期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 108, 期 3, 页码 453-475出版社
OXFORD UNIV PRESS
DOI: 10.1093/ajcn/nqy107
关键词
BMI; telomere length; obesity; low-grade inflammation; meta-analysis; observational studies
资金
- Wellcome Trust
- European Community
- National Institute for Health Research (NIHR) BioResource Clinical Research Facility and Biomedical Research Centre based at Guy's and St. Thomas' NHS Foundation Trust
- King's College London
- National Center for Advancing Translational Sciences of the NIH [UL1TR001105]
- National Heart, Lung, and Blood Institute [N01-HC-95159, N01-HC-95165, N01-HC-95169]
- MacArthur Foundation
- NIH, the National Institute of Diabetes and Digestive and Kidney Diseases [5K01DK082729-04]
- British Heart Foundation [RG008/08, FS/06/053, RG/10/005/28296, PG/16/49/32176, PG/12/9/29376]
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
- EC Concerted Action [BMH1 CT92-0206]
- Age UK (The Disconnected Mind project)
- Biotechnology and Biological Sciences Research Counci
- Medical Research Council (MRC)
- Intramural Research Program of the NIH, National Institute of Environmental Health Sciences [Z01 ES 044005]
- Chief Scientist of the Israel Ministry of Health [300000-5352]
- Israel Science Foundation [593/01]
- US-Israel Binational Science Foundation [87-00419]
- USAID MERC program [TA-MOU-01-M2-1002]
- DCURE Israel
- Australian National Health and Medical Research Council [17805, 418020]
- Tiroler Wissenschaftsfonds, Austria
- Dr Johannes and Hertha Tuba Foundation
- NIH [R03AG023251, R01HD012252, R01DK091369, K01AG034259, R21HL092363, U01HL65520, U01HL41642, U01HL41652, U01HL41654, U01HL65521, DA12854, RR20649, ES10126]
- NIH/NIAMS [T32AR07611, K24AR002138, P60 AR064464]
- Kirkland Scholar Award
- AFMR Summer Clinical and the Eleanor Wood-Prince grant: A Project of the Woman's Board of Northwestern Memorial Hospital
- Ministry of Education and Culture
- Juho Vainio Foundation
- Finnish Heart Research Foundation
- Paavo Nurmi Foundation
- Finnish Cultural Foundation
- Medical Society of Finland, Finska Lakaresallskapet
- Academy of Finland
- ENGAGE-European Network for Genetic and Genomic Epidemiology [201413]
- Academy of Finland Center of Excellence in Complex Disease Genetics [213506, 129680]
- Academy of Finland [141054, 265240, 263278, 286294, 294154]
- intramural research program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Helmholtz Zentrum Munchen-German Research Center for Environmental Health
- German Federal Ministry of Education and Research (BMBF)
- State of Bavaria
- Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universitat, as part of LMUinnovativ
- Netherlands Organisation for Scientific Research (NWO)
- Erasmus MC
- Center for Medical Systems Biology (CMSB)
- ENGAGE Consortium [HEALTH-F4-2007-201413]
- Netherlands Consortium for Healthy Ageing [050-060-810]
- Erasmus University Rotterdam
- Netherlands Organization for Scientific Research (NWO)
- Netherlands Organization for Health Research and Development (ZonMw)
- Research Institute for Diseases in the Elderly (RIDE)
- Netherlands Genomics Initiative (NGI)
- Ministry of Education, Culture, and Sciences
- Ministry of Health, Welfare, and Sports
- European Commission (DG XII)
- Municipality of Rotterdam
- National Institute on Aging [R01 AG033592]
- Netherlands Prevention Foundation (Preventiefonds)
- Danone
- Susan G Komen for the Cure [BCTR 0600562]
- US NIH Cancer Center [P30 CA016056]
- Medical Research Council, United Kingdom
- British Heart Foundation
- Sohlberg Foundation
- Jahnsson Foundation
- Gustav Voch Victoria Frimurarestiftelse
- Helsinki University Central Hospital
- Oulu University Hospital (VTR/EVO-funding)
- NSF [BCS-0962282]
- Wenner-Gren Foundation [8111]
- Northwestern University
- Geestkracht program of the Netherlands Organization for Health Research and Development (Zon-Mw) [10-000-1002]
- NWO-VICI grant [91811602]
- Sao Paulo Research Foundation (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP) [2010/08800-8, 2012/11566-2, 2012/11069-9]
- National Health and Medical Research Council of Australia [APP1123472]
- Baden-Wurttemberg State Ministry of Science, Research, and Arts (Stuttgart, Germany)
- Federal Ministry of Education and Research (Berlin, Germany)
- Federal Ministry of Family Affairs, Senior Citizens, Women, and Youth (Berlin, Germany)
- German Federal Ministry of Education and Research (BMBF) [16SV5536K, 16SV5537, 16SV5538, 01UW0808]
- BMBF [01GL1716A, 01GL1716B]
- Max Planck Institute for Human Development (MPIB) in Berlin, Germany
- Max Planck Institute for Molecular Genetics (MPIMG) in Berlin, Germany
- Charite-Universiatsmedizin, University Medicine, German in Berlin, Germany
- Institute for Economic Research (DIW) Humboldt-Universitat zu Berlin in Berlin, Germany
- University of Lubeck in Lubeck
- University of Tubingen, Germany
- Canadian Institutes of Health Research (CIHR) [MOP 79456, 111017]
- Montreal Heart Institute Foundation
- Singapore Ministry of Education
- AXA Research Foundation
- Templeton World Charity Foundation, Inc.
- Swedish Research Council
- FORTE
- National Heart, Lung, and Blood Institute of the NIH [R01HL116381]
- Komisarenko Institute of Endocrinology and Metabolism (National Academy of Medical Sciences) [0116 U 002166]
- [R01 HL076831]
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR001105] Funding Source: NIH RePORTER
Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. Objective: A collaborative cross-sectionalmeta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Design: Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Study-specific age-and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute [base pairs (bp)] and relative telomere to single-copy gene ratio (T/S ratio) TLs were regressed against BMI. Stratified analysis was performed by 3 age categories (young: 18-60 y; middle: 61-75 y; and old: > 75 y), sex, and ethnicity. Results: Each unit increase in BMI corresponded to a-3.99 bp (95% CI: -5.17, -2.81 bp) difference in TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -7.67 bp (95% CI:-10.03,-5.31 bp) difference. Each unit increase in BMI corresponded to a -1.58 x 10(-3) unit T/S ratio (0.16% decrease; 95% CI: -2.14 x 10(-3), -1.01 x 10(-3)) difference in ageand sex-adjusted relative TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -2.58 x 10(-3) unit T/S ratio (0.26% decrease; 95% CI: -3.92 x 10(-3), -1.25 x 10(-3)). The associations were predominantly for the white pooled population. No sex differences were observed. Conclusions: A higher BMI is associated with shorter telomeres, especially in younger individuals. The presently observed difference is not negligible. Meta-analyses of longitudinal studies evaluating change in body weight alongside change in TL are warranted.
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