期刊
AGING CELL
卷 17, 期 3, 页码 -出版社
WILEY
DOI: 10.1111/acel.12746
关键词
ageing; aging; caloric restriction; cellular senescence; SASP
资金
- National Center for Research Resources [UL1 RR024992]
- National Natural Science Foundation of China [91649108]
- Biotechnology and Biological Sciences Research Council [G009953/1]
- Bakewell Foundation
- Longer Life Foundation
- BBSRC [BB/G009953/1, BB/J020028/1] Funding Source: UKRI
Calorie restriction (CR) is an effective strategy to delay the onset and progression of aging phenotypes in a variety of organisms. Several molecular players are involved in the anti-aging effects of CR, but mechanisms of regulation are poorly understood. Cellular senescence-a cellular state of irreversible growth arrest-is considered a basic mechanism of aging. Senescent cells accumulate with age and promote a number of age-related pathologies. Whether environmental conditions such as diet affect the accumulation of cellular senescence with age is still unclear. Here, we show that a number of classical transcriptomic markers of senescent cells are reduced in adult but relatively young mice under CR. Moreover, we demonstrate that such senescence markers are not induced in the colon of middle-age human volunteers under CR in comparison with age-matched volunteers consuming normal Western diets. Our data support the idea that the improvement in health span observed in different organisms under CR might be partly due to a reduction in the number of senescent cells.
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