Article
Multidisciplinary Sciences
Ling-Xin Li, Jing-Kang Lu, Bao-Jin Li, Qiang Gao, Cheng-Qi He, Shi-Hong Zhang, You-Jin Zhao, Shuai He, Qian Wen
Summary: This study aims to evaluate the optimum parameters of rTMS for patients with post-stroke cognition impairment and explores its effects on brain network function. The results of this study would facilitate the standardized application of rTMS in cognition impairment rehabilitation.
Article
Rehabilitation
Chun Ming Yang, Yi-Ching Wang, Chia-Hua Lee, Mei-Hsiang Chen, Ching-Lin Hsieh
Summary: This study aimed to compare the test-retest reliability and random measurement errors of the Barthel Index (BI) and modified Barthel Index (MBI) in patients with chronic stroke. The results showed that the MBI had better test-retest reliability and relatively lower random measurement error, suggesting that it may be a better measure for activities of daily living (ADL) in these patients.
DISABILITY AND REHABILITATION
(2022)
Article
Chemistry, Multidisciplinary
Akhilesh Vyas, Fotis Aisopos, Maria-Esther Vidal, Peter Garrard, George Paliouras
Summary: The study examines various clinical attributes of dementia patients, using machine learning models to calibrate MMSE scores accurately determining cognitive status and provides an effective classification mechanism to identify inaccurate MMSE values.
APPLIED SCIENCES-BASEL
(2021)
Article
Neurosciences
Knut Engedal, Jurate Saltyte Benth, Linda Gjora, Havard Kjesbu Skjellegrind, Marit Navik, Geir Selbaek
Summary: This study examined normative scores for the third Norwegian version of the MMSE and found that age and years of education influenced MMSE scores, with education being the strongest predictor.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Cell Biology
Silvia Pelucchi, Chiara Macchi, Laura D'Andrea, Paolo Dionigi Rossi, Michela Carola Speciani, Ramona Stringhi, Massimiliano Ruscica, Beatrice Arosio, Monica Di Luca, Matteo Cesari, Valeria Edefonti, Elena Marcello
Summary: Frailty is a geriatric syndrome resulting from age-associated accumulation of deficits. The study found a significant inverse association between circulating CAP2 concentration and frailty index in older adults. This suggests that CAP2 may serve as a biomarker for age-related deficits, highlighting its potential for personalized care.
Article
Multidisciplinary Sciences
Angelo Ippolito, Hans Urban, Kimia Ghoroghi, Nicolas Rosbach, Neelam Lingwal, Elisabeth H. Adam, Benjamin Friedrichson, Andrea U. Steinbicker, Elke Hattingen, Katharina J. Wenger
Summary: This study aimed to compare critically ill COVID-19 patients with and without VV-ECMO treatment in terms of acute neurological symptoms, pathological neuroimaging findings, and long-term deficits. The study found that COVID-19 patients receiving VV-ECMO treatment had a lower survival rate and were more likely to develop acute neurological symptoms. However, the association between VV-ECMO treatment and pathological neuroimaging findings was negligible.
SCIENTIFIC REPORTS
(2022)
Article
Rehabilitation
Yi-Ching Wang, Pei-Fen Chang, Yi-Miau Chen, Ya-Chen Lee, Sheau-Ling Huang, Mei-Hsiang Chen, Ching-Lin Hsieh
Summary: The study aimed to compare the group- and individual-level responsiveness of the Barthel Index (BI) and modified BI (MBI) in patients with early subacute stroke. The results showed that the MBI had better responsiveness than the BI at both the group and individual levels, and it is recommended as an outcome measure for patients with stroke.
DISABILITY AND REHABILITATION
(2023)
Review
Biochemistry & Molecular Biology
Jongha Lee, Suhyuk Chi, Moon-Soo Lee
Summary: Depressive disorder in childhood and adolescence is a common mood disorder that can have a significant impact on a patient's quality of life. Research has shown that certain biomarkers, including cytokines and BDNF, may be associated with depressive disorder, but clinical biomarker tests for diagnosis and treatment prognosis are not yet available.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Mohammad Taheri, Mahsa Ghanbari
Summary: BDNF-AS is a long non-coding RNA that regulates the pathoetiology of neurodevelopmental diseases and is down-regulated in various cancers. It interacts with multiple factors and signaling pathways, with its down-regulation in prostate and breast cancers associated with poor prognosis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Psychology, Clinical
Leticia Pophal da Silva, Natalia Boneti Moreira, Andre Luiz Felix Rodacki
Summary: This study investigates the relationship between spatiotemporal gait parameters at different walking speeds and cognitive status in older adults. The results indicate that stride length, step time, and single support time can predict cognitive status, and longer stride lengths and faster step times are associated with better cognitive performance.
JOURNAL OF MENTAL HEALTH
(2023)
Article
Geriatrics & Gerontology
Alexandra Kautzky-Willer, Juergen Harreiter, Anita Thomas, Johannes Burger, Ulrich Schneeweiss, Carola Deischinger, Wolfhard Klein, Hermann Moser
Summary: Gender differences exist in poststroke neurorehabilitation outcomes, with women presenting worse functional status at admission but showing similar rehabilitation effectiveness as men. Early access to neurorehabilitation and gender-sensitive, personalized care could further improve outcomes.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Caroline C. Claus, Salka S. Staekenborg, Kim H. W. Verweij, Jacqueline Schuur, Sieberen P. van der Werf, Philip Scheltens, Jules J. Claus
Summary: The clock drawing test (CDT) is an important additional screening tool to the Mini Mental State Examination (MMSE). An abnormal CDT with a normal MMSE is an indicator for cognitive impairment, while an abnormal CDT in combination with an abnormal MMSE can be considered as an indicator of disease progression. The CDT significantly contributes to discriminating patients with subjective cognitive impairment (SCI) from both mild cognitive impairment (MCI) and Alzheimer's disease (AD).
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Ya-Chen Lee, Shu-Chun Lee, En-Chi Chiu
Summary: The study demonstrated that the practice effect could be minimized when alternate forms of the MMSE-2 were used. The MMSE-2 had good to excellent test-retest reliability, except for three subtests: visual-constructional ability, registration, and recall.
Article
Health Care Sciences & Services
Jie Wang, Zhuo Wang, Ning Liu, Caiyan Liu, Chenhui Mao, Liling Dong, Jie Li, Xinying Huang, Dan Lei, Shanshan Chu, Jianyong Wang, Jing Gao
Summary: This study optimized a cognitive assessment model through machine learning, which can be used for the diagnosis of MCI and dementia in patients with normal MMSE. It not only optimizes the content of cognitive evaluation, but also improves diagnosis accuracy and reduces missed diagnosis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Alma M. Bueno-Cayo, Minerva del Rio Carmona, Rosa Castell-Enguix, Isabel Iborra-Marmolejo, Mike Murphy, Tatiana Quarti Irigaray, Jose Francisco Cervera, Carmen Moret-Tatay
Summary: The study examines the relationship between language components and MMSE scores, finding that participants with higher MMSE scores have higher lexical density, longer speeches, and more tokens related to Time, Space and Action. These findings have potential significance in the screening of MCI.
BEHAVIORAL SCIENCES
(2022)
Article
Medicine, General & Internal
Pablo Gomez-Rubio, Isabel Trapero, Omar Cauli, Cristina Buigues
Summary: This study analyzed the relationship between frailty syndrome and IL-6 levels obtained from saliva tests. The results showed a significant positive correlation between salivary IL-6 concentration and frailty score, with significant differences observed for weight loss and low physical activity. Receiver operating characteristic curve analysis demonstrated that IL-6 concentration can potentially be used as a biomarker for monitoring the progression of frailty syndrome.
Article
Biochemistry & Molecular Biology
Javier Garcia-Sanchez, Mayra Alejandra Mafla-Espana, Maria Dolores Torregrosa, Omar Cauli
Summary: This study aimed to evaluate the relationship between gonadal hormone concentrations in blood and frailty syndrome, as well as whether these hormone concentrations could predict the progression of frailty syndrome. The results showed that high androstenedione levels and low follicle-stimulating hormone (FSH) levels were significantly associated with the worsening of frailty syndrome. These hormone concentrations could be potential biomarkers to predict the progression of frailty syndrome.
Article
Nursing
Silvia Corchon, Vanessa Sanchez-Martinez, Omar Cauli
Summary: The aim of this study was to explore the emotional experience and perceived mental health of experienced family caregivers of people with mental disorders. The findings revealed that emotions among caregivers included irritability, painful emotions, pressure, emotions oriented towards coping, and positive emotions. Perceived mental health encompassed anxiety, burden and exhaustion, need for psychological or psychiatric treatment, insomnia, and suicidal thoughts. The emotional trajectories of the participants shifted from negative emotions towards coping, culminating in positive emotions. The quantitative analysis partially replicated the qualitative findings.
ARCHIVES OF PSYCHIATRIC NURSING
(2022)
Article
Oncology
Javier Garcia-Sanchez, Mayra Alejandra Mafla-Espana, Maria Dolores Torregrosa, Omar Cauli
Summary: This study aimed to investigate the effects of AROi treatment on cognitive function, depressive symptoms, and sleep quality in postmenopausal women. The results showed that AROi treatment did not significantly worsen cognitive function after 6 months and 12 months, but there were significant increases in depressive symptoms and sleep disturbances.
Article
Nutrition & Dietetics
Rut Navarro-Martinez, Mayra Alejandra Mafla-Espana, Omar Cauli
Summary: Adherence to the Mediterranean diet is low among older individuals in a major Spanish city, and socio-family factors may play a role. Public health and governmental strategies should reinforce adherence to the Mediterranean diet among older individuals.
Article
Neurosciences
Lorenzo Brognara, Mayra Alejandra Mafla-Espana, Isabel Gil-Molina, Yolanda Castillo-Verdejo, Omar Cauli
Summary: Recent scientific evidence suggests that mechanical plantar stimulation can enhance functional connectivity in brain regions and improve gait and posture in older individuals. Acute plantar stimulation was found to have positive effects on various parameters, indicating the need for larger clinical trials to further investigate its efficacy.
Article
Nursing
Vanessa Ibanez-del Valle, Maria Luisa Ballestar-Tarin, Mayra Alejandra Mafla-Espana, Omar Cauli, Rut Navarro-Martinez
Summary: This study evaluated the relationship between insomnia and salivary IL-1 beta concentration in older individuals. It found a significant inverse correlation between IL-1 beta levels and insomnia symptoms. Factors such as depression, use of hypnotics, intake of caffeinated beverages, smoking, and alcohol use were also associated with insomnia in this population.
BIOLOGICAL RESEARCH FOR NURSING
(2023)
Article
Dermatology
Mar Sempere-Bigorra, Lorenzo Brognara, Ivan Julian-Rochina, Antonio Mazzotti, Omar Cauli
Summary: This study explores the potential usefulness of gait analysis parameters using a single sensor unit to detect peripheral neuropathy in diabetic patients with diabetic foot. The study finds significant correlations between impaired deep sensory pathways and gait impairments in diabetic patients, as well as significant correlations between all gait parameters and the superficial sensory pathway. The findings suggest that inertial sensors could be a useful tool for diagnosing gait alterations and evaluating treatment effects in diabetic patients to improve gait and reduce the risk of falls.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Health Care Sciences & Services
Mayra Alejandra Mafla-Espana, Maria Dolores Torregrosa, Omar Cauli
Summary: Most elderly patients with metastatic prostate cancer should undergo a comprehensive geriatric assessment (CGA) to identify frailty syndrome, which is crucial for clinical decisions. Frailty is associated with lower quality of life and can affect the feasibility and side effects of treatments. Evaluation of frailty syndrome should be considered in clinical decision-making and when selecting the most appropriate active treatment for increased survival.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Mayra Alejandra Mafla-Espana, Maria Dolores Torregrosa, Manel Beamud-Cortes, Lorena Bermell-Marco, Jose Rubio-Briones, Omar Cauli
Summary: Prostate cancer is highly prevalent in males and is associated with frailty symptoms, including decreased gait speed and muscle strength, and increased insomnia symptoms, in patients undergoing androgen-deprivation therapy. Interventions should be implemented to address these issues and improve patient outcomes and quality of life.
Article
Geriatrics & Gerontology
Cristina Buigues, Olga Theou, Rosa Fonfria-Vivas, Francisco M. Martinez-Arnau, Kenneth Rockwood, Omar Cauli
Summary: Sarcopenia and frailty are common age-related conditions. This study investigated whether supplementation of leucine, an essential amino acid, could reduce frailty in older institutionalized individuals. The results showed that leucine did not significantly modify the frailty index in this population.
Article
Nutrition & Dietetics
Vanessa Ibanez-del Valle, Rut Navarro-Martinez, Omar Cauli
Summary: With university admission, there are major changes in students' daily habits that can lead to mental health problems. Adherence to a healthy diet, such as the Mediterranean diet, can be very beneficial for mental health. This study found that poor adherence to the Mediterranean diet was significantly associated with depressive symptoms among Spanish nursing students, highlighting the importance of prevention programs focused on health and mental health issues in universities.
Article
Biology
Mar Sempere-Bigorra, Ivan Julian-Rochina, Pilar Perez-Ros, Emmanuel Navarro-Flores, Francisco Miguel Martinez-Arnau, Omar Cauli
Summary: Aging and diabetes both contribute to neurological damage, and this study explores the relationships between peripheral sensory system decline and cognitive functions, symptoms of depression, and quality of life in older adults. The findings suggest that superficial sensitivity damage is related to cognitive impairment, while deep sensation alterations are related to depression and poor quality of life, with diabetes further strengthening these relationships.
Article
Biochemistry & Molecular Biology
Mayra Alejandra Mafla-Espana, Maria Dolores Torregrosa, Manel Beamud-Cortes, Lorena Bermell-Marco, Jose Rubio-Briones, Omar Cauli
Summary: This study investigated the association between blood androgen concentrations and functional status and psychological alterations in prostate cancer patients receiving androgen deprivation therapy. The results showed a significant correlation between high concentrations of androstenedione and frailty syndrome, as well as a relationship between androstenedione levels and decreased gait speed.
Article
Medicine, Research & Experimental
Vanessa Ibanez-del Valle, Mayra Alejandra Mafla-Espana, Josep Silva, Omar Cauli, Alessandra Stacchiotti
Summary: Sleep disorders are common in older individuals, especially in those who are institutionalized. They are often comorbid with medical and neuro-psychiatric illnesses and associated with polypharmacy. This study found a significant correlation between salivary IL-6 and sleep parameters, with lower salivary IL-6 levels associated with worse sleep efficiency and more night awakenings. Actigraphy also detected alterations in sleep patterns in individuals with dementia. These results are important for future research and interventions aimed at improving sleep quality in institutionalized individuals.
