Article
Biochemistry & Molecular Biology
Ivana Smoljan, Dijana Detel, Suncica Buljevic, Igor Erjavec, Ivana Maric
Summary: This study found that systemic administration of BMP7 can reduce the adverse effects of chronic colitis by suppressing the inflammatory response and triggering changes in the cytokine balance and RANKL/OPG system. Additionally, BMP7 has therapeutic potential in managing osteoporosis in chronic colitis and should be further evaluated for the treatment of IBD.
Review
Cell Biology
Luodan Zhang, Fa Zeng, Minmin Jiang, Maozhen Han, Binbin Huang
Summary: This article reviews the potential role and therapeutic potential of osteoprotegerin in endocrine and metabolic diseases. It mainly focuses on the effects of osteoprotegerin through the RANKL/RANK/OPG system on various processes such as bone remodeling, vascular calcification, and beta-cell proliferation, providing a comprehensive understanding of osteoprotegerin as a potential drug for these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yongchao Zhao, Guoxi Shao, Xingang Liu, Zhengwei Li
Summary: This review comprehensively summarizes the current understanding of melatonin's regulation of bone metabolism, including its effects on mesenchymal stem cells and bone cells to promote bone formation and inhibit bone resorption. Experimental studies and clinical trials have shown that melatonin has a protective effect against osteoporosis and may be a potential novel therapy for this condition.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Rheumatology
Kenneth G. Saag, Michele T. McDermott, Jonathan Adachi, Willem Lems, Nancy E. Lane, Piet Geusens, Robert Kees Stad, Li Chen, Shuang Huang, Robin Dore, Stanley Cohen
Summary: A study on RA patients receiving glucocorticoid treatment showed that discontinuation of denosumab resulted in an increase in bone turnover and a return to baseline lumbar spine and total hip BMD.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ewa Tomaszewska, Halyna Rudyk, Izabela Swietlicka, Monika Hulas-Stasiak, Janine Donaldson, Marta Arczewska, Siemowit Muszynski, Piotr Dobrowolski, Iwona Puzio, Volodymyr Kushnir, Oksana Brezvyn, Viktor Muzyka, Ihor Kotsyumbas
Summary: The study revealed that exposure of pregnant dams to fumonisins can lead to negative effects on offspring bone metabolism and properties, with impacts depending on dose and sex. Effects were observed in body weight, bone length, and bone mechanical resistance, all linked to alterations in bone metabolism proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Zhihao Chen, Karthik Rajan Rajamanickam, Mina Ding, Sang Kyoon Kim, Sang-wook Park, Eunae Kim, Sunwoo Lee, Tae-Hoon Lee
Summary: In this study, we discovered a potent candidate, PMSA derivative 11, for suppressing mature osteoclasts formation in vitro through a TRAP staining assay. The bioactivity of PMSA derivatives was evaluated and 11 showed the most promising bioactivity, with an IC50 value of 322.9 nM, which was 15-fold better than PMSA-3-Ac. Mechanistically, 11 decreased the expression of genes required for osteoclastogenesis by blocking NFATc1 translocation. In vivo investigation demonstrated that 11 prevented excessive osteoclastogenesis-mediated bone loss in ovariectomized osteoporosis mimic mice. These findings highlight the therapeutic potential of 11 as a lead compound for anti-osteoporosis by targeting NFATc1 translocation.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Qian Lu, Chao Jiang, Jialong Hou, Hao Qian, Feifan Chu, Weiqi Zhang, Mengke Ye, Ziyi Chen, Jian Liu, Hanbing Yao, Jianfeng Zhang, Jiake Xu, Te Wang, Shunwu Fan, Qingqing Wang
Summary: The incidence of osteoporosis is increasing, especially in postmenopausal women. Patchouli alcohol (PA), a natural compound with anti-inflammatory effects, has shown inhibitory effects on osteoclasts and may be a potential treatment for osteoporosis in the future.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Ayumu Takeshita, Keiichiro Nishida, Aki Yoshida, Yoshihisa Nasu, Ryuichi Nakahara, Daisuke Kaneda, Hideki Ohashi, Toshifumi Ozaki
Summary: The study found that RANKL expression is higher in cartilage of RA patients and correlated with cartilage degeneration. LT-alpha stimulates human chondrocytes to produce RANKL and promote osteoclastic differentiation of PBMCs. This suggests that RANKL may contribute to cartilage destruction during RA and LT-alpha could promote its expression in human chondrocytes.
Article
Endocrinology & Metabolism
Michael Frech, Gregor Schuster, Fabian T. Andes, Georg Schett, Mario M. Zaiss, Kerstin Sarter
Summary: The study revealed the involvement of the immunomodulatory molecule Btn2a2 in osteoclast differentiation and function, with potential implications in bone homeostasis. Btn2a2 deficiency led to abnormal osteoclast function and numbers, affecting bone architecture.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Anita J. W. M. Brouns, Lizza E. L. Hendriks, Iris J. Robbesom-van den Berge, Annemariek J. H. M. Driessen, Guido M. J. M. Roemen, Britt L. . J. van Herpen, Zoe Dekkers, Bas Heitzer, Daphne J. G. Leunissen, Laura Moonen, Ragnar Lunde, Marcel Westenend, Marjolein van Driel, Ernst-Jan M. Speel, Anne-Marie C. Dingemans
Summary: Bone metastases are common in NSCLC patients and are associated with increased RANKL gene expression and RANKL/OPG gene ratio.
FRONTIERS IN ONCOLOGY
(2023)
Article
Orthopedics
Joseph H. Choi, Zhiwei Wang, Frederick P. Ross, Marjolein C. H. van der Meulen, Mathias P. G. Bostrom
Summary: The study found that OPG does not enhance osseointegration and may have detrimental effects, particularly at high doses.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kerstin M. Galler, Eva-Maria Gratz, Matthias Widbiller, Wolfgang Buchalla, Helge Knuttel
Summary: This scoping review systematically explores the cellular and molecular processes of trauma-associated root resorption, revealing a lack of discussion on the pathophysiological mechanisms in the literature. Further research is needed to address these gaps.
Article
Pharmacology & Pharmacy
Huijiang Liu, Ronghe Gu, Qian Huang, Yun Liu, Chong Liu, Shijie Liao, Wenyu Feng, Tianyu Xie, Jinmin Zhao, Jiake Xu, Qian Liu, Xinli Zhan
Summary: This study found that isoliensinine can inhibit the differentiation of osteoclasts and reduce bone loss, showing great potential for treating osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ragaa H. M. Salama, Safaa S. Ali, Tarek Hamdy M. Salama, Mohamed Abu Almged, Tasneem A. Alsanory, Aya A. Alsanory, Hesham Aboutaleb, Ghada M. Ezzat
Summary: This study evaluated the effects of nanopowder eggshell (NPES) on healthy and ovariectomy-induced osteoporosis rats. The results showed that NPES increased biomarkers of bone formation and bone trace elements, and alleviated osteoporosis.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Amirhossein Jafariandehkordi, Alireza Daneshmehr
Summary: This study aims to investigate the effects of chemical factors on bone biological activities and mechanical properties, and assess the possibility of bone injury under uniform mastication pressure in the presence of these chemical factors. The results showed that RANKL and PTH increased the risk of bone injury, while OPG protected the bone from injury.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Oncology
Rajiv Agarwal, Paul Shin, Andrea Knezevic, Judith E. Nelson, Danielle R. Romano, Camila Bernal, Anjali Desai, Andrew S. Epstein
Summary: This study assessed the accuracy of cure expectations in gastrointestinal cancer patients and found that inaccurate expectations were prevalent across all stages of the disease, particularly in those with metastatic or unresectable cancer. The accuracy was lower in advanced stages and higher in early-stage patients who received adjuvant chemotherapy. Hospitalization and location of death also had an impact on accuracy.
Article
Immunology
Markella Zanni, Borek Foldyna, Sara McCallum, Tricia H. Burdo, Sara E. Looby, Kathleen Fitch, Evelynne S. Fulda, Patrick Autissier, Gerald S. Bloomfield, Carlos D. Malvestutto, Carl J. Fichtenbaum, Edgar T. Overton, Judith A. Aberg, Kristine M. Erlandson, Thomas B. Campbell, Grant B. Ellsworth, Anandi N. Sheth, Babafemi Taiwo, Judith S. Currier, Udo Hoffmann, Michael T. Lu, Pamela S. Douglas, Heather J. Ribaudo, Steven K. Grinspoon
Summary: Among people with HIV in the United States, females have a lower prevalence of coronary plaque, specifically noncalcified or vulnerable plaque, compared to males. Additionally, there are differences in immune and inflammatory biomarkers between males and females.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Rheumatology
Arezou Khosroshahi, David Tong, Gaobin Bao, Jinan Al-Naqeeb, Pranab Ghosh, Elena Peeva, Kirk A. Easley, Roberta Weiss, S. Sam Lim
Summary: A retrospective cohort study was conducted in a predominantly Black population with lupus nephritis to estimate the incidence and risk factors of complete response (CR) according to modified Aspreva Lupus Management Study and modified Belimumab International Study in Lupus Nephritis criteria by 12 months. The results showed that the incidence of mALMS CR was 20.6% and mBLISS CR was 33.7%. Factors associated with mBLISS CR included commercial insurance, albumin levels, and low C4 levels. Despite similar CR rates at 12 months, the incidence of end-stage renal disease and death in this primarily Black and uninsured population exceeded those observed in controlled clinical trials with placebo arms.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Immunology
Ayako Wendy Fujita, Nora Loughry, DeLante E. Moore, Andrea E. Carter, Sophia A. Hussen, Hannah Cooper, Jonathan A. Colasanti, Anandi N. Sheth
Summary: This study found a very low prevalence and uneven geographic distribution of infectious diseases physicians with buprenorphine waivers. There is an urgent need to increase the number of infectious diseases physicians who are waivered to prescribe buprenorphine and to integrate opioid use disorder education into infectious diseases training and continuing medical education.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Sophia A. Hussen, Kamini Doraivelu, Madeleine H. Goldstein, Neeta Shenvi, Kirk A. Easley, Brian C. Zanoni, Andres Camacho-Gonzalez, Carlos del Rio
Summary: This prospective study aimed to assess healthcare outcomes for HIV patients during the transition from pediatric to adult care. The study found that while most patients successfully linked to adult care, retention rates declined over the 24-month follow-up period. The proportion of patients with viral suppression remained relatively stable in adult care.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Obstetrics & Gynecology
Carolynn M. Dude, Naima T. Joseph, Alexandra D. Forrest, Hans P. Verkerke, Narayanaiah Cheedarla, Sakthivel Govindaraj, Les'Shon S. Irby, Kirk A. Easley, Alicia K. Smith, Sean R. Stowell, Andrew Neish, Rama Rao Amara, Denise J. Jamieson, Anne L. Dunlop, Martina L. Badell, Vijayakumar Velu
Summary: This study explored the immune response following COVID-19 vaccination in pregnant women. The results showed that vaccinated pregnant women had higher levels of antibodies and transfer ratios compared to those who were naturally infected. However, antibody levels declined as time from vaccination to delivery increased.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Transplantation
Aileen C. Johnson, Geeta M. Karadkhele, Neeta Shenvi, Kirk A. Easley, Christian P. Larsen, I. Raul Badell
Summary: This study aimed to determine whether belatacept given every 2 months (q2m) is noninferior to the standard monthly (q1m) maintenance. The results showed that there were no significant differences in renal graft function and adverse events between the two groups of kidney transplant recipients. Therefore, q2m belatacept may be a potentially viable maintenance immunosuppressive strategy in low immunologic risk patients.
TRANSPLANTATION DIRECT
(2023)
Article
Oncology
Ritesh R. Kotecha, Andrea Knezevic, Kanika Arora, Chaitanya Bandlamudi, Fengshen Kuo, Maria I. Carlo, Kelly N. Fitzgerald, Darren R. Feldman, Neil J. Shah, Ed Reznik, A. Ari Hakimi, Jian Carrot-Zhang, Diana Mandelker, Michael Berger, Chung-Han Lee, Robert J. Motzer, Martin H. Voss
Summary: This study examines the differences in clinical and molecular data among different genetic ancestry groups in patients with renal cell carcinoma (RCC). The findings suggest that genetic ancestry may contribute to variations in clinical and molecular characteristics of RCC, and significant differences were identified in angiogenesis and inflammatory pathways. This study highlights the importance of exploring both genetic and nongenetic variables in order to reduce health-related disparities.
Article
Oncology
Samuel A. Funt, Andrea Knezevic, Kaamilah Wilson, Maria Bromberg, Amy Budnick, Kerri L. O'Connor, Deaglan J. Mchugh, Erik Larsen, Dean F. Bajorin, Robert J. Motzer, Emily S. Tonorezos, Sujata Patil, Darren R. Feldman
Summary: This study confirms the hearing impairment caused by high-dose carboplatin in GCT patients, with most patients experiencing moderate to profound HL in the speech frequencies.
Article
Biochemistry & Molecular Biology
Ken Mautner, Michael Gottschalk, Scott D. Boden, Alison Akard, Won C. Bae, Lora Black, Blake Boggess, Paramita Chatterjee, Christine B. Chung, Kirk A. Easley, Greg Gibson, Josh Hackel, Katie Jensen, Linda Kippner, Chad Kurtenbach, Joanne Kurtzberg, R. Amadeus Mason, Benjamin Noonan, Krishnendu Roy, Verle Valentine, Carolyn Yeago, Hicham Drissi
Summary: This study compared the safety and efficacy of various cellular injections to corticosteroid injections for knee osteoarthritis. The results showed that none of the orthobiologic injections were superior to corticosteroid injection in terms of pain outcomes at 1 year post treatment.
Article
Nutrition & Dietetics
Tanicia Daley, Benjamin Cousineau, Paula-Dene Nesbeth, Elizabeth Ivie, Moriah Bellissimo, Kirk Easley, Priyathama Vellanki, Miriam Vos, William Hunt, Arlene Stecenko, Thomas Ziegler, Jessica Alvarez
Summary: This study aimed to investigate the relationship between dietary macronutrient quality and glucose homeostasis in adults with cystic fibrosis (CF). The results showed that individuals with cystic fibrosis-related diabetes (CFRD) consumed less total fat and monounsaturated fatty acids (MUFA), and higher unsaturated dietary fat, higher plant protein, and higher carbohydrate quality were associated with better glucose tolerance indicators in adults with CF.
FRONTIERS IN NUTRITION
(2023)
Article
Clinical Neurology
Cathrin M. Buetefisch, Marc W. Haut, Kate P. Revill, Scott Shaeffer, Lauren Edwards, Deborah A. Barany, Samir R. Belagaje, Fadi Nahab, Neeta Shenvi, Kirk Easley
Summary: After stroke, the damaged brain cortex and corticospinal tract undergo reorganization, and the extent of reorganization is related to the impaired hand function. This study found that the size of the lesion and the extent of damage to the corticospinal tract determine the extent of reorganization, and severe hand impairment is associated with larger lesion size and higher lesion load.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Meeting Abstract
Oncology
Darren R. Feldman, Robert J. Motzer, Andrea Knezevic, Chung-Han Lee, Martin H. Voss, Serge K. Lyashchenko, Hijin Park, Steven M. Larson, Neeta Pandit-Taskar
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Kelly N. Fitzgerald, Cihan Duzgol, Andrea Knezevic, Natalie Shapnik, Ritesh R. Kotecha, David H. Aggen, Maria Isabel Carlo, Neil J. Shah, Martin H. Voss, Darren R. Feldman, Robert J. Motzer, Chung-Han Lee
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Meeting Abstract
Immunology
M. Y. H. Lee, G. Li, J. Ma, R. Mopuri, K. A. Karunakaran, T. Ton, S. A. Lapp, A. M. Metz, K. Engelman, S. Liang, M. C. Lin, K. A. Easley, V. Govindu, A. D. Silva Trenkle, K. Gill, E. A. Mahar, N. Schoof, K. Pellegrini, M. Mavigner, G. A. Kwong, D. Magnani, J. D. Altman, A. Chahroudi, L. Su, R. R. Amara, S. E. Bosinger
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2023)