Article
Critical Care Medicine
Martin Cour, Kada Klouche, Bertrand Souweine, Jean-Pierre Quenot, Carole Schwebel, Sophie Perinel, Camille Amaz, Marielle Buisson, Michel Ovize, Nathan Mewton, Laurent Argaud
Summary: The study did not find that remote ischemic conditioning (RECO) reduces the severity of organ failure in patients with septic shock, but the cumulative mortality within 90 days was slightly lower in the RECO group compared to the control group.
INTENSIVE CARE MEDICINE
(2022)
Article
Health Care Sciences & Services
Mahmoud Al-Obeidallah, Dagmar Jarkovska, Lenka Valesova, Jan Horak, Jan Jedlicka, Lukas Nalos, Jiri Chvojka, Jitka Sviglerova, Jitka Kuncova, Jan Benes, Martin Matejovic, Milan Stengl
Summary: The porcine model of peritonitis-induced sepsis is a clinically relevant model of human disease, but the interindividual variability of response complicates the interpretation of findings. By comparing the progression of disease between animals with sepsis and septic shock, significant differences were found early on in the sequential organ failure assessment score, hemodynamic parameters, and body temperature, indicating their potential as early discriminators between sepsis and septic shock.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Infectious Diseases
Angela McBride, Nguyen Lam Vuong, Nguyen Van Hao, Nguyen Quang Huy, Ho Quang Chanh, Nguyen Thi Xuan Chau, Nguyen Minh Nguyet, Damien K. Ming, Nguyen Thanh Ngoc, Phung Tran Huy Nhat, Nguyen Thanh Phong, Luong Thi Hue Tai, Phan Vinh Tho, Dinh The Trung, Dong Thi Hoai Tam, Huynh Trung Trieu, Ronald Bertus Geskus, Martin J. Llewelyn, C. Louise Thwaites, Sophie Yacoub
Summary: This study investigated the clinical endpoints in dengue patients and found that the modified Sequential Organ Failure Assessment (mSOFA) score performed well in assessing clinical outcomes, such as duration of ICU and hospital admission, requirement for organ support, and mortality.
BMC INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Chun-Yo Laih, Po-Jen Hsiao, Po-Fan Hsieh, Yu-De Wang, Chun-Ming Lai, Chao-Tung Yang, Chu-Hsing Lin, Chi-Ping Huang
Summary: This study aimed to evaluate the feasibility of using the SOFA and qSOFA scores to predict post-ureteroscopic lithotripsy (URSL) sepsis. The study found that older age, proximal ureteral stones, severe hydronephrosis, and high preoperative qSOFA or SOFA scores were significantly associated with postoperative sepsis.
Article
Infectious Diseases
Dimitri Durr, Tapio Niemi, Jeremie Despraz, Selin Tusgul, Fabrice Dami, Rachid Akrour, Pierre-Nicolas Carron, Marie-Annick Le Pogam, Thierry Calandra, Sylvain Meylan
Summary: In emergency department patients with suspected sepsis, NEWS score had higher sensitivity while qSOFA score had higher specificity and positive predictive values.
Article
Multidisciplinary Sciences
Ayaka Saito, Itsuki Osawa, Junichiro Shibata, Tomohiro Sonoo, Kensuke Nakamura, Tadahiro Goto
Summary: By analyzing data from the emergency department of a tertiary medical center in Japan, it was found that the combined use of prehospital and ED qSOFA improves the screening ability of sepsis among patients with suspected infection at the ED.
Article
Multidisciplinary Sciences
Tae Han Kim, Daun Jeong, Jong Eun Park, Sung Yeon Hwang, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim, Gun Tak Lee, T. G. Shin
Summary: This study compared the prognostic accuracy of the initial SOFA score and the maximum SOFA score in predicting in-hospital mortality in septic shock patients. The results showed that the maximum SOFA score had significantly higher accuracy in predicting mortality compared to the initial SOFA score.
Article
Emergency Medicine
Renqi Yao, Yibing Zhu, Yue Yu, Zhixuan Li, Lixue Wang, Liyu Zheng, Jingyan Li, Huibin Huang, Guosheng Wu, Feng Zhu, Zhaofan Xia, Chao Ren, Yongming Yao
Summary: The combination therapy of vitamin C and thiamine with or without hydrocortisone did not significantly reduce short-term mortality in patients with sepsis and septic shock, but was associated with a significant reduction in SOFA score and duration of vasopressor usage. Other outcomes did not show significant differences between the combination therapy and placebo.
Article
Medicine, General & Internal
Myrto Bolanaki, Martin Mockel, Johannes Winning, Michael Bauer, Konrad Reinhart, Angelika Stacke, Peter Hajdu, Anna Slagman
Summary: The use of PCT as a biomarker in emergency departments can aid in early identification of sepsis patients. PCT demonstrated high sensitivity and specificity for identifying septic patients in EDs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Carolina Lorencio Cardenas, Juan Carlos Yebenes, Emili Vela, Montserrat Cleries, Josep Ma Sirvent, Cristina Fuster-Bertolin, Clara Reina, Alejandro Rodriguez, Juan Carlos Ruiz-Rodriguez, Josep Trenado, Elisabeth Esteban Torne
Summary: The incidence of sepsis has been increasing in recent years, but hospital mortality has significantly decreased. In septic patients, all organ failures, except liver failure, have shown a statistically significant reduction in associated mortality.
Article
Biochemistry & Molecular Biology
Knut Anders Mosevoll, Bent Are Hansen, Ingunn Margareetta Gundersen, Hakon Reikvam, Oyvind Bruserud, Oystein Bruserud, Oystein Wendelbo
Summary: This study investigated the serum metabolomic profile of patients with bacterial sepsis at hospital admission. The results showed significant differences in metabolites between Sepsis-3 and Sepsis-2/SIRS patients, indicating distinct metabolic characteristics at the time of hospitalization. Additionally, some Sepsis-3 patients had metabolic profiles similar to Sepsis-2/SIRS patients, even with a high total SOFA score. Overall, the metabolic profile of patients with bacterial sepsis at hospital admission is heterogeneous.
Article
Urology & Nephrology
Yonghan Peng, Wei Zhang, Yalong Xu, Ling Li, Weixing Yu, Jianwen Zeng, Shaoxiong Ming, Ziyu Fang, Zeyu Wang, Xiaofeng Gao
Summary: The new clinical criteria SOFA and qSOFA were found to be more accurate than SIRS in predicting septic shock after PCNL. SOFA showed slightly better performance compared to qSOFA and SIRS. It is recommended to use a combination of criteria for early detection of septic shock after PCNL.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Shelton W. Wright, Viriya Hantrakun, Kristina E. Rudd, Chuen-Yen Lau, Khie Chen Lie, Nguyen Van Vinh Chau, Prapit Teparrukkul, T. Eoin West, Direk Limmathurotsakul
Summary: In low-resource settings, combining point-of-care venous lactate with the quick Sequential Organ Failure Assessment (qSOFA) score can accurately identify patients at risk of sepsis-related mortality in Southeast Asia, with similar accuracy to a modified Sequential Organ Failure Assessment (SOFA) score.
LANCET GLOBAL HEALTH
(2022)
Article
Immunology
Amal Abouda, Z. Hajjej, A. Mansart, W. Kaabechi, D. Elhaj Mahmoud, O. Lamine, E. Ghazouani, M. Ferjani, I. Labbene
Summary: This study aimed to assess the predictive ability of antiphospholipid antibody biomarkers for in-hospital mortality in ICU septic patients. The results showed that antiphospholipid antibodies were useful biomarkers for predicting mortality, and there was a positive correlation with SOFA score.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Emergency Medicine
Hai Hu, Jing-yuan Jiang, Ni Yao
Summary: This study compares the performance of different versions of qSOFA in predicting sepsis mortality in the emergency department, finding that LqSOFA and MqSOFA are superior to qSOFA in predicting in-hospital mortality.
WORLD JOURNAL OF EMERGENCY MEDICINE
(2022)