: This study aims to create a predictive model involving biomarkers to evaluate its ability to predict adverse perinatal outcomes in patients with late-onset small fetuses, thus providing individualized counseling at the time of diagnosis.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Acoustics
L. Trigo, E. Eixarch, I. Bottura, M. Dalaqua, A. A. Barbosa, L. De Catte, P. Demaerel, S. Dymarkowski, J. Deprest, D. A. Lapa, M. Aertsen, E. Gratacos
Summary: This study aims to explore the prevalence of brain anomalies and their relationship with spinal defects in fetuses eligible for prenatal open spina bifida repair. The results showed that more than half of the fetuses had abnormal corpus callosum and/or abnormal ventricular wall before the prenatal repair. Furthermore, non-sacral lesions and wider lateral ventricles were associated with an increased risk of brain abnormalities. Therefore, a detailed preoperative evaluation of the central nervous system is crucial in fetuses with open spina bifida.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Ben Van Calster, Alexandra Benachi, Kypros H. Nicolaides, Eduard Gratacos, Christoph Berg, Nicola Persico, Glenn J. Gardener, Michael Belfort, Yves Ville, Greg Ryan, Anthony Johnson, Haruhiko Sago, Przemyslaw Kosinski, Pietro Bagolan, Tim Van Mieghem, Philip L. J. DeKoninck, Francesca M. Russo, Stuart B. Hooper, Jan A. Deprest
Summary: This analysis suggests that fetoscopic endoluminal tracheal occlusion improves survival in cases of moderate and severe lung hypoplasia. The timing of balloon insertion may impact the treatment effect, but further research is needed to determine its precise influence due to the limited sample size and confounding factors. In particular, early insertion of the balloon greatly increases the risk of preterm delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Multidisciplinary Sciences
Sergio Alonso, Marti Catala, Daniel Lopez, Enric Alvarez-Lacalle, Iolanda Jordan, Juan Jose Garcia-Garcia, Victoria Fumado, Carmen Munoz-Almagro, Eduard Gratacos, Nuria Balanza, Rosauro Varo, Pere Millat, Barbara Baro, Sara Ajanovic, Sara Arias, Joana Claverol, Mariona Fernandez de Sevilla, Elisenda Bonet-Carne, Aleix Garcia-Miquel, Ermengol Coma, Manuel Medina-Peralta, Francesc Fina, Clara Prats, Quique Bassat
Summary: The reopening of schools in Catalonia appeared to be safe and the preventive measures in place were effective in detecting and containing transmission. The risk of transmission within schools was found to be relatively low.
Letter
Acoustics
E. Eixarch, E. Gratacos
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Correction
Multidisciplinary Sciences
Xavier P. Burgos-Artizzu, David Coronado-Gutierrez, Brenda Valenzuela-Alcaraz, Elisenda Bonet-Carne, Elisenda Eixarch, Fatima Crispi, Eduard Gratacos
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Carlota Dobano, Selena Alonso, Marta Vidal, Alfons Jimenez, Rocio Rubio, Rebeca Santano, Diana Barrios, Gemma Pons Tomas, Maria Mele Casas, Maria Hernandez Garcia, Monica Girona-Alarcon, Laura Puyol, Barbara Baro, Pere Millat-Martinez, Sara Ajanovic, Nuria Balanza, Sara Arias, Natalia Rodrigo Melero, Carlo Carolis, Aleix Garcia-Miquel, Elisenda Bonet-Carne, Joana Claverol, Marta Cubells, Claudia Fortuny, Victoria Fumado, Anna Codina, Quique Bassat, Carmen Munoz-Almagro, Mariona Fernandez de Sevilla, Eduard Gratacos, Luis Izquierdo, Juan Jose Garcia-Garcia, Ruth Aguilar, Iolanda Jordan, Gemma Moncunill
Summary: COVID-19 has a lesser impact on children compared to adults, but they can still get infected and transmit the virus. A study evaluated the use of high-throughput Luminex assays to measure SARS-CoV-2 antibodies in saliva and compared them to serum/plasma samples in infected children and adults. The results showed a correlation between saliva and serum/plasma antibody levels, and infected children had higher antibody levels, suggesting stronger clinical immunity. Therefore, measuring saliva antibodies could be a useful tool to determine COVID-19 prevalence and transmission in pediatric populations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Acoustics
A. Hawkins-Villarreal, A. L. Moreno-Espinosa, K. Castillo, N. Hahner, O. Picone, L. Mandelbrot, I. Simon, E. Gratacos, A. Gonce, E. Eixarch
Summary: The study aimed to assess the cortical maturation pattern in fetuses with CMV infection using MRI, and compare it with healthy controls. Results showed that even in non-severely affected fetuses, CMV infection could be associated with altered brain cortical structure.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
D. L. Lip-Sosa, M. Perez-Cruz, P. Ahumada-Droguett, T. Ribas-Prats, M. Puertollano, M. A. Garcia-Gomez, E. Mazarico, E. Eixarch, C. Escera, M. D. Gomez-Roig
Summary: This study aimed to investigate the measurements of midbrain morphology on neurosonography in late-onset small fetuses classified as small-for-gestational-age (SGA) or growth-restricted (FGR). The results showed that small fetuses had significantly shorter corpus callosum-fastigium length and tectal length compared to controls, and these differences were more pronounced in fetuses with more severe smallness. These findings suggest the potential value of midbrain measurements as biomarkers for brain development in a high-risk population.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
A. Hawkins-Villarreal, K. Castillo, A. Nadal, S. Planas, A. L. Moreno-Espinosa, A. Alarcon, M. Rebollo-Polo, F. Figueras, E. Gratacos, E. Eixarch, A. Gonce
Summary: The study aimed to evaluate the correlation between the periventricular echogenic halo (halo sign) and histopathological findings, as well as its association with other brain imaging abnormalities in fetuses with cytomegalovirus (CMV) infection. The study included CMV-infected fetuses diagnosed with severe CNS abnormalities seen on ultrasound. The halo sign was observed in 91% of the fetuses, with ventriculitis being more frequent in cases with a non-isolated halo sign. Histopathological analysis showed that fetuses with an isolated halo sign had mild ventriculitis without severe brain lesions. The study suggests that detailed neurosonographic follow-up and MRI examination should be considered in the early third trimester for prognostic evaluation of CMV-infected fetuses with the halo sign as an isolated finding. Rating: 8/10.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Andrea Urru, Ayako Nakaki, Oualid Benkarim, Francesca Crovetto, Laura Segales, Valentin Comte, Nadine Hahner, Elisenda Eixarch, Eduard Gratacos, Fatima Crispi, Gemma Piella, Miguel A. Gonzalez Ballester
Summary: In this study, a new pipeline for fetal and neonatal segmentation has been developed, along with the creation of two new fetal atlases. The results show that the use of the new templates and segmentation strategy leads to accurate results, outperforming a reference pipeline in early and late-onset fetal brain segmentation.
Article
Acoustics
S. Sanchez-Martinez, P. C. Randanne, A. Hawkins-Villarreal, K. Rezaei, R. Fucho, S. Bobillo-Perez, E. Bonet-Carne, M. Illa, E. Eixarch, B. Bijnens, F. Crispi, E. Gratacos
Summary: This study aimed to describe the acute cardiovascular adaptation of the fetus after connection to an artificial placenta (AP) using ultrasound and invasive and non-invasive hemodynamic assessment. The results showed that the connection to the AP system resulted in a reduction in the pulsatility index and increased umbilical venous peak velocity. While cardiac structure and function were preserved in the short term, the system led to non-physiologically elevated venous pressure and pulsatile flow.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elisenda Eixarch, Miriam Illa, Raquel Fucho, Kambiz Rezaei, Ameth Hawkins-Villarreal, Sara Bobillo-Perez, Paula C. Randanne, Miguel Moran, Marina Chorda, Sergio Sanchez-Martinez, Yolanda J. D. de Roo-Puente, Maria del Mar Velilla, Ruth del Rio, Marc Gallego, Daniel Sanin-Ramirez, Victor Narvaez, Fatima Crispi, Elisenda Bonet-Carne, Eduard Gratacos
Summary: This study describes the development of an artificial placenta (AP) system in sheep, facing challenges and bottlenecks but ultimately achieving survival up to one week. A total of 28 fetal sheep were transferred to the AP system, with progressively increased survival goals. Results showed improved success rates over the course of the study, but common issues still hindered the system in the first two groups. The study concludes that developing a reproducible AP system requires significant time, effort, and a highly multidisciplinary team.
Article
Obstetrics & Gynecology
Lucas Trigo, Elisenda Eixarch, Fernanda Faig-Leite, Marta Gomez-Chiari, Monica Rebollo, Mariana Dalaqua, Eduard Gratacos, Denise Lapa
Summary: This study investigated the changes in central nervous system anomalies before and after prenatal open spina bifida repair and their relationship with postnatal neurologic outcomes. The results showed a reduction in hindbrain herniation and a normalization of the clivus supraocciput angle after surgery, but no significant increase in abnormal corpus callosum or heterotopia. However, the presence of abnormal corpus callosum and severe ventriculomegaly was associated with an increased risk of suboptimal neurodevelopment.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Obstetrics & Gynecology
Javier Caradeux, Javier Caradeux Bull, Francisco Avila, Francisco Vargas, Benjamin Fernandez, Carolina Winkler, Mauricio Mondion, Ivan Rojas, Francesc Figueras
Summary: This study found that pregnancies conceived through assisted reproductive techniques (ART) have a higher risk of placental related disease in the third trimester. Comparing pregnancies conceived with autologous oocytes to those conceived with donated oocytes, it was observed that ART pregnancies have a lower fetal growth velocity from the second trimester to delivery, particularly in pregnancies with donated oocytes. These findings suggest that pregnancies achieved through ART, especially with donated oocytes, may be at a higher risk of placental dysfunction and require closer follow-up.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Obstetrics & Gynecology
Talita Micheletti, Elisenda Eixarch, German Febas, Sergio Berdun, Johanna Parra, Albert Hernansanz, Salvador Borros, Eduard Gratacos
Summary: This study evaluated the feasibility of inserting an integrated semirigid bioadhesive patch through fetoscopic technique for sealing fetal membranes. The results showed that the patch could be successfully inserted and had good adhesion in both ex vivo and in vivo settings.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)