Article
Agronomy
Qin Lu, Yan Li, Jing Liao, Zhaohong Ni, Shunchao Xia, Maofa Yang, Haiyin Li, Jianjun Guo
Summary: This study investigated the role of histone H3 acetylation in diapause of the cotton bollworm and found that it is closely related to pupal diapause, suggesting its potential as a target for pest control.
PEST MANAGEMENT SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Xiao-Shuai ZHANG, Xiao-Long SU, Shao-Lei GENG, Zheng-Hao WANG
Summary: Diapause is an important strategy for insects to survive extreme environments. In this study, it was found that mitochondrial ROS play a crucial role in diapause by regulating insulin signaling pathway. Injection of a glucose metabolism inhibitor could delay pupal development, while injection of a metabolite mixture could prevent diapause. Furthermore, ROS could activate HSP60 expression, promoting the degradation of mitochondrial transcription factor A and decreasing mitochondrial activity.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2022)
Article
Entomology
Xinxin Gao, Jihong Zhang, Qilian Qin, Peipei Wu, Huan Zhang, Qian Meng
Summary: Energy metabolism is crucial in insect metamorphosis, particularly in the larval-pupal stage of holometabolous insects. In this study, metabolome and transcriptome analyses were conducted to elucidate the metabolic changes and regulatory mechanisms during larval-pupal metamorphosis of the cotton bollworm, Helicoverpa armigera. The findings revealed that aerobic glycolysis supported cell proliferation and lipid synthesis during the feeding stage, while triglyceride degradation and acylcarnitine accumulation were activated during non-feeding stages. This study provides valuable insights into the metabolic regulation mechanism of lepidopteran larvae during their final stage of development.
Article
Entomology
Haiyin Li, Qin Lu, Yan Li, Yufang Yan, Zhiyong Yin, Jianjun Guo, Weihua Xu
Summary: The E3 ubiquitin ligase Smurf was found to be involved in diapause regulation in Helicoverpa armigera by modulating the TGF-beta signaling pathway. The ubiquitination of TGF beta RI and Smad2 by Smurf plays a crucial role in pupal development during diapause.
Article
Biochemistry & Molecular Biology
X. W. Lin, Z. Z. Fan, Y. H. Liu, J. Li, Q. Ma, R. H. Yan
Summary: The study reveals that reactive oxygen species activate MEK/ERK signaling pathway, leading to the maintenance of diapause state. Inhibiting MEK/ERK activity can terminate the progress of diapause.
INSECT MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhiqiang Tian, Lin Zhu, J. P. Michaud, Meng Zha, Jie Cheng, Zhongjian Shen, Xiaoming Liu, Xiaoxia Liu
Summary: Baculoviruses genetically reprogram their host insects to create a suitable environment for virus replication. In this study, infected larvae of Helicoverpa armigera showed an accumulation of glucose in the midgut, which altered metabolism and immunity. The insulin signalling pathway played a crucial role in regulating the virus infection process. Dietary restriction reduced mortality and viral replication, while glucose supplementation had the opposite effects. This research highlights the importance of metabolic reprogramming and immune suppression in successful baculovirus infections.
Article
Food Science & Technology
Meng Gu, Zhaoxiang Xue, Shenglan Lv, Yuhao Cai, Lei Zhang, Xiwu Gao
Summary: The cotton bollworm is a global noctuid pest that can harm various crops, with its adaptation to the allelochemical 2-tridecanone possibly related to its symbiotic bacteria.
Article
Biotechnology & Applied Microbiology
Wenli Zhao, Bo Zhang, Zichen Geng, Yanpeng Chang, Jizhen Wei, Shiheng An
Summary: This study investigated the function and molecular mechanism of GAPDH in larval metamorphosis in Helicoverpa armigera and Spodoptera frugiperda. The results showed that GAPDH controls glucose content to ensure glucose metabolism and metamorphosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shao-Lei Geng, Hai-Yin Li, Xiao-Shuai Zhang, Tao Wang, Shi-Pei Zhou, Wei-Hua Xu
Summary: This study found that diapause-destined pupae of the moth Helicoverpa armigera have higher levels of protein carbonylation in the brain compared to nondiapause-destined pupae. The study also showed that ROS activate Akt, which phosphorylates CREB and facilitates its nuclear import, leading to the regulation of CBR1 expression and reduction of protein carbonyl levels.
Article
Biochemistry & Molecular Biology
Yang Cheng, Tengfei Lu, Junliang Guo, Zhe Lin, Qiao Jin, Xiaoming Zhang, Zhen Zou
Summary: Insect hormones and microRNAs play a role in regulating lipid metabolism, and it has been discovered that juvenile hormone can regulate lipid synthesis by modulating miR-2055 levels. These findings provide new insights into the regulatory mechanisms of metabolism in insects.
Article
Agronomy
Danielly A. M. Rios, Alexandre Specht, Vania F. Roque-Specht, Daniel R. Sosa-Gomez, Julia Fochezato, Juaci Malaquias, Gislene L. Goncalves, Gilson R. P. Moreira
Summary: Hybridization between Helicoverpa armigera and H. zea was investigated, with heterosis observed during immature development. However, reproductive incompatibilities were also found between parental species and subsequent hybrids. Interspecific gene flow and introgression events were confirmed, suggesting the need to monitor hybridization and resistance to pesticides. Management strategies should be implemented to prevent interspecific crosses and minimize the selection of resistant individuals.
PEST MANAGEMENT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yu Shi, Qianqian Jiang, Yihua Yang, Rene Feyereisen, Yidong Wu
Summary: P450s of the CYP6B and CYP9A subfamilies in Lepidopteran insects are crucial for host plant adaptation and insecticide resistance, with many paralogs and orthologs being identified in recent genome projects. Functional assays on these enzymes in the generalist herbivore, Helicoverpa armigera, revealed their ability to efficiently metabolize esfenvalerate. The diversity and redundancy of these genes challenge resistance management and pest control strategies.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kai Tian, Jing Feng, Jiang Zhu, Jiagao Cheng, Mei Li, Xinghui Qiu
Summary: The study found that three paralogous CYP9As were capable of metabolizing multiple pyrethroids, with a greater efficiency in transforming pyrethrin-resembling pyrethroids. These results support the hypothesis that herbivorous insects can cope with synthetic insecticides through their physiological systems.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Entomology
Sali Li, Zhichao Cao, Yuhong Wu, Rui Tang, Shaolei Sun, Zhen Yang, Tong-Xian Liu, Xiangfeng Jing
Summary: This study focused on the function of DGAT1 in Helicoverpa armigera and found that DGAT1 played important roles in triglyceride synthesis in the midgut and ovaries, as well as in reproduction. This work provides valuable information for understanding lipid metabolism in insects.
ENTOMOLOGIA GENERALIS
(2022)
Article
Food Science & Technology
Zhongyuan Deng, Yuting Zhang, Liying Fang, Min Zhang, Lixiang Wang, Xinzhi Ni, Xianchun Li
Summary: This study reveals the role of flavone in plant defense against pests and identifies differentially expressed genes and their associated cis-regulatory elements. The findings provide insights into the interaction between plants and herbivorous insects.
Article
Biochemistry & Molecular Biology
Hai-Yin Li, Xian-Wu Lin, Shao-Lei Geng, Wei-Hua Xu
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Zhe Song, Yong-Pan Yang, Wei-Hua Xu
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2018)
Article
Cell Biology
Jiangbo Jin, Zhuo Lu, Xiaomei Wang, Yufeng Liu, Tianyu Han, Yanan Wang, Tao Wang, Mingxi Gan, Caifeng Xie, Jianbin Wang, Bentong Yu
CELLULAR SIGNALLING
(2020)
Article
Biochemistry & Molecular Biology
Xiao-Xue Wang, Shao-Lei Geng, Xiao-Shuai Zhang, Wei-Hua Xu
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Shao-Lei Geng, Xiao-Shuai Zhang, Wei-Hua Xu
Summary: The study found that changes in mitochondrial ROS levels and COXIV expression can affect diapause occurrence and pupal lifespan in Helicoverpa armigera. PKA and TFAM are also involved in this process, and G6PD activity plays a crucial role in maintaining ROS levels.
Article
Cell Biology
Tianyu Han, Pengcheng Wang, Yanan Wang, Wenze Xun, Jiapeng Lei, Tao Wang, Zhuo Lu, Mingxi Gan, Wei Zhang, Bentong Yu, Jian-Bin Wang
Summary: The research uncovered that FAIM promotes tetramer formation of GAC and stabilizes GAC by modulating the MTOR pathway, leading to increased production of alpha-ketoglutarate. Furthermore, FAIM inhibits autophagy induction, thereby furthering the development of lung adenocarcinoma.
Article
Ophthalmology
Dan Xu, Kun Zhang, Xin-Hui Qu, Tao Wang, Ping Yang, Yun Yang, Li -Ping Jiang, Yu-Ying Wan, Fang-Fang Tou, Zhi-Ping Chen, Xiao-Jian Han
Summary: Curcumin protects retinal neuronal cells against oxidative stress-induced injury by promoting mitochondrial fusion.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Tao Wang, Zhuo Lu, Xin-Hui Qu, Zi-Ying Xiong, Ya-Ting Wu, Yong Luo, Zi-Yu Zhang, Xiao-Jian Han, Cai-Feng Xie
Summary: This study evaluates the protective effect of chrysophanol-8-O-glucoside (CPOG) on lipopolysaccharide (LPS)/D-GalN-induced acute liver failure (ALF) and demonstrates that it inhibits oxidative stress, inflammation response, and autophagy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhuo Lu, Gui-Feng Sun, Xiao-An Pan, Xin-Hui Qu, Ping Yang, Zhi-Ping Chen, Xiao-Jian Han, Tao Wang
Summary: This study investigates the role of branched chain amino acid (BCAA) metabolism in the development of nonalcoholic fatty liver disease (NAFLD) and the potential protective effect of BCATc Inhibitor 2. The results show that supplementation of BCAAs exacerbates lipid accumulation and apoptosis, while treatment with BCATc Inhibitor 2 ameliorates these damages. Molecularly, BCATc Inhibitor 2 regulates the expression of genes related to lipogenesis and maintains mitochondrial function. Additionally, BCATc Inhibitor 2 treatment inhibits the activation of several signaling pathways associated with apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Yi-Yi Xiao, Jin-Xing Xiao, Xiao-Yu Wang, Tao Wang, Xin-Hui Qu, Li-Ping Jiang, Fang-Fang Tou, Zhi-Ping Chen, Xiao-Jian Han
Summary: This study investigated the mechanism of metformin-induced cisplatin resistance in gastric cancer (GC). The results showed that metformin increased mitochondrial fission and mitophagy, leading to decreased ATP production and protection against cisplatin cytotoxicity in GC cells. Inhibition of autophagy alleviated the protective effect of metformin. Furthermore, metformin activated AMPK signaling and increased the expression of mitophagy markers. Therefore, metformin-induced AMPK activation and PINK1/Parkin-dependent mitophagy may play a crucial role in the development of cisplatin resistance in GC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shao-Lei Geng, Hai-Yin Li, Xiao-Shuai Zhang, Tao Wang, Shi-Pei Zhou, Wei-Hua Xu
Summary: This study found that diapause-destined pupae of the moth Helicoverpa armigera have higher levels of protein carbonylation in the brain compared to nondiapause-destined pupae. The study also showed that ROS activate Akt, which phosphorylates CREB and facilitates its nuclear import, leading to the regulation of CBR1 expression and reduction of protein carbonyl levels.
Article
Biochemistry & Molecular Biology
Guang-Ping Zou, Tao Wang, Jin-Xing Xiao, Xiao-Yu Wang, Li-Ping Jiang, Fang-Fang Tou, Zhi-Ping Chen, Xin-Hui Qu, Xiao-Jian Han
Summary: Age-related macular degeneration, a common cause of blindness in the elderly, is primarily attributed to oxidative stress and dysregulated autophagy in retinal pigment epithelium cells. Lactate has been found to act as a signaling molecule that protects against oxidative stress. This study aimed to investigate the protective effect of lactate against oxidative stress-induced retinal degeneration. The results showed that lactate alleviated oxidative stress-induced cell death and retinal degeneration by activating autophagy and preserving mitochondrial function.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tao Wang, Zhuo Lu, Tianyu Han, Yanan Wang, Mingxi Gan, Jian-Bin Wang
Summary: This study reveals a novel mechanism of GAC regulation through acetylation and ubiquitination in non-small cell lung cancer, suggesting that targeting this pathway could be a promising strategy for cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)