Article
Cell Biology
Yang Yang, Jianhua Xue, Lili Qin, Jiaxuan Zhang, Jiajia Liu, Junbo Yu
Summary: NEAT1 inhibits the progression of sepsis induced by LPS in RAW264.7 cells by modulating the miR-31-5p/POU2F1 axis, suggesting NEAT1 as a potential therapeutic target for sepsis.
Article
Cell Biology
Kun Li, Ziqiang Wang
Summary: Neurodegenerative diseases are a leading cause of disability worldwide, and the search for biomarkers and therapeutic targets is urgent. Long non-coding RNAs (lncRNAs), including NEAT1, have emerged as important regulators in these diseases. NEAT1 is upregulated in various neurodegenerative diseases, but its role in these diseases is still unclear. This review summarizes the current knowledge of NEAT1's association with misfolded protein aggregation in different neurodegenerative diseases and aims to inspire further research for more precise and effective treatments.
AGEING RESEARCH REVIEWS
(2023)
Article
Oncology
Qingmin Chen, Yi Qin, Min Lin, Zhao Li, Weizhong Tang
Summary: NEAT1 is significantly upregulated in colorectal cancer patients and associated with poor prognosis. In vitro and in vivo experiments demonstrate that NEAT1 promotes the proliferation and migration of colorectal cancer cells through inducing inflammatory response. Therefore, NEAT1 may serve as a potential biomarker for the diagnosis and prognosis of colorectal cancer.
JOURNAL OF ONCOLOGY
(2022)
Article
Neurosciences
Xue-biao Wei, Wen-qiang Jiang, Ju-hao Zeng, Lin-qiang Huang, Hong-guang Ding, Yuan-wen Jing, Yong-li Han, Yi-chen Li, Sheng-long Chen
Summary: This study found that sepsis can cause severe sepsis-associated encephalopathy (SAE) and exacerbate the disease by promoting ferroptosis. The blood-brain barrier is damaged, leading to the accumulation of iron ions in the brain, oxidative stress, and ultimately cell death. NEAT1 in exosomes enhances ferroptosis stress by regulating the miR-9-5p/TFRC and GOT1 axis, further exacerbating sepsis-associated encephalopathy.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Jingshan Liang, Changtao Liu, Dezhi Xu, Kang Xie, Aimin Li
Summary: This study found that the long noncoding RNA NEAT1 promotes glioma progression by stabilizing PGK1. Overexpression of NEAT1 is associated with poor overall survival in GBM patients, indicating that the NEAT1/PGK1 axis may be a candidate therapeutic target for glioma treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Shirin Azizidoost, Farhoodeh Ghaedrahmati, Omid Anbiyaee, Riyadh Ahmad Ali, Maryam Cheraghzadeh, Maryam Farzaneh
Summary: Colorectal cancer is the third leading cause of cancer death in the world. Recent studies have shown that long non-coding RNAs play important roles in colorectal cancer cells, and NEAT1 is a key factor involved in the development and progression of colorectal cancer.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Yoshinori Nishimoto, Shinichi Nakagawa, Hideyuki Okano
Summary: Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease caused by factors such as RNA-binding proteins and genetic mutations, which play different roles in different stages; research has found that C9orf72 gene repeat expansion has a significant impact on the pathology of ALS.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Immunology
Qing Zhu, Cuiting Zhao, Yonghuai Wang, Xinxin Li, Yixue Xue, Chunyan Ma
Summary: This study demonstrates the independent predictive value of plasma sICAM-1, miR-148b-3p, and NEAT1 for the diagnosis of CSF. NEAT1 functions as a competing endogenous RNA to regulate ICAM-1 expression in the progression of the disease.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Behavioral Sciences
Xiaoming Wu, Tingting Jiang, Rui Huang, Xue Xiao
Summary: GAS8-AS1 is downregulated while lncRNA NEAT1 is upregulated in GBM patients. Alterations in the expression levels of GAS8-AS1 and NEAT1 can distinguish GBM patients from healthy controls. The expression of GAS8-AS1 and NEAT1 is inversely correlated in GBM patients.
BRAIN AND BEHAVIOR
(2021)
Article
Genetics & Heredity
Shanhui Ge, Jiaxin Hu, Shijuan Gao, Jianwei Ren, Guangfa Zhu
Summary: This study aimed to identify the core genes associated with ARDS and the mechanisms by which ceRNAs regulate the disease's progression. Through mRNA microarray analysis, common DEGs related to ALI were identified and subjected to enrichment and functional analysis. MiRNAs and lncRNAs involved in gene expression regulation were predicted. Experimental validation confirmed the key role of NEAT1/miR-21-5p/CXCL5/MMP9 in regulating the inflammatory response in ALI.
Article
Neurosciences
Yuanlong Li, Hua Fan, Ming Ni, Wei Zhang, Fengqin Fang, Jun Sun, Pin Lyu, Peizhi Ma
Summary: This study found that the reduction of lnc-NEAT1 in Alzheimer's disease can alleviate neuron injury, inflammation, and oxidative stress by activating the microRNA-193a-mediated CREB/BDNF and NRF2/NQO1 pathways.
Article
Medicine, Research & Experimental
Wenyu Dai, Manyi Wang, Peiqi Wang, Ji Wen, Jiangyue Wang, Sa Cha, Xueling Xiao, Yiruo He, Rui Shu, Ding Bai
Summary: The study found that stimulation of MG63 cells with LPS led to downregulation of NEAT1, increase in expression of inflammatory cytokines, inhibition of autophagy and osteogenesis-related proteins, promotion of apoptosis, and alteration of the cell cycle.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Immunology
Yanbin Meng, Zhenming Hao, Hairui Zhang, Peiyi Bai, Wanli Guo, Xiaorui Tian, Jun Xu
Summary: In this study, the role of lncRNA NEAT1 in angiogenesis of HUVECs and its potential involvement in burn sepsis (BS) pathogenesis were investigated. The results showed that NEAT1 regulates angiogenesis and activates the TGF beta 1/SMAD signaling pathway during the occurrence of BS.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Immunology
Yi Gong, Jiaxi Li, Lili Huang, Yi Liu, Ju Cao
Summary: This study found that CXCL16 levels were significantly higher in the serum of sepsis patients compared to healthy volunteers, and correlated with disease severity. Soluble CXCL16 levels had significant prognostic value for 28-day mortality in sepsis patients. The study also showed that CXCL16 could be a potential target for therapeutic intervention in sepsis treatment.
MICROBES AND INFECTION
(2022)
Article
Biology
Xin Cheng, Senbing Zhang, Ye Wen, Zhihua Shi
Summary: This study found that SIRT1 levels were decreased in sepsis patients compared to healthy controls, and could help differentiate sepsis patients. SIRT1 was negatively correlated with inflammatory markers and disease severity scores, and positively correlated with survival rates.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Letter
Emergency Medicine
Zhao-Yu Hsieh, Chen-Xiong Hsu
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Laura E. Walker, Jessica A. Stanich, Fernanda Bellolio
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
E. Tekin
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amanda S. Dupont, Patrick S. Walsh
Summary: Recent research indicates that children who unintentionally ingest cannabis often undergo extensive additional testing, such as head imaging or lumbar puncture. However, the yield of these tests is limited. While head imaging and lumbar puncture are frequently performed, diagnoses such as skull fracture, intracranial hemorrhage, intracranial neoplasm, meningitis, or intracranial abscess are rare. Additionally, discharge diagnoses related to other drugs are infrequent. The most common co-diagnoses are cocaine and opioids. Therefore, prompt consideration of cannabis ingestion and quick identification through testing may result in more effective neuroimaging outcomes.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
Mio Nagata, Shunsuke Kudo, Motoyasu Nakamura
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Andy Hung-Yi Lee, Katherine Dickerson Mayes, Regan Marsh, Christina Toledo-Cornell, Eric Goralnick, Michael Wilson, Leon D. Sanchez, Alice Bukhman, Damarcus Baymon, Dana Im, Paul C. Chen
Summary: This study assessed the disparities in transferring patients from an academic medical center emergency department to a community hospital general medical service, revealing healthcare disparities among different patient populations.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Annabelle Croskey, William Trautman, David Barton, Mary Kathleen Ratay, Joshua Shulman
Summary: This case report describes a successful management of ocular palytoxin exposure in a young male, highlighting the importance of prompt recognition and treatment of ocular PTX toxicity.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Matthew K. Kolbeck, Rachel F. Schult, Nicholas Nacca
Summary: This article presents four cases of adolescents who experienced seizures after acute fluoxetine overdose. Although seizures are an uncommon complication after fluoxetine overdose, they occurred in some patients at doses lower than those reported in the literature.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Daven Patel, John Bailitz, Simone Ymson, Jonas Neichin, Gary D. Peksa, Michael Gottlieb
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amichai Gutgold, Shaden Salameh, Jeries Nashashibi, Yonatan Gershinsky
Summary: This study aimed to test the prognosis of patients with a pH lower than 6.9 on emergency department admission. The findings showed that a small but significant portion of these patients survived at least 24 hours and until hospital discharge.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Na-Yeon Emily Song, Ki Hong Kim, Ki Jeong Hong
Summary: This study aimed to evaluate the effect of the duration of no-flow (NF) interval on the vaso-pressor effect of initial epinephrine administration in a porcine model of cardiac arrest. The results showed that a shorter NF interval can enhance the vasopressor effect of epinephrine.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Kenneth A. Scheppke, Paul E. Pepe, Jonathan Jui, Remle P. Crowe, Eric K. Scheppke, Nancy G. Klimas, Aileen M. Marty
Summary: This study reported cases of rapid and complete remission of severe long COVID after receiving monoclonal antibody treatment. The findings suggest that monoclonal antibody infusions may be effective in treating severe debilitation caused by long COVID.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Suhrith Bhattaram, Varsha S. Shinde
Summary: Nerve blocks have emerged as promising options for targeted pain relief in the Emergency Department, providing effective analgesia without compromising motor function. The successful use of ultrasound-guided genicular nerve blocks (GNBs) in this case series demonstrates their potential as an alternative to traditional nerve blocks and opioid-based pain control strategies in the ED.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Rick Kye Gan, Jude Chukwuebuka Ogbodo, Yong Zheng Wee, Ann Zee Gan, Pedro Arcos Gonzalez
Summary: The aim of this study was to evaluate and compare the performance of ChatGPT, Google Bard, and medical students in performing START triage during mass casualty situations. The results showed that Google Bard had significantly higher accuracy compared to ChatGPT, while there was no significant difference between Google Bard and medical students.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Nancy Clemens, Paria M. Wilson, Matthew J. Lipshaw, Holly Depinet, Yin Zhang, Michelle Eckerle
Summary: This study compared clinical features and outcomes between pediatric sepsis patients with blood cultures positive versus negative for bacterial pathogens. The results showed that children with blood culture positive sepsis had higher rates of organ dysfunction, a larger base deficit, and higher procalcitonin levels.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)