期刊
EXPERIMENTAL BIOLOGY AND MEDICINE
卷 240, 期 6, 页码 718-724出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370215583802
关键词
Vascular endothelial growth factor-C; autocrine; cancer stem cells; drug resistance; lymphangiogenesis; immunomodulation
资金
- Ministry of Sciences and Technology, Taiwan [MOST 103-2321-B-006-020-MY3]
- National Research Program for Biopharmaceuticals [NSC 101-2325-B-006-017]
- National Health Research Institute [NHRI-EX-102-10244BI]
- Top University grant of National Cheng Kung University [D103-35A17]
It has been shown in many clinical studies that the level of vascular endothelial growth factor-C (VEGF-C) positively correlates with lymph node metastasis. Nevertheless, beyond the canonical role of VEGF-C in stimulating lymphangiogenesis and thus promoting lymph node/distant metastasis, emerging evidence indicates that expression of VEGF-C contributes to various aspects of carcinogenicity via autocrine regulation. The newly identified functions of VEGF-C include but are not limited to proliferation, migration, invasion, and chemo-resistance. Besides tumor cell autocrine regulation, VEGF-C can also modulate the immune system such that tumor cells more easily escape immune surveillance. Therefore, understanding the functional roles and regulatory mechanisms related to the VEGF-C axis may lead to alternative strategies for cancer treatment. This mini-review will focus on summarizing recent discoveries regarding the unconventional functions of VEGF-C in cancer progression.
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