Review
Chemistry, Multidisciplinary
Yanan Wang, Chunhui Wang, Keyang Li, Xinyu Song, Xuefeng Yan, Liangmin Yu, Zhiyu He
Summary: This review comprehensively summarizes the application of nanomedicine in the diagnosis and monitoring of diabetes, emphasizing its potential in managing diabetes and complications, as well as its effectiveness in improving the quality of life for diabetic patients. Several critical issues regarding the application of nanomedicine-based strategies need to be addressed to ensure stability, long-term safety effects, and standard formulation administration in vivo.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Medicine, Research & Experimental
Mahsa Bagheri, Cornelus F. van Nostrum, Robbert Jan Kok, Gert Storm, Wim E. Hennink, Michal Heger
Summary: This review investigates whether intravenous nanoformulations of curcumin improve its pharmacokinetics and whether improved pharmacokinetics leads to greater therapeutic efficacy. The study found that nanoencapsulation generally improved curcumin's pharmacokinetics, but the correlation between pharmacokinetics and pharmacodynamics was not significant.
MOLECULAR PHARMACEUTICS
(2022)
Article
Instruments & Instrumentation
Rosario Pignatello, Roberta Corsaro, Angela Bonaccorso, Elide Zingale, Claudia Carbone, Teresa Musumeci
Summary: This study characterized Soluplus(R) nanomicelles to enhance the apparent solubility of drugs in BCS class II. The prepared nanomicelles showed small and stable particle size and could be easily filtered. The freeze-dried powder materials maintained the micelle size upon reconstitution. Additionally, the nanomicelles demonstrated potential applications in topical ocular administration.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Roya Karimi Alavijeh, Kamran Akhbari, Jonathan M. White
Summary: A new nano bio-coordination polymer was synthesized using ultrasonic irradiation in water, which exhibited reversible structure changes under wet conditions. This polymer, named bio-CP 2, was thermodynamically stable and capable of improving the solubility of curcumin. Experimental results showed that loading curcumin onto bio-CP 2 enhanced its cytotoxicity, leading to increased apoptosis in cancer cells.
Review
Pharmacology & Pharmacy
Anas Ahmad, Mohammad Imran, Nisha Sharma
Summary: The assessment of human and environmental risks of nanoparticulate material is crucial and requires the development of scientific tools and techniques. Challenges exist in toxicology assessment and regulatory guidance for nanocarriers. Nanotoxicology plays a significant role in pharmaceutical drug development and commercialization potential.
Article
Chemistry, Multidisciplinary
W. Chen, P. Liu
Summary: Researchers have successfully developed a novel dendritic polyurethane-based prodrug using ultrasound technology, which enables precise localized drug delivery. The prodrug exhibits excellent pH/ultrasound dual-triggered drug release performance and demonstrates enhanced inhibition of tumor growth under ultrasound stimulation.
MATERIALS TODAY CHEMISTRY
(2022)
Review
Polymer Science
Azeez Yusuf, Awatif Rashed Z. Almotairy, Hanan Henidi, Ohoud Y. Alshehri, Mohammed S. Aldughaim
Summary: Nanotechnology has experienced rapid development in the past four decades and has revolutionized various aspects of everyday life. It has had significant impacts on fields like medicine and food industry, leading to improvements in shelf life of food, drug delivery, and development of specific therapeutics.
Article
Chemistry, Multidisciplinary
Jolinde van Strien, Oscar Escalona-Rayo, Wim Jiskoot, Bram Slutter, Alexander Kros
Summary: ELP-based nanomaterials, particularly micelles assembled from amphiphilic ELP diblock copolymers, show great potential as drug delivery systems due to their biodegradability and the ability to control particle design. The cargo can be shielded inside the micelle core or reside in the corona through site-specific attachment to the hydrophobic or hydrophilic block of the ELP. Various types of cargo, including protein, peptide, and small molecule drugs, can be loaded onto or entrapped inside the micelles.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Multidisciplinary
Yun Liu, Guangze Yang, Yue Hui, Supun Ranaweera, Chun-Xia Zhao
Summary: Nanoparticles (NPs) have gained significant interest in drug delivery, and microfluidics shows promise in their precise control and manufacturing. The successful use of microfluidic NPs in mRNA vaccines represents a major milestone and demonstrates the feasibility of industrial-scale production. This article provides a critical review of recent progress in microfluidic NPs for drug delivery, including the synthesis of organic and inorganic NPs, and their various applications.
Article
Chemistry, Multidisciplinary
Yaxuan Zhao, Kai Feng, Guojun Lei, Jingjing Shen, Yang Liu, Yiling Ruan, Xiaolian Sun
Summary: This study constructs a nanosystem for the sequential release of TRAIL and GOx to achieve synergistic cancer treatment. The nanosystem can quickly release TRAIL to induce tumor cell apoptosis and enhance the cellular uptake of the cores. It can also release GOx to trigger a cascade reaction to generate free radicals for tumor inhibition. Experimental results demonstrate the separate delivery of TRAIL and GOx and their remarkable synergistic anti-cancer effect.
Article
Polymer Science
Wei Chen, Peng Liu
Summary: Unimolecular micelles, as drug delivery systems, have attracted attention due to their stability. By designing GSH-triggered disintegrable dendritic polyurethane, drug leakage during circulation can be minimized and tumor-specific chemotherapy can be achieved.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Hannah C. Zierden, Rachel L. Shapiro, Kevin DeLong, Davell M. Carter, Laura M. Ensign
Summary: Preterm birth is defined as delivery before 37 weeks of gestation, with 15 million infants born prematurely globally each year, increasing the risk of mortality and health challenges. While the only FDA approved therapy for preventing preterm birth in the U.S. has faced recent setbacks, interdisciplinary efforts are underway to develop next generation therapies to prevent preterm birth and save infant lives. This research aims to better identify women at risk for preterm birth, prevent premature labor, and ultimately improve outcomes for newborns.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Polymer Science
Julio C. Cuggino, Matias L. Picchio, Agustina Gugliotta, Milagros Burgi, Ludmila Ronco, Marcelo Calderon, Marina Etcheverrigaray, Cecilia I. Alvarez Igarzabal, Roque J. Minari, Luis M. Gugliotta
Summary: Nanomedicine for cancer therapy has shown success in reducing the side effects of chemotherapeutics like paclitaxel through the use of alternative nanocarriers. Casein micelles, a low-cost protein, can efficiently encapsulate PTX and be used as promising nanoformulations for cancer therapy. The chemically crosslinked casein micelles present a potential candidate for parenteral administration with passive targeting and controlled drug release in tumor microenvironment.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Fangyu Yang, Jianjiang Xue, Guixue Wang, Qizhi Diao
Summary: Cardiovascular disease is a common health problem worldwide, and current pharmaceutical treatment is suboptimal. Nanoparticle-based drug delivery systems have shown significant therapeutic effects and offer a safer and more effective strategy for the treatment of cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Filippo Prencipe, Carlo Diaferia, Filomena Rossi, Luisa Ronga, Diego Tesauro
Summary: Precision medicine relies on innovative management methods for active components, delivering drugs to specific tissues to enhance therapeutic effects and reduce side effects. Utilizing drug-encapsulated micelles for active targeting marks a new frontier in precision medicine. By decorating micelles with targeting bioactive moieties like peptides, it is possible to direct drugs towards a range of molecular targets, particularly on cancer cells and vasculature.
Article
Multidisciplinary Sciences
Hongjun Li, Zejun Wang, Zhaowei Chen, Tianyuan Ci, Guojun Chen, Di Wen, Ruoxin Li, Jinqiang Wang, Huan Meng, R. Bryan Bell, Zhifeng Gu, Gianpietro Dotti, Zhen Gu
Summary: The authors of the study show that disrupting tumor vasculature could recruit and activate anti-PD-L1 engineered platelets at metastatic tumor sites to block the PD-1/PD-L1 crosstalk and enhance the anticancer immunotherapy.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Takuro Shirasu, Nisakorn Yodsanit, Xiujie Xie, Yi Zhao, Yuyuan Wang, Ruosen Xie, Yitao Huang, Bowen Wang, Go Urabe, Shaoqin Gong, Lian-Wang Guo, K. Craig Kent
Summary: A new modality of directly painting drug-loaded unimolecular micelles to the adventitia has been developed to mitigate postoperative intimal hyperplasia, showing pronounced therapeutic effect without obvious toxicity, offering a promising approach for anti-stenosis therapy in open vascular reconstructions.
Article
Multidisciplinary Sciences
Hongjun Li, Zejun Wang, Edikan Archibong, Qing Wu, Guojun Chen, Quanyin Hu, Tianyuan Ci, Zhaowei Chen, Jinqiang Wang, Di Wen, Hongwei Du, Jie Jiang, Jie Sun, Xingcai Zhang, Gianpietro Dotti, Zhen Gu
Summary: A porous microneedle patch is used to load CAR T cells and escort them to solid tumors, breaking the physical barrier without losing cellular activity. This patch offers a transformative platform for scattered seeding of living cells for treating various tumors.
NATIONAL SCIENCE REVIEW
(2022)
Article
Chemistry, Multidisciplinary
Ruosen Xie, Xiuxiu Wang, Yuyuan Wang, Mingzhou Ye, Yi Zhao, Brian S. Yandell, Shaoqin Gong
Summary: This study reports the development of a facilely fabricated pH-responsive polymer nanoparticle for safe and efficient delivery of CRISPR-associated protein 9 (Cas9) for gene editing. These nanoparticles possess many desirable properties, making them potential candidates for clinical applications in genome editing.
ADVANCED MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Zhitong Chen, Guojun Chen, Richard Obenchain, Rui Zhang, Fan Bai, Tianxu Fang, Hanwen Wang, Yingjie Lu, Richard E. Wirz, Zhen Gu
Summary: This article introduces the delivery methods of cold atmospheric plasma (CAP) in biomedical applications, such as sterilization, wound healing, and cancer therapy. It also presents the future research needs in this field, providing insights for researchers from various disciplines.
Article
Nanoscience & Nanotechnology
Mingzhou Ye, Yi Zhao, Yuyuan Wang, Ruosen Xie, Yao Tong, John-Demian Sauer, Shaoqin Gong
Summary: Researchers have developed NAD-loaded nanoparticles that can effectively replenish energy, suppress inflammation, and improve multiorgan injuries, providing an innovative and translational approach to treat sepsis efficiently.
NATURE NANOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Tianxu Fang, Xiaona Cao, Mysha Ibnat, Guojun Chen
Summary: The CRISPR-Cas9 technology has revolutionized genome editing, showing great potential for treating currently incurable diseases. Efficient intracellular delivery of CRISPR-Cas9 components has been a major focus for expanding the impact of this technology. Stimuli-responsive non-viral delivery systems have been explored for their safety and controllable properties in genome editing. In this review, recent advances in stimuli-responsive nanoformulations for CRISPR-Cas9 delivery are discussed, along with their rationale and biomedical applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qian Chen, Zhisheng Xiao, Chao Wang, Guojun Chen, Yuqi Zhang, Xudong Zhang, Xiao Han, Jinqiang Wang, Xiao Ye, Mark R. Prausnitz, Song Li, Zhen Gu
Summary: A glucose-responsive insulin delivery microneedle array patch has been developed to achieve rapid release of insulin under high blood glucose conditions, effectively controlling blood glucose levels and avoiding hypoglycemia.
Review
Pharmacology & Pharmacy
Xiaona Cao, Guojun Chen
Summary: This review provides an overview of recent advances in microneedle technology for non-transdermal applications, with a particular focus on its applications in ocular, vascular, oral, mucosal, and cancer tissues. The improved design of microneedles has expanded their potential for non-transdermal applications.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yingjie Lu, Huanyu Song, Fan Bai, Long Li, Qiu Wang, Guojun Chen, Zhitong Chen
Summary: This review discusses the various mechanisms behind the use of cold atmospheric plasma (CAP) as an anticancer treatment, including apoptosis, bystander effect, ferroptosis, DNA damage, cell cycle arrest, amino acid modification, calreticulin exposure, and immune cell maturation. The review also addresses the drawbacks and future prospects of CAP treatment.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2022)
Article
Engineering, Biomedical
Jeanette M. Metzger, Yuyuan Wang, Samuel S. Neuman, Kathy J. Snow, Stephen A. Murray, Cathleen M. Lutz, Viktoriya Bondarenko, Jesi Felton, Kirstan Gimse, Ruosen Xie, Dongdong Li, Yi Zhao, Matthew T. Flowers, Heather A. Simmons, Subhojit Roy, Krishanu Saha, Jon E. Levine, Marina E. Emborg, Shaoqin Gong
Summary: Genome editing of somatic cells using CRISPR offers hope for treating genetic disorders, including neurological diseases. However, the complex brain parenchyma and post-mitotic state of neurons pose challenges for efficient editing. Our study developed non-viral and biodegradable PEGylated nanocapsules that successfully delivered Cas9-sgRNA ribonucleoproteins to neurons in the mouse brain, resulting in safe and efficient genome editing.
Article
Chemistry, Multidisciplinary
Di Wen, Tingxizi Liang, Guojun Chen, Hongjun Li, Zejun Wang, Jinqiang Wang, Ruxing Fu, Xiao Han, Tianyuan Ci, Yuqi Zhang, Peter Abdou, Ruoxin Li, Linlin Bu, Gianpietro Dotti, Zhen Gu
Summary: This study reveals that tumor-associated adipocytes can recruit monocytes and promote their differentiation into tumor-associated macrophages, thus supporting tumor growth. By engineering these cells, TAMs can be polarized into the tumor-suppressive M1 phenotype. This study also demonstrates that loading a toll-like receptor agonist into lipid droplets of adipocytes can enhance immune response and suppress tumor growth.
Article
Nanoscience & Nanotechnology
Min Zhu, Xiuxiu Wang, Ruosen Xie, Yuyuan Wang, Xianghui Xu, Jacobus Burger, Shaoqin Gong
Summary: This study presents a lipopeptide-based nanoparticle (LNP) that can efficiently deliver CRISPR Cas9/sgRNA ribonucleoprotein (RNP) for genome editing both in vitro and in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Materials Science, Biomaterials
Han Zhang, Jiafei Zhu, Tianxu Fang, Meng Li, Guojun Chen, Qian Chen
Summary: Cancer immunotherapy has achieved promising clinical results, but there are still limitations. Engineering biomaterials to deliver immunotherapeutic reagents has been suggested as an effective strategy to improve cancer immunotherapy. Supramolecular biomaterials with flexible and versatile structures and functions have demonstrated unparalleled advantages in promoting cancer immunotherapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Materials Science, Multidisciplinary
Pooyan Makvandi, Aziz Maleki, Majid Shabani, Aaron R. J. Hutton, Melissa Kirkby, Rezvan Jamaledin, Tianxu Fang, Jiahuan He, Jesse Lee, Barbara Mazzolai, Ryan F. Donnelly, Franklin R. Tay, Guojun Chen, Virgilio Mattoli
Summary: This review discusses the biomimetic design, fabrication methods, and medical applications of bioinspired microneedles (BMNs), highlighting their potential in drug delivery, regenerative medicine, and other fields, as well as the future opportunities and challenges in clinical translation.
