期刊
AMERICAN JOURNAL OF CARDIOLOGY
卷 121, 期 8, 页码 956-960出版社
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjcard.2018.01.003
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资金
- Finnish Foundation for Cardiovascular Research, Helsinki, Finland
The benefits of aerobic fitness in relation to all-cause and cardiovascular mortality is well established; however, the associations of long-term change in cardiorespiratory fitness (CRF) with incident heart failure (HF) and atrial fibrillation (AF) have not been studied before. The Kuopio Ischaemic Heart Disease Risk Factor Study is a prospective cohort comprising men aged 42 to 60 years from the city of Kuopio and its surroundings, with a baseline examination between 1984 and 1989 (V1), a re-examination at 11 years (V2), and up to 15 years of follow-up from V2. CRF, as assessed by VO(2)max, was measured at both visits using respiratory gas exchange during maximal exercise tolerance test. The difference (Delta VO(2)max) was estimated as VO(2)max(V2) - VO(2)max (V1). Participants with no missing data on both baseline and 11-year exercise test were included (n = 481). The mean Delta VO(2)max was -5.4 ml/min.kg (standard deviation 5.4). During a median follow-up of 14.3 years (interquartile range 13.3 to 15.1), 46 incident HF (9.6%) and 73 incident AF (15.2%) events were recorded. In a multivariate analysis adjusted for baseline age, baseline VO(2)max, systolic blood pressure, smoking, type 2 diabetes, and cardiovascular disease, per 1 ml/min.kg higher Delta VO(2)max was log linearly associated with incident HF with a 10% relative risk reduction of HF (hazard ratio 0.90, 95% confidence interval 0.83 to 0.97). No significant relation of Delta VO(2)max with incident AF was observed. In conclusion, overall long-term improvement in CRF is associated with reduced risk of HF, indicating the importance of maintaining good CRF over time. (C) 2018 Elsevier Inc. All rights reserved.
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