Article
Oncology
Quan Quan, Hui Peng, Sainan Gong, Jiali Liu, Yunfeng Lu, Rongsheng Chen, Xiaoling Mu
Summary: This study evaluated the role of the apparent diffusion coefficient (ADC) value in the individualized management of stage I endometrial carcinoma (EC). Lower ADC values were associated with higher grades, specific histological subtypes, and deeper myometrial invasion. Additionally, patients with higher ADC values showed better disease-free survival and overall survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Xiaoliang Ma, Limin Xu, Fenghua Ma, Jialiang Zhang, Guofu Zhang, Jinwei Qiang
Summary: This study investigated the application of whole-tumor ADC histogram metrics for preoperative risk stratification in endometrial endometrioid adenocarcinoma (EEA). The findings suggest that these metrics can be helpful in identifying low- and (low + intermediate)-risk EEA, facilitating personalized therapeutic planning.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jian Wang, Chao Ma, Panpan Yang, Zhen Wang, Yufei Chen, Yun Bian, Chengwei Shao, Jianping Lu
Summary: This study investigated the effects of gradient nonlinearity (GNL) in abdominal apparent diffusion coefficient (ADC) measurements and developed a bias correction procedure. The results showed the presence of ADC bias and successfully corrected it using the proposed method. This study highlights the importance of considering GNL in ADC measurements in the abdomen.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Quan Quan, Yunfeng Lu, Beibei Xuan, Jingxian Wu, Wanchun Yin, Yi Hua, Rongsheng Chen, Siling Ren, Shuwei Zhou, Fenfen Zhang, Yu Meng, Kunying Rao, Xiaoling Mu
Summary: This study found that ADC values can be used to assess high-risk factors of EC before treatment and are significantly related to the prognosis of EC. It suggests that ADC values may contribute to managing personalized treatment schedules and improving outcomes in EC patients.
Article
Medicine, General & Internal
Yiang Wang, Mengge He, Peng Cao, Philip P. C. Ip, Chien-Yuan Lin, Weiyin Liu, Chia-Wei Lee, Elaine Y. P. Lee
Summary: This study investigated the association of T1, T2, proton density (PD), and the apparent diffusion coefficient (ADC) with histopathologic features of endometrial carcinoma (EC) using synthetic magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI). The results showed that low T2, PD, and ADC were associated with aggressive histopathologic features of EC.
Article
Medicine, Research & Experimental
Dan Costachescu, Ioana Ionita, Ema-Cristina Borsi, Ovidiu Potre, Cristina Potre, Dan-Bogdan Navolan, Alexandru Blidisel, Hortensia Ionita, Adelina Erimescu, Gheorghe Nicusor Pop, Daniel Claudiu Malita
Summary: In this study, it was found that ADC values measured in newly diagnosed MM patients were inversely correlated with disease progression and survival time, with higher ADC values indicating shorter survival. Bortezomib therapy was also identified as a predictor of increased survival length. The study also highlighted the importance of using MRI for detecting bone marrow infiltration and assessing prognostic factors in MM.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Zanxia Zhang, Jie Liu, Weijian Wang, Yong Zhang, Feifei Qu, Tom Hilbert, Tobias Kober, Jingliang Cheng, Shujian Li, Jinxia Zhu
Summary: This study aimed to determine the quantitative T2 values in endometrial carcinoma (EMC) and evaluate their potential for detection, classification, and grading. The results showed significantly lower T2 values in EMC compared to normal endometrium. T2 values could differentiate different pathological features of EMC, while ADC values could not. Combining T2 and ADC values improved the prediction of histological grades in endometrioid adenocarcinoma (EA).
FRONTIERS IN ONCOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Maja Bruvo, Faisal Mahmood
Summary: There is discrepancy in reported ADC values of the parotid gland, with factors such as gustatory stimulation, diffusion weighting factors, and timing of follow-up after radiotherapy influencing the measurements. Interestingly, the choice of regions of interest may not affect the ADC measurements.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao-qian Chen, Bang-guo Tan, Min Xu, Hai-ying Zhou, Jing Ou, Xiao-ming Zhang, Zi-yi Yu, Tian-wu Chen
Summary: This study evaluated the feasibility of using ADC at different b-values to differentiate tumor, tumor-adjacent tissue and tumor-distant tissue in rectal adenocarcinoma. The results showed that ADC could effectively differentiate between these tissues.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qian Chen, Shu Fang, Yuchen Yang, Ruokun Li, Rong Deng, Yongjun Chen, Di Ma, Huimin Lin, Fuhua Yan
Summary: This study investigated the effect of deep learning reconstruction (DLR) on image quality and apparent diffusion coefficient (ADC) quantification of liver diffusion-weighted imaging (DWI) at 3 Tesla. The results showed that DLR improved image quality of liver DWI, with higher qualitative scores, SNRs, CNRs, and boundary sharpness in the DLR group compared to the non-DLR group. DLR reduced the ADC value of malignant tumors, but did not affect the diagnostic performance of ADC in distinguishing malignant tumors on a 3.0-T MRI system. The phantom experiment confirmed the impact of DLR on ADC in images with low resolution and heterogeneous structures.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Oncology
Baohong Wen, Zanxia Zhang, Jing Zhu, Liang Liu, Yinhua Li, Haoyu Huang, Yong Zhang, Jingliang Cheng
Summary: The study utilized radiomics features based on ADC maps to accurately stratify parotid gland tumors, aiding clinicians in distinguishing PA and WT from MTs.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Annemarie K. Knill, Matthew D. Blackledge, Andra Curcean, James Larkin, Samra Turajlic, Angela Riddell, Dow Mu Koh, Christina Messiou, Jessica M. Winfield
Summary: This study aims to establish the optimal diffusion weighting (b-value) for whole-body diffusion-weighted MRI (WB-DWI) to estimate the apparent diffusion coefficient (ADC) in patients with metastatic melanoma (MM). The results suggest that the optimal high b-value is 1100 s/mm(2) and higher b-values lead to increased geometric distortion and reduced signal.
EUROPEAN RADIOLOGY
(2023)
Article
Health Care Sciences & Services
Ana Sofia Linhares Moreira, Vera Ribeiro, Giacomo Aringhieri, Salvatore Claudio Fanni, Lorenzo Tumminello, Lorenzo Faggioni, Dania Cioni, Emanuele Neri
Summary: This study aimed to assess the predictive value of apparent diffusion coefficient (ADC) measurements in determining the histological grade of endometrial cancer. The findings showed that ADC values were not effective in predicting the grade of endometrial cancer, despite good agreement between MRI interpretation and histopathology in staging the cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Yang Peng, Yan Luo, Xuemei Hu, Yaqi Shen, Daoyu Hu, Zhen Li, Ihab Kamel
Summary: The study found a positive correlation between R2* values and several histopathological prognostic factors of rectal cancer, while ADC values were negatively correlated with most prognostic factors. R2* and ADC showed a high diagnostic performance in discriminating prognostic factors of rectal cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yasuo Takatsu, Masafumi Nakamura, Yuichi Suzuki, Tosiaki Miyati
Summary: The position dependence of the apparent diffusion coefficient (ADC) in MRI using EPI-DWI and TSE-DWI was assessed by studying phantoms. It was found that ADC decreases with an increase in distance from the magnetic field center, and the signal-to-noise ratio (SNR) varies significantly at different positions for both sequences. Therefore, caution should be taken when comparing and quantitatively evaluating ADC at different sites in the long-axis direction.
MAGNETIC RESONANCE IMAGING
(2023)